The network for 'regulation of wnt signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of wnt signaling pathway

Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.

NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Fgfr1fibroblast growth factor receptor 11.000
Fgfr2fibroblast growth factor receptor 21.000
Apcadenomatosis polyposis coli0.999
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Tbx3T-box 30.997
Smosmoothened homolog (Drosophila)0.995
Trp53transformation related protein 530.994
Gli3GLI-Kruppel family member GLI30.994
Ntf3neurotrophin 30.994
Gli2GLI-Kruppel family member GLI20.993
Shhsonic hedgehog0.990
Wnt3awingless-related MMTV integration site 3A0.990
Bmp4bone morphogenetic protein 40.974
Pitx2paired-like homeodomain transcription factor 20.971
Wnt5awingless-related MMTV integration site 5A0.970
Dvl2dishevelled 2, dsh homolog (Drosophila)0.969
Pitx1paired-like homeodomain transcription factor 10.961
Pax3paired box gene 30.953
Ptk2PTK2 protein tyrosine kinase 20.953
Otx2orthodenticle homolog 2 (Drosophila)0.948
Ccnd1cyclin D10.938
Foxc1forkhead box C10.929
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.919
Prrx1paired related homeobox 10.908
Pax2paired box gene 20.902
Fgf10fibroblast growth factor 100.902
Zeb1zinc finger E-box binding homeobox 10.893
Lrp6low density lipoprotein receptor-related protein 60.893
Msx1homeobox, msh-like 10.887
Lef1lymphoid enhancer binding factor 10.885
Gata4GATA binding protein 40.877
Sox2SRY-box containing gene 20.875
Trp63transformation related protein 630.866
Bmpr1abone morphogenetic protein receptor, type 1A0.866
Ptenphosphatase and tensin homolog0.863
Smad6MAD homolog 6 (Drosophila)0.855
Dvl3dishevelled 3, dsh homolog (Drosophila)0.851
Foxa2forkhead box A20.846
Hand2heart and neural crest derivatives expressed transcript 20.829
Prrx2paired related homeobox 20.826
Gsk3bglycogen synthase kinase 3 beta0.824
Hand1heart and neural crest derivatives expressed transcript 10.815
Hes1hairy and enhancer of split 1 (Drosophila)0.807
Wwtr1WW domain containing transcription regulator 10.787
Ror1receptor tyrosine kinase-like orphan receptor 10.771
Ahraryl-hydrocarbon receptor0.764
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.762
Tbx2T-box 20.751
Pou3f3POU domain, class 3, transcription factor 30.751
Nr3c1nuclear receptor subfamily 3, group C, member 10.746
Cdk4cyclin-dependent kinase 40.746
Sall4sal-like 4 (Drosophila)0.742
Bdnfbrain derived neurotrophic factor0.737
Dkk1dickkopf homolog 1 (Xenopus laevis)0.730
Eya1eyes absent 1 homolog (Drosophila)0.720
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.717
Ptk7PTK7 protein tyrosine kinase 70.709
Ror2receptor tyrosine kinase-like orphan receptor 20.702
Cdkn1bcyclin-dependent kinase inhibitor 1B0.699
Gata6GATA binding protein 60.686
Gas1growth arrest specific 10.683
Foxc2forkhead box C20.682
Zic3zinc finger protein of the cerebellum 30.680
Wnt4wingless-related MMTV integration site 40.677
Mapk14mitogen-activated protein kinase 140.675
Vangl1vang-like 1 (van gogh, Drosophila)0.671
Bmp5bone morphogenetic protein 50.670
Gdnfglial cell line derived neurotrophic factor0.664
Fgf8fibroblast growth factor 80.661
Fgfr3fibroblast growth factor receptor 30.656
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.649
Hoxa1homeobox A10.624
Acvr1activin A receptor, type 10.611
Esr2estrogen receptor 2 (beta)0.611
Arandrogen receptor0.610
Fgf3fibroblast growth factor 30.609
Lhx1LIM homeobox protein 10.608
Bmp7bone morphogenetic protein 70.608
Thbs1thrombospondin 10.604
Hoxa2homeobox A20.595
Retret proto-oncogene0.595
Sox9SRY-box containing gene 90.595
Sfrp2secreted frizzled-related protein 20.591
Snai1snail homolog 1 (Drosophila)0.587
Hoxd13homeobox D130.585
Sox7SRY-box containing gene 70.581
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.565
Ptgs2prostaglandin-endoperoxide synthase 20.561
Tead2TEA domain family member 20.555
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.547
Fzd8frizzled homolog 8 (Drosophila)0.545
Pax8paired box gene 80.544
Gata3GATA binding protein 30.534
Tcf21transcription factor 210.533
Lrp2low density lipoprotein receptor-related protein 20.532
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pry-1Protein PRY-10.831
cst-1Protein CST-10.179
egl-30Protein EGL-300.161
egl-18Protein EGL-180.156
lag-1Protein LAG-10.118
Y44E3A.6Protein Y44E3A.60.114
vang-1Protein VANG-10.095
dsh-1Protein DSH-10.086
bar-1Protein BAR-10.082
dpy-22Protein DPY-220.076
let-60Protein LET-600.075
pkn-1Protein PKN-10.068
eor-1Protein EOR-10.066
axl-1Protein AXL-10.064
let-756Protein LET-7560.064
gsk-3Protein GSK-30.062
cst-2Protein CST-20.062
egl-8Protein EGL-80.060
lin-17Protein LIN-170.053
swsn-7Protein SWSN-70.053
R10E12.2Protein R10E12.20.048
sel-12Protein SEL-120.047
hlh-1Protein HLH-10.046
kqt-1Protein KQT-10.043
unc-5Protein UNC-50.042
F28B3.1Protein F28B3.10.040
cyn-5Protein CYN-50.036
gpb-1Protein GPB-10.031
pop-1Protein POP-10.031
F21A10.2Protein F21A10.20.030
daf-12Protein DAF-120.029
lin-25Protein LIN-250.028
unc-62Protein UNC-620.028
daf-10Protein DAF-100.028
wrm-1Protein WRM-10.027
trim-9Protein TRIM-90.026
tag-315Protein TAG-3150.025
smp-1Protein SMP-10.024
osm-6Protein OSM-60.024
mec-2Protein MEC-20.024
sel-8Protein SEL-80.024
sur-2Protein SUR-20.022
vab-3Protein VAB-30.022
ham-1Protein HAM-10.022
rpn-2Protein RPN-20.022
CELE_F54D5.5Protein F54D5.50.021
hid-1Protein HID-10.021
che-3Protein CHE-30.020
gex-3Protein GEX-30.020
gon-2Protein GON-20.020
T28F4.1Protein T28F4.10.020
ztf-7Protein ZTF-70.020
mig-2Protein MIG-20.020
magi-1Protein MAGI-10.020
CELE_Y53F4B.9Protein Y53F4B.90.020
unc-57Protein UNC-570.019
CELE_R06A4.2Protein R06A4.20.018
T20F5.6Protein T20F5.60.018
lin-5Protein LIN-50.017
C05D9.7Protein C05D9.70.017
grd-2Protein GRD-20.017
igcm-4Protein IGCM-40.017
pxf-1Protein PXF-10.016
sma-6Protein SMA-60.016
csnk-1Protein CSNK-10.016
gei-4Protein GEI-40.016
attf-2Protein ATTF-20.016
icp-1Protein ICP-10.016
lin-36Protein LIN-360.015
lin-11Protein LIN-110.015
ncx-3Protein NCX-30.015
gon-4Protein GON-40.015
unc-7Protein UNC-70.015
lin-29Protein LIN-290.015
T04F8.2Protein T04F8.20.014
apm-3Protein APM-30.014
pat-3Protein PAT-30.014
unc-26Protein UNC-260.014
akt-2Protein AKT-20.014
cdl-1Protein CDL-10.014
lin-44Protein LIN-440.014
vab-2Protein VAB-20.014
lsy-12Protein LSY-120.013
lis-1Protein LIS-10.013
gld-2Protein GLD-20.013
lin-23Protein LIN-230.013
pqn-51Protein PQN-510.013
aha-1Protein AHA-10.012
ain-1Protein AIN-10.012
cey-1Protein CEY-10.012
R09A8.2Protein R09A8.20.012
mel-28Protein MEL-280.012
chd-7Protein CHD-70.012
mat-3Protein MAT-30.012
zyg-8Protein ZYG-80.012
cog-1Protein COG-10.012
pad-1Protein PAD-10.012
elt-6Protein ELT-60.012
eya-1Protein EYA-10.012
xpo-1Protein XPO-10.012
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
crb2acrumbs homolog 2a0.911
bmp4bone morphogenetic protein 40.875
tcf7transcription factor 7 (T-cell specific, HMG-box)0.782
ephb4beph receptor B4b0.658
mibmind bomb0.587
smosmoothened homolog (Drosophila)0.581
wnt3wingless-type MMTV integration site family, member 30.577
fgf3fibroblast growth factor 30.561
tbx1T-box 10.492
epha4beph receptor A4b0.481
ift88intraflagellar transport 88 homolog0.448
wnt5bwingless-type MMTV integration site family, member 5b0.444
wnt4awingless-type MMTV integration site family, member 4a0.437
per3period homolog 3 (Drosophila)0.398
dusp6dual specificity phosphatase 60.392
wnt3awingless-type MMTV integration site family, member 3A0.360
fgfr1afibroblast growth factor receptor 1a0.355
spry2sprouty homolog 20.347
wnt8bwingless-type MMTV integration site family, member 8b0.346
sparcsecreted acidic cysteine rich glycoprotein0.337
wlswntless homolog (Drosophila)0.331
fzd7afrizzled homolog 7a0.315
sfrp1asecreted frizzled-related protein 1a0.309
osr2odd-skipped related 2 (Drosophila)0.297
gpc4glypican 40.288
lfnglunatic fringe homolog0.276
bmp2abone morphogenetic protein 2a0.260
ndr2nodal-related 20.250
snai1bsnail homolog 1b (Drosophila)0.245
alcambactivated leukocyte cell adhesion molecule b0.237
lef1lymphocyte enhancer binding factor 10.214
foxa2forkhead box A20.211
fzd5frizzled homolog 50.205
hs6st1bheparan sulfate 6-O-sulfotransferase 1b0.197
kif17kinesin family member 170.196
wnt1wingless-type MMTV integration site family, member 10.191
irx3biroquois homeobox protein 3b0.191
pou5f1POU domain, class 5, transcription factor 10.190
flhfloating head0.186
etv5bets variant 5b0.185
shhbsonic hedgehog b0.184
pea3ETS-domain transcription factor pea30.184
h1mlinker histone H1M0.181
wnt8awingless-type MMTV integration site family, member 8a0.181
sox9aSRY-box containing gene 9a0.178
col2a1acollagen type II, alpha-1a0.173
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.169
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.166
epb41l5erythrocyte membrane protein band 4.1 like 50.164
notch3notch homolog 30.159
gdf6agrowth differentiation factor 6a0.158
wnt7aawingless-type MMTV integration site family, member 7Aa0.155
pcdh10bprotocadherin 10b0.154
shhasonic hedgehog a0.152
hoxb1bhomeo box B1b0.148
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.136
yap1Yes-associated protein 10.133
gli3GLI-Kruppel family member GLI30.128
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.128
igfbp3insulin-like growth factor binding protein 30.127
fgfr1bfibroblast growth factor receptor 1b0.126
hgfahepatocyte growth factor a0.125
her5hairy-related 50.124
sept6septin 60.116
wif1wnt inhibitory factor 10.116
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.115
bmpr1aabone morphogenetic protein receptor, type 1aa0.114
fras1Fraser syndrome 10.113
notch1anotch homolog 1a0.111
gro1groucho 10.111
ntlano tail a0.109
wnt11wingless-type MMTV integration site family, member 110.109
tp53tumor protein p530.108
ptch2patched 20.104
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.104
spon2aspondin 2a, extracellular matrix protein0.103
nanos3nanos homolog 30.103
ptpraprotein tyrosine phosphatase, receptor type, A0.103
chst11carbohydrate (chondroitin 4) sulfotransferase 110.102
gli1GLI-Kruppel family member 10.100
rargaretinoic acid receptor gamma a0.098
snai1asnail homolog 1a (Drosophila)0.098
arl13bADP-ribosylation factor-like 13b0.097
lamc1laminin, gamma 10.097
crabp2bcellular retinoic acid binding protein 2, b0.094
rasl11bRAS-like, family 11, member B0.094
col1a2collagen, type I, alpha 20.094
axin1axin 10.094
robo1roundabout homolog 10.093
sulf2sulfatase 20.093
hapln1ahyaluronan and proteoglycan link protein 1a0.092
frzbfrizzled-related protein0.092
crb2bcrumbs homolog 2b0.091
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
nkdnaked cuticle0.760
cicubitus interruptus0.643
Cdc42CG12530 gene product from transcript CG12530-RA0.639
numbCG3779 gene product from transcript CG3779-RB0.573
Klp64DKinesin-like protein at 64D0.543
WnkCG7177 gene product from transcript CG7177-RA0.488
Akt1CG4006 gene product from transcript CG4006-RA0.469
eyaeyes absent0.426
Tsc1CG6147 gene product from transcript CG6147-RA0.414
fz2frizzled 20.390
Pka-C1cAMP-dependent protein kinase 10.388
LamCLamin C0.371
CtBPC-terminal Binding Protein0.357
SmoxSmad on X0.352
hipkhomeodomain interacting protein kinase0.299
Hs6stHeparan sulfate 6-O-sulfotransferase0.287
Tak1TGF-beta activated kinase 10.281
dallydivision abnormally delayed0.269
ash2absent, small, or homeotic discs 20.268
aopanterior open0.264
Wnt2Wnt oncogene analog 20.247
RbfRetinoblastoma-family protein0.242
CycDCyclin D0.218
RASSF8CG5053 gene product from transcript CG5053-RA0.212
slmbsupernumerary limbs0.212
Zyx102EFCG32018 gene product from transcript CG32018-RA0.208
CycACyclin A0.190
opaodd paired0.182
l(1)dd4lethal (1) discs degenerate 40.182
Cdk4Cyclin-dependent kinase 40.181
poloCG12306 gene product from transcript CG12306-RA0.148
trioCG18214 gene product from transcript CG18214-RA0.148
TER94CG2331 gene product from transcript CG2331-RA0.141
mib1mind bomb 10.140
SceSex combs extra0.132
B52CG10851 gene product from transcript CG10851-RB0.131
jingCG9397 gene product from transcript CG9397-RI0.131
G-oalpha47AG protein oalpha 47A0.125
p38bCG7393 gene product from transcript CG7393-RA0.122
EndoGIEndonuclease G inhibitor0.120
NFATNFAT homolog0.117
p53CG33336 gene product from transcript CG33336-RB0.117
zfh2Zn finger homeodomain 20.114
Mef2Myocyte enhancer factor 20.112
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
SMAD2SMAD family member 21.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.997
SMAD4SMAD family member 40.995
SMAD3SMAD family member 30.994
APCadenomatous polyposis coli0.993
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.992
GSK3Bglycogen synthase kinase 3 beta0.985
AXIN1axin 10.983
CREBBPCREB binding protein0.968
FHL2four and a half LIM domains 20.963
SMAD7SMAD family member 70.955
ZFYVE9zinc finger, FYVE domain containing 90.945
FN1fibronectin 10.933
SMURF2SMAD specific E3 ubiquitin protein ligase 20.915
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.911
HIC1hypermethylated in cancer 10.852
ARandrogen receptor0.839
EP300E1A binding protein p3000.819
DVL3dishevelled, dsh homolog 3 (Drosophila)0.809
FGFR1fibroblast growth factor receptor 10.791
COL1A1collagen, type I, alpha 10.789
CSNK1Ecasein kinase 1, epsilon0.778
ATXN1ataxin 10.775
PSEN1presenilin 10.747
PMLpromyelocytic leukemia0.745
SMAD9SMAD family member 90.736
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.707
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.695
UBE3Aubiquitin protein ligase E3A0.691
PTPN1protein tyrosine phosphatase, non-receptor type 10.691
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.681
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.680
HDAC1histone deacetylase 10.679
YAP1Yes-associated protein 10.678
SKP1S-phase kinase-associated protein 10.675
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.663
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.653
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.649
SMN1survival of motor neuron 1, telomeric0.631
TP53tumor protein p530.621
EGFRepidermal growth factor receptor0.609
ERBB2IPerbb2 interacting protein0.585
CDK6cyclin-dependent kinase 60.575
CCNYcyclin Y0.572
PAX3paired box 30.555
HIPK3homeodomain interacting protein kinase 30.555
XIAPX-linked inhibitor of apoptosis0.549
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.546
MDM4Mdm4 p53 binding protein homolog (mouse)0.543
FOXD3forkhead box D30.522
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.518
DDR2discoidin domain receptor tyrosine kinase 20.515
STRN3striatin, calmodulin binding protein 30.513
SKILSKI-like oncogene0.502
BTBD2BTB (POZ) domain containing 20.499
NCOA1nuclear receptor coactivator 10.495
POU3F2POU class 3 homeobox 20.486
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.482
ESR1estrogen receptor 10.474
SOX2SRY (sex determining region Y)-box 20.455
FZD1frizzled homolog 1 (Drosophila)0.448
BMP7bone morphogenetic protein 70.445
AXIN2axin 20.444
CTGFconnective tissue growth factor0.442
SIRT1sirtuin 10.434
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.427
GRB10growth factor receptor-bound protein 100.419
FGF1fibroblast growth factor 1 (acidic)0.417
ARHGAP1Rho GTPase activating protein 10.416
CDK14cyclin-dependent kinase 140.416
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.413
NCOR2nuclear receptor corepressor 20.400
FBXW11F-box and WD repeat domain containing 110.396
RCN3reticulocalbin 3, EF-hand calcium binding domain0.389
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.387
MDM2Mdm2 p53 binding protein homolog (mouse)0.379
BTRCbeta-transducin repeat containing0.377
SLMAPsarcolemma associated protein0.364
ARID1BAT rich interactive domain 1B (SWI1-like)0.361
NOTCH3notch 30.359
BCAR1breast cancer anti-estrogen resistance 10.356
SOX10SRY (sex determining region Y)-box 100.355
ITGB5integrin, beta 50.350
BIRC2baculoviral IAP repeat containing 20.350
LRP6low density lipoprotein receptor-related protein 60.348
SKIv-ski sarcoma viral oncogene homolog (avian)0.328
TBX5T-box 50.321
AFF1AF4/FMR2 family, member 10.320
DCAF7DDB1 and CUL4 associated factor 70.318
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.318
BMPR1Abone morphogenetic protein receptor, type IA0.317
WWP2WW domain containing E3 ubiquitin protein ligase 20.308
MIB1mindbomb homolog 1 (Drosophila)0.301
GLIS2GLIS family zinc finger 20.299
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.297
CCND3cyclin D30.293
MARK3MAP/microtubule affinity-regulating kinase 30.292
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.144
Tcf12transcription factor 120.059
Golph3golgi phosphoprotein 3 (coat-protein)0.048
Ralav-ral simian leukemia viral oncogene homolog A (ras related)0.039
FosFBJ osteosarcoma oncogene0.038
Taok1TAO kinase 10.029
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.028
Dusp6dual specificity phosphatase 60.023
Slc30a1solute carrier family 30 (zinc transporter), member 10.023
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.021
Dchs1dachsous 1 (Drosophila)0.021
Stxbp5syntaxin binding protein 5 (tomosyn)0.019
Plagl1pleiomorphic adenoma gene-like 10.018
Dlg1discs, large homolog 1 (Drosophila)0.018
Col3a1collagen, type III, alpha 10.017
Stat3signal transducer and activator of transcription 30.017
Ireb2iron responsive element binding protein 20.016
Rps9ribosomal protein S90.016
Igf2rinsulin-like growth factor 2 receptor0.016
Col5a2collagen, type V, alpha 20.015
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.014
Nraddneurotrophin receptor associated death domain0.013
Col12a1collagen, type XII, alpha 10.013
Dock1dedicator of cyto-kinesis 10.013
Vcpvalosin-containing protein0.013
Nrd1nardilysin 10.011
RGD1309414similar to KIAA0913 protein0.011
Axin1axin 10.011
Myo1bmyosin Ib0.010
Gpc3glypican 30.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism