The network for 'glucose homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glucose homeostasis

Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.

NameDescriptionProbabilityFunc Analog Organism
Esr1estrogen receptor 1 (alpha)0.991
Leprleptin receptor0.989
Neurod1neurogenic differentiation 10.951
Rargretinoic acid receptor, gamma0.944
Pdx1pancreatic and duodenal homeobox 10.942
Nos1nitric oxide synthase 1, neuronal0.905
Sox9SRY-box containing gene 90.888
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.851
Pnpla2patatin-like phospholipase domain containing 20.850
AxlAXL receptor tyrosine kinase0.848
Efnb2ephrin B20.846
Ppargperoxisome proliferator activated receptor gamma0.835
Foxo1forkhead box O10.832
Ephb2Eph receptor B20.832
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.820
Per2period homolog 2 (Drosophila)0.806
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.796
Pax3paired box gene 30.783
Lef1lymphoid enhancer binding factor 10.782
Shhsonic hedgehog0.774
Pax6paired box gene 60.764
Cdkn1bcyclin-dependent kinase inhibitor 1B0.748
Eya1eyes absent 1 homolog (Drosophila)0.732
Cav1caveolin 1, caveolae protein0.722
Kiss1KiSS-1 metastasis-suppressor0.722
Fgfr2fibroblast growth factor receptor 20.705
Nr2f2nuclear receptor subfamily 2, group F, member 20.679
Nrxn1neurexin I0.668
Ascl1achaete-scute complex homolog 1 (Drosophila)0.667
Lmx1aLIM homeobox transcription factor 1 alpha0.630
Pax8paired box gene 80.610
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.610
Foxc2forkhead box C20.599
Onecut1one cut domain, family member 10.595
Nr3c1nuclear receptor subfamily 3, group C, member 10.593
Arntlaryl hydrocarbon receptor nuclear translocator-like0.582
Clockcircadian locomotor output cycles kaput0.580
Aldoaaldolase A, fructose-bisphosphate0.570
Gli3GLI-Kruppel family member GLI30.566
Bmp4bone morphogenetic protein 40.565
Npy1rneuropeptide Y receptor Y10.550
Ghrgrowth hormone receptor0.539
Lyz2lysozyme 20.520
Grid2glutamate receptor, ionotropic, delta 20.517
Isl1ISL1 transcription factor, LIM/homeodomain0.503
Foxa2forkhead box A20.492
Ptpn11protein tyrosine phosphatase, non-receptor type 110.484
Lhx3LIM homeobox protein 30.477
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.473
Insrinsulin receptor0.448
Otx2orthodenticle homolog 2 (Drosophila)0.448
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.443
Drd2dopamine receptor D20.439
Ldb3LIM domain binding 30.433
Galr1galanin receptor 10.424
Il6stinterleukin 6 signal transducer0.418
Efnb1ephrin B10.416
Igf1insulin-like growth factor 10.415
Nkx6-1NK6 homeobox 10.409
Nrxn3neurexin III0.409
Insm1insulinoma-associated 10.403
Sox4SRY-box containing gene 40.393
Srrm4serine/arginine repetitive matrix 40.387
Npy2rneuropeptide Y receptor Y20.385
Htr75-hydroxytryptamine (serotonin) receptor 70.379
Zeb1zinc finger E-box binding homeobox 10.367
Fgfr1fibroblast growth factor receptor 10.365
Pbx1pre B-cell leukemia transcription factor 10.358
Gnrhrgonadotropin releasing hormone receptor0.354
Thbs1thrombospondin 10.345
Hif1ahypoxia inducible factor 1, alpha subunit0.344
Hand1heart and neural crest derivatives expressed transcript 10.324
Foxc1forkhead box C10.322
Pou4f3POU domain, class 4, transcription factor 30.312
Kcnab3potassium voltage-gated channel, shaker-related subfamily, beta member 30.310
Fgf8fibroblast growth factor 80.309
Pkm2pyruvate kinase, muscle0.308
Lrp1low density lipoprotein receptor-related protein 10.307
Apoeapolipoprotein E0.306
Fgfr3fibroblast growth factor receptor 30.305
Adam11a disintegrin and metallopeptidase domain 110.302
Adra2badrenergic receptor, alpha 2b0.299
Ece1endothelin converting enzyme 10.296
Cry1cryptochrome 1 (photolyase-like)0.295
Ror2receptor tyrosine kinase-like orphan receptor 20.289
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.283
Mertkc-mer proto-oncogene tyrosine kinase0.282
Adra2aadrenergic receptor, alpha 2a0.279
Bglapbone gamma carboxyglutamate protein0.275
Thrbthyroid hormone receptor beta0.274
Stat5bsignal transducer and activator of transcription 5B0.274
Chst8carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 80.273
Ednraendothelin receptor type A0.271
LOC100048884novel member of the major urinary protein (Mup) gene family0.266
Sox11SRY-box containing gene 110.265
Vav2vav 2 oncogene0.259
Chd7chromodomain helicase DNA binding protein 70.258
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ascl1aachaete-scute complex-like 1a (Drosophila)0.706
adipoqladiponectin, C1Q and collagen domain containing, like0.431
per3period homolog 3 (Drosophila)0.382
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.371
sox9aSRY-box containing gene 9a0.370
sox9bSRY-box containing gene 9b0.296
mycamyelocytomatosis oncogene a0.275
hlxb9lahomeo box HB9 like a0.263
tm4sf4transmembrane 4 L six family member 40.262
mapk3mitogen-activated protein kinase 30.262
rnasel1ribonuclease like 10.256
thtyrosine hydroxylase0.254
s1pr2sphingosine-1-phosphate receptor 20.244
per2period homolog 2 (Drosophila)0.244
foxa1forkhead box A10.239
furinafurin (paired basic amino acid cleaving enzyme) a0.226
esr2aestrogen receptor 2a0.224
pdx1pancreatic and duodenal homeobox 10.221
kal1aKallmann syndrome 1a sequence0.217
robo3roundabout homolog 30.217
fgf8afibroblast growth factor 8 a0.203
jag1ajagged 1a0.203
mical3flavoprotein oxidoreductase MICAL30.200
cnn3acalponin 3, acidic a0.198
foxa3forkhead box A30.198
rpl4ribosomal protein L40.194
myh11amyosin, heavy polypeptide 11, smooth muscle a0.184
prox1prospero-related homeobox gene 10.165
eya1eyes absent homolog 10.164
esr1estrogen receptor 10.157
nkx2.2aNK2 transcription factor related 2a0.155
rpl5bribosomal protein L5b0.150
metmet proto-oncogene (hepatocyte growth factor receptor)0.148
ptf1apancreas specific transcription factor, 1a0.145
nr0b1nuclear receptor subfamily 0, group B, member 10.145
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.144
tp53tumor protein p530.144
ogt.2O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 20.139
rxrbaretinoid x receptor, beta a0.134
adipor2adiponectin receptor 20.133
hhexhematopoietically expressed homeobox0.131
slc16a1solute carrier family 16 (monocarboxylic acid transporters), member 10.129
gdnfglial cell derived neurotrophic factor0.126
rpsaribosomal protein SA0.124
eng2bengrailed 2b0.123
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.119
aqp12aquaporin 120.118
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.116
rps2ribosomal protein S20.115
ihhaIndian hedgehog homolog a0.114
pgam2phosphoglycerate mutase 2 (muscle)0.113
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.113
sst1.1somatostatin 1, tandem duplicate 10.111
tnfatumor necrosis factor a (TNF superfamily, member 2)0.107
irx4biroquois homeobox protein 4b0.103
glud1aglutamate dehydrogenase 1a0.101
rpl15ribosomal protein L150.099
fasFas (TNF receptor superfamily, member 6)0.096
pou3f3bPOU class 3 homeobox 3b0.096
myoz1bmyozenin 1b0.094
vtg1vitellogenin 10.093
nadl1.2neural adhesion molecule L1.20.093
cry3cryptochrome 30.091
gbx2gastrulation brain homeo box 20.091
cd63Cd63 antigen0.090
trim13tripartite motif-containing 130.088
pax5paired box gene 50.086
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.083
ahctf1AT hook containing transcription factor 10.082
ntd5ntl-dependent gene 50.082
esr2bestrogen receptor 2b0.082
sec61gSec61 gamma subunit0.082
col17a1bcollagen, type XVII, alpha 1b0.081
notch2notch homolog 20.081
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.081
rpl7aribosomal protein L7a0.080
mpp1membrane protein, palmitoylated 10.079
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.078
ldb1aLIM-domain binding factor 1a0.078
aqp3aaquaporin 3a0.078
mchr1amelanin-concentrating hormone receptor 1a0.077
neurod6aneurogenic differentiation 6a0.077
wnt8bwingless-type MMTV integration site family, member 8b0.077
pbx1apre-B-cell leukemia transcription factor 1a0.077
rxrbbretinoid x receptor, beta b0.075
rpl6ribosomal protein L60.075
gata4GATA-binding protein 40.075
grk7aG-protein-coupled receptor kinase 7a0.074
pum1pumilio homolog 1 (Drosophila)0.074
uts1urotensin 10.074
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
S6kRPS6-p70-protein kinase0.121
jebjelly belly0.044
RicRas which interacts with Calmodulin0.037
salmspalt major0.034
Atg9Autophagy-specific gene 90.030
Gyc76CGuanylyl cyclase at 76C0.030
CG42672CG42672 gene product from transcript CG42672-RD0.024
kibrakibra ortholog0.020
Eip74EFEcdysone-induced protein 74EF0.020
Ilp6Insulin-like peptide 60.020
Syx1ASyntaxin 1A0.019
OdaOrnithine decarboxylase antizyme0.016
Eip75BEcdysone-induced protein 75B0.014
fkhfork head0.014
AceAcetylcholine esterase0.013
CG3597CG3597 gene product from transcript CG3597-RA0.012
jingCG9397 gene product from transcript CG9397-RI0.011
Akt1CG4006 gene product from transcript CG4006-RA0.011
CG10237CG10237 gene product from transcript CG10237-RA0.010
Stat92ESignal-transducer and activator of transcription protein at 92E0.010
Mekk1CG7717 gene product from transcript CG7717-RB0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein0.941
PTPN1protein tyrosine phosphatase, non-receptor type 10.939
NCOR2nuclear receptor corepressor 20.800
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.787
PMLpromyelocytic leukemia0.742
IGF1Rinsulin-like growth factor 1 receptor0.682
DAXXdeath-domain associated protein0.621
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.609
SLC2A14solute carrier family 2 (facilitated glucose transporter), member 140.586
IL1R1interleukin 1 receptor, type I0.519
ARandrogen receptor0.501
MDM2Mdm2 p53 binding protein homolog (mouse)0.451
ESR1estrogen receptor 10.433
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 30.433
SIRT1sirtuin 10.362
HDAC3histone deacetylase 30.331
IRS2insulin receptor substrate 20.321
CCND3cyclin D30.317
GHRgrowth hormone receptor0.303
CCNYcyclin Y0.300
HLA-DRB5major histocompatibility complex, class II, DR beta 50.265
PLAURplasminogen activator, urokinase receptor0.253
OASL2'-5'-oligoadenylate synthetase-like0.246
NCOR1nuclear receptor corepressor 10.243
IL1Binterleukin 1, beta0.218
AXLAXL receptor tyrosine kinase0.217
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.213
CRHR1corticotropin releasing hormone receptor 10.211
PPARAperoxisome proliferator-activated receptor alpha0.211
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.202
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.196
HNF4Ahepatocyte nuclear factor 4, alpha0.195
MPDZmultiple PDZ domain protein0.185
RARAretinoic acid receptor, alpha0.178
IL1RAPinterleukin 1 receptor accessory protein0.175
MT1Ametallothionein 1A0.170
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.164
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.161
ULK1unc-51-like kinase 1 (C. elegans)0.157
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.153
SNAP23synaptosomal-associated protein, 23kDa0.135
HIPK2homeodomain interacting protein kinase 20.134
GRB10growth factor receptor-bound protein 100.132
PLSCR1phospholipid scramblase 10.129
PGRprogesterone receptor0.127
MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)0.125
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.124
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.121
S100BS100 calcium binding protein B0.114
MAP3K5mitogen-activated protein kinase kinase kinase 50.097
SNAP25synaptosomal-associated protein, 25kDa0.096
HLA-DMBmajor histocompatibility complex, class II, DM beta0.095
PRDX1peroxiredoxin 10.095
RUNX1runt-related transcription factor 10.094
RXRBretinoid X receptor, beta0.086
ARRB2arrestin, beta 20.083
VCPvalosin containing protein0.083
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.082
IRF2interferon regulatory factor 20.079
STRADASTE20-related kinase adaptor alpha0.077
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.077
PKM2pyruvate kinase, muscle0.075
INCENPinner centromere protein antigens 135/155kDa0.074
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.072
HLA-DPB1major histocompatibility complex, class II, DP beta 10.071
RNASE4ribonuclease, RNase A family, 40.070
ATXN3ataxin 30.068
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.068
NR2E3nuclear receptor subfamily 2, group E, member 30.067
ONECUT1one cut homeobox 10.066
PSEN2presenilin 2 (Alzheimer disease 4)0.065
IL6Rinterleukin 6 receptor0.065
RANBP9RAN binding protein 90.063
RXRAretinoid X receptor, alpha0.062
NR0B2nuclear receptor subfamily 0, group B, member 20.060
ICAM1intercellular adhesion molecule 10.060
WDYHV1WDYHV motif containing 10.059
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.059
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.058
INSRinsulin receptor0.054
C16orf75chromosome 16 open reading frame 750.054
HNF1BHNF1 homeobox B0.052
SOCS1suppressor of cytokine signaling 10.051
IL1RNinterleukin 1 receptor antagonist0.050
SMAD3SMAD family member 30.049
MAPK6mitogen-activated protein kinase 60.049
PROX1prospero homeobox 10.047
PDX1pancreatic and duodenal homeobox 10.047
MX2myxovirus (influenza virus) resistance 2 (mouse)0.046
CDX2caudal type homeobox 20.046
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.044
CREBZFCREB/ATF bZIP transcription factor0.044
SMAD2SMAD family member 20.044
TDGF1teratocarcinoma-derived growth factor 10.044
CSNK2Bcasein kinase 2, beta polypeptide0.043
PLATplasminogen activator, tissue0.043
HLA-DRB4major histocompatibility complex, class II, DR beta 40.043
BHLHE40basic helix-loop-helix family, member e400.042
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Foxa3forkhead box A30.125
Timp1TIMP metallopeptidase inhibitor 10.124
DbpD site of albumin promoter (albumin D-box) binding protein0.113
Lgals5lectin, galactose binding, soluble 50.094
Celcarboxyl ester lipase0.089
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.088
Il1r1interleukin 1 receptor, type I0.079
Gjb3gap junction protein, beta 30.078
Sftpdsurfactant protein D0.069
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.069
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.068
Ptgfrprostaglandin F receptor0.062
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.061
Lgals9lectin, galactoside-binding, soluble, 90.061
Agtr2angiotensin II receptor, type 20.061
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.059
Atp2a3ATPase, Ca++ transporting, ubiquitous0.059
Slc22a1solute carrier family 22 (organic cation transporter), member 10.058
Ifitm3interferon induced transmembrane protein 30.057
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.057
Cpb1carboxypeptidase B1 (tissue)0.056
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.054
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.054
Scnn1asodium channel, nonvoltage-gated 1 alpha0.053
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.053
Slc6a1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.052
Foxa2forkhead box A20.050
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.048
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.048
Kcnj2potassium inwardly-rectifying channel, subfamily J, member 20.047
LOC171161common salivary protein 10.047
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.046
Ageradvanced glycosylation end product-specific receptor0.045
Krt15keratin 150.045
Flt1FMS-related tyrosine kinase 10.045
Gja1gap junction protein, alpha 10.045
Syt8synaptotagmin VIII0.045
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.045
Foxa1forkhead box A10.044
Hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.044
Glra1glycine receptor, alpha 10.044
Capn9calpain 90.044
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.044
Thrspthyroid hormone responsive0.041
Slc22a6solute carrier family 22 (organic anion transporter), member 60.041
RGD1559748similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)0.041
Ccr1chemokine (C-C motif) receptor 10.041
Myo1amyosin IA0.041
Mcpt1mast cell protease 10.041
Tcf21transcription factor 210.041
Ptgs2prostaglandin-endoperoxide synthase 20.040
Pax6paired box 60.040
Htr65-hydroxytryptamine (serotonin) receptor 60.040
Gpx3glutathione peroxidase 30.040
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.039
Kcnk2potassium channel, subfamily K, member 20.039
Slco2b1solute carrier organic anion transporter family, member 2b10.039
Prl8a2prolactin family 8, subfamily a, member 20.039
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.039
Tbxa2rthromboxane A2 receptor0.039
Nr1d2nuclear receptor subfamily 1, group D, member 20.038
Gad2glutamate decarboxylase 20.037
Pdzk1ip1PDZK1 interacting protein 10.037
Apoa4apolipoprotein A-IV0.037
Dio1deiodinase, iodothyronine, type I0.037
RGD1305627hypothetical LOC3144670.037
Prss3protease, serine, 30.037
Scn10asodium channel, voltage-gated, type X, alpha subunit0.037
Nckap1NCK-associated protein 10.036
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.036
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.035
RhagRh-associated glycoprotein0.035
Dll3delta-like 3 (Drosophila)0.035
RGD1564664similar to LOC387763 protein0.035
Csn2casein beta0.035
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.034
Cfpcomplement factor properdin0.034
Pcnxl3pecanex-like 3 (Drosophila)0.034
Obp1fodorant binding protein I f0.034
Pzppregnancy-zone protein0.034
Adora2aadenosine A2a receptor0.034
Hmox1heme oxygenase (decycling) 10.034
Smcpsperm mitochondria-associated cysteine-rich protein0.034
Tead1TEA domain family member 10.034
Avparginine vasopressin0.034
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.033
Acsm3acyl-CoA synthetase medium-chain family member 30.033
Arhgap1Rho GTPase activating protein 10.033
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.033
Gipgastric inhibitory polypeptide0.033
Hoxc8homeo box C80.033
Nr1h4nuclear receptor subfamily 1, group H, member 40.033
Ak1adenylate kinase 10.032
Lrp3low density lipoprotein receptor-related protein 30.032
Ccl2chemokine (C-C motif) ligand 20.032
Pcsk9proprotein convertase subtilisin/kexin type 90.032
Wisp1WNT1 inducible signaling pathway protein 10.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism