The network for 'morphogenesis of a branching structure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

morphogenesis of a branching structure

The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.

NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Pitx2paired-like homeodomain transcription factor 21.000
Pax2paired box gene 21.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Ctnnb1catenin (cadherin associated protein), beta 10.999
Shhsonic hedgehog0.999
Rargretinoic acid receptor, gamma0.998
Bcl2B-cell leukemia/lymphoma 20.998
Hoxd11homeobox D110.998
Pax8paired box gene 80.998
Ptenphosphatase and tensin homolog0.998
Lhx1LIM homeobox protein 10.997
Hand2heart and neural crest derivatives expressed transcript 20.997
Esr1estrogen receptor 1 (alpha)0.995
Retret proto-oncogene0.995
Pax3paired box gene 30.994
Prrx1paired related homeobox 10.994
Vegfavascular endothelial growth factor A0.993
Fgfr1fibroblast growth factor receptor 10.993
Meox2mesenchyme homeobox 20.992
Vdrvitamin D receptor0.992
Fgf8fibroblast growth factor 80.990
Nos1nitric oxide synthase 1, neuronal0.990
Drd2dopamine receptor D20.989
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.989
Arandrogen receptor0.986
Foxc1forkhead box C10.986
Fgfr3fibroblast growth factor receptor 30.985
Tbx2T-box 20.984
Leprleptin receptor0.981
Wnt5awingless-related MMTV integration site 5A0.980
Ror2receptor tyrosine kinase-like orphan receptor 20.976
Gdnfglial cell line derived neurotrophic factor0.974
Tbx3T-box 30.974
Acvr1activin A receptor, type 10.973
Egfrepidermal growth factor receptor0.971
Gli2GLI-Kruppel family member GLI20.971
Ptpn11protein tyrosine phosphatase, non-receptor type 110.970
Ptgs2prostaglandin-endoperoxide synthase 20.965
Rararetinoic acid receptor, alpha0.965
Bmp4bone morphogenetic protein 40.965
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.961
Pbx1pre B-cell leukemia transcription factor 10.958
Epha4Eph receptor A40.955
Eya1eyes absent 1 homolog (Drosophila)0.955
Rarbretinoic acid receptor, beta0.951
Apcadenomatosis polyposis coli0.951
Emx2empty spiracles homolog 2 (Drosophila)0.949
Efnb2ephrin B20.935
Lef1lymphoid enhancer binding factor 10.933
Sox7SRY-box containing gene 70.932
Emx1empty spiracles homolog 1 (Drosophila)0.931
Snai1snail homolog 1 (Drosophila)0.926
Ror1receptor tyrosine kinase-like orphan receptor 10.920
Tcfap2ctranscription factor AP-2, gamma0.917
Dlx1distal-less homeobox 10.914
Wt1Wilms tumor 1 homolog0.913
Ptch1patched homolog 10.912
Bmp5bone morphogenetic protein 50.898
CblCasitas B-lineage lymphoma0.895
Sox9SRY-box containing gene 90.893
Nos2nitric oxide synthase 2, inducible0.893
Hspg2perlecan (heparan sulfate proteoglycan 2)0.893
Wnt3awingless-related MMTV integration site 3A0.892
Hoxa11homeobox A110.892
Fzd1frizzled homolog 1 (Drosophila)0.887
Csf1colony stimulating factor 1 (macrophage)0.884
Acvrl1activin A receptor, type II-like 10.882
Tcf21transcription factor 210.881
Ccr2chemokine (C-C motif) receptor 20.877
Dkk1dickkopf homolog 1 (Xenopus laevis)0.875
Bmp7bone morphogenetic protein 70.872
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.872
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.871
Wnt4wingless-related MMTV integration site 40.867
Insrinsulin receptor0.864
Smad3MAD homolog 3 (Drosophila)0.858
Plauplasminogen activator, urokinase0.855
Ccl2chemokine (C-C motif) ligand 20.853
Fgf10fibroblast growth factor 100.850
Il6stinterleukin 6 signal transducer0.850
Lamc1laminin, gamma 10.847
Msx2homeobox, msh-like 20.845
Il10interleukin 100.845
Hoxb4homeobox B40.841
Hoxb3homeobox B30.839
Nos3nitric oxide synthase 3, endothelial cell0.839
Cd44CD44 antigen0.838
Gata6GATA binding protein 60.836
Notch3Notch gene homolog 3 (Drosophila)0.832
Ptk7PTK7 protein tyrosine kinase 70.832
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.827
Zic3zinc finger protein of the cerebellum 30.824
Hoxa9homeobox A90.823
Inpp5dinositol polyphosphate-5-phosphatase D0.822
Tbx1T-box 10.821
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch3notch homolog 30.829
tbx1T-box 10.808
shhasonic hedgehog a0.766
pitx3paired-like homeodomain transcription factor 30.716
bmp2bbone morphogenetic protein 2b0.618
hey1hairy/enhancer-of-split related with YRPW motif 10.605
etv2ets variant gene 20.556
nrp1aneuropilin 1a0.556
jag2jagged 20.543
aldh1a2aldehyde dehydrogenase 1 family, member A20.479
kdrlkinase insert domain receptor like0.459
traf4atnf receptor-associated factor 4a0.426
dlx5adistal-less homeobox gene 5a0.423
wt1bwilms tumor 1b0.409
slit3slit (Drosophila) homolog 30.406
notch1anotch homolog 1a0.404
alcambactivated leukocyte cell adhesion molecule b0.362
ptgs1prostaglandin-endoperoxide synthase 10.308
bmp4bone morphogenetic protein 40.300
bmp2abone morphogenetic protein 2a0.273
metmet proto-oncogene (hepatocyte growth factor receptor)0.271
osr2odd-skipped related 2 (Drosophila)0.262
six4bsine oculis homeobox homolog 4b0.261
cdh2cadherin 2, neuronal0.255
wnt11wingless-type MMTV integration site family, member 110.248
jag1bjagged 1b0.232
sema3esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E0.226
mmp2matrix metalloproteinase 20.221
ntn1anetrin 1a0.212
plce1phospholipase C, epsilon 10.210
hoxb2ahomeo box B2a0.209
sema3aasemaphorin 3aa0.209
edn1endothelin 10.204
foxd3forkhead box D30.199
unc45aunc-45 homolog A (C. elegans)0.193
nrarpanotch-regulated ankyrin repeat protein a0.190
tbx20T-box 200.182
wnt3awingless-type MMTV integration site family, member 3A0.169
foxa1forkhead box A10.166
wnt3wingless-type MMTV integration site family, member 30.165
mecomMDS1 and EVI1 complex locus0.152
plcg1phospholipase C, gamma 10.139
foxa3forkhead box A30.138
aplnraapelin receptor a0.131
bocbrother of CDO0.130
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.129
nkx2.3NK2 transcription factor related 30.116
hmx1H6 homeo box 10.116
grem2gremlin 2, cysteine knot superfamily0.111
hnf1baHNF1 homeobox Ba0.110
frem3Fras1 related extracellular matrix 30.110
ntn1bnetrin 1b0.107
cxcr4bchemokine (C-X-C motif), receptor 4b0.104
pax6bpaired box gene 6b0.104
fbn2bfibrillin 2b0.103
fgf3fibroblast growth factor 30.100
eng1aengrailed 1a0.097
foxj1bforkhead box J1b0.097
igfbp3insulin-like growth factor binding protein 30.096
hoxa13bhomeo box A13b0.095
wnt2bbwingless-type MMTV integration site family, member 2Bb0.093
rhoubras homolog gene family, member Ub0.093
pea3ETS-domain transcription factor pea30.090
efnb2aephrin B2a0.085
eya1eyes absent homolog 10.085
osr1odd-skipped related 1 (Drosophila)0.081
dusp6dual specificity phosphatase 60.078
runx2arunt-related transcription factor 2a0.078
cxcr4achemokine (C-X-C motif) receptor 4a0.076
hoxa2bhomeo box A2b0.075
angpt1angiopoietin 10.075
prrx1apaired related homeobox 1a0.075
nrp2aneuropilin 2a0.074
wnt5bwingless-type MMTV integration site family, member 5b0.073
aplnrbapelin receptor b0.073
insm1ainsulinoma-associated 1a0.072
hoxd10ahomeo box D10a0.072
hey2hairy/enhancer-of-split related with YRPW motif 20.072
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.070
wnt10awingless-type MMTV integration site family, member 10a0.065
col14a1collagen, type XIV, alpha 10.065
hoxb3ahomeo box B3a0.062
hhexhematopoietically expressed homeobox0.062
flncbfilamin C, gamma b (actin binding protein 280)0.061
hlxb9lbhomeo box HB9 like b0.061
pax2apaired box gene 2a0.060
pld1aphospholipase D1a0.060
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.060
hoxb8ahomeo box B8a0.060
sox1aSRY-box containing gene 1a0.059
nkx2.5NK2 transcription factor related 50.059
fgf8afibroblast growth factor 8 a0.058
runx3runt-related transcription factor 30.058
hoxd12ahomeo box D12a0.056
fibinfin bud initiation factor0.056
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mewmultiple edematous wings0.921
MadMothers against dpp0.886
salmspalt major0.739
stumpsCG31317 gene product from transcript CG31317-RC0.621
DadDaughters against dpp0.603
nocno ocelli0.593
rheaCG6831 gene product from transcript CG6831-RA0.579
vvlventral veins lacking0.573
aopanterior open0.570
EgfrEpidermal growth factor receptor0.537
lolalongitudinals lacking0.495
Rab5Rab-protein 50.411
lunaCG33473 gene product from transcript CG33473-RB0.352
elBelbow B0.346
argosCG4531 gene product from transcript CG4531-RA0.337
PtenCG5671 gene product from transcript CG5671-RB0.321
sosine oculis0.267
Nrx-IVNeurexin IV0.258
eyaeyes absent0.232
LanB2Laminin B20.226
Nsf2NEM-sensitive fusion protein 20.221
Sema-1aCG18405 gene product from transcript CG18405-RD0.215
stanstarry night0.210
CkIIalphaCasein kinase II alpha subunit0.195
BicDBicaudal D0.188
GckIIIGerminal centre kinase III0.169
MrtfMyocardin-related transcription factor0.168
gcmglial cells missing0.160
jingCG9397 gene product from transcript CG9397-RI0.159
cicubitus interruptus0.148
shotshort stop0.146
Gyc76CGuanylyl cyclase at 76C0.137
Traf4TNF-receptor-associated factor 40.133
AdarAdenosine deaminase acting on RNA0.133
LanALaminin A0.129
Cip4CG15015 gene product from transcript CG15015-RA0.128
HphHIF prolyl hydroxylase0.126
Sema-2aCG4700 gene product from transcript CG4700-RC0.118
DAAMDishevelled Associated Activator of Morphogenesis0.104
Sra-1specifically Rac1-associated protein 10.100
RalaRas-related protein0.099
wbwing blister0.095
Ptp69DProtein tyrosine phosphatase 69D0.089
Mef2Myocyte enhancer factor 20.083
nkdnaked cuticle0.083
fs(1)M3female sterile (1) M30.083
EphrinCG1862 gene product from transcript CG1862-RA0.081
Grasp65CG7809 gene product from transcript CG7809-RA0.081
beta-Specbeta Spectrin0.079
Fak56DFocal Adhesion Kinase0.076
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
VEGFAvascular endothelial growth factor A0.989
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.986
NRP1neuropilin 10.975
EGFRepidermal growth factor receptor0.964
MDM2Mdm2 p53 binding protein homolog (mouse)0.962
RARAretinoic acid receptor, alpha0.944
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.943
THBS1thrombospondin 10.941
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.940
CREBBPCREB binding protein0.936
FN1fibronectin 10.932
EGR1early growth response 10.907
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.893
COL4A1collagen, type IV, alpha 10.888
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.873
FGFR1fibroblast growth factor receptor 10.858
FGF1fibroblast growth factor 1 (acidic)0.845
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.815
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.809
JAG1jagged 10.793
NCOR2nuclear receptor corepressor 20.760
HOXA10homeobox A100.686
BMPR1Abone morphogenetic protein receptor, type IA0.675
PMLpromyelocytic leukemia0.659
GAS6growth arrest-specific 60.639
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.639
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.637
PKD2polycystic kidney disease 2 (autosomal dominant)0.618
TIMP3TIMP metallopeptidase inhibitor 30.617
COL4A2collagen, type IV, alpha 20.608
IL1R1interleukin 1 receptor, type I0.602
LRRK2leucine-rich repeat kinase 20.595
ESR1estrogen receptor 10.582
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.527
COL2A1collagen, type II, alpha 10.495
PLATplasminogen activator, tissue0.492
CAV1caveolin 1, caveolae protein, 22kDa0.487
METmet proto-oncogene (hepatocyte growth factor receptor)0.486
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.443
FGF10fibroblast growth factor 100.437
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.411
TGFB1transforming growth factor, beta 10.387
COL6A1collagen, type VI, alpha 10.379
COL5A1collagen, type V, alpha 10.376
CTGFconnective tissue growth factor0.374
RUNX1runt-related transcription factor 10.374
PLCG1phospholipase C, gamma 10.352
PGFplacental growth factor0.340
NCOA6nuclear receptor coactivator 60.319
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.308
COL1A1collagen, type I, alpha 10.302
COL4A4collagen, type IV, alpha 40.300
DAXXdeath-domain associated protein0.299
MEIS1Meis homeobox 10.293
TM4SF1transmembrane 4 L six family member 10.279
COL4A6collagen, type IV, alpha 60.272
CTNND1catenin (cadherin-associated protein), delta 10.268
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.255
IQGAP1IQ motif containing GTPase activating protein 10.247
TGFB2transforming growth factor, beta 20.239
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.224
TGFB3transforming growth factor, beta 30.207
EGR3early growth response 30.197
SIRT1sirtuin 10.196
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.190
POU5F1POU class 5 homeobox 10.188
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.188
NOTCH3notch 30.186
EP300E1A binding protein p3000.185
MEIS2Meis homeobox 20.181
FGF2fibroblast growth factor 2 (basic)0.173
HSPG2heparan sulfate proteoglycan 20.163
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.160
PTPN1protein tyrosine phosphatase, non-receptor type 10.159
FOXF1forkhead box F10.158
TP53tumor protein p530.152
RB1retinoblastoma 10.151
PARVAparvin, alpha0.151
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.148
S100A2S100 calcium binding protein A20.148
BMP7bone morphogenetic protein 70.147
AKT1v-akt murine thymoma viral oncogene homolog 10.146
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.143
SORBS3sorbin and SH3 domain containing 30.139
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.135
IGFBP5insulin-like growth factor binding protein 50.130
PTGISprostaglandin I2 (prostacyclin) synthase0.129
COL4A5collagen, type IV, alpha 50.128
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.128
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.126
TNCtenascin C0.124
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.116
COL1A2collagen, type I, alpha 20.112
EGR2early growth response 20.111
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism