The network for 'cellular response to cytokine stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to cytokine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Ifnginterferon gamma1.000
Il1r1interleukin 1 receptor, type I0.999
Casp4caspase 4, apoptosis-related cysteine peptidase0.999
Ccr2chemokine (C-C motif) receptor 20.999
Lyz2lysozyme 20.998
Jak2Janus kinase 20.998
Stat3signal transducer and activator of transcription 30.997
Leprleptin receptor0.995
Ccl2chemokine (C-C motif) ligand 20.990
Myd88myeloid differentiation primary response gene 880.985
Casp1caspase 10.983
Cd44CD44 antigen0.978
Csf1colony stimulating factor 1 (macrophage)0.977
Tlr4toll-like receptor 40.977
Stat6signal transducer and activator of transcription 60.975
Apcadenomatosis polyposis coli0.974
Apoeapolipoprotein E0.971
Stat1signal transducer and activator of transcription 10.962
Il4interleukin 40.959
Gbp7guanylate binding protein 70.953
Map3k8mitogen-activated protein kinase kinase kinase 80.953
Irf9interferon regulatory factor 90.948
Nos2nitric oxide synthase 2, inducible0.942
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.941
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.940
Igtpinterferon gamma induced GTPase0.939
Il6interleukin 60.930
Ptpn11protein tyrosine phosphatase, non-receptor type 110.921
Ifngr1interferon gamma receptor 10.917
Ccr1chemokine (C-C motif) receptor 10.915
Cd40CD40 antigen0.914
Irf1interferon regulatory factor 10.911
Cxcl10chemokine (C-X-C motif) ligand 100.909
Il1binterleukin 1 beta0.902
Mmp9matrix metallopeptidase 90.899
Icosinducible T-cell co-stimulator0.892
Cdkn1bcyclin-dependent kinase inhibitor 1B0.888
Arandrogen receptor0.877
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.869
Ltblymphotoxin B0.866
Gbp2guanylate binding protein 20.865
Socs3suppressor of cytokine signaling 30.863
Batfbasic leucine zipper transcription factor, ATF-like0.857
FasFas (TNF receptor superfamily member 6)0.856
Iigp1interferon inducible GTPase 10.856
Ptgs2prostaglandin-endoperoxide synthase 20.853
Il10interleukin 100.851
Tnfaip3tumor necrosis factor, alpha-induced protein 30.849
Cd86CD86 antigen0.843
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.835
Ikzf1IKAROS family zinc finger 10.828
Mx2myxovirus (influenza virus) resistance 20.826
Birc3baculoviral IAP repeat-containing 30.804
Krt17keratin 170.804
Plcg1phospholipase C, gamma 10.798
Selpselectin, platelet0.793
Il1rninterleukin 1 receptor antagonist0.788
Prf1perforin 1 (pore forming protein)0.772
Ccl8chemokine (C-C motif) ligand 80.771
Map3k14mitogen-activated protein kinase kinase kinase 140.764
Cxcl13chemokine (C-X-C motif) ligand 130.764
Ch25hcholesterol 25-hydroxylase0.755
Nlrp3NLR family, pyrin domain containing 30.753
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.751
Il18rapinterleukin 18 receptor accessory protein0.745
BtkBruton agammaglobulinemia tyrosine kinase0.743
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.738
H2-Aahistocompatibility 2, class II antigen A, alpha0.733
Osmroncostatin M receptor0.731
Bbs4Bardet-Biedl syndrome 4 (human)0.728
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.726
Ifit1interferon-induced protein with tetratricopeptide repeats 10.726
Nos1nitric oxide synthase 1, neuronal0.723
Mndalmyeloid nuclear differentiation antigen like0.706
Ccl9chemokine (C-C motif) ligand 90.691
Tlr2toll-like receptor 20.691
Cxcl12chemokine (C-X-C motif) ligand 120.688
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.684
Trp63transformation related protein 630.684
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.683
Esr1estrogen receptor 1 (alpha)0.676
C3complement component 30.674
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.673
Foxp3forkhead box P30.670
PycardPYD and CARD domain containing0.670
Egfrepidermal growth factor receptor0.657
Ifit3interferon-induced protein with tetratricopeptide repeats 30.657
Gbp5guanylate binding protein 50.655
Itgb2integrin beta 20.652
Rpl6ribosomal protein L60.650
Aim2absent in melanoma 20.637
C1qacomplement component 1, q subcomponent, alpha polypeptide0.636
Fcgr1Fc receptor, IgG, high affinity I0.636
Serpina3gserine (or cysteine) peptidase inhibitor, clade A, member 3G0.636
Il18r1interleukin 18 receptor 10.632
Il12rb2interleukin 12 receptor, beta 20.622
Rps2ribosomal protein S20.622
Tgtp2T-cell specific GTPase 20.615
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ef1aelongation factor 1-alpha0.117
spry4sprouty (Drosophila) homolog 40.096
mmp9matrix metalloproteinase 90.093
cxcr4bchemokine (C-X-C motif), receptor 4b0.059
ikzf1IKAROS family zinc finger 1 (Ikaros)0.058
anxa1aannexin A1a0.057
il6rinterleukin 6 receptor0.051
il6stinterleukin 6 signal transducer0.033
rag1recombination activating gene 10.026
tlr3toll-like receptor 30.025
mapk3mitogen-activated protein kinase 30.025
junbjun B proto-oncogene0.025
cdh1cadherin 1, epithelial0.024
nrp2bneuropilin 2b0.023
bmp4bone morphogenetic protein 40.022
col1a2collagen, type I, alpha 20.020
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.020
hspd1heat shock 60kD protein 1 (chaperonin)0.019
metmet proto-oncogene (hepatocyte growth factor receptor)0.017
elovl2elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 20.016
socs3asuppressor of cytokine signaling 3a0.016
ghragrowth hormone receptor a0.014
bcl2l1bcl2-like 10.014
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.014
fabp2fatty acid binding protein 2, intestinal0.014
il7rinterleukin 7 receptor0.013
fzd7bfrizzled homolog 7b0.013
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.013
stc1lstanniocalcin 1, like0.013
jag1ajagged 1a0.012
cyt1type I cytokeratin, enveloping layer0.012
stat3signal transduction and activation of transcription 30.012
stat1bsignal transducer and activator of transcription 1b0.012
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.012
ntn2netrin 20.012
slc2a1bsolute carrier family 2 (facilitated glucose transporter), member 1b0.012
lmo4aLIM domain only 4a0.011
hoxd3ahomeo box D3a0.011
ighzimmunoglobulin heavy constant zeta0.010
adipor1aadiponectin receptor 1a0.010
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.010
mapk4mitogen-activated protein kinase 40.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
STAT1signal transducer and activator of transcription 1, 91kDa0.997
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.988
BIRC3baculoviral IAP repeat containing 30.988
TRAF6TNF receptor-associated factor 60.986
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.980
CAV1caveolin 1, caveolae protein, 22kDa0.978
MT1Hmetallothionein 1H0.965
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.958
SOCS3suppressor of cytokine signaling 30.958
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.958
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.952
IL1Binterleukin 1, beta0.952
MT1Fmetallothionein 1F0.949
GHRgrowth hormone receptor0.933
MT1Xmetallothionein 1X0.933
IL1R1interleukin 1 receptor, type I0.932
PTPN1protein tyrosine phosphatase, non-receptor type 10.928
ZNF43zinc finger protein 430.927
IFITM1interferon induced transmembrane protein 1 (9-27)0.924
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.912
MT2Ametallothionein 2A0.907
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.905
MT1Emetallothionein 1E0.901
MDM2Mdm2 p53 binding protein homolog (mouse)0.890
TRAF5TNF receptor-associated factor 50.887
MAPK1mitogen-activated protein kinase 10.880
MAP3K3mitogen-activated protein kinase kinase kinase 30.873
IRAK1interleukin-1 receptor-associated kinase 10.861
SOCS1suppressor of cytokine signaling 10.854
FASFas (TNF receptor superfamily, member 6)0.852
CCR7chemokine (C-C motif) receptor 70.852
IFIT3interferon-induced protein with tetratricopeptide repeats 30.847
CCL5chemokine (C-C motif) ligand 50.840
ISG15ISG15 ubiquitin-like modifier0.838
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.833
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.831
TAL1T-cell acute lymphocytic leukemia 10.830
MAP3K7mitogen-activated protein kinase kinase kinase 70.823
IFIT1interferon-induced protein with tetratricopeptide repeats 10.802
C1QAcomplement component 1, q subcomponent, A chain0.802
NCOR1nuclear receptor corepressor 10.771
IRF9interferon regulatory factor 90.764
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.755
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.753
CXCL9chemokine (C-X-C motif) ligand 90.751
TNFtumor necrosis factor0.748
GRB2growth factor receptor-bound protein 20.745
IFIT2interferon-induced protein with tetratricopeptide repeats 20.737
CCR5chemokine (C-C motif) receptor 50.733
SIRT1sirtuin 10.732
RUNX1runt-related transcription factor 10.731
CCL22chemokine (C-C motif) ligand 220.729
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.724
IL2RBinterleukin 2 receptor, beta0.722
ICAM1intercellular adhesion molecule 10.721
ZNF273zinc finger protein 2730.718
NMIN-myc (and STAT) interactor0.710
CCL2chemokine (C-C motif) ligand 20.707
HCKhemopoietic cell kinase0.701
TRADDTNFRSF1A-associated via death domain0.697
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.693
UBE2L6ubiquitin-conjugating enzyme E2L 60.690
IRAK2interleukin-1 receptor-associated kinase 20.685
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.683
TNFRSF9tumor necrosis factor receptor superfamily, member 90.667
IL1R2interleukin 1 receptor, type II0.665
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.657
MAPK14mitogen-activated protein kinase 140.634
PTPN11protein tyrosine phosphatase, non-receptor type 110.625
CCL4chemokine (C-C motif) ligand 40.623
IL1RNinterleukin 1 receptor antagonist0.622
ZNF253zinc finger protein 2530.619
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.593
CASP8caspase 8, apoptosis-related cysteine peptidase0.580
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.579
TUBBtubulin, beta0.575
TNFAIP3tumor necrosis factor, alpha-induced protein 30.572
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.558
CXCL3chemokine (C-X-C motif) ligand 30.547
GDF9growth differentiation factor 90.545
IRF1interferon regulatory factor 10.541
TRAF2TNF receptor-associated factor 20.538
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.536
CXCL5chemokine (C-X-C motif) ligand 50.527
IL6interleukin 6 (interferon, beta 2)0.524
IFITM3interferon induced transmembrane protein 3 (1-8U)0.521
STAT2signal transducer and activator of transcription 2, 113kDa0.519
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.516
PDZD3PDZ domain containing 30.514
MAP3K5mitogen-activated protein kinase kinase kinase 50.513
SQSTM1sequestosome 10.509
IL10interleukin 100.502
CDC37cell division cycle 37 homolog (S. cerevisiae)0.501
KEAP1kelch-like ECH-associated protein 10.497
IFNGinterferon, gamma0.496
CXCL10chemokine (C-X-C motif) ligand 100.492
PTPRJprotein tyrosine phosphatase, receptor type, J0.491
JAK1Janus kinase 10.491
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.485
IL8interleukin 80.483
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il6interleukin 60.888
Il1r1interleukin 1 receptor, type I0.809
Cxcl10chemokine (C-X-C motif) ligand 100.761
Il1binterleukin 1 beta0.754
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.691
RT1-BaRT1 class II, locus Ba0.685
Col1a1collagen, type I, alpha 10.641
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.637
Hckhemopoietic cell kinase0.604
Ccl4chemokine (C-C motif) ligand 40.577
Orm1orosomucoid 10.572
Socs3suppressor of cytokine signaling 30.569
Sellselectin L0.547
Mmp12matrix metallopeptidase 120.540
Cxcl2chemokine (C-X-C motif) ligand 20.491
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.455
Ccl2chemokine (C-C motif) ligand 20.450
Fosl1fos-like antigen 10.441
Ptger2prostaglandin E receptor 2 (subtype EP2)0.433
Mmp3matrix metallopeptidase 30.431
Ccl20chemokine (C-C motif) ligand 200.426
RT1-Db1RT1 class II, locus Db10.393
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.383
Col3a1collagen, type III, alpha 10.359
Ggt1gamma-glutamyltransferase 10.358
Ccl5chemokine (C-C motif) ligand 50.357
Fshbfollicle stimulating hormone, beta polypeptide0.346
Mx1myxovirus (influenza virus) resistance 10.340
FosFBJ osteosarcoma oncogene0.318
Cd14CD14 molecule0.316
Col1a2collagen, type I, alpha 20.309
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.307
Stat3signal transducer and activator of transcription 30.307
Junbjun B proto-oncogene0.302
Ripk3receptor-interacting serine-threonine kinase 30.292
Il2rainterleukin 2 receptor, alpha0.291
Tgm1transglutaminase 1, K polypeptide0.291
Tpothyroid peroxidase0.285
Egr2early growth response 20.285
Il6stinterleukin 6 signal transducer0.284
Icam1intercellular adhesion molecule 10.278
Usp18ubiquitin specific peptidase 180.274
Ehfets homologous factor0.271
Il4rainterleukin 4 receptor, alpha0.270
Bdkrb1bradykinin receptor B10.270
Dnase1l3deoxyribonuclease 1-like 30.270
Klrg1killer cell lectin-like receptor subfamily G, member 10.268
Runx1runt-related transcription factor 10.268
Krt18keratin 180.260
Ier3immediate early response 30.258
Nos3nitric oxide synthase 3, endothelial cell0.256
Ccr2chemokine (C-C motif) receptor 20.251
Atf3activating transcription factor 30.248
Flt1FMS-related tyrosine kinase 10.243
Bcl2B-cell CLL/lymphoma 20.242
Nos2nitric oxide synthase 2, inducible0.227
Map3k8mitogen-activated protein kinase kinase kinase 80.227
Ptgs2prostaglandin-endoperoxide synthase 20.226
Eif5aeukaryotic translation initiation factor 5A0.224
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.224
Reg3gregenerating islet-derived 3 gamma0.223
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.221
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.220
Ptgisprostaglandin I2 (prostacyclin) synthase0.218
Mmp7matrix metallopeptidase 70.215
Ier2immediate early response 20.211
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.208
Cd44Cd44 molecule0.206
Itgamintegrin, alpha M0.204
Kynukynureninase (L-kynurenine hydrolase)0.203
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.201
Ccl3chemokine (C-C motif) ligand 30.201
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.200
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.198
Slit3slit homolog 3 (Drosophila)0.198
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.198
Il8rbinterleukin 8 receptor, beta0.192
Cd2Cd2 molecule0.192
C1scomplement component 1, s subcomponent0.187
Jak2Janus kinase 20.187
Calcbcalcitonin-related polypeptide, beta0.183
Col5a1collagen, type V, alpha 10.182
Ctskcathepsin K0.181
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.181
Angpt2angiopoietin 20.179
Itgadintegrin, alpha D0.177
Nrg1neuregulin 10.172
FasFas (TNF receptor superfamily, member 6)0.169
F2rl1coagulation factor II (thrombin) receptor-like 10.169
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.168
Inhbainhibin beta-A0.168
Plauplasminogen activator, urokinase0.165
Pde3aphosphodiesterase 3A, cGMP inhibited0.165
Kcnt1potassium channel, subfamily T, member 10.165
Gzmcgranzyme C0.164
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism