The network for 'purine nucleobase biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

purine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

NameDescriptionProbabilityFunc Analog Organism
Ren1renin 1 structural0.265
Gja1gap junction protein, alpha 10.249
Phgdh3-phosphoglycerate dehydrogenase0.105
Hif1ahypoxia inducible factor 1, alpha subunit0.086
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.079
Shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.077
Cdt1chromatin licensing and DNA replication factor 10.071
Atad3aATPase family, AAA domain containing 3A0.053
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.047
Msh2mutS homolog 2 (E. coli)0.039
E2f1E2F transcription factor 10.033
Umpsuridine monophosphate synthetase0.033
Ptgs2prostaglandin-endoperoxide synthase 20.030
Rcc1regulator of chromosome condensation 10.030
Shkbp1Sh3kbp1 binding protein 10.029
NadkNAD kinase0.028
Galegalactose-4-epimerase, UDP0.028
BC048355cDNA sequence BC0483550.028
Mapk13mitogen-activated protein kinase 130.026
Cmpk1cytidine monophosphate (UMP-CMP) kinase 10.026
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.025
Agtr1aangiotensin II receptor, type 1a0.024
Mdm2transformed mouse 3T3 cell double minute 20.023
Rb1retinoblastoma 10.023
Dazap1DAZ associated protein 10.023
Pgls6-phosphogluconolactonase0.023
Ranbp1RAN binding protein 10.023
Cpsf3lcleavage and polyadenylation specific factor 3-like0.022
Pdcd6programmed cell death 60.022
Ccne1cyclin E10.022
Mybl2myeloblastosis oncogene-like 20.022
Orc1origin recognition complex, subunit 10.022
Psmg4proteasome (prosome, macropain) assembly chaperone 40.021
Ube2cubiquitin-conjugating enzyme E2C0.021
Rrp9RRP9, small subunit (SSU) processome component, homolog (yeast)0.021
Ptrh1peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)0.020
Psma4proteasome (prosome, macropain) subunit, alpha type 40.018
Slc25a5solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 50.018
Hmga1-rs1high mobility group AT-hook I, related sequence 10.017
Smyd5SET and MYND domain containing 50.016
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.016
Rps6ka1ribosomal protein S6 kinase polypeptide 10.016
Gpx1glutathione peroxidase 10.015
Ccnfcyclin F0.015
Haus4HAUS augmin-like complex, subunit 40.014
Fpgsfolylpolyglutamyl synthetase0.013
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.013
Chaf1bchromatin assembly factor 1, subunit B (p60)0.013
Prelid1PRELI domain containing 10.013
Pgk1phosphoglycerate kinase 10.013
Cdca5cell division cycle associated 50.013
Gtse1G two S phase expressed protein 10.012
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.012
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.012
Pop4processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)0.012
Slc7a5solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.012
Acy1aminoacylase 10.011
Aprtadenine phosphoribosyl transferase0.011
Psat1phosphoserine aminotransferase 10.011
Tk1thymidine kinase 10.011
Acot9acyl-CoA thioesterase 90.011
E2f8E2F transcription factor 80.011
Mtx1metaxin 10.011
Arntlaryl hydrocarbon receptor nuclear translocator-like0.011
Mifmacrophage migration inhibitory factor0.011
Slc19a1solute carrier family 19 (sodium/hydrogen exchanger), member 10.011
Ap1g2adaptor protein complex AP-1, gamma 2 subunit0.011
Polepolymerase (DNA directed), epsilon0.010
Kprpkeratinocyte expressed, proline-rich0.010
Ptpn11protein tyrosine phosphatase, non-receptor type 110.010
Naa20N(alpha)-acetyltransferase 20, NatB catalytic subunit0.010
Syce2synaptonemal complex central element protein 20.010
Timelesstimeless homolog (Drosophila)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
WDYHV1WDYHV motif containing 10.449
MARSmethionyl-tRNA synthetase0.279
PRTFDC1phosphoribosyl transferase domain containing 10.174
YARStyrosyl-tRNA synthetase0.144
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.096
AARSalanyl-tRNA synthetase0.074
GARSglycyl-tRNA synthetase0.072
PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.062
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.046
LONP1lon peptidase 1, mitochondrial0.046
CARScysteinyl-tRNA synthetase0.042
PTGES3prostaglandin E synthase 3 (cytosolic)0.040
GMPSguanine monphosphate synthetase0.039
PHGDHphosphoglycerate dehydrogenase0.038
TRIB3tribbles homolog 3 (Drosophila)0.034
FTSJ1FtsJ homolog 1 (E. coli)0.034
RABAC1Rab acceptor 1 (prenylated)0.022
PSAT1phosphoserine aminotransferase 10.021
CASP4caspase 4, apoptosis-related cysteine peptidase0.019
HSD17B14hydroxysteroid (17-beta) dehydrogenase 140.019
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.018
PSMG1proteasome (prosome, macropain) assembly chaperone 10.017
RPIAribose 5-phosphate isomerase A0.014
SARSseryl-tRNA synthetase0.014
JUPjunction plakoglobin0.013
PPIHpeptidylprolyl isomerase H (cyclophilin H)0.013
ODC1ornithine decarboxylase 10.012
SLBPstem-loop binding protein0.012
SLC1A5solute carrier family 1 (neutral amino acid transporter), member 50.011
PGRMC1progesterone receptor membrane component 10.011
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.011
USP50ubiquitin specific peptidase 500.011
PRPSAP1phosphoribosyl pyrophosphate synthetase-associated protein 10.011
IARSisoleucyl-tRNA synthetase0.010
H2AFZH2A histone family, member Z0.010
TMEM97transmembrane protein 970.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ADE12Ade12p0.014
ADE13Ade13p0.013
ADE1Ade1p0.012