The network for 'glutathione biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

NameDescriptionProbabilityFunc Analog Organism
Gclmglutamate-cysteine ligase, modifier subunit0.953
Gclcglutamate-cysteine ligase, catalytic subunit0.941
Sept1septin 10.019
Zfp335zinc finger protein 3350.019
Ndufb9NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 90.014
Mceemethylmalonyl CoA epimerase0.014
Ndufa6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14)0.013
Cyb5cytochrome b-50.012
Fgd3FYVE, RhoGEF and PH domain containing 30.011
Creg1cellular repressor of E1A-stimulated genes 10.011
Fbxo9f-box protein 90.010
Htra3HtrA serine peptidase 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GCLMglutamate-cysteine ligase, modifier subunit0.944
GCLCglutamate-cysteine ligase, catalytic subunit0.932
ME1malic enzyme 1, NADP(+)-dependent, cytosolic0.083
MAPK3mitogen-activated protein kinase 30.062
METRNmeteorin, glial cell differentiation regulator0.060
MAGEA11melanoma antigen family A, 110.053
ETFBelectron-transfer-flavoprotein, beta polypeptide0.024
NDUFS4NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)0.023
NQO1NAD(P)H dehydrogenase, quinone 10.019
CHMP2Achromatin modifying protein 2A0.018
PIRpirin (iron-binding nuclear protein)0.016
GSRglutathione reductase0.011
PINK1PTEN induced putative kinase 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
UgdhUDP-glucose dehydrogenase0.155
Ubqln1ubiquilin 10.147
Mgst3microsomal glutathione S-transferase 30.058
Txnrd1thioredoxin reductase 10.046
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.027
Nqo1NAD(P)H dehydrogenase, quinone 10.027
Gsrglutathione reductase0.026
St13suppression of tumorigenicity 130.025
Suclg1succinate-CoA ligase, alpha subunit0.023
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.023
Enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.021
Gmfbglia maturation factor, beta0.021
Ptgr1prostaglandin reductase 10.021
Coq3coenzyme Q3 homolog, methyltransferase (S. cerevisiae)0.020
Gsta5glutathione S-transferase Yc2 subunit0.019
Qdprquinoid dihydropteridine reductase0.017
Cd14CD14 molecule0.016
Gssglutathione synthetase0.016
Ebpemopamil binding protein (sterol isomerase)0.015
MlxMAX-like protein X0.015
PVRpoliovirus receptor0.015
Sgk2serum/glucocorticoid regulated kinase 20.015
Creg1cellular repressor of E1A-stimulated genes 10.015
Tmem205transmembrane protein 2050.013
March5membrane-associated ring finger (C3HC4) 50.013
Chac2ChaC, cation transport regulator homolog 2 (E. coli)0.013
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.012
Me1malic enzyme 1, NADP(+)-dependent, cytosolic0.012
Akr1b8aldo-keto reductase family 1, member B80.012
Akr7a3aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)0.012
Enpp3ectonucleotide pyrophosphatase/phosphodiesterase 30.011
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.010
Ephx1epoxide hydrolase 1, microsomal0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism