The network for 'toll like receptor 4 signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

toll like receptor 4 signaling pathway

Any series of molecular signals generated as a consequence of binding to toll-like receptor 4.

NameDescriptionProbabilityFunc Analog Organism
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1051.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Myd88myeloid differentiation primary response gene 880.998
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.988
Traf6TNF receptor-associated factor 60.984
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.972
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.893
Ikzf1IKAROS family zinc finger 10.892
Tnftumor necrosis factor0.873
Tnfaip3tumor necrosis factor, alpha-induced protein 30.812
Ldb3LIM domain binding 30.599
Ighimmunoglobulin heavy chain complex0.564
FasFas (TNF receptor superfamily member 6)0.506
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.497
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.471
BlnkB-cell linker0.424
Il2rginterleukin 2 receptor, gamma chain0.416
Stat3signal transducer and activator of transcription 30.380
Map3k8mitogen-activated protein kinase kinase kinase 80.367
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.364
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.358
Cd19CD19 antigen0.354
Tnip1TNFAIP3 interacting protein 10.338
Csf1colony stimulating factor 1 (macrophage)0.262
Inpp5dinositol polyphosphate-5-phosphatase D0.255
Cxcl2chemokine (C-X-C motif) ligand 20.216
Plcg2phospholipase C, gamma 20.206
Map3k14mitogen-activated protein kinase kinase kinase 140.188
Irak4interleukin-1 receptor-associated kinase 40.155
Prkceprotein kinase C, epsilon0.151
Ptpreprotein tyrosine phosphatase, receptor type, E0.133
Cd40CD40 antigen0.127
Ptprcprotein tyrosine phosphatase, receptor type, C0.105
Ptk2bPTK2 protein tyrosine kinase 2 beta0.102
Bcl3B-cell leukemia/lymphoma 30.100
Lcklymphocyte protein tyrosine kinase0.099
Ccr6chemokine (C-C motif) receptor 60.093
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.092
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.092
Hcls1hematopoietic cell specific Lyn substrate 10.089
CblCasitas B-lineage lymphoma0.084
Cd247CD247 antigen0.073
Irak3interleukin-1 receptor-associated kinase 30.067
Icam1intercellular adhesion molecule 10.066
Grb2growth factor receptor bound protein 20.065
Dab1disabled homolog 1 (Drosophila)0.063
Cyldcylindromatosis (turban tumor syndrome)0.062
TifaTRAF-interacting protein with forkhead-associated domain0.062
Pou2af1POU domain, class 2, associating factor 10.057
Il1rninterleukin 1 receptor antagonist0.056
Jak3Janus kinase 30.053
WasWiskott-Aldrich syndrome homolog (human)0.050
Tiraptoll-interleukin 1 receptor (TIR) domain-containing adaptor protein0.050
S100a8S100 calcium binding protein A8 (calgranulin A)0.047
Prkcdprotein kinase C, delta0.046
C3complement component 30.046
Cd22CD22 antigen0.045
FybFYN binding protein0.044
Ticam1toll-like receptor adaptor molecule 10.040
FynFyn proto-oncogene0.040
Skap2src family associated phosphoprotein 20.038
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.038
FaddFas (TNFRSF6)-associated via death domain0.038
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.037
Il4rainterleukin 4 receptor, alpha0.036
Sykbspleen tyrosine kinase0.036
Tnfaip2tumor necrosis factor, alpha-induced protein 20.035
Cdcp1CUB domain containing protein 10.034
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.030
Birc3baculoviral IAP repeat-containing 30.030
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.028
TcraT-cell receptor alpha chain0.027
Ptpn6protein tyrosine phosphatase, non-receptor type 60.027
Ikbkginhibitor of kappaB kinase gamma0.027
Il2rbinterleukin 2 receptor, beta chain0.027
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.026
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.026
Ptenphosphatase and tensin homolog0.026
Ltbrlymphotoxin B receptor0.026
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.025
Plaurplasminogen activator, urokinase receptor0.024
Clockcircadian locomotor output cycles kaput0.022
Ptpraprotein tyrosine phosphatase, receptor type, A0.022
BC013712cDNA sequence BC0137120.022
Traf3ip2TRAF3 interacting protein 20.022
Lrg1leucine-rich alpha-2-glycoprotein 10.021
Ltalymphotoxin A0.021
Il1r1interleukin 1 receptor, type I0.021
Ptk2PTK2 protein tyrosine kinase 20.021
Zfp36zinc finger protein 360.021
Lcn2lipocalin 20.020
Ifnar1interferon (alpha and beta) receptor 10.020
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.020
Tlr2toll-like receptor 20.020
Ltblymphotoxin B0.020
Dynlt1bdynein light chain Tctex-type 1D0.019
Socs3suppressor of cytokine signaling 30.019
Dok1docking protein 10.019
Itgaxintegrin alpha X0.018
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MYD88myeloid differentiation primary response gene (88)0.979
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.839
IRAK2interleukin-1 receptor-associated kinase 20.690
S100A1S100 calcium binding protein A10.678
RXRAretinoid X receptor, alpha0.676
PELI3pellino homolog 3 (Drosophila)0.595
TLR4toll-like receptor 40.496
MDM2Mdm2 p53 binding protein homolog (mouse)0.428
S100A16S100 calcium binding protein A160.388
S100A14S100 calcium binding protein A140.370
MED25mediator complex subunit 250.353
IRAK4interleukin-1 receptor-associated kinase 40.317
IRAK1interleukin-1 receptor-associated kinase 10.259
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.252
TRAF6TNF receptor-associated factor 60.238
IRAK3interleukin-1 receptor-associated kinase 30.235
S100BS100 calcium binding protein B0.224
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.111
S100A6S100 calcium binding protein A60.087
AGERadvanced glycosylation end product-specific receptor0.070
MAP3K5mitogen-activated protein kinase kinase kinase 50.060
RARAretinoic acid receptor, alpha0.044
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.043
MAP3K8mitogen-activated protein kinase kinase kinase 80.036
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.032
S100PS100 calcium binding protein P0.032
SPOPspeckle-type POZ protein0.024
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.022
BIRC3baculoviral IAP repeat containing 30.022
TNFAIP3tumor necrosis factor, alpha-induced protein 30.022
NCOA1nuclear receptor coactivator 10.021
SAMHD1SAM domain and HD domain 10.019
IL1R1interleukin 1 receptor, type I0.019
IL1RAPinterleukin 1 receptor accessory protein0.014
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.014
BRAFv-raf murine sarcoma viral oncogene homolog B10.014
IRF7interferon regulatory factor 70.013
S100A9S100 calcium binding protein A90.012
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.012
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.012
ITGB1BP2integrin beta 1 binding protein (melusin) 20.011
PELI2pellino homolog 2 (Drosophila)0.011
TRAF1TNF receptor-associated factor 10.011
MED1mediator complex subunit 10.011
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.010
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism