The network for 'negative regulation of t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of t cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.

NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 31.000
Foxp3forkhead box P30.998
Gli2GLI-Kruppel family member GLI20.961
Socs1suppressor of cytokine signaling 10.921
Il6stinterleukin 6 signal transducer0.807
Cd40CD40 antigen0.782
Bcl3B-cell leukemia/lymphoma 30.766
H2-Ab1histocompatibility 2, class II antigen A, beta 10.749
Stat6signal transducer and activator of transcription 60.727
Ifnginterferon gamma0.721
Jak2Janus kinase 20.718
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.717
Casp4caspase 4, apoptosis-related cysteine peptidase0.716
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.707
Batfbasic leucine zipper transcription factor, ATF-like0.680
Nf1neurofibromatosis 10.680
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.677
Cd80CD80 antigen0.663
Ltalymphotoxin A0.626
Tnftumor necrosis factor0.621
Myd88myeloid differentiation primary response gene 880.609
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.591
H2-Aahistocompatibility 2, class II antigen A, alpha0.567
Icosinducible T-cell co-stimulator0.550
Lyz2lysozyme 20.545
Tlr4toll-like receptor 40.535
Ticam1toll-like receptor adaptor molecule 10.525
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.516
Zeb1zinc finger E-box binding homeobox 10.514
Stat1signal transducer and activator of transcription 10.503
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.496
Stat2signal transducer and activator of transcription 20.487
Ccr7chemokine (C-C motif) receptor 70.466
Pdcd1programmed cell death 10.439
FasFas (TNF receptor superfamily member 6)0.437
Ren1renin 1 structural0.413
H2-DMahistocompatibility 2, class II, locus DMa0.411
Ptpn11protein tyrosine phosphatase, non-receptor type 110.410
Fcgr2bFc receptor, IgG, low affinity IIb0.410
Il1binterleukin 1 beta0.406
Clec4dC-type lectin domain family 4, member d0.394
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.382
Rb1retinoblastoma 10.370
Ikzf1IKAROS family zinc finger 10.367
Irf1interferon regulatory factor 10.366
Il27rainterleukin 27 receptor, alpha0.331
Irf4interferon regulatory factor 40.330
Tnfaip3tumor necrosis factor, alpha-induced protein 30.330
Itgb2integrin beta 20.315
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.314
Neurog3neurogenin 30.313
Cd28CD28 antigen0.308
Stat5asignal transducer and activator of transcription 5A0.308
Cd5CD5 antigen0.306
TcrdT-cell receptor delta chain0.298
Prf1perforin 1 (pore forming protein)0.293
Il2rbinterleukin 2 receptor, beta chain0.291
Birc3baculoviral IAP repeat-containing 30.285
Cd4CD4 antigen0.282
Tgfb1transforming growth factor, beta 10.282
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.275
Dlg4discs, large homolog 4 (Drosophila)0.267
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.267
Jak1Janus kinase 10.265
Clec4eC-type lectin domain family 4, member e0.261
Hif1ahypoxia inducible factor 1, alpha subunit0.259
Tbx21T-box 210.256
Ptch1patched homolog 10.252
Ciitaclass II transactivator0.245
Ifnar1interferon (alpha and beta) receptor 10.238
Prkcdprotein kinase C, delta0.229
Ccl24chemokine (C-C motif) ligand 240.226
Ifnar2interferon (alpha and beta) receptor 20.223
Il10rainterleukin 10 receptor, alpha0.220
Foxp1forkhead box P10.219
H2-Eb1histocompatibility 2, class II antigen E beta0.216
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.215
Ifnb1interferon beta 1, fibroblast0.215
Foxc1forkhead box C10.214
Hhexhematopoietically expressed homeobox0.214
Nlrp3NLR family, pyrin domain containing 30.212
Ptprcprotein tyrosine phosphatase, receptor type, C0.209
Batf3basic leucine zipper transcription factor, ATF-like 30.203
Pthlhparathyroid hormone-like peptide0.199
Twist2twist homolog 2 (Drosophila)0.193
Cd209bCD209b antigen0.193
Il2interleukin 20.192
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.190
Cd14CD14 antigen0.186
Bdkrb2bradykinin receptor, beta 20.185
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.185
Sufusuppressor of fused homolog (Drosophila)0.184
Pstpip2proline-serine-threonine phosphatase-interacting protein 20.175
Lag3lymphocyte-activation gene 30.175
Nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.175
Egfrepidermal growth factor receptor0.174
Rag1recombination activating gene 10.172
Map3k14mitogen-activated protein kinase kinase kinase 140.167
Il6interleukin 60.166
Socs5suppressor of cytokine signaling 50.160
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Bmajor histocompatibility complex, class I, B0.908
B2Mbeta-2-microglobulin0.879
CD80CD80 molecule0.548
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.505
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.494
PTPN6protein tyrosine phosphatase, non-receptor type 60.353
HLA-Fmajor histocompatibility complex, class I, F0.338
HLA-DMBmajor histocompatibility complex, class II, DM beta0.263
HLA-Gmajor histocompatibility complex, class I, G0.249
PILRApaired immunoglobin-like type 2 receptor alpha0.165
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.157
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.136
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.121
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.114
HLA-Emajor histocompatibility complex, class I, E0.109
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.100
BMPR1Abone morphogenetic protein receptor, type IA0.100
CCL4chemokine (C-C motif) ligand 40.085
HLA-DRB5major histocompatibility complex, class II, DR beta 50.079
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.078
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.077
IL4Rinterleukin 4 receptor0.075
CCR5chemokine (C-C motif) receptor 50.068
HLA-DRB4major histocompatibility complex, class II, DR beta 40.065
IL2RGinterleukin 2 receptor, gamma0.064
CASP9caspase 9, apoptosis-related cysteine peptidase0.064
CXCL9chemokine (C-X-C motif) ligand 90.063
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.062
ICAM1intercellular adhesion molecule 10.060
HLA-DPB1major histocompatibility complex, class II, DP beta 10.059
FSTL1follistatin-like 10.053
CD86CD86 molecule0.052
HLA-Cmajor histocompatibility complex, class I, C0.045
XIAPX-linked inhibitor of apoptosis0.043
HK3hexokinase 3 (white cell)0.041
HLA-Amajor histocompatibility complex, class I, A0.040
LATlinker for activation of T cells0.038
CD247CD247 molecule0.038
RNF11ring finger protein 110.037
ADAM17ADAM metallopeptidase domain 170.036
SIGLEC7sialic acid binding Ig-like lectin 70.036
CXCL10chemokine (C-X-C motif) ligand 100.035
TRAF1TNF receptor-associated factor 10.035
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.035
CCR7chemokine (C-C motif) receptor 70.034
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.033
CD40CD40 molecule, TNF receptor superfamily member 50.032
CCL8chemokine (C-C motif) ligand 80.032
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.030
CCL13chemokine (C-C motif) ligand 130.030
IL10interleukin 100.029
CCL5chemokine (C-C motif) ligand 50.029
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.027
EGFRepidermal growth factor receptor0.027
BTN3A1butyrophilin, subfamily 3, member A10.027
APAF1apoptotic peptidase activating factor 10.026
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.026
CCR1chemokine (C-C motif) receptor 10.025
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.025
DPP4dipeptidyl-peptidase 40.024
TFF1trefoil factor 10.024
BIRC3baculoviral IAP repeat containing 30.024
TNFRSF9tumor necrosis factor receptor superfamily, member 90.023
IFNGinterferon, gamma0.022
TAPBPTAP binding protein (tapasin)0.022
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.022
IL4interleukin 40.022
GRAP2GRB2-related adaptor protein 20.021
IDEinsulin-degrading enzyme0.021
LAIR1leukocyte-associated immunoglobulin-like receptor 10.021
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.020
MICAMHC class I polypeptide-related sequence A0.020
VAV1vav 1 guanine nucleotide exchange factor0.020
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.019
NCOR2nuclear receptor corepressor 20.019
CD300CCD300c molecule0.018
CCR4chemokine (C-C motif) receptor 40.018
DRD2dopamine receptor D20.018
CCL2chemokine (C-C motif) ligand 20.017
CXCL11chemokine (C-X-C motif) ligand 110.017
NAMPTnicotinamide phosphoribosyltransferase0.017
CMKLR1chemokine-like receptor 10.016
CFLARCASP8 and FADD-like apoptosis regulator0.016
CD163CD163 molecule0.016
BTN2A2butyrophilin, subfamily 2, member A20.016
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.015
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.015
CD2CD2 molecule0.015
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.015
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.015
APPamyloid beta (A4) precursor protein0.015
C1QBcomplement component 1, q subcomponent, B chain0.014
IL2RAinterleukin 2 receptor, alpha0.014
CCL7chemokine (C-C motif) ligand 70.013
BTN3A3butyrophilin, subfamily 3, member A30.013
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.013
HDAC9histone deacetylase 90.013
INSRinsulin receptor0.013
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.013
SHC1SHC (Src homology 2 domain containing) transforming protein 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.985
RT1-Db1RT1 class II, locus Db10.969
RT1-DMbRT1 class II, locus DMb0.809
RT1-DaRT1 class II, locus Da0.512
RT1-BaRT1 class II, locus Ba0.318
RT1-BbRT1 class II, locus Bb0.202
Cd37CD37 molecule0.075
Cd2Cd2 molecule0.013
Spnsialophorin0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism