The network for 'retinal metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retinal metabolic process

The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.

NameDescriptionProbabilityFunc Analog Organism
Foxc1forkhead box C10.330
Rargretinoic acid receptor, gamma0.208
Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 10.134
Wnt5awingless-related MMTV integration site 5A0.122
Tcfap2atranscription factor AP-2, alpha0.116
Foxc2forkhead box C20.096
Aldh1a7aldehyde dehydrogenase family 1, subfamily A70.078
MecomMDS1 and EVI1 complex locus0.064
Aadacarylacetamide deacetylase (esterase)0.059
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.056
Ednraendothelin receptor type A0.054
Lratlecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)0.049
Cps1carbamoyl-phosphate synthetase 10.048
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.048
Hrghistidine-rich glycoprotein0.042
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.040
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.039
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.038
C9complement component 90.037
C1qtnf5C1q and tumor necrosis factor related protein 50.036
Rarbretinoic acid receptor, beta0.034
Nrp1neuropilin 10.033
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.032
Akr1c6aldo-keto reductase family 1, member C60.030
Mbl1mannose-binding lectin (protein A) 10.028
Aadataminoadipate aminotransferase0.028
Gsta3glutathione S-transferase, alpha 30.028
Rdh16retinol dehydrogenase 160.028
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.026
Rdh10retinol dehydrogenase 10 (all-trans)0.024
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.023
Fbln1fibulin 10.023
Hand2heart and neural crest derivatives expressed transcript 20.023
Slc17a1solute carrier family 17 (sodium phosphate), member 10.023
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.021
Car5acarbonic anhydrase 5a, mitochondrial0.021
G6pcglucose-6-phosphatase, catalytic0.020
Bmp4bone morphogenetic protein 40.019
Acox2acyl-Coenzyme A oxidase 2, branched chain0.018
Dmgdhdimethylglycine dehydrogenase precursor0.017
Cyp2d12cytochrome P450, family 2, subfamily d, polypeptide 120.017
Mbl2mannose-binding lectin (protein C) 20.016
Nr1i3nuclear receptor subfamily 1, group I, member 30.016
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.016
Inmtindolethylamine N-methyltransferase0.016
Mesp1mesoderm posterior 10.016
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.016
Ece1endothelin converting enzyme 10.016
Sgk2serum/glucocorticoid regulated kinase 20.015
Ces1ccarboxylesterase 1C0.015
Cdhr5cadherin-related family member 50.015
Apohapolipoprotein H0.015
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.015
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.014
Pon1paraoxonase 10.014
Acsm3acyl-CoA synthetase medium-chain family member 30.014
Agxtalanine-glyoxylate aminotransferase0.013
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.013
Nme5non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)0.013
Apoc4apolipoprotein C-IV0.013
Acsm1acyl-CoA synthetase medium-chain family member 10.012
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.012
Tattyrosine aminotransferase0.012
Aqp8aquaporin 80.012
Ch25hcholesterol 25-hydroxylase0.012
Fmn1formin 10.012
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.011
Fgfr2fibroblast growth factor receptor 20.011
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.011
Habp2hyaluronic acid binding protein 20.011
Chd7chromodomain helicase DNA binding protein 70.011
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.011
Uoxurate oxidase0.010
Slc22a1solute carrier family 22 (organic cation transporter), member 10.010
F9coagulation factor IX0.010
C4bpcomplement component 4 binding protein0.010
Sirt3sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)0.010
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
aldh1a2aldehyde dehydrogenase 1 family, member A20.922
tbx1T-box 10.275
dctdopachrome tautomerase0.169
gata5GATA-binding protein 50.119
foxa3forkhead box A30.096
hnf1baHNF1 homeobox Ba0.087
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.087
ntlano tail a0.080
hand2heart and neural crest derivatives expressed transcript 20.069
wnt3awingless-type MMTV integration site family, member 3A0.063
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.063
dhrs3adehydrogenase/reductase (SDR family) member 3a0.063
nr5a5nuclear receptor subfamily 5, group A, member 50.061
rgrbretinal G protein coupled receptor b0.060
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.059
pax3apaired box gene 3a0.058
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.056
restRE1-silencing transcription factor0.051
rasl11bRAS-like, family 11, member B0.048
cdx4caudal type homeo box transcription factor 40.046
edn1endothelin 10.043
crabp2acellular retinoic acid binding protein 2, a0.042
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.042
nkx2.5NK2 transcription factor related 50.040
srd5a2asteroid-5-alpha-reductase, alpha polypeptide 2a0.040
fgf8afibroblast growth factor 8 a0.037
furinbfurin (paired basic amino acid cleaving enzyme) b0.037
hprt1hypoxanthine phosphoribosyltransferase 10.037
wnt11wingless-type MMTV integration site family, member 110.037
stra6stimulated by retinoic acid gene 6 homolog (mouse)0.036
ncf1neutrophil cytosolic factor 10.035
tyrp1btyrosinase-related protein 1b0.035
fn1fibronectin 10.032
apoebapolipoprotein Eb0.032
krt18keratin 180.032
osr1odd-skipped related 1 (Drosophila)0.030
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.030
fgf24fibroblast growth factor 240.029
tbx5aT-box 5a0.029
bmp2bbone morphogenetic protein 2b0.029
egr1early growth response 10.028
agxtaalanine-glyoxylate aminotransferase a0.027
lgals9l1lectin, galactoside-binding, soluble, 9 (galectin 9)-like 10.026
adra2badrenergic, alpha-2B-, receptor0.026
cyp1acytochrome P450, family 1, subfamily A0.025
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.025
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.025
prdm16PR domain containing 160.025
smoc1SPARC related modular calcium binding 10.024
tbpTATA box binding protein0.024
gcgaglucagon a and glucagon a-like0.024
lmo4aLIM domain only 4a0.024
hspb1heat shock protein, alpha-crystallin-related, 10.024
slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.023
faddFas (tnfrsf6)-associated via death domain0.023
her1hairy-related 10.022
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.022
tp53tumor protein p530.022
pcdh18bprotocadherin 18b0.021
slc3a2solute carrier family 3, member 20.020
nme4non-metastatic cells 4, protein expressed in0.020
acta2actin, alpha 2, smooth muscle, aorta0.020
arl3l2ADP-ribosylation factor-like 3, like 20.019
flrt3fibronectin leucine rich transmembrane 30.019
cyp51cytochrome P450, family 510.019
tbx2bT-box 2b0.019
ocrloculocerebrorenal syndrome of Lowe0.018
prdm1aPR domain containing 1a, with ZNF domain0.018
foxl1forkhead box L10.018
LOC100001321hypothetical protein LOC1000013210.018
cdk7cyclin-dependent kinase 70.017
slc31a1solute carrier family 31 (copper transporters), member 10.017
rgs4regulator of G-protein signalling 40.016
mpp1membrane protein, palmitoylated 10.016
ppp1r3caprotein phosphatase 1, regulatory (inhibitor) subunit 3Ca0.016
kdrlkinase insert domain receptor like0.016
lbx2ladybird homeobox homolog 2 (Drosophila)0.015
esrraestrogen-related receptor alpha0.015
bcdo2lbeta-carotene 15, 15-dioxygenase 2, like0.015
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.015
meis3myeloid ecotropic viral integration site 30.015
rbp7bretinol binding protein 7b, cellular0.015
oepone-eyed pinhead0.015
slmo2slowmo homolog 2 (Drosophila)0.015
chst11carbohydrate (chondroitin 4) sulfotransferase 110.015
pmelbpremelanosome protein b0.014
itgb1b.1integrin, beta 1b.10.014
acsl4aacyl-CoA synthetase long-chain family member 4a0.014
ctsccathepsin C0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
GstE6Glutathione S transferase E60.024
NacalphaNascent polypeptide associated complex protein alpha subunit0.020
CG2852CG2852 gene product from transcript CG2852-RA0.014
CG15754CG15754 gene product from transcript CG15754-RA0.011
retinophilinCG10233 gene product from transcript CG10233-RA0.011
CG17597CG17597 gene product from transcript CG17597-RA0.011
CG11151CG11151 gene product from transcript CG11151-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.997
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.994
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.962
ALDH1A1aldehyde dehydrogenase 1 family, member A10.101
ALDH2aldehyde dehydrogenase 2 family (mitochondrial)0.063
PEX14peroxisomal biogenesis factor 140.044
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.032
ZHX1zinc fingers and homeoboxes 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyb5acytochrome b5 type A (microsomal)0.746
Tuba1ctubulin, alpha 1C0.411
Cyp2j4cytochrome P450, family 2, subfamily j, polypeptide 40.153
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.143
Ephx1epoxide hydrolase 1, microsomal0.135
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.130
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.112
Dad1defender against cell death 10.110
Pgam1phosphoglycerate mutase 1 (brain)0.103
Mgst1microsomal glutathione S-transferase 10.103
Hadhhydroxyacyl-Coenzyme A dehydrogenase0.098
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.095
Dpyddihydropyrimidine dehydrogenase0.091
Akr1c14aldo-keto reductase family 1, member C140.086
Mosc1MOCO sulphurase C-terminal domain containing 10.084
Fahfumarylacetoacetate hydrolase0.084
Mgst2microsomal glutathione S-transferase 20.082
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.082
Ube2fubiquitin-conjugating enzyme E2F (putative)0.082
Acp2acid phosphatase 2, lysosomal0.081
Rpn1ribophorin I0.080
Akr1c12aldo-keto reductase family 1, member C120.080
Fmo2flavin containing monooxygenase 20.078
Rplp2ribosomal protein, large P20.077
Fmo3flavin containing monooxygenase 30.073
Decr22,4-dienoyl CoA reductase 2, peroxisomal0.072
Gstp1glutathione S-transferase pi 10.069
Dpm2dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit0.069
Eci1enoyl-Coenzyme A delta isomerase 10.068
Adh1alcohol dehydrogenase 1 (class I)0.063
LOC100360843ribosomal protein S19-like0.059
Aldh6a1aldehyde dehydrogenase 6 family, member A10.055
Dapk3death-associated protein kinase 30.055
Ptgr1prostaglandin reductase 10.053
Slc22a18solute carrier family 22, member 180.053
Slc35b1solute carrier family 35, member B10.053
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.053
Slc40a1solute carrier family 39 (iron-regulated transporter), member 10.052
Obp3alpha-2u globulin PGCL40.049
Akr1c19aldo-keto reductase family 1, member C190.048
Pkhd1l1polycystic kidney and hepatic disease 1-like 10.048
Mettl7amethyltransferase like 7A0.048
Gstm2glutathione S-transferase mu 20.042
Tas2r105taste receptor, type 2, member 1050.042
Rpn2ribophorin II0.042
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.042
Mosc2MOCO sulphurase C-terminal domain containing 20.042
Fmo1flavin containing monooxygenase 10.041
Selenbp1selenium binding protein 10.041
Cyp27a1cytochrome P450, family 27, subfamily a, polypeptide 10.041
Ppargperoxisome proliferator-activated receptor gamma0.041
PCOLCE2procollagen C-endopeptidase enhancer 20.041
Fabp12fatty acid binding protein 120.040
Slc5a7solute carrier family 5 (choline transporter), member 70.038
Bbox1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 10.038
Dpp4dipeptidylpeptidase 40.038
Ghrgrowth hormone receptor0.036
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.036
Rup2urinary protein 20.036
Il7rinterleukin 7 receptor0.036
Bdh23-hydroxybutyrate dehydrogenase, type 20.034
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.034
Ang1angiogenin, ribonuclease A family, member 10.033
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.033
Adfpadipose differentiation related protein0.033
Il15interleukin 150.033
Calm1calmodulin 10.032
Ces1dcarboxylesterase 1D0.032
G6pdglucose-6-phosphate dehydrogenase0.032
Asgr2asialoglycoprotein receptor 20.031
Xpnpep2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.031
Copz1coatomer protein complex, subunit zeta 10.030
Bphlbiphenyl hydrolase-like (serine hydrolase)0.030
Mup5major urinary protein 50.029
Cyp2c7cytochrome P450, family 2, subfamily c, polypeptide 70.029
Nqo1NAD(P)H dehydrogenase, quinone 10.029
Gsta3glutathione S-transferase A30.028
Rarres1retinoic acid receptor responder (tazarotene induced) 10.028
Slco1b3solute carrier organic anion transporter family, member 1b30.028
Kbtbd3kelch repeat and BTB (POZ) domain containing 30.028
Cd36CD36 molecule (thrombospondin receptor)0.027
Tmem66transmembrane protein 660.026
Nqo2NAD(P)H dehydrogenase, quinone 20.026
Tysnd1trypsin domain containing 10.026
PVRpoliovirus receptor0.026
Nat1N-acetyltransferase 10.025
Pex11aperoxisomal biogenesis factor 11 alpha0.025
Otcornithine carbamoyltransferase0.025
Anxa2annexin A20.025
Ephx2epoxide hydrolase 2, cytoplasmic0.025
Gcdhglutaryl-Coenzyme A dehydrogenase0.024
Ttpatocopherol (alpha) transfer protein0.024
Ces1fcarboxylesterase 1F0.024
RGD1309534similar to RIKEN cDNA 4931406C070.024
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism