The network for 'positive regulation of cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell activation

Any process that activates or increases the frequency, rate or extent of activation.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.999
FasFas (TNF receptor superfamily member 6)0.997
Cd40CD40 antigen0.997
Tnftumor necrosis factor0.984
Cd19CD19 antigen0.982
Tlr4toll-like receptor 40.981
Efnb2ephrin B20.980
Myd88myeloid differentiation primary response gene 880.979
Leprleptin receptor0.967
Il4interleukin 40.963
Map3k14mitogen-activated protein kinase kinase kinase 140.963
Rnf2ring finger protein 20.947
Tnfaip3tumor necrosis factor, alpha-induced protein 30.943
Pax2paired box gene 20.942
Gli2GLI-Kruppel family member GLI20.935
Ltalymphotoxin A0.932
Ccr2chemokine (C-C motif) receptor 20.931
Ccl2chemokine (C-C motif) ligand 20.926
Stat3signal transducer and activator of transcription 30.922
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.918
Cd28CD28 antigen0.898
Ptprcprotein tyrosine phosphatase, receptor type, C0.885
Ccr6chemokine (C-C motif) receptor 60.879
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.872
Rargretinoic acid receptor, gamma0.867
Cd6CD6 antigen0.865
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.860
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.854
Cd44CD44 antigen0.853
Pdcd1programmed cell death 10.847
Socs1suppressor of cytokine signaling 10.845
Lcklymphocyte protein tyrosine kinase0.837
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.834
Stat5bsignal transducer and activator of transcription 5B0.831
Ltblymphotoxin B0.830
Ccr1chemokine (C-C motif) receptor 10.828
Gli3GLI-Kruppel family member GLI30.827
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.818
Icosinducible T-cell co-stimulator0.809
Sox9SRY-box containing gene 90.807
Smad3MAD homolog 3 (Drosophila)0.807
Ciitaclass II transactivator0.805
Jak2Janus kinase 20.805
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.801
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.800
Cd247CD247 antigen0.797
BtkBruton agammaglobulinemia tyrosine kinase0.796
Tgfbr1transforming growth factor, beta receptor I0.793
RybpRING1 and YY1 binding protein0.787
Ccl4chemokine (C-C motif) ligand 40.785
Fgfr2fibroblast growth factor receptor 20.782
Cd86CD86 antigen0.777
Gpr132G protein-coupled receptor 1320.773
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.771
Il1r1interleukin 1 receptor, type I0.746
Il2rbinterleukin 2 receptor, beta chain0.745
Il6interleukin 60.741
Tlr2toll-like receptor 20.735
Ephb2Eph receptor B20.719
H2-Aahistocompatibility 2, class II antigen A, alpha0.713
Map3k8mitogen-activated protein kinase kinase kinase 80.702
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.697
Batfbasic leucine zipper transcription factor, ATF-like0.697
Fgf8fibroblast growth factor 80.670
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.665
Cxcr5chemokine (C-X-C motif) receptor 50.652
Nos3nitric oxide synthase 3, endothelial cell0.644
Ccl17chemokine (C-C motif) ligand 170.643
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.640
C3ar1complement component 3a receptor 10.637
Il10interleukin 100.636
Lyz2lysozyme 20.632
Itgb2integrin beta 20.628
Ifnginterferon gamma0.626
Il4rainterleukin 4 receptor, alpha0.624
Nos2nitric oxide synthase 2, inducible0.622
Emx2empty spiracles homolog 2 (Drosophila)0.622
Pitx1paired-like homeodomain transcription factor 10.618
H2-DMb2histocompatibility 2, class II, locus Mb20.616
Pitx2paired-like homeodomain transcription factor 20.611
Cdh5cadherin 50.600
Fgf10fibroblast growth factor 100.585
Lhx3LIM homeobox protein 30.578
Zeb1zinc finger E-box binding homeobox 10.576
C1qccomplement component 1, q subcomponent, C chain0.575
Fgfr3fibroblast growth factor receptor 30.562
Cd4CD4 antigen0.557
Ccr7chemokine (C-C motif) receptor 70.554
Cd5CD5 antigen0.543
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.541
Il1rninterleukin 1 receptor antagonist0.540
Cd80CD80 antigen0.539
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.536
Gdf3growth differentiation factor 30.532
Cd14CD14 antigen0.529
Ptgs2prostaglandin-endoperoxide synthase 20.529
Efna1ephrin A10.527
Birc3baculoviral IAP repeat-containing 30.525
Hoxd13homeobox D130.525
Clec4nC-type lectin domain family 4, member n0.523
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.572
tlr3toll-like receptor 30.423
ikzf1IKAROS family zinc finger 1 (Ikaros)0.393
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.335
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.275
cdx4caudal type homeo box transcription factor 40.251
eya2eyes absent homolog 2 (Drosophila)0.229
ighzimmunoglobulin heavy constant zeta0.225
il6rinterleukin 6 receptor0.184
lcp1lymphocyte cytosolic plastin 10.174
mmp9matrix metalloproteinase 90.170
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.165
bhlhe40basic helix-loop-helix family, member e400.163
ptch2patched 20.152
tgfb3transforming growth factor, beta 30.145
cd247CD247 antigen0.143
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.136
cxcr4bchemokine (C-X-C motif), receptor 4b0.135
mpxmyeloid-specific peroxidase0.134
epha4aeph receptor A4a0.124
foxd3forkhead box D30.103
igf2ainsulin-like growth factor 2a0.102
kitakit receptor a0.102
efnb3bephrin B3b0.100
arpc1bactin related protein 2/3 complex, subunit 1B0.099
lrrc33leucine rich repeat containing 330.098
bmp2bbone morphogenetic protein 2b0.097
ca2carbonic anhydrase II0.093
cldn5bclaudin 5b0.092
rargaretinoic acid receptor gamma a0.091
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.091
eomesbeomesodermin homolog b0.090
mibmind bomb0.089
cd8aCD8 antigen, alpha polypeptide0.089
spry2sprouty homolog 20.088
nr2f5nuclear receptor subfamily 2, group F, member 50.088
clic2chloride intracellular channel 20.087
tlr18toll-like receptor 180.086
LOC566708FL cytokine receptor-like0.086
lrrc15leucine rich repeat containing 150.085
tlr2toll-like receptor 20.083
crfa31.2IL-4RA-like protein 20.083
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.081
msnamoesin a0.081
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.080
ifng1-2interferon, gamma 1-20.080
abcg2cATP-binding cassette, sub-family G (WHITE), member 2c0.079
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.078
cd247lCD247 antigen like0.078
LOC100003514protein kinase C alpha type-like0.078
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.077
LOC553366hypothetical protein LOC5533660.077
arrb2barrestin, beta 2b0.076
ss18synovial sarcoma translocation, chromosome 18 (H. sapiens)0.076
spns2spinster homolog 2 (Drosophila)0.076
pomt2protein-O-mannosyltransferase 20.075
il7rinterleukin 7 receptor0.075
ptpn6protein tyrosine phosphatase, non-receptor type 60.074
amotl2aangiomotin like 2a0.074
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.074
slc39a1solute carrier family 39 (zinc transporter), member 10.074
bocbrother of CDO0.072
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.071
gmpsguanine monphosphate synthetase0.071
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.070
gpr126G protein-coupled receptor 1260.070
tfectranscription factor EC0.069
stc1lstanniocalcin 1, like0.069
mfsd4amajor facilitator superfamily domain containing 4a0.069
egr2bearly growth response 2b0.069
il22interleukin 220.068
ryr1bryanodine receptor 1b (skeletal)0.067
prdm1aPR domain containing 1a, with ZNF domain0.067
cyp1d1cytochrome P450, family 1, subfamily D, polypeptide 10.066
igf2binsulin-like growth factor 2b0.066
cx43connexin 430.066
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.066
axin2axin 2 (conductin, axil)0.065
LOC100332505hypothetical protein LOC1003325050.064
tmem144btransmembrane protein 144b0.064
crip2cysteine-rich protein 20.064
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.064
foxp1bforkhead box P1b0.063
aldh1a2aldehyde dehydrogenase 1 family, member A20.063
bmperBMP binding endothelial regulator0.062
coro1acoronin, actin binding protein, 1A0.061
ocrloculocerebrorenal syndrome of Lowe0.061
ddr2bdiscoidin domain receptor family, member 2b0.061
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.060
gata1aGATA binding protein 1a0.060
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.060
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.059
pomt1protein-O-mannosyltransferase 10.059
dnmt4DNA (cytosine-5-)-methyltransferase 40.059
sla1Src-like-adaptor 10.058
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.998
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.995
EGFRepidermal growth factor receptor0.994
PTPN6protein tyrosine phosphatase, non-receptor type 60.985
CAV1caveolin 1, caveolae protein, 22kDa0.985
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.968
SYKspleen tyrosine kinase0.968
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.950
TRAF1TNF receptor-associated factor 10.942
FGFR2fibroblast growth factor receptor 20.934
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.918
GRB2growth factor receptor-bound protein 20.897
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.896
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.888
IL4Rinterleukin 4 receptor0.888
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.872
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.865
CASP8caspase 8, apoptosis-related cysteine peptidase0.850
BIRC3baculoviral IAP repeat containing 30.838
INSRinsulin receptor0.831
CCR7chemokine (C-C motif) receptor 70.820
ICAM1intercellular adhesion molecule 10.815
HLA-Fmajor histocompatibility complex, class I, F0.806
FASFas (TNF receptor superfamily, member 6)0.805
LATlinker for activation of T cells0.786
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.773
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.756
HLA-Gmajor histocompatibility complex, class I, G0.749
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.716
IL2RGinterleukin 2 receptor, gamma0.714
CD86CD86 molecule0.707
HLA-Bmajor histocompatibility complex, class I, B0.705
IL2RBinterleukin 2 receptor, beta0.689
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.681
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.679
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.678
PTPRCprotein tyrosine phosphatase, receptor type, C0.677
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.671
CXCL9chemokine (C-X-C motif) ligand 90.669
CD80CD80 molecule0.668
JAK2Janus kinase 20.668
CD40CD40 molecule, TNF receptor superfamily member 50.639
CCL5chemokine (C-C motif) ligand 50.635
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.625
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.619
BCL2B-cell CLL/lymphoma 20.615
BTN3A1butyrophilin, subfamily 3, member A10.610
CD247CD247 molecule0.598
IRAK1interleukin-1 receptor-associated kinase 10.586
HCKhemopoietic cell kinase0.583
PTPN1protein tyrosine phosphatase, non-receptor type 10.567
IL1R1interleukin 1 receptor, type I0.557
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.544
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.535
SHC1SHC (Src homology 2 domain containing) transforming protein 10.528
BTN3A3butyrophilin, subfamily 3, member A30.506
NCOA3nuclear receptor coactivator 30.492
METmet proto-oncogene (hepatocyte growth factor receptor)0.482
TNFAIP3tumor necrosis factor, alpha-induced protein 30.470
CFLARCASP8 and FADD-like apoptosis regulator0.468
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.446
HLA-DMBmajor histocompatibility complex, class II, DM beta0.442
BTN3A2butyrophilin, subfamily 3, member A20.438
IL10RAinterleukin 10 receptor, alpha0.412
TNFRSF9tumor necrosis factor receptor superfamily, member 90.403
CCL22chemokine (C-C motif) ligand 220.389
SOCS3suppressor of cytokine signaling 30.383
STAT4signal transducer and activator of transcription 40.372
CCR5chemokine (C-C motif) receptor 50.353
BCL10B-cell CLL/lymphoma 100.350
H2AFXH2A histone family, member X0.348
HLA-Cmajor histocompatibility complex, class I, C0.335
TNFtumor necrosis factor0.324
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.322
HLA-Emajor histocompatibility complex, class I, E0.320
CARD11caspase recruitment domain family, member 110.314
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.312
LST1leukocyte specific transcript 10.303
ITKIL2-inducible T-cell kinase0.299
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.298
HLA-DRB5major histocompatibility complex, class II, DR beta 50.288
RIPK2receptor-interacting serine-threonine kinase 20.285
IRF4interferon regulatory factor 40.283
SIGLEC7sialic acid binding Ig-like lectin 70.279
LIN9lin-9 homolog (C. elegans)0.278
MAPK3mitogen-activated protein kinase 30.274
MAPK14mitogen-activated protein kinase 140.272
CCL19chemokine (C-C motif) ligand 190.270
BCL2L11BCL2-like 11 (apoptosis facilitator)0.268
HDAC9histone deacetylase 90.258
NCOR2nuclear receptor corepressor 20.248
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.247
CASP10caspase 10, apoptosis-related cysteine peptidase0.241
ESR1estrogen receptor 10.237
IL7Rinterleukin 7 receptor0.235
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.235
IRS1insulin receptor substrate 10.234
CD3GCD3g molecule, gamma (CD3-TCR complex)0.232
CXCL10chemokine (C-X-C motif) ligand 100.231
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd37CD37 molecule0.433
Cxcr3chemokine (C-X-C motif) receptor 30.301
RT1-BaRT1 class II, locus Ba0.196
Ccr5chemokine (C-C motif) receptor 50.163
Gzmkgranzyme K0.151
TcrbT-cell receptor beta chain0.150
Vipvasoactive intestinal peptide0.149
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.148
Cybbcytochrome b-245, beta polypeptide0.147
Il2rbinterleukin 2 receptor, beta0.144
Csf1colony stimulating factor 1 (macrophage)0.140
Cfpcomplement factor properdin0.131
Reg3gregenerating islet-derived 3 gamma0.123
Cd3gCD3 molecule, gamma0.120
Iappislet amyloid polypeptide0.115
Casp1caspase 10.114
RT1-DaRT1 class II, locus Da0.104
Calcrlcalcitonin receptor-like0.104
Ccl5chemokine (C-C motif) ligand 50.096
Ptafrplatelet-activating factor receptor0.086
Cd38CD38 molecule0.086
Itgb7integrin, beta 70.085
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.084
Il10interleukin 100.083
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.081
Cd5Cd5 molecule0.079
Nkg7natural killer cell group 7 sequence0.078
Olr1500olfactory receptor 15000.078
Socs3suppressor of cytokine signaling 30.076
Olfml2bolfactomedin-like 2B0.074
Cd247Cd247 molecule0.072
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.072
Il1r1interleukin 1 receptor, type I0.069
Phkg1phosphorylase kinase, gamma 10.065
Cd40lgCD40 ligand0.064
Itgadintegrin, alpha D0.063
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.062
Reg3bregenerating islet-derived 3 beta0.061
Prl8a9prolactin family 8, subfamily a, member 90.060
Cd2Cd2 molecule0.060
Il9rinterleukin 9 receptor0.058
Gfra2GDNF family receptor alpha 20.058
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.057
Prkg2protein kinase, cGMP-dependent, type II0.056
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.056
Dock8dedicator of cytokinesis 80.055
Cntn1contactin 10.053
Rassf5Ras association (RalGDS/AF-6) domain family member 50.053
RT1-Db1RT1 class II, locus Db10.053
Il1binterleukin 1 beta0.051
NrarpNotch-regulated ankyrin repeat protein0.050
Olr1469olfactory receptor Olr14690.049
Icosinducible T-cell co-stimulator0.049
Cmklr1chemokine-like receptor 10.049
Ciitaclass II, major histocompatibility complex, transactivator0.049
Oxtroxytocin receptor0.048
Psd4pleckstrin and Sec7 domain containing 40.048
Mcpt2mast cell protease 20.047
Gja4gap junction protein, alpha 40.046
Edn1endothelin 10.046
Cd53Cd53 molecule0.045
Olr1496olfactory receptor 14960.045
Ptger4prostaglandin E receptor 4 (subtype EP4)0.044
Hcsthematopoietic cell signal transducer0.044
Scn11asodium channel, voltage-gated, type XI, alpha0.043
Glp1rglucagon-like peptide 1 receptor0.043
Kynukynureninase (L-kynurenine hydrolase)0.042
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.041
Il13ra2interleukin 13 receptor, alpha 20.040
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.040
Cd4Cd4 molecule0.040
P2ry14purinergic receptor P2Y, G-protein coupled, 140.039
Cxcl9chemokine (C-X-C motif) ligand 90.039
Il2rginterleukin 2 receptor, gamma0.038
Mylk2myosin light chain kinase 20.037
Hckhemopoietic cell kinase0.035
Hdac7histone deacetylase 70.035
Ednraendothelin receptor type A0.035
Klrd1killer cell lectin-like receptor, subfamily D, member 10.035
Lyz2lysozyme 20.034
Glp2rglucagon-like peptide 2 receptor0.034
Dnase1l3deoxyribonuclease 1-like 30.034
Jak1Janus kinase 10.034
RT1-BbRT1 class II, locus Bb0.034
Cpa3carboxypeptidase A3, mast cell0.033
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.032
Calhm2calcium homeostasis modulator 20.032
Syt8synaptotagmin VIII0.031
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.031
Reg3aregenerating islet-derived 3 alpha0.030
Foxs1forkhead box S10.030
Oprk1opioid receptor, kappa 10.030
Stag3stromal antigen 30.029
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.028
Pthparathyroid hormone0.028
Alox5arachidonate 5-lipoxygenase0.028
Olr1078olfactory receptor 10780.028
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.027
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism