The network for 'cellular component disassembly involved in execution phase of apoptosis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular component disassembly involved in execution phase of apoptosis

The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.

NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.841
Il18interleukin 180.662
Gbp5guanylate binding protein 50.633
PycardPYD and CARD domain containing0.456
Il1binterleukin 1 beta0.329
DffbDNA fragmentation factor, beta subunit0.243
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.204
Aim2absent in melanoma 20.178
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.148
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.133
Casp1caspase 10.109
Cideccell death-inducing DFFA-like effector c0.102
SharpinSHANK-associated RH domain interacting protein0.064
Plin1perilipin 10.053
Apaf1apoptotic peptidase activating factor 10.047
Rbl1retinoblastoma-like 1 (p107)0.046
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.042
Casp3caspase 30.037
Scn5asodium channel, voltage-gated, type V, alpha0.035
Hif1ahypoxia inducible factor 1, alpha subunit0.034
Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A0.033
Cox5acytochrome c oxidase, subunit Va0.032
Eya2eyes absent 2 homolog (Drosophila)0.030
Prc1protein regulator of cytokinesis 10.029
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.029
Serpinb9serine (or cysteine) peptidase inhibitor, clade B, member 90.029
NmiN-myc (and STAT) interactor0.028
Rb1retinoblastoma 10.028
Safbscaffold attachment factor B0.027
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.027
Bak1BCL2-antagonist/killer 10.026
Plin4perilipin 40.024
Casp7caspase 70.024
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.023
Gja5gap junction protein, alpha 50.023
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.023
Gcshglycine cleavage system protein H (aminomethyl carrier)0.022
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.022
Nfyanuclear transcription factor-Y alpha0.022
BidBH3 interacting domain death agonist0.021
Bmpr1abone morphogenetic protein receptor, type 1A0.021
Rnf31ring finger protein 310.021
Dckdeoxycytidine kinase0.021
Adam10a disintegrin and metallopeptidase domain 100.020
Tbx3T-box 30.020
Ctslcathepsin L0.018
Gbp7guanylate binding protein 70.018
Nlrp6NLR family, pyrin domain containing 60.018
Gja1gap junction protein, alpha 10.017
Psmb10proteasome (prosome, macropain) subunit, beta type 100.016
Atrataxia telangiectasia and Rad3 related0.016
Kitlkit ligand0.015
Stat1signal transducer and activator of transcription 10.015
Gbp3guanylate binding protein 30.015
Ripk3receptor-interacting serine-threonine kinase 30.015
Cfdcomplement factor D (adipsin)0.015
Myd88myeloid differentiation primary response gene 880.015
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.015
Alx1ALX homeobox 10.014
Arpc3actin related protein 2/3 complex, subunit 30.014
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.014
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.013
Wlswntless homolog (Drosophila)0.012
Cbfbcore binding factor beta0.012
Tlr4toll-like receptor 40.011
Pola1polymerase (DNA directed), alpha 10.011
Pabpn1poly(A) binding protein, nuclear 10.011
Ikbkginhibitor of kappaB kinase gamma0.011
Thrspthyroid hormone responsive SPOT14 homolog (Rattus)0.011
Srsf4serine/arginine-rich splicing factor 40.011
Casp8caspase 80.011
Uqcrc2ubiquinol cytochrome c reductase core protein 20.010
Brca1breast cancer 10.010
FaddFas (TNFRSF6)-associated via death domain0.010
Ndufaf4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Y97E10AL.3Protein Y97E10AL.30.012
CELE_Y18D10A.16Protein Y18D10A.160.012
CELE_F25B4.4Protein F25B4.40.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EXOSC3exosome component 30.697
CASP9caspase 9, apoptosis-related cysteine peptidase0.658
BCL2L1BCL2-like 10.492
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.386
BCL2B-cell CLL/lymphoma 20.384
DFFADNA fragmentation factor, 45kDa, alpha polypeptide0.324
BAK1BCL2-antagonist/killer 10.319
BAXBCL2-associated X protein0.284
XIAPX-linked inhibitor of apoptosis0.276
CASP3caspase 3, apoptosis-related cysteine peptidase0.272
BMP2bone morphogenetic protein 20.230
FKBP1AFK506 binding protein 1A, 12kDa0.188
SYVN1synovial apoptosis inhibitor 1, synoviolin0.181
TGFB1transforming growth factor, beta 10.167
DFFBDNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)0.164
BCL2L11BCL2-like 11 (apoptosis facilitator)0.137
APAF1apoptotic peptidase activating factor 10.122
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.091
POU5F1POU class 5 homeobox 10.077
GDF5growth differentiation factor 50.064
PARP1poly (ADP-ribose) polymerase 10.044
C4orf14chromosome 4 open reading frame 140.040
BIDBH3 interacting domain death agonist0.039
EIF2C1eukaryotic translation initiation factor 2C, 10.037
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.032
BMPR1Abone morphogenetic protein receptor, type IA0.030
FSTL1follistatin-like 10.027
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.026
TGFBR1transforming growth factor, beta receptor 10.023
GATA4GATA binding protein 40.023
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.022
MAPK8mitogen-activated protein kinase 80.022
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.019
PRKG1protein kinase, cGMP-dependent, type I0.016
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.015
TGFB3transforming growth factor, beta 30.015
EXOSC4exosome component 40.015
MDH2malate dehydrogenase 2, NAD (mitochondrial)0.014
ZMYND11zinc finger, MYND-type containing 110.014
SMURF2SMAD specific E3 ubiquitin protein ligase 20.014
WWP2WW domain containing E3 ubiquitin protein ligase 20.014
SOX2SRY (sex determining region Y)-box 20.013
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.013
UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast)0.013
NRP1neuropilin 10.013
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.013
TP53tumor protein p530.013
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.012
AGLamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase0.012
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.012
NAF1nuclear assembly factor 1 homolog (S. cerevisiae)0.011
SMAD7SMAD family member 70.011
RNF144Bring finger protein 144B0.011
BECN1beclin 1, autophagy related0.011
DIS3LDIS3 mitotic control homolog (S. cerevisiae)-like0.011
DIS3DIS3 mitotic control homolog (S. cerevisiae)0.011
VDAC1voltage-dependent anion channel 10.011
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.011
ARandrogen receptor0.011
FOXRED1FAD-dependent oxidoreductase domain containing 10.010
RANBP3RAN binding protein 30.010
TARBP2TAR (HIV-1) RNA binding protein 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism