The network for 'intra s dna damage checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intra s dna damage checkpoint

A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.

NameDescriptionProbabilityFunc Analog Organism
Rb1retinoblastoma 10.991
Ptenphosphatase and tensin homolog0.957
Trp53transformation related protein 530.957
Xpaxeroderma pigmentosum, complementation group A0.928
Cdkn1bcyclin-dependent kinase inhibitor 1B0.918
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.885
Mapk14mitogen-activated protein kinase 140.839
Timelesstimeless homolog (Drosophila)0.829
Brca2breast cancer 20.745
Atmataxia telangiectasia mutated homolog (human)0.507
Stk11serine/threonine kinase 110.473
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.464
Prim1DNA primase, p49 subunit0.456
Brca1breast cancer 10.428
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.409
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.361
Msh2mutS homolog 2 (E. coli)0.334
Mdm2transformed mouse 3T3 cell double minute 20.319
Mapk1mitogen-activated protein kinase 10.276
E2f1E2F transcription factor 10.272
Mlh1mutL homolog 1 (E. coli)0.268
Mapk8mitogen-activated protein kinase 80.256
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.256
Rpa1replication protein A10.213
Apcadenomatosis polyposis coli0.204
Rbl2retinoblastoma-like 20.190
Hprthypoxanthine guanine phosphoribosyl transferase0.189
Mms22lMMS22-like, DNA repair protein0.188
Men1multiple endocrine neoplasia 10.179
Rfc3replication factor C (activator 1) 30.170
Lig1ligase I, DNA, ATP-dependent0.168
Tcf3transcription factor 30.154
Rad50RAD50 homolog (S. cerevisiae)0.144
Foxo3forkhead box O30.135
Usp33ubiquitin specific peptidase 330.130
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.126
Cdt1chromatin licensing and DNA replication factor 10.126
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.122
Prim2DNA primase, p58 subunit0.118
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.112
Ptch1patched homolog 10.110
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.103
Rfc1replication factor C (activator 1) 10.090
Pola1polymerase (DNA directed), alpha 10.083
Tsc1tuberous sclerosis 10.083
Rbl1retinoblastoma-like 1 (p107)0.080
Wdhd1WD repeat and HMG-box DNA binding protein 10.070
BrafBraf transforming gene0.070
Rfc4replication factor C (activator 1) 40.066
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.064
AW549877expressed sequence AW5498770.060
Parp2poly (ADP-ribose) polymerase family, member 20.059
Pcnaproliferating cell nuclear antigen0.059
Eef1a1eukaryotic translation elongation factor 1 alpha 10.058
Kitkit oncogene0.055
Usp9xubiquitin specific peptidase 9, X chromosome0.055
Rps6ka5ribosomal protein S6 kinase, polypeptide 50.052
Lrrc40leucine rich repeat containing 400.051
Mapk11mitogen-activated protein kinase 110.047
Tle1transducin-like enhancer of split 1, homolog of Drosophila E(spl)0.043
Mdm4transformed mouse 3T3 cell double minute 40.039
Syce2synaptonemal complex central element protein 20.039
Myo6myosin VI0.039
Vrk1vaccinia related kinase 10.039
Ighimmunoglobulin heavy chain complex0.037
Orc6origin recognition complex, subunit 60.037
Hmmrhyaluronan mediated motility receptor (RHAMM)0.036
Bmi1Bmi1 polycomb ring finger oncogene0.036
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.036
Cdkn2acyclin-dependent kinase inhibitor 2A0.034
Ahraryl-hydrocarbon receptor0.034
Tcf19transcription factor 190.032
Haus1HAUS augmin-like complex, subunit 10.031
4930427A07RikRIKEN cDNA 4930427A07 gene0.030
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.029
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.029
Cdca7lcell division cycle associated 7 like0.028
Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.028
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.027
Kitlkit ligand0.027
Pou5f1POU domain, class 5, transcription factor 10.027
Ints9integrator complex subunit 90.026
Ep300E1A binding protein p3000.026
Rrm1ribonucleotide reductase M10.026
Alms1Alstrom syndrome 1 homolog (human)0.026
Rfc2replication factor C (activator 1) 20.025
Ndfip1Nedd4 family interacting protein 10.025
Hellshelicase, lymphoid specific0.024
Nr3c1nuclear receptor subfamily 3, group C, member 10.023
Mapk9mitogen-activated protein kinase 90.023
Topbp1topoisomerase (DNA) II binding protein 10.023
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.023
Haus5HAUS augmin-like complex, subunit 50.022
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.021
Ppihpeptidyl prolyl isomerase H0.021
Rmnd5arequired for meiotic nuclear division 5 homolog A (S. cerevisiae)0.021
WwoxWW domain-containing oxidoreductase0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rasl11bRAS-like, family 11, member B0.324
trmt2atrm2 tRNA methyltransferase 2 homolog A (S. cerevisiae)0.284
ddb2damage-specific DNA binding protein 20.185
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.178
id3inhibitor of DNA binding 30.153
vldlrvery low density lipoprotein receptor0.151
nup43nucleoporin 430.145
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.131
rnaseh2bribonuclease H2, subunit B0.119
lfnglunatic fringe homolog0.111
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.109
mab21l1mab-21-like 10.102
gins2GINS complex subunit 20.096
rpa3replication protein A30.094
gmnngeminin, DNA replication inhibitor0.070
thoc3THO complex 30.069
fanciFanconi anemia, complementation group I0.066
mtx1bmetaxin 1b0.065
tymsthymidylate synthase0.062
id1inhibitor of DNA binding 10.061
her9hairy-related 90.059
prim1primase polypeptide 10.058
mdkbmidkine-related growth factor b0.057
pdcd8programmed cell death 8 (apoptosis-inducing factor)0.051
inka1ainduced in neural crest by AP2, 1a0.048
hat1histone acetyltransferase 10.047
brip1BRCA1 interacting protein C-terminal helicase 10.046
setdb1aSET domain, bifurcated 1a0.044
gstmglutathione S-transferase M0.043
dhfrdihydrofolate reductase0.043
umpsuridine monophosphate synthetase0.042
sox11aSRY-box containing gene 11a0.042
coro1bcoronin, actin binding protein, 1B0.041
palb2partner and localizer of BRCA20.041
arl4abADP-ribosylation factor-like 4ab0.040
mbd3bmethyl-CpG binding domain protein 3b0.040
cdk2cyclin-dependent kinase 20.039
gemin5gem (nuclear organelle) associated protein 50.039
adkaadenosine kinase a0.038
nap1l1nucleosome assembly protein 1, like 10.036
fen1flap structure-specific endonuclease 10.035
gins1GINS complex subunit 1 (Psf1 homolog)0.035
wdr76WD repeat domain 760.035
crabp2bcellular retinoic acid binding protein 2, b0.033
lap3leucine aminopeptidase 30.032
thumpd3THUMP domain containing 30.032
cited3Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 30.032
orc1origin recognition complex, subunit 10.031
pcnaproliferating cell nuclear antigen0.031
triap1TP53 regulated inhibitor of apoptosis 10.029
rps2ribosomal protein S20.028
ccdc58coiled-coil domain containing 580.028
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.027
cox4i2cytochrome c oxidase subunit IV isoform 20.026
xbp1X-box binding protein 10.025
fabp7afatty acid binding protein 7, brain, a0.025
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.025
csrp1acysteine and glycine-rich protein 1a0.025
naspnuclear autoantigenic sperm protein (histone-binding)0.025
lmo4aLIM domain only 4a0.025
adnp2bADNP homeobox 2b0.024
dync2i1dynein, cytoplasmic 2, intermediate chain 10.024
hellshelicase, lymphoid-specific0.024
lrig1leucine-rich repeats and immunoglobulin-like domains 10.023
wdhd1WD repeat and HMG-box DNA binding protein 10.023
frzbfrizzled-related protein0.023
eaf1ELL associated factor 10.023
dnmt1DNA (cytosine-5-)-methyltransferase 10.022
stmn1bstathmin 1b0.022
cxcr4achemokine (C-X-C motif) receptor 4a0.022
als2bamyotrophic lateral sclerosis 2b (juvenile)0.022
fscn1fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)0.021
fstl1bfollistatin-like 1b0.021
nutf2lnuclear transport factor 2, like0.021
pole2polymerase (DNA directed), epsilon 20.021
cacnb3acalcium channel, voltage-dependent, beta 3a0.020
orc5origin recognition complex, subunit 50.020
msh6mutS homolog 6 (E. coli)0.020
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.020
setd6SET domain containing 60.019
ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.019
fam84afamily with sequence similarity 84, member A0.019
map1lc3bmicrotubule-associated protein 1 light chain 3 beta0.019
impdh2IMP (inosine monophosphate) dehydrogenase 20.019
mycamyelocytomatosis oncogene a0.019
mpped2metallophosphoesterase domain containing 20.019
ppdpfbpancreatic progenitor cell differentiation and proliferation factor b0.019
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DNApol-etaCG7143 gene product from transcript CG7143-RA0.022
rad50CG6339 gene product from transcript CG6339-RD0.017
mus101mutagen-sensitive 1010.011
RecQ5homolog of RecQ0.011
CG5524CG5524 gene product from transcript CG5524-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene0.984
FOSFBJ murine osteosarcoma viral oncogene homolog0.929
ATF3activating transcription factor 30.777
MSH6mutS homolog 6 (E. coli)0.735
JUNBjun B proto-oncogene0.584
RAD50RAD50 homolog (S. cerevisiae)0.515
RBBP8retinoblastoma binding protein 80.398
BRCA1breast cancer 1, early onset0.377
ATF2activating transcription factor 20.290
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.210
DUSP1dual specificity phosphatase 10.188
JUNDjun D proto-oncogene0.155
JDP2Jun dimerization protein 20.148
DDIT3DNA-damage-inducible transcript 30.142
EEF1A1eukaryotic translation elongation factor 1 alpha 10.114
MDM2Mdm2 p53 binding protein homolog (mouse)0.104
MAPK14mitogen-activated protein kinase 140.093
RAD17RAD17 homolog (S. pombe)0.093
MAPK8mitogen-activated protein kinase 80.089
FANCD2Fanconi anemia, complementation group D20.080
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.075
MSH3mutS homolog 3 (E. coli)0.068
OCIAD1OCIA domain containing 10.068
RB1retinoblastoma 10.065
ATMataxia telangiectasia mutated0.061
NEK6NIMA (never in mitosis gene a)-related kinase 60.061
RPL39ribosomal protein L390.050
DDB2damage-specific DNA binding protein 2, 48kDa0.048
FOSL1FOS-like antigen 10.043
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.043
MDC1mediator of DNA-damage checkpoint 10.039
MDM4Mdm4 p53 binding protein homolog (mouse)0.037
RFWD2ring finger and WD repeat domain 20.035
MAPK10mitogen-activated protein kinase 100.032
RPA2replication protein A2, 32kDa0.030
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.028
FHL2four and a half LIM domains 20.026
SS18synovial sarcoma translocation, chromosome 180.026
RPL41ribosomal protein L410.024
HUS1HUS1 checkpoint homolog (S. pombe)0.023
TIMELESStimeless homolog (Drosophila)0.023
IER2immediate early response 20.021
BRCA2breast cancer 2, early onset0.021
FANCEFanconi anemia, complementation group E0.020
CHEK1CHK1 checkpoint homolog (S. pombe)0.020
RAD1RAD1 homolog (S. pombe)0.019
BTRCbeta-transducin repeat containing0.019
RPL34ribosomal protein L340.018
SMAD1SMAD family member 10.018
IRF2BP1interferon regulatory factor 2 binding protein 10.018
EIF1eukaryotic translation initiation factor 10.017
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.017
RECQL4RecQ protein-like 40.016
ERCC4excision repair cross-complementing rodent repair deficiency, complementation group 40.016
PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)0.015
BCL6B-cell CLL/lymphoma 60.015
UHRF2ubiquitin-like with PHD and ring finger domains 20.015
DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 110.014
ATXN3ataxin 30.013
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.013
KLF5Kruppel-like factor 5 (intestinal)0.013
NEDD9neural precursor cell expressed, developmentally down-regulated 90.012
ATRataxia telangiectasia and Rad3 related0.012
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.012
RPS27ribosomal protein S270.012
POLHpolymerase (DNA directed), eta0.011
MAPK9mitogen-activated protein kinase 90.011
SMC1Astructural maintenance of chromosomes 1A0.011
TSC22D1TSC22 domain family, member 10.011
BTG2BTG family, member 20.011
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.010
MUTYHmutY homolog (E. coli)0.010
PGRprogesterone receptor0.010
CREBBPCREB binding protein0.010
CUX1cut-like homeobox 10.010
RAD9ARAD9 homolog A (S. pombe)0.010
RFC1replication factor C (activator 1) 1, 145kDa0.010
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism