The network for 'regulation of response to dna damage stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of response to dna damage stimulus

Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.999
Arntlaryl hydrocarbon receptor nuclear translocator-like0.970
Rb1retinoblastoma 10.944
Mdm2transformed mouse 3T3 cell double minute 20.928
Brca1breast cancer 10.814
Clockcircadian locomotor output cycles kaput0.779
Per2period homolog 2 (Drosophila)0.756
Brca2breast cancer 20.676
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.655
Cry1cryptochrome 1 (photolyase-like)0.596
Cdk4cyclin-dependent kinase 40.573
Mdm4transformed mouse 3T3 cell double minute 40.485
Cdkn1bcyclin-dependent kinase inhibitor 1B0.480
Ptenphosphatase and tensin homolog0.425
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.382
Pnp2purine-nucleoside phosphorylase 20.318
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.285
2500003M10RikRIKEN cDNA 2500003M10 gene0.274
Nbnnibrin0.258
Stag1stromal antigen 10.256
Hbb-b1hemoglobin, beta adult major chain0.247
Ighimmunoglobulin heavy chain complex0.220
Cdk9cyclin-dependent kinase 9 (CDC2-related kinase)0.210
Pcnaproliferating cell nuclear antigen0.205
Atmataxia telangiectasia mutated homolog (human)0.198
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.197
Ncoa3nuclear receptor coactivator 30.183
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.168
Vaspvasodilator-stimulated phosphoprotein0.162
Cry2cryptochrome 2 (photolyase-like)0.161
Trp73transformation related protein 730.152
Huwe1HECT, UBA and WWE domain containing 10.141
Qrich1glutamine-rich 10.138
H2-Aahistocompatibility 2, class II antigen A, alpha0.132
DaxxFas death domain-associated protein0.125
Arid1aAT rich interactive domain 1A (SWI-like)0.122
Asxl1additional sex combs like 1 (Drosophila)0.122
Hdac1histone deacetylase 10.118
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.117
Cul3cullin 30.112
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.111
Trraptransformation/transcription domain-associated protein0.110
Emx1empty spiracles homolog 1 (Drosophila)0.106
Wdr26WD repeat domain 260.102
Raver2ribonucleoprotein, PTB-binding 20.100
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.094
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.092
EvlEna-vasodilator stimulated phosphoprotein0.091
Ewsr1Ewing sarcoma breakpoint region 10.088
Enahenabled homolog (Drosophila)0.085
Eif2c1eukaryotic translation initiation factor 2C, 10.085
Smad4MAD homolog 4 (Drosophila)0.084
SkilSKI-like0.083
Apaf1apoptotic peptidase activating factor 10.079
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.079
Btg1B-cell translocation gene 1, anti-proliferative0.078
Fbxw7F-box and WD-40 domain protein 70.077
Hprthypoxanthine guanine phosphoribosyl transferase0.076
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.075
Prim1DNA primase, p49 subunit0.073
Zfp362zinc finger protein 3620.073
Cxcr4chemokine (C-X-C motif) receptor 40.072
Slc20a1solute carrier family 20, member 10.072
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.072
Ccna2cyclin A20.070
Srsf4serine/arginine-rich splicing factor 40.069
En1engrailed 10.069
Ccnd1cyclin D10.068
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.068
Apcadenomatosis polyposis coli0.066
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.066
Map3k7mitogen-activated protein kinase kinase kinase 70.065
Thbs1thrombospondin 10.063
Smad7MAD homolog 7 (Drosophila)0.062
Nup37nucleoporin 370.060
Rnf19aring finger protein 19A0.059
H2-Eb1histocompatibility 2, class II antigen E beta0.059
Ncoa6nuclear receptor coactivator 60.057
Hdac2histone deacetylase 20.057
Scaf11SR-related CTD-associated factor 110.054
Hat1histone aminotransferase 10.053
Mycmyelocytomatosis oncogene0.053
H2-DMahistocompatibility 2, class II, locus DMa0.053
Kdm2blysine (K)-specific demethylase 2B0.053
Exoc6exocyst complex component 60.051
Smad2MAD homolog 2 (Drosophila)0.050
Ikzf1IKAROS family zinc finger 10.048
Tab2TGF-beta activated kinase 1/MAP3K7 binding protein 20.047
Trp63transformation related protein 630.046
Rfc3replication factor C (activator 1) 30.046
Spnb1spectrin beta 10.046
Trip12thyroid hormone receptor interactor 120.045
Ppp2r2aprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform0.045
Egr2early growth response 20.044
H2-Ab1histocompatibility 2, class II antigen A, beta 10.043
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.043
Plagl2pleiomorphic adenoma gene-like 20.043
Sox2SRY-box containing gene 20.043
Sf3b1splicing factor 3b, subunit 10.042
Msh2mutS homolog 2 (E. coli)0.041
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cxcr4bchemokine (C-X-C motif), receptor 4b0.013
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.543
panpangolin0.354
lokloki0.328
HLHmgammaE(spl) region transcript mgamma0.302
HLHm7E(spl) region transcript m70.272
HLHm3E(spl) region transcript m30.245
CG31198CG31198 gene product from transcript CG31198-RA0.228
mus205mutagen-sensitive 2050.223
CG31343CG31343 gene product from transcript CG31343-RA0.218
HLHmdeltaE(spl) region transcript mdelta0.162
HLHmbetaE(spl) region transcript mbeta0.152
rad50CG6339 gene product from transcript CG6339-RD0.144
Brca2Breast cancer 2, early onset homolog0.115
malphaE(spl) region transcript malpha0.107
CG5524CG5524 gene product from transcript CG5524-RA0.096
hayhaywire0.088
CtBPC-terminal Binding Protein0.088
l(1)dd4lethal (1) discs degenerate 40.083
agoarchipelago0.079
CG15220CG15220 gene product from transcript CG15220-RA0.075
DNApol-etaCG7143 gene product from transcript CG7143-RA0.069
Smc5CG32438 gene product from transcript CG32438-RE0.064
mus308mutagen-sensitive 3080.061
CG2865CG2865 gene product from transcript CG2865-RA0.060
mip130Myb-interacting protein 1300.058
nufnuclear fallout0.057
scscute0.054
E(var)3-9Enhancer of variegation 3-90.053
cpocouch potato0.049
Cul-3Cullin-30.045
CG14641CG14641 gene product from transcript CG14641-RA0.045
mlemaleless0.043
O-fut1O-fucosyltransferase 10.042
LrrkLeucine-rich repeat kinase0.042
ebiCG4063 gene product from transcript CG4063-RA0.042
Ncc69sodium chloride cotransporter 690.042
shgshotgun0.040
CG14814CG14814 gene product from transcript CG14814-RA0.039
Grip84gamma-tubulin ring protein 840.037
HLHm5E(spl) region transcript m50.037
CG5794CG5794 gene product from transcript CG5794-RB0.036
CG32473CG32473 gene product from transcript CG32473-RA0.036
alphalphabet0.035
CG9894CG9894 gene product from transcript CG9894-RB0.034
bonbonus0.034
CG5506CG5506 gene product from transcript CG5506-RA0.034
CG31716CG31716 gene product from transcript CG31716-RH0.034
Sema-2aCG4700 gene product from transcript CG4700-RC0.033
CG10133CG10133 gene product from transcript CG10133-RA0.033
forforaging0.033
NT1Neurotrophin 10.033
pr-set7CG3307 gene product from transcript CG3307-RC0.032
cbtcabut0.032
His2AvHistone H2A variant0.032
l(2)dtllethal-(2)-denticleless0.031
CG18273CG18273 gene product from transcript CG18273-RA0.031
mus101mutagen-sensitive 1010.031
Caf1Chromatin assembly factor 1 subunit0.031
nopono poles0.030
esgescargot0.028
Akap200A kinase anchor protein 2000.027
SmrSmrter0.027
pydpolychaetoid0.027
poloCG12306 gene product from transcript CG12306-RA0.027
ChroChromator0.027
CG7376CG7376 gene product from transcript CG7376-RA0.027
TomTwin of m40.026
CG32685CG32685 gene product from transcript CG32685-RC0.026
cdc16CG6759 gene product from transcript CG6759-RA0.025
UtxCG5640 gene product from transcript CG5640-RD0.025
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.024
TORCCG6064 gene product from transcript CG6064-RA0.024
dpndeadpan0.024
Pat1Protein interacting with APP tail-10.023
MED19Mediator complex subunit 190.023
mofmales absent on the first0.023
kelkelch0.023
hhairy0.023
trbltribbles0.023
edechinoid0.022
egreiger0.022
Nup75Nucleoporin 750.022
CG16826CG16826 gene product from transcript CG16826-RA0.022
CG2182CG2182 gene product from transcript CG2182-RA0.022
Eip63EEcdysone-induced protein 63E0.022
crccryptocephal0.022
fzyfizzy0.021
CG10417CG10417 gene product from transcript CG10417-RA0.021
CTCFCG8591 gene product from transcript CG8591-RA0.020
Rnp4FRNA-binding protein 4F0.020
chifchiffon0.020
Mcm3Minichromosome maintenance 30.020
CG14614CG14614 gene product from transcript CG14614-RA0.020
ik2IkappaB kinase-like 20.019
p53CG33336 gene product from transcript CG33336-RB0.019
Mnn1Menin 10.019
18w18 wheeler0.019
taitaiman0.019
rnorhinoceros0.019
CG8486CG8486 gene product from transcript CG8486-RE0.019
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset1.000
TP53tumor protein p530.999
H2AFXH2A histone family, member X0.995
CASP8caspase 8, apoptosis-related cysteine peptidase0.941
NBNnibrin0.934
RPA1replication protein A1, 70kDa0.924
FGFR2fibroblast growth factor receptor 20.914
HNRNPKheterogeneous nuclear ribonucleoprotein K0.906
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.901
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.900
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.897
CHEK1CHK1 checkpoint homolog (S. pombe)0.883
CREBBPCREB binding protein0.873
RBBP8retinoblastoma binding protein 80.872
BCL2L11BCL2-like 11 (apoptosis facilitator)0.807
BRCC3BRCA1/BRCA2-containing complex, subunit 30.798
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.795
MDC1mediator of DNA-damage checkpoint 10.758
BAXBCL2-associated X protein0.753
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.734
CASP3caspase 3, apoptosis-related cysteine peptidase0.703
XIAPX-linked inhibitor of apoptosis0.697
WRNWerner syndrome, RecQ helicase-like0.669
BCL2L1BCL2-like 10.652
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.640
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.633
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.630
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.628
CDK4cyclin-dependent kinase 40.606
SMEK1SMEK homolog 1, suppressor of mek1 (Dictyostelium)0.596
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.593
DAXXdeath-domain associated protein0.549
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.546
THOC4THO complex 40.539
NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae)0.528
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.528
VIMvimentin0.523
TSC22D1TSC22 domain family, member 10.521
EP300E1A binding protein p3000.517
BIDBH3 interacting domain death agonist0.517
CUL2cullin 20.504
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.475
PCNAproliferating cell nuclear antigen0.452
TOP1topoisomerase (DNA) I0.425
SMC6structural maintenance of chromosomes 60.422
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.421
CDK6cyclin-dependent kinase 60.420
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.407
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.407
TWIST1twist homolog 1 (Drosophila)0.405
H3F3CH3 histone, family 3C0.390
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.372
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.371
CCND1cyclin D10.370
CHEK2CHK2 checkpoint homolog (S. pombe)0.354
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.349
RAD18RAD18 homolog (S. cerevisiae)0.344
PMLpromyelocytic leukemia0.336
THOC2THO complex 20.333
CCNE1cyclin E10.330
PTPRCprotein tyrosine phosphatase, receptor type, C0.321
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.319
APAF1apoptotic peptidase activating factor 10.317
ESR1estrogen receptor 10.298
DDB1damage-specific DNA binding protein 1, 127kDa0.293
FGFR1fibroblast growth factor receptor 10.292
BCAS2breast carcinoma amplified sequence 20.291
RAD50RAD50 homolog (S. cerevisiae)0.290
UHRF2ubiquitin-like with PHD and ring finger domains 20.286
PARP1poly (ADP-ribose) polymerase 10.284
ATRataxia telangiectasia and Rad3 related0.282
FASFas (TNF receptor superfamily, member 6)0.278
CASP7caspase 7, apoptosis-related cysteine peptidase0.276
MAGEA2melanoma antigen family A, 20.274
CCNT1cyclin T10.271
POLHpolymerase (DNA directed), eta0.271
FANCD2Fanconi anemia, complementation group D20.264
MEN1multiple endocrine neoplasia I0.263
BREbrain and reproductive organ-expressed (TNFRSF1A modulator)0.260
RCC1regulator of chromosome condensation 10.260
TMPOthymopoietin0.253
SETD8SET domain containing (lysine methyltransferase) 80.253
SMC2structural maintenance of chromosomes 20.245
CDK9cyclin-dependent kinase 90.243
MDM4Mdm4 p53 binding protein homolog (mouse)0.242
CFLARCASP8 and FADD-like apoptosis regulator0.240
TOPBP1topoisomerase (DNA) II binding protein 10.239
ZNF512Bzinc finger protein 512B0.238
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.233
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.229
CLSPNclaspin0.225
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.224
WDR5WD repeat domain 50.222
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.221
FGF10fibroblast growth factor 100.220
BAK1BCL2-antagonist/killer 10.219
TP53BP1tumor protein p53 binding protein 10.216
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.214
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.211
NCOA3nuclear receptor coactivator 30.208
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SPT5Spt5p0.717
SPT16Spt16p0.635
RTF1Rtf1p0.625
CTR9Ctr9p0.591
PSY4Psy4p0.541
PAF1Paf1p0.429
TPD3Tpd3p0.318
CKA1Cka1p0.298
RAD23Rad23p0.224
RPO21Rpo21p0.153
CDC55Cdc55p0.139
DNA2Dna2p0.137
LEO1Leo1p0.133
CKS1Cks1p0.122
VPS64Vps64p0.110
RPN14Rpn14p0.107
PPH3Pph3p0.090
UBC13Ubc13p0.082
RFA1Rfa1p0.074
RPB3Rpb3p0.070
GBP2Gbp2p0.068
ROX1Rox1p0.065
TOP1Top1p0.056
RPT6Rpt6p0.052
POL30Pol30p0.047
SSN3Ssn3p0.046
FPK1Fpk1p0.046
PSY2Psy2p0.045
OPY2Opy2p0.044
TIP41Tip41p0.041
CKB1Ckb1p0.041
REV7Rev7p0.040
NRD1Nrd1p0.039
THP2Thp2p0.038
HAL5Hal5p0.038
RPS5Rps5p0.036
MEC1Mec1p0.036
MIG1Mig1p0.036
ESF1Esf1p0.035
HDA1Hda1p0.035
NRG1Nrg1p0.034
SGS1Sgs1p0.034
MYO5Myo5p0.034
MMS1Mms1p0.032
CAB3Cab3p0.032
RAD5Rad5p0.031
PRR2Prr2p0.031
GIP2Gip2p0.031
TBS1Tbs1p0.031
POB3Pob3p0.030
RAD55Rad55p0.030
SUB2Sub2p0.030
ECM2Ecm2p0.030
CUP9Cup9p0.030
NOP10Nop10p0.028
SPT6Spt6p0.028
RTG3Rtg3p0.028
AFT1Aft1p0.027
VPS41Vps41p0.026
HPR1Hpr1p0.026
AHP1Ahp1p0.026
CTK3Ctk3p0.026
HRB1Hrb1p0.025
SEM1Sem1p0.025
TSR1Tsr1p0.025
CTK1Ctk1p0.024
UBC4Ubc4p0.023
FSH1Fsh1p0.022
PRP45Prp45p0.021
PCM1Pcm1p0.021
YLR264C-Ahypothetical protein0.021
GLN3Gln3p0.020
CWC21Cwc21p0.020
FAR11Far11p0.019
CYC8Cyc8p0.019
RHO1Rho1p0.019
RIM13Rim13p0.019
HSF1Hsf1p0.019
RMI1Rmi1p0.019
CAK1Cak1p0.019
SRD1Srd1p0.019
RPN2Rpn2p0.018
SIZ1Siz1p0.018
PCL7Pcl7p0.018
CKB2Ckb2p0.018
LEU2Leu2p0.018
SUB1Sub1p0.018
TRX2Trx2p0.018
STP2Stp2p0.018
YNL234Whypothetical protein0.017
ARP10Arp10p0.017
CDC73Cdc73p0.017
CET1Cet1p0.017
SWI6Swi6p0.017
SAK1Sak1p0.017
REB1Reb1p0.016
YIR035Chypothetical protein0.016
ATG21Atg21p0.016
DST1Dst1p0.016
PRS2Prs2p0.016