The network for 'nephron development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nephron development

The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.

NameDescriptionProbabilityFunc Analog Organism
Bmp4bone morphogenetic protein 41.000
Fgfr2fibroblast growth factor receptor 21.000
Wt1Wilms tumor 1 homolog1.000
Pax2paired box gene 21.000
Sox2SRY-box containing gene 21.000
Bcl2B-cell leukemia/lymphoma 21.000
Lhx1LIM homeobox protein 10.999
Shhsonic hedgehog0.998
Gdnfglial cell line derived neurotrophic factor0.997
Emx2empty spiracles homolog 2 (Drosophila)0.997
Nos3nitric oxide synthase 3, endothelial cell0.997
Retret proto-oncogene0.994
Pbx1pre B-cell leukemia transcription factor 10.990
Fgfr1fibroblast growth factor receptor 10.987
Otx2orthodenticle homolog 2 (Drosophila)0.986
Tcf21transcription factor 210.981
Pax3paired box gene 30.978
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.978
Gli3GLI-Kruppel family member GLI30.978
Notch1Notch gene homolog 1 (Drosophila)0.974
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.971
Smad6MAD homolog 6 (Drosophila)0.965
Pax8paired box gene 80.965
Foxc1forkhead box C10.964
Sox7SRY-box containing gene 70.956
Tbx2T-box 20.955
Hoxd9homeobox D90.953
Ror2receptor tyrosine kinase-like orphan receptor 20.952
Rargretinoic acid receptor, gamma0.947
Foxa2forkhead box A20.947
Jag1jagged 10.945
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.940
Lhx3LIM homeobox protein 30.935
Fgf8fibroblast growth factor 80.934
Foxc2forkhead box C20.928
Hoxd11homeobox D110.927
Dkk1dickkopf homolog 1 (Xenopus laevis)0.927
Gbx2gastrulation brain homeobox 20.924
Hoxa11homeobox A110.922
Ascl1achaete-scute complex homolog 1 (Drosophila)0.919
Arandrogen receptor0.916
Snai1snail homolog 1 (Drosophila)0.910
Gpc3glypican 30.910
Hand1heart and neural crest derivatives expressed transcript 10.909
Fgf10fibroblast growth factor 100.908
Lamc1laminin, gamma 10.907
Foxf1aforkhead box F1a0.905
Pax6paired box gene 60.903
Efnb2ephrin B20.900
Mks1Meckel syndrome, type 10.893
Bnc1basonuclin 10.893
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.889
Flt4FMS-like tyrosine kinase 40.885
Gas1growth arrest specific 10.885
Bicc1bicaudal C homolog 1 (Drosophila)0.881
Ren1renin 1 structural0.878
Nr5a1nuclear receptor subfamily 5, group A, member 10.873
Shesrc homology 2 domain-containing transforming protein E0.872
Hes1hairy and enhancer of split 1 (Drosophila)0.863
Meox2mesenchyme homeobox 20.862
Pou4f3POU domain, class 4, transcription factor 30.857
Emx1empty spiracles homolog 1 (Drosophila)0.843
Hoxd4homeobox D40.842
Eya1eyes absent 1 homolog (Drosophila)0.838
Bmp7bone morphogenetic protein 70.836
Pou5f1POU domain, class 5, transcription factor 10.820
Cdh5cadherin 50.802
Sall4sal-like 4 (Drosophila)0.802
Lef1lymphoid enhancer binding factor 10.802
Col4a2collagen, type IV, alpha 20.794
Hand2heart and neural crest derivatives expressed transcript 20.791
Gata6GATA binding protein 60.783
Wnt4wingless-related MMTV integration site 40.780
Nkx2-1NK2 homeobox 10.776
Hey1hairy/enhancer-of-split related with YRPW motif 10.760
Vangl2vang-like 2 (van gogh, Drosophila)0.757
Otx1orthodenticle homolog 1 (Drosophila)0.755
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.753
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.751
Hoxb5homeobox B50.750
Tead3TEA domain family member 30.749
Tgfb2transforming growth factor, beta 20.747
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.740
Hoxd10homeobox D100.740
Hoxa10homeobox A100.739
Notch3Notch gene homolog 3 (Drosophila)0.733
Amhr2anti-Mullerian hormone type 2 receptor0.733
Lmx1aLIM homeobox transcription factor 1 alpha0.731
Msx1homeobox, msh-like 10.727
Hoxb6homeobox B60.726
Esr1estrogen receptor 1 (alpha)0.724
C1qccomplement component 1, q subcomponent, C chain0.724
C1qbcomplement component 1, q subcomponent, beta polypeptide0.723
Sox10SRY-box containing gene 100.714
Hoxc6homeobox C60.712
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.703
Itgb1integrin beta 1 (fibronectin receptor beta)0.697
Krt14keratin 140.694
Pitx2paired-like homeodomain transcription factor 20.694
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.989
tbx1T-box 10.963
pax2apaired box gene 2a0.935
osr1odd-skipped related 1 (Drosophila)0.926
osr2odd-skipped related 2 (Drosophila)0.888
bmp4bone morphogenetic protein 40.845
wt1bwilms tumor 1b0.834
lhx1aLIM homeobox 1a0.759
mecomMDS1 and EVI1 complex locus0.755
cdh2cadherin 2, neuronal0.684
myf5myogenic factor 50.599
hnf1bbHNF1 homeobox Bb0.593
myod1myogenic differentiation 10.578
hapln1ahyaluronan and proteoglycan link protein 1a0.536
notch3notch homolog 30.511
eya1eyes absent homolog 10.509
wt1awilms tumor 1a0.508
fgf10afibroblast growth factor 10a0.493
wnt5bwingless-type MMTV integration site family, member 5b0.479
foxd3forkhead box D30.452
epha4aeph receptor A4a0.438
jag2jagged 20.431
prdm1aPR domain containing 1a, with ZNF domain0.423
gdnfglial cell derived neurotrophic factor0.403
fgf8afibroblast growth factor 8 a0.396
sox2SRY-box containing gene 20.388
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.374
otpborthopedia homolog b0.360
sulf1sulfatase 10.358
gli1GLI-Kruppel family member 10.357
emx3empty spiracles homeobox 30.338
foxa2forkhead box A20.313
bmp2abone morphogenetic protein 2a0.298
wnt3wingless-type MMTV integration site family, member 30.291
wnt8bwingless-type MMTV integration site family, member 8b0.286
slc4a4asolute carrier family 4, member 4a0.277
mibmind bomb0.273
jag1bjagged 1b0.271
lef1lymphocyte enhancer binding factor 10.270
dlx6adistal-less homeobox gene 6a0.267
gli2aGLI-Kruppel family member GLI2a0.261
sox11bSRY-box containing gene 11b0.258
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.255
lhx2bLIM homeobox 2b0.244
neurog1neurogenin 10.235
notch1anotch homolog 1a0.228
hoxa13ahomeo box A13a0.224
wnt2bawingless-type MMTV integration site family, member 2Ba0.220
vegfaavascular endothelial growth factor Aa0.218
lmx1b.1LIM homeobox transcription factor 1, beta 10.211
plce1phospholipase C, epsilon 10.209
hnf1baHNF1 homeobox Ba0.202
crb2bcrumbs homolog 2b0.196
wlswntless homolog (Drosophila)0.184
hoxb5ahomeo box B5a0.182
sim1asingle-minded homolog 1a (Drosophila)0.177
scube2signal peptide, CUB domain, EGF-like 20.170
cdh23cadherin-like 230.167
robo3roundabout homolog 30.167
fgf3fibroblast growth factor 30.159
znf703zinc finger protein 7030.157
ndr2nodal-related 20.154
nrarpanotch-regulated ankyrin repeat protein a0.151
wnt3awingless-type MMTV integration site family, member 3A0.150
pitx3paired-like homeodomain transcription factor 30.149
gbx2gastrulation brain homeo box 20.147
dusp6dual specificity phosphatase 60.139
gyltl1bglycosyltransferase-like 1b0.139
emx1empty spiracles homeobox 10.136
nkx3.2NK3 homeobox 20.129
hoxd10ahomeo box D10a0.128
wnt2bbwingless-type MMTV integration site family, member 2Bb0.126
klf2aKruppel-like factor 2a0.125
ift88intraflagellar transport 88 homolog0.124
fzd7afrizzled homolog 7a0.122
itgavintegrin, alpha V0.119
rfx2regulatory factor X, 2 (influences HLA class II expression)0.119
aldh1a2aldehyde dehydrogenase 1 family, member A20.114
lama2laminin, alpha 20.113
spry1sprouty homolog 1 (Drosophila)0.112
crb3bcrumbs homolog 3b0.111
olig2oligodendrocyte lineage transcription factor 20.110
hoxa9ahomeo box A9a0.108
fstafollistatin a0.105
wnt1wingless-type MMTV integration site family, member 10.105
fibinfin bud initiation factor0.105
igfbp3insulin-like growth factor binding protein 30.103
hoxa11ahomeo box A11a0.102
her12hairy-related 120.101
vegfabvascular endothelial growth factor Ab0.100
tbx18T-box 180.100
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.998
EgfrEpidermal growth factor receptor0.983
E(spl)Enhancer of split0.960
HLHm7E(spl) region transcript m70.856
eyaeyes absent0.850
LanB2Laminin B20.800
aopanterior open0.758
bowlbrother of odd with entrails limited0.726
HLHmdeltaE(spl) region transcript mdelta0.705
gbbglass bottom boat0.632
HLHmbetaE(spl) region transcript mbeta0.623
Fas2Fasciclin 20.604
m2E(spl) region transcript m20.569
HLHm3E(spl) region transcript m30.557
MadMothers against dpp0.483
HLHmgammaE(spl) region transcript mgamma0.441
argosCG4531 gene product from transcript CG4531-RA0.398
LanALaminin A0.382
LanB1CG7123 gene product from transcript CG7123-RA0.353
18w18 wheeler0.322
SsdpSequence-specific single-stranded DNA-binding protein0.277
rheaCG6831 gene product from transcript CG6831-RA0.256
rolsrolling pebbles0.240
Vrp1Verprolin 10.236
sogshort gastrulation0.228
nocno ocelli0.228
snssticks and stones0.187
CG3880CG3880 gene product from transcript CG3880-RA0.185
sosine oculis0.174
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.164
DadDaughters against dpp0.153
cindrCIN85 and CD2AP orthologue0.146
mbcmyoblast city0.142
fasfaint sausage0.141
calypsoCG8445 gene product from transcript CG8445-RB0.141
slp1sloppy paired 10.129
elBelbow B0.108
abd-Aabdominal A0.108
SmoxSmad on X0.107
taptarget of Poxn0.106
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.987
FGFR2fibroblast growth factor receptor 20.983
NOTCH1notch 10.982
JAG1jagged 10.979
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.977
FHL2four and a half LIM domains 20.862
NOTCH3notch 30.654
FGF1fibroblast growth factor 1 (acidic)0.575
COL4A1collagen, type IV, alpha 10.511
COL4A2collagen, type IV, alpha 20.464
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.396
BMPR1Abone morphogenetic protein receptor, type IA0.387
FSTL1follistatin-like 10.383
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.348
TIMP3TIMP metallopeptidase inhibitor 30.306
PLCG1phospholipase C, gamma 10.305
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.303
FN1fibronectin 10.293
METmet proto-oncogene (hepatocyte growth factor receptor)0.285
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.262
EGR1early growth response 10.247
COL2A1collagen, type II, alpha 10.235
VEGFAvascular endothelial growth factor A0.230
MEIS1Meis homeobox 10.227
ADRB1adrenergic, beta-1-, receptor0.224
FGF10fibroblast growth factor 100.218
THBS1thrombospondin 10.206
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.199
NR4A1nuclear receptor subfamily 4, group A, member 10.173
EGR3early growth response 30.170
COL4A6collagen, type IV, alpha 60.167
LAMC1laminin, gamma 1 (formerly LAMB2)0.155
NRP1neuropilin 10.151
CTGFconnective tissue growth factor0.144
CFL1cofilin 1 (non-muscle)0.140
MEIS2Meis homeobox 20.136
PARVAparvin, alpha0.124
BMP7bone morphogenetic protein 70.115
EGR2early growth response 20.109
SKILSKI-like oncogene0.108
COL4A5collagen, type IV, alpha 50.107
KLHL12kelch-like 12 (Drosophila)0.099
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.098
ADAM17ADAM metallopeptidase domain 170.096
PTPRCprotein tyrosine phosphatase, receptor type, C0.094
NKX2-1NK2 homeobox 10.093
ARNTaryl hydrocarbon receptor nuclear translocator0.092
GLIS2GLIS family zinc finger 20.090
PDIA3protein disulfide isomerase family A, member 30.086
BMPR1Bbone morphogenetic protein receptor, type IB0.084
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.082
CCNE1cyclin E10.081
PAX8paired box 80.080
SOX2SRY (sex determining region Y)-box 20.078
CUL3cullin 30.078
FGF8fibroblast growth factor 8 (androgen-induced)0.073
NGFRnerve growth factor receptor0.070
DPYSL4dihydropyrimidinase-like 40.070
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.067
FOSFBJ murine osteosarcoma viral oncogene homolog0.066
TEKTEK tyrosine kinase, endothelial0.065
TSC22D4TSC22 domain family, member 40.064
FGF18fibroblast growth factor 180.063
MEOX1mesenchyme homeobox 10.063
PDGFAplatelet-derived growth factor alpha polypeptide0.063
FGFR1fibroblast growth factor receptor 10.061
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.059
FGF3fibroblast growth factor 30.057
ANGPT2angiopoietin 20.056
NFE2L2nuclear factor (erythroid-derived 2)-like 20.056
COL1A1collagen, type I, alpha 10.055
NOTCH2notch 20.055
TGFB2transforming growth factor, beta 20.055
IGFBP5insulin-like growth factor binding protein 50.055
HMGA2high mobility group AT-hook 20.054
DUSP6dual specificity phosphatase 60.053
CDC25Bcell division cycle 25 homolog B (S. pombe)0.053
HOXA10homeobox A100.052
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.051
CDH5cadherin 5, type 2 (vascular endothelium)0.049
FGF4fibroblast growth factor 40.049
FRS2fibroblast growth factor receptor substrate 20.048
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.047
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.046
DLL1delta-like 1 (Drosophila)0.046
JAG2jagged 20.045
SFRP1secreted frizzled-related protein 10.043
WNT1wingless-type MMTV integration site family, member 10.043
PBKPDZ binding kinase0.042
CFL2cofilin 2 (muscle)0.042
KLHL2kelch-like 2, Mayven (Drosophila)0.041
SMAD3SMAD family member 30.041
NID1nidogen 10.040
LBX1ladybird homeobox 10.040
PAX2paired box 20.040
POU5F1POU class 5 homeobox 10.040
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.197
Nr4a1nuclear receptor subfamily 4, group A, member 10.051
JunJun oncogene0.041
FosFBJ osteosarcoma oncogene0.039
Idi1isopentenyl-diphosphate delta isomerase 10.038
Flt1FMS-related tyrosine kinase 10.030
Efnb1ephrin B10.026
Igf2insulin-like growth factor 20.025
Aif1lallograft inflammatory factor 1-like0.024
Baiap2BAI1-associated protein 20.024
Nos3nitric oxide synthase 3, endothelial cell0.023
Trhr2thyrotropin releasing hormone receptor 20.023
Cd4Cd4 molecule0.022
Nek9NIMA (never in mitosis gene a)- related kinase 90.021
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.020
Pou2f3POU class 2 homeobox 30.019
Tgfbr2transforming growth factor, beta receptor II0.019
Lgals7lectin, galactoside-binding, soluble, 70.018
Plauplasminogen activator, urokinase0.017
Krt15keratin 150.016
Ptger4prostaglandin E receptor 4 (subtype EP4)0.016
Pax8paired box 80.016
Irs3insulin receptor substrate 30.016
Egr3early growth response 30.015
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.015
Rararetinoic acid receptor, alpha0.015
Nr5a1nuclear receptor subfamily 5, group A, member 10.014
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.014
Twist2twist homolog 2 (Drosophila)0.014
AxlAxl receptor tyrosine kinase0.014
Egr2early growth response 20.014
Gpr20G protein-coupled receptor 200.014
Ccl6chemokine (C-C motif) ligand 60.014
Igfbp5insulin-like growth factor binding protein 50.014
Sp110SP110 nuclear body protein0.013
Gata3GATA binding protein 30.013
Robo1roundabout homolog 1 (Drosophila)0.013
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.013
Sardhsarcosine dehydrogenase0.013
Prrx1paired related homeobox 10.013
Tceb3transcription elongation factor B (SIII), polypeptide 30.013
Prelpproline/arginine-rich end leucine-rich repeat protein0.013
Aebp1AE binding protein 10.013
Has2hyaluronan synthase 20.013
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
AclyATP citrate lyase0.012
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.012
Pnliprp2pancreatic lipase-related protein 20.012
Igfbp3insulin-like growth factor binding protein 30.012
Sod3superoxide dismutase 3, extracellular0.012
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.011
GperG protein-coupled estrogen receptor 10.011
Dusp6dual specificity phosphatase 60.011
Emr1EGF-like module containing, mucin-like, hormone receptor-like 10.011
Sirpasignal-regulatory protein alpha0.011
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.011
Kdrkinase insert domain receptor0.011
Sqlesqualene epoxidase0.011
Jak2Janus kinase 20.011
Egr1early growth response 10.011
Il6stinterleukin 6 signal transducer0.011
Slit3slit homolog 3 (Drosophila)0.011
F13a1coagulation factor XIII, A1 polypeptide0.010
Fh1fumarate hydratase 10.010
Amhanti-Mullerian hormone0.010
Hbegfheparin-binding EGF-like growth factor0.010
Krt5keratin 50.010
Cyth3cytohesin 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism