The network for 'response to steroid hormone' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to steroid hormone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.

NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.979
Ptpn11protein tyrosine phosphatase, non-receptor type 110.927
Esr1estrogen receptor 1 (alpha)0.912
Stat3signal transducer and activator of transcription 30.889
Rxraretinoid X receptor alpha0.869
Nos1nitric oxide synthase 1, neuronal0.839
Trp53transformation related protein 530.820
Ptenphosphatase and tensin homolog0.804
Apoeapolipoprotein E0.776
Drd2dopamine receptor D20.721
Bglapbone gamma carboxyglutamate protein0.702
Tgfbr2transforming growth factor, beta receptor II0.698
Fshrfollicle stimulating hormone receptor0.687
Vegfavascular endothelial growth factor A0.678
Arandrogen receptor0.676
Ptgs2prostaglandin-endoperoxide synthase 20.612
Fbn1fibrillin 10.602
Lyz2lysozyme 20.570
Prlrprolactin receptor0.512
Ghrgrowth hormone receptor0.488
Csf1colony stimulating factor 1 (macrophage)0.437
Ppargperoxisome proliferator activated receptor gamma0.430
Foxp3forkhead box P30.404
Cdk4cyclin-dependent kinase 40.389
Robo1roundabout homolog 1 (Drosophila)0.382
Pax8paired box gene 80.382
Notch2Notch gene homolog 2 (Drosophila)0.379
Fgfr2fibroblast growth factor receptor 20.368
Nos3nitric oxide synthase 3, endothelial cell0.366
Tgfb2transforming growth factor, beta 20.364
Ldlrlow density lipoprotein receptor0.353
Gdnfglial cell line derived neurotrophic factor0.349
Kitkit oncogene0.332
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.330
Cdkn1bcyclin-dependent kinase inhibitor 1B0.328
FasFas (TNF receptor superfamily member 6)0.327
Gpc3glypican 30.320
Itgb1integrin beta 1 (fibronectin receptor beta)0.313
Tgfb1transforming growth factor, beta 10.313
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.311
Mup5major urinary protein 50.285
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.285
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.275
Kiss1KiSS-1 metastasis-suppressor0.265
Dlx5distal-less homeobox 50.261
Ahraryl-hydrocarbon receptor0.260
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.257
Egfrepidermal growth factor receptor0.252
Il1r1interleukin 1 receptor, type I0.247
Oprm1opioid receptor, mu 10.239
Wt1Wilms tumor 1 homolog0.238
LOC100048884novel member of the major urinary protein (Mup) gene family0.231
Nr3c1nuclear receptor subfamily 3, group C, member 10.231
Mup19major urinary protein 190.229
Hbb-b1hemoglobin, beta adult major chain0.227
H2-Ab1histocompatibility 2, class II antigen A, beta 10.226
Fgfr1fibroblast growth factor receptor 10.220
Jak2Janus kinase 20.220
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.218
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.217
Apoa1apolipoprotein A-I0.213
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.207
Jag1jagged 10.207
Inpp5dinositol polyphosphate-5-phosphatase D0.203
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.196
Ccl2chemokine (C-C motif) ligand 20.195
Dsg4desmoglein 40.192
Inhbainhibin beta-A0.189
Amhr2anti-Mullerian hormone type 2 receptor0.189
Cfhcomplement component factor h0.186
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.183
Pgrprogesterone receptor0.182
Il6interleukin 60.178
Stat5asignal transducer and activator of transcription 5A0.177
Gpr50G-protein-coupled receptor 500.174
Mmp9matrix metallopeptidase 90.171
Casp4caspase 4, apoptosis-related cysteine peptidase0.171
Socs1suppressor of cytokine signaling 10.171
Mesp1mesoderm posterior 10.170
Retret proto-oncogene0.164
Cdk2cyclin-dependent kinase 20.162
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.162
Shhsonic hedgehog0.161
Fgf8fibroblast growth factor 80.160
Bmp2bone morphogenetic protein 20.160
Npy2rneuropeptide Y receptor Y20.158
Nos2nitric oxide synthase 2, inducible0.158
Npy1rneuropeptide Y receptor Y10.158
Isl1ISL1 transcription factor, LIM/homeodomain0.157
Rbbp5retinoblastoma binding protein 50.151
Sfrp1secreted frizzled-related protein 10.151
Ren1renin 1 structural0.147
Cnr1cannabinoid receptor 1 (brain)0.147
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.145
Ezh2enhancer of zeste homolog 2 (Drosophila)0.145
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rbp4retinol binding protein 4, plasma0.581
thtyrosine hydroxylase0.536
vtg3vitellogenin 3, phosvitinless0.515
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.472
bmp2bbone morphogenetic protein 2b0.443
hmgb1ahigh-mobility group box 1a0.436
aldobaldolase b, fructose-bisphosphate0.433
alcamaactivated leukocyte cell adhesion molecule a0.398
epas1bendothelial PAS domain protein 1b0.320
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.307
vasavasa homolog0.292
pcnaproliferating cell nuclear antigen0.280
bdnfbrain-derived neurotrophic factor0.271
igf1insulin-like growth factor 10.259
mcoln1mucolipin 10.254
esr1estrogen receptor 10.242
ptmaaprothymosin, alpha a0.224
rspo1R-spondin homolog (Xenopus laevis)0.218
foxa3forkhead box A30.214
wnt10awingless-type MMTV integration site family, member 10a0.208
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.202
notch1anotch homolog 1a0.193
plcg1phospholipase C, gamma 10.190
ghrbgrowth hormone receptor b0.183
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.183
fbp1bfructose-1,6-bisphosphatase 1b0.175
anxa1bannexin A1b0.173
casrlcalcium-sensing receptor, like0.170
nrg2aneuregulin 2a0.163
myod1myogenic differentiation 10.162
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.159
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.159
sepp1aselenoprotein P, plasma, 1a0.157
lhcgrluteinizing hormone/choriogonadotropin receptor0.147
robo3roundabout homolog 30.146
apoebapolipoprotein Eb0.145
bcl2l1bcl2-like 10.127
ptgs2aprostaglandin-endoperoxide synthase 2a0.126
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.124
mt2metallothionein 20.122
gnrh3gonadotropin-releasing hormone 30.121
socs3asuppressor of cytokine signaling 3a0.121
cnr1cannabinoid receptor 10.120
igf2binsulin-like growth factor 2b0.119
osr1odd-skipped related 1 (Drosophila)0.119
fabp11afatty acid binding protein 11a0.117
mapk12mitogen-activated protein kinase 120.115
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.114
otpaorthopedia homolog a0.111
trpv6transient receptor potential cation channel, subfamily V, member 60.107
bcl2B-cell leukemia/lymphoma 20.107
id1inhibitor of DNA binding 10.105
krt18keratin 180.105
hspb1heat shock protein, alpha-crystallin-related, 10.104
serpinc1serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 10.102
wnt11rwingless-type MMTV integration site family, member 11, related0.100
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.100
hspa5heat shock protein 50.098
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.097
gamtguanidinoacetate N-methyltransferase0.096
egr2bearly growth response 2b0.095
rbp1aretinol binding protein 1a, cellular0.095
junbljun B proto-oncogene, like0.094
prox1prospero-related homeobox gene 10.093
aqp1a.1aquaporin 1a, tandem duplicate 10.093
cpt1bcarnitine palmitoyltransferase 1B (muscle)0.093
nrp2aneuropilin 2a0.092
rag1recombination activating gene 10.091
cyp1acytochrome P450, family 1, subfamily A0.090
krit1KRIT1, ankyrin repeat containing0.090
c3ccomplement component c3c0.087
ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.086
tp53bp2tumor protein p53 binding protein, 20.086
tnnt2atroponin T2a, cardiac0.086
csadcysteine sulfinic acid decarboxylase0.084
ca2carbonic anhydrase II0.083
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.083
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.083
cdkn1acyclin-dependent kinase inhibitor 1A0.082
fn1bfibronectin 1b0.082
grnbgranulin b0.082
cav1caveolin 10.081
sgpl1sphingosine-1-phosphate lyase 10.081
cldnhclaudin h0.080
ptger2aprostaglandin E receptor 2a (subtype EP2)0.080
dab1adisabled homolog 1a (Drosophila)0.079
shbgsex hormone binding globulin0.078
igf2ainsulin-like growth factor 2a0.078
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.076
vdravitamin D receptor a0.074
crabp2acellular retinoic acid binding protein 2, a0.073
card14caspase recruitment domain family, member 140.070
il8interleukin 80.070
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
EGFRepidermal growth factor receptor0.999
TP53tumor protein p530.989
PTPN1protein tyrosine phosphatase, non-receptor type 10.986
CREBBPCREB binding protein0.981
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.980
CAV1caveolin 1, caveolae protein, 22kDa0.963
MDM2Mdm2 p53 binding protein homolog (mouse)0.894
BRCA1breast cancer 1, early onset0.866
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.856
HNF4Ahepatocyte nuclear factor 4, alpha0.757
NCOA6nuclear receptor coactivator 60.756
ANXA1annexin A10.732
IL8interleukin 80.721
SMAD2SMAD family member 20.719
GSTM1glutathione S-transferase mu 10.711
ARandrogen receptor0.709
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.663
ATF2activating transcription factor 20.571
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.568
SMN1survival of motor neuron 1, telomeric0.542
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.529
SMAD4SMAD family member 40.527
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.519
FGFR2fibroblast growth factor receptor 20.510
EPORerythropoietin receptor0.506
JUNjun proto-oncogene0.488
HDAC1histone deacetylase 10.486
NCOR2nuclear receptor corepressor 20.470
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.468
NCOA1nuclear receptor coactivator 10.455
TRADDTNFRSF1A-associated via death domain0.412
WDR5WD repeat domain 50.410
ARIH2ariadne homolog 2 (Drosophila)0.409
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.400
CASP3caspase 3, apoptosis-related cysteine peptidase0.385
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 20.382
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.379
XIAPX-linked inhibitor of apoptosis0.369
BCAR1breast cancer anti-estrogen resistance 10.359
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.352
NR4A1nuclear receptor subfamily 4, group A, member 10.350
THBS1thrombospondin 10.345
IL1R1interleukin 1 receptor, type I0.341
SOCS3suppressor of cytokine signaling 30.325
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.323
RBBP5retinoblastoma binding protein 50.321
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.311
KRT6Bkeratin 6B0.308
BCL2B-cell CLL/lymphoma 20.307
SOCS1suppressor of cytokine signaling 10.301
RNF144Bring finger protein 144B0.290
SUZ12suppressor of zeste 12 homolog (Drosophila)0.280
GSTM2glutathione S-transferase mu 2 (muscle)0.272
TGFB1transforming growth factor, beta 10.266
IL6interleukin 6 (interferon, beta 2)0.262
TAL1T-cell acute lymphocytic leukemia 10.259
RXRAretinoid X receptor, alpha0.258
NRP1neuropilin 10.257
CDK11Bcyclin-dependent kinase 11B0.255
BAXBCL2-associated X protein0.254
SKILSKI-like oncogene0.254
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.249
GHRgrowth hormone receptor0.240
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.234
HDAC2histone deacetylase 20.233
PLAUplasminogen activator, urokinase0.231
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.230
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 40.229
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.228
TSC22D1TSC22 domain family, member 10.227
CDK2cyclin-dependent kinase 20.226
EP300E1A binding protein p3000.225
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.222
STAT1signal transducer and activator of transcription 1, 91kDa0.221
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.217
MTA3metastasis associated 1 family, member 30.215
RB1retinoblastoma 10.209
RARAretinoic acid receptor, alpha0.209
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.208
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.207
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.205
POU5F1POU class 5 homeobox 10.203
PTENphosphatase and tensin homolog0.202
APPamyloid beta (A4) precursor protein0.200
FOXO1forkhead box O10.198
KRT8keratin 80.194
TEKTEK tyrosine kinase, endothelial0.194
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.188
MAPK3mitogen-activated protein kinase 30.187
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.184
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.181
NCF4neutrophil cytosolic factor 4, 40kDa0.181
ESR2estrogen receptor 2 (ER beta)0.180
NRIP1nuclear receptor interacting protein 10.180
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.180
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.179
APAF1apoptotic peptidase activating factor 10.177
MAPK14mitogen-activated protein kinase 140.174
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism