The network for 'regulation of defense response to bacterium' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of defense response to bacterium

Any process that modulates the frequency, rate or extent of defense response to bacterium.

NameDescriptionProbabilityFunc Analog Organism
Ikbkginhibitor of kappaB kinase gamma1.000
Casp4caspase 4, apoptosis-related cysteine peptidase1.000
Tnftumor necrosis factor0.999
Ikbkbinhibitor of kappaB kinase beta0.991
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.984
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.981
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.978
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.957
Lyz2lysozyme 20.945
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.943
Trp53transformation related protein 530.903
PycardPYD and CARD domain containing0.883
Il1binterleukin 1 beta0.868
Cd44CD44 antigen0.848
Gbp2guanylate binding protein 20.702
Gbp3guanylate binding protein 30.652
Casp1caspase 10.621
Irf1interferon regulatory factor 10.614
FasFas (TNF receptor superfamily member 6)0.599
Iigp1interferon inducible GTPase 10.582
Cxcl1chemokine (C-X-C motif) ligand 10.543
Cd14CD14 antigen0.539
Nlrp3NLR family, pyrin domain containing 30.526
Gbp7guanylate binding protein 70.522
Il18interleukin 180.492
Cxcl2chemokine (C-X-C motif) ligand 20.481
Bcl3B-cell leukemia/lymphoma 30.478
Tlr4toll-like receptor 40.472
Il1rninterleukin 1 receptor antagonist0.456
Stat3signal transducer and activator of transcription 30.449
Map3k14mitogen-activated protein kinase kinase kinase 140.428
Per1period homolog 1 (Drosophila)0.408
Ccl2chemokine (C-C motif) ligand 20.378
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.355
Socs1suppressor of cytokine signaling 10.331
Gbp5guanylate binding protein 50.329
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.307
Il10interleukin 100.304
Csf1colony stimulating factor 1 (macrophage)0.287
Mmp13matrix metallopeptidase 130.277
Ifit1interferon-induced protein with tetratricopeptide repeats 10.263
Myd88myeloid differentiation primary response gene 880.258
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.256
Map3k7mitogen-activated protein kinase kinase kinase 70.240
Cxcl10chemokine (C-X-C motif) ligand 100.230
Ccl7chemokine (C-C motif) ligand 70.225
Ccl12chemokine (C-C motif) ligand 120.218
Il6interleukin 60.216
Irg1immunoresponsive gene 10.214
Map3k8mitogen-activated protein kinase kinase kinase 80.213
Per2period homolog 2 (Drosophila)0.213
Ccr1chemokine (C-C motif) receptor 10.209
Cd40CD40 antigen0.208
Aim2absent in melanoma 20.207
Irgm1immunity-related GTPase family M member 10.193
Traf6TNF receptor-associated factor 60.193
Ighimmunoglobulin heavy chain complex0.189
Ifih1interferon induced with helicase C domain 10.183
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.178
Ccl4chemokine (C-C motif) ligand 40.171
Irgm2immunity-related GTPase family M member 20.159
Ccl3chemokine (C-C motif) ligand 30.156
Ifi44interferon-induced protein 440.155
Ubdubiquitin D0.143
Il1r1interleukin 1 receptor, type I0.139
Ticam1toll-like receptor adaptor molecule 10.135
Ifit3interferon-induced protein with tetratricopeptide repeats 30.134
Runx1runt related transcription factor 10.133
Chukconserved helix-loop-helix ubiquitous kinase0.130
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.127
Igtpinterferon gamma induced GTPase0.124
Ifi47interferon gamma inducible protein 470.123
Rsad2radical S-adenosyl methionine domain containing 20.121
Tgtp2T-cell specific GTPase 20.118
Clec4dC-type lectin domain family 4, member d0.115
Klra2killer cell lectin-like receptor, subfamily A, member 20.114
Rnf31ring finger protein 310.113
Ooepoocyte expressed protein homolog (dog)0.109
Cry2cryptochrome 2 (photolyase-like)0.107
CrebbpCREB binding protein0.107
Msr1macrophage scavenger receptor 10.104
E2f1E2F transcription factor 10.102
MefvMediterranean fever0.102
C3ar1complement component 3a receptor 10.096
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.091
Bcl6B-cell leukemia/lymphoma 60.091
Saa3serum amyloid A 30.090
Zc3h12azinc finger CCCH type containing 12A0.089
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.088
Irf7interferon regulatory factor 70.088
Niacr1niacin receptor 10.087
Ms4a7membrane-spanning 4-domains, subfamily A, member 70.086
Il2rginterleukin 2 receptor, gamma chain0.085
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.080
Stk4serine/threonine kinase 40.080
Smad1MAD homolog 1 (Drosophila)0.079
Tnfaip3tumor necrosis factor, alpha-induced protein 30.079
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.078
Mx2myxovirus (influenza virus) resistance 20.077
2410004A20RikRIKEN cDNA 2410004A20 gene0.076
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.997
ird5immune response deficient 50.908
DptBDiptericin B0.897
PGRP-SAPeptidoglycan recognition protein SA0.881
Spn27ASerpin 27A0.864
PGRP-SDCG7496 gene product from transcript CG7496-RA0.739
IrcImmune-regulated catalase0.703
grassGram-positive Specific Serine protease0.667
imdimmune deficiency0.628
Spn1Serine protease inhibitor 10.586
PGRP-LFPeptidoglycan recognition protein LF0.407
PGRP-LBPeptidoglycan recognition protein LB0.386
BG4CG12297 gene product from transcript CG12297-RA0.360
Sp7Serine protease 70.285
CG9184CG9184 gene product from transcript CG9184-RB0.282
Spn28DSerpin 28D0.251
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.247
Mpk2CG5475 gene product from transcript CG5475-RB0.228
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.199
Myd88CG2078 gene product from transcript CG2078-RA0.140
CG32185CG32185 gene product from transcript CG32185-RA0.138
pirkpoor Imd response upon knock-in0.127
Mekk1CG7717 gene product from transcript CG7717-RB0.108
modSPmodular serine protease0.106
CG15065CG15065 gene product from transcript CG15065-RA0.100
DreddDeath related ced-3/Nedd2-like protein0.100
Eip71CDEcdysone-induced protein 28/29kD0.097
CG6361CG6361 gene product from transcript CG6361-RA0.091
GNBP1Gram-negative bacteria binding protein 10.084
GNBP3Gram-negative bacteria binding protein 30.080
CecA2Cecropin A20.077
ird1immune response deficient 10.076
CG18594CG18594 gene product from transcript CG18594-RA0.074
SPESpatzle-Processing Enzyme0.070
CG13422CG13422 gene product from transcript CG13422-RA0.069
spiritSerine Protease Immune Response Integrator0.066
DuoxDual oxidase0.062
IceCG7788 gene product from transcript CG7788-RA0.061
piepineapple eye0.060
CecCCecropin C0.054
Tak1TGF-beta activated kinase 10.054
CG13641CG13641 gene product from transcript CG13641-RA0.049
eaterCG6124 gene product from transcript CG6124-RB0.047
IM18Immune induced molecule 180.046
NcNedd2-like caspase0.044
CG5791CG5791 gene product from transcript CG5791-RA0.043
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.042
upd3unpaired 30.041
PGRP-LEPeptidoglycan recognition protein LE0.036
CskC-terminal Src kinase0.035
CycJCyclin J0.033
CG15917CG15917 gene product from transcript CG15917-RA0.032
CG31038CG31038 gene product from transcript CG31038-RA0.032
CG14567CG14567 gene product from transcript CG14567-RA0.032
CG12766CG12766 gene product from transcript CG12766-RA0.031
bbgbig bang0.031
CG16772CG16772 gene product from transcript CG16772-RA0.030
Spn4Serine protease inhibitor 40.030
CG42863CG42863 gene product from transcript CG42863-RB0.030
Traf4TNF-receptor-associated factor 40.029
TepIIIThiolester containing protein III0.029
18w18 wheeler0.028
OatOrnithine aminotransferase precursor0.028
CG18067CG18067 gene product from transcript CG18067-RA0.028
CG16718CG16718 gene product from transcript CG16718-RA0.027
CG16836CG16836 gene product from transcript CG16836-RA0.027
CG13962CG13962 gene product from transcript CG13962-RA0.026
TM9SF4CG7364 gene product from transcript CG7364-RA0.026
Traf6TNF-receptor-associated factor 60.026
CG1103CG1103 gene product from transcript CG1103-RA0.025
upd2unpaired 20.024
JupiterCG31363 gene product from transcript CG31363-RD0.022
CG11841CG11841 gene product from transcript CG11841-RA0.022
nAcRbeta-21Cnicotinic acetylcholine receptor beta 21C0.022
IM10Immune induced molecule 100.022
Apc2Adenomatous polyposis coli tumor suppressor homolog 20.022
CG9812CG9812 gene product from transcript CG9812-RB0.022
CG14317CG14317 gene product from transcript CG14317-RA0.021
Tab2TAK1-associated binding protein 20.021
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.998
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.991
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.979
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.890
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.870
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.833
CHUKconserved helix-loop-helix ubiquitous kinase0.819
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.769
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.346
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.331
TNIP2TNFAIP3 interacting protein 20.278
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.205
NLRC4NLR family, CARD domain containing 40.197
MAP3K14mitogen-activated protein kinase kinase kinase 140.168
MAP3K8mitogen-activated protein kinase kinase kinase 80.163
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.118
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.089
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.069
CASP4caspase 4, apoptosis-related cysteine peptidase0.065
MDM4Mdm4 p53 binding protein homolog (mouse)0.062
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.050
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.047
RIPK2receptor-interacting serine-threonine kinase 20.046
BTRCbeta-transducin repeat containing0.025
PYCARDPYD and CARD domain containing0.024
BCL3B-cell CLL/lymphoma 30.024
SQSTM1sequestosome 10.022
FKBP5FK506 binding protein 50.022
NLRC5NLR family, CARD domain containing 50.022
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.021
CASP10caspase 10, apoptosis-related cysteine peptidase0.021
SFRS18splicing factor, arginine/serine-rich 180.020
ITGB1BP1integrin beta 1 binding protein 10.020
MAP3K3mitogen-activated protein kinase kinase kinase 30.020
ATMataxia telangiectasia mutated0.019
CARD11caspase recruitment domain family, member 110.018
MYL12Amyosin, light chain 12A, regulatory, non-sarcomeric0.017
TRAF6TNF receptor-associated factor 60.017
ELF4E74-like factor 4 (ets domain transcription factor)0.017
KEAP1kelch-like ECH-associated protein 10.017
CARD16caspase recruitment domain family, member 160.016
GOLGA6L9golgin A6 family-like 90.016
IL18interleukin 18 (interferon-gamma-inducing factor)0.015
CAV1caveolin 1, caveolae protein, 22kDa0.015
USP20ubiquitin specific peptidase 200.014
INADLInaD-like (Drosophila)0.014
BCL10B-cell CLL/lymphoma 100.013
URODuroporphyrinogen decarboxylase0.013
XIAPX-linked inhibitor of apoptosis0.013
MED12mediator complex subunit 120.013
TNFAIP3tumor necrosis factor, alpha-induced protein 30.013
MDN1MDN1, midasin homolog (yeast)0.013
SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 10.012
MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like0.012
BEND5BEN domain containing 50.012
PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14A0.011
DCLRE1CDNA cross-link repair 1C0.011
IFI16interferon, gamma-inducible protein 160.011
ELP2elongation protein 2 homolog (S. cerevisiae)0.011
MEN1multiple endocrine neoplasia I0.011
TNIP1TNFAIP3 interacting protein 10.010
PSME4proteasome (prosome, macropain) activator subunit 40.010
MAP3K1mitogen-activated protein kinase kinase kinase 10.010
NCOA5nuclear receptor coactivator 50.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism