The network for 'tumor necrosis factor production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tumor necrosis factor production

The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.971
Map3k14mitogen-activated protein kinase kinase kinase 140.938
Tlr4toll-like receptor 40.934
Map3k8mitogen-activated protein kinase kinase kinase 80.899
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.885
Casp4caspase 4, apoptosis-related cysteine peptidase0.878
Tnftumor necrosis factor0.868
Clec4dC-type lectin domain family 4, member d0.859
Ccr1chemokine (C-C motif) receptor 10.836
Gzmagranzyme A0.830
Otx2orthodenticle homolog 2 (Drosophila)0.817
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.808
Neurod1neurogenic differentiation 10.802
Pax6paired box gene 60.788
Traf6TNF receptor-associated factor 60.771
Myd88myeloid differentiation primary response gene 880.737
Cd14CD14 antigen0.726
Socs1suppressor of cytokine signaling 10.694
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.676
Tnfaip3tumor necrosis factor, alpha-induced protein 30.663
Shhsonic hedgehog0.641
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.632
Klrk1killer cell lectin-like receptor subfamily K, member 10.625
Nhlh1nescient helix loop helix 10.599
Ptprcprotein tyrosine phosphatase, receptor type, C0.594
Lyz2lysozyme 20.589
Ccr2chemokine (C-C motif) receptor 20.582
Itgaxintegrin alpha X0.566
Il2rbinterleukin 2 receptor, beta chain0.566
Il1binterleukin 1 beta0.545
FaslFas ligand (TNF superfamily, member 6)0.538
Ccl4chemokine (C-C motif) ligand 40.518
Clec4nC-type lectin domain family 4, member n0.517
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.515
Klrd1killer cell lectin-like receptor, subfamily D, member 10.506
Neurog2neurogenin 20.493
Ccl2chemokine (C-C motif) ligand 20.491
Ascl1achaete-scute complex homolog 1 (Drosophila)0.483
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.461
Klra9killer cell lectin-like receptor subfamily A, member 90.430
Cd44CD44 antigen0.428
C3ar1complement component 3a receptor 10.422
Il2rginterleukin 2 receptor, gamma chain0.419
BlkB lymphoid kinase0.411
Casp1caspase 10.394
Lhx3LIM homeobox protein 30.379
Gnrh1gonadotropin releasing hormone 10.372
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.352
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.346
Emx2empty spiracles homolog 2 (Drosophila)0.330
Ikzf1IKAROS family zinc finger 10.312
Snai1snail homolog 1 (Drosophila)0.311
Il12binterleukin 12b0.309
Cd180CD180 antigen0.305
Cd7CD7 antigen0.293
TcraT-cell receptor alpha chain0.290
Gpr132G protein-coupled receptor 1320.289
Ncr1natural cytotoxicity triggering receptor 10.285
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.277
AF251705cDNA sequence AF2517050.274
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.270
Ccr7chemokine (C-C motif) receptor 70.269
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.269
Clec4eC-type lectin domain family 4, member e0.267
Neurod4neurogenic differentiation 40.263
Gab1growth factor receptor bound protein 2-associated protein 10.262
Sfpi1SFFV proviral integration 10.261
Clec7aC-type lectin domain family 7, member a0.260
AxlAXL receptor tyrosine kinase0.257
Il27rainterleukin 27 receptor, alpha0.248
Isl2insulin related protein 2 (islet 2)0.248
Msr1macrophage scavenger receptor 10.243
Klra2killer cell lectin-like receptor, subfamily A, member 20.239
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.238
Il1rninterleukin 1 receptor antagonist0.229
Slamf8SLAM family member 80.222
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.220
Il10rainterleukin 10 receptor, alpha0.218
Cxcl2chemokine (C-X-C motif) ligand 20.207
Ccl3chemokine (C-C motif) ligand 30.207
Tnip1TNFAIP3 interacting protein 10.205
Emx1empty spiracles homolog 1 (Drosophila)0.202
Inpp5dinositol polyphosphate-5-phosphatase D0.201
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.199
Flt3FMS-like tyrosine kinase 30.197
Pyhin1pyrin and HIN domain family, member 10.196
Casp8caspase 80.194
Il18r1interleukin 18 receptor 10.194
Arrb2arrestin, beta 20.190
Ccr6chemokine (C-C motif) receptor 60.190
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.186
Nr5a1nuclear receptor subfamily 5, group A, member 10.186
Hand2heart and neural crest derivatives expressed transcript 20.183
Ptf1apancreas specific transcription factor, 1a0.183
Lhx9LIM homeobox protein 90.181
Fcgr2bFc receptor, IgG, low affinity IIb0.181
Slpisecretory leukocyte peptidase inhibitor0.178
Pax2paired box gene 20.177
Gzmbgranzyme B0.174
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BIRC3baculoviral IAP repeat containing 31.000
MYD88myeloid differentiation primary response gene (88)0.995
C1QAcomplement component 1, q subcomponent, A chain0.977
IRAK2interleukin-1 receptor-associated kinase 20.950
IRAK3interleukin-1 receptor-associated kinase 30.849
TRAF1TNF receptor-associated factor 10.715
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.676
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.630
CCR1chemokine (C-C motif) receptor 10.600
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.588
CXCL2chemokine (C-X-C motif) ligand 20.542
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.534
SYKspleen tyrosine kinase0.511
MAPK14mitogen-activated protein kinase 140.489
TNFtumor necrosis factor0.463
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.441
TRAF2TNF receptor-associated factor 20.431
TLR2toll-like receptor 20.411
IL10RAinterleukin 10 receptor, alpha0.406
RXRAretinoid X receptor, alpha0.374
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.350
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.343
TRADDTNFRSF1A-associated via death domain0.335
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.334
IRAK1interleukin-1 receptor-associated kinase 10.332
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.312
PTPN6protein tyrosine phosphatase, non-receptor type 60.272
PILRApaired immunoglobin-like type 2 receptor alpha0.272
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.249
GAS6growth arrest-specific 60.220
CCL4chemokine (C-C motif) ligand 40.215
CD163CD163 molecule0.213
TRAF5TNF receptor-associated factor 50.211
HSF1heat shock transcription factor 10.204
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.195
CASP8caspase 8, apoptosis-related cysteine peptidase0.188
CXCL10chemokine (C-X-C motif) ligand 100.175
PTAFRplatelet-activating factor receptor0.171
CCR5chemokine (C-C motif) receptor 50.167
MEFVMediterranean fever0.166
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.163
AXLAXL receptor tyrosine kinase0.162
TICAM2toll-like receptor adaptor molecule 20.162
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.160
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.159
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.156
C1QBcomplement component 1, q subcomponent, B chain0.156
IDEinsulin-degrading enzyme0.155
IL8interleukin 80.154
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.154
CXCL5chemokine (C-X-C motif) ligand 50.151
TLR4toll-like receptor 40.147
SIGLEC7sialic acid binding Ig-like lectin 70.145
CXCL9chemokine (C-X-C motif) ligand 90.145
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.144
CCL2chemokine (C-C motif) ligand 20.140
CCL5chemokine (C-C motif) ligand 50.139
USP4ubiquitin specific peptidase 4 (proto-oncogene)0.116
FASFas (TNF receptor superfamily, member 6)0.116
CD48CD48 molecule0.115
ZNF263zinc finger protein 2630.115
MED15mediator complex subunit 150.109
CCL8chemokine (C-C motif) ligand 80.108
HSPB1heat shock 27kDa protein 10.103
TNFAIP3tumor necrosis factor, alpha-induced protein 30.102
TYMPthymidine phosphorylase0.101
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.100
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.097
C1QCcomplement component 1, q subcomponent, C chain0.096
TMEM173transmembrane protein 1730.094
EPORerythropoietin receptor0.086
SETD8SET domain containing (lysine methyltransferase) 80.086
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.085
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.085
HK3hexokinase 3 (white cell)0.084
CXCL3chemokine (C-X-C motif) ligand 30.080
CXCL11chemokine (C-X-C motif) ligand 110.080
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.079
CMKLR1chemokine-like receptor 10.079
CCL20chemokine (C-C motif) ligand 200.078
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.078
RUNX1runt-related transcription factor 10.077
MAP3K5mitogen-activated protein kinase kinase kinase 50.075
BLNKB-cell linker0.074
SOCS3suppressor of cytokine signaling 30.071
ZC3H12Azinc finger CCCH-type containing 12A0.070
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.069
SLAMF8SLAM family member 80.069
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.069
CLEC7AC-type lectin domain family 7, member A0.067
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.066
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.066
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.065
RARAretinoic acid receptor, alpha0.065
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.062
TEKTEK tyrosine kinase, endothelial0.061
CSF1Rcolony stimulating factor 1 receptor0.061
IGSF6immunoglobulin superfamily, member 60.059
ZBTB48zinc finger and BTB domain containing 480.059
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 30.140
Cd14CD14 molecule0.112
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.107
Ccl7chemokine (C-C motif) ligand 70.083
Icam1intercellular adhesion molecule 10.074
Ifitm3interferon induced transmembrane protein 30.046
Ccl2chemokine (C-C motif) ligand 20.046
Junbjun B proto-oncogene0.041
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.040
Cxcl2chemokine (C-X-C motif) ligand 20.039
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.034
Cfdcomplement factor D (adipsin)0.030
Klrd1killer cell lectin-like receptor, subfamily D, member 10.029
Litaflipopolysaccharide-induced TNF factor0.029
Timp1TIMP metallopeptidase inhibitor 10.029
Hpgdshematopoietic prostaglandin D synthase0.027
Xdhxanthine dehydrogenase0.027
Ier3immediate early response 30.026
Il1binterleukin 1 beta0.024
Folr2folate receptor 2 (fetal)0.023
Tbc1d2bTBC1 domain family, member 2B0.022
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.022
Rgs1regulator of G-protein signaling 10.022
C5ar1complement component 5a receptor 10.021
Cxcl10chemokine (C-X-C motif) ligand 100.020
Mrc1mannose receptor, C type 10.019
Ccl3chemokine (C-C motif) ligand 30.019
Adrb2adrenergic, beta-2-, receptor, surface0.018
Il6interleukin 60.018
Jak1Janus kinase 10.017
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.017
Grprgastrin releasing peptide receptor0.017
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.017
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.017
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.017
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.016
Selpselectin P0.015
Hmox1heme oxygenase (decycling) 10.014
Klf4Kruppel-like factor 4 (gut)0.014
Hrh2histamine receptor H 20.014
Ccl4chemokine (C-C motif) ligand 40.014
Il2rbinterleukin 2 receptor, beta0.013
Fabp4fatty acid binding protein 4, adipocyte0.013
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.013
Plscr1phospholipid scramblase 10.012
Nkg7natural killer cell group 7 sequence0.012
Myd88myeloid differentiation primary response gene 880.012
Csf1colony stimulating factor 1 (macrophage)0.012
Plauplasminogen activator, urokinase0.012
Rab32RAB32, member RAS oncogene family0.012
Mmp12matrix metallopeptidase 120.012
Slpisecretory leukocyte peptidase inhibitor0.011
Bcl3B-cell CLL/lymphoma 30.011
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.011
Reg3bregenerating islet-derived 3 beta0.011
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.011
Hbbhemoglobin, beta0.011
Igsf6immunoglobulin superfamily, member 60.011
Igsf7immunoglobulin superfamily, member 70.010
Tlr2toll-like receptor 20.010
Smad1SMAD family member 10.010
Arl11ADP-ribosylation factor-like 110.010
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism