The network for 'connective tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

connective tissue development

The progression of a connective tissue over time, from its formation to the mature structure.

NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 11.000
Fgfr2fibroblast growth factor receptor 20.999
Fgfr1fibroblast growth factor receptor 10.999
Gli3GLI-Kruppel family member GLI30.999
Fgf8fibroblast growth factor 80.999
Shhsonic hedgehog0.998
Pkd1polycystic kidney disease 1 homolog0.996
Gli2GLI-Kruppel family member GLI20.996
Ror2receptor tyrosine kinase-like orphan receptor 20.996
Sox9SRY-box containing gene 90.995
Fgfr3fibroblast growth factor receptor 30.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.992
Vegfavascular endothelial growth factor A0.986
Bmp4bone morphogenetic protein 40.985
Chrdchordin0.985
Ptenphosphatase and tensin homolog0.984
Fbn1fibrillin 10.980
Rargretinoic acid receptor, gamma0.975
Pax8paired box gene 80.974
Pthlhparathyroid hormone-like peptide0.973
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.971
Foxa2forkhead box A20.971
Prrx1paired related homeobox 10.969
Smad3MAD homolog 3 (Drosophila)0.968
Lmx1aLIM homeobox transcription factor 1 alpha0.966
Hoxd13homeobox D130.965
Pax2paired box gene 20.964
Pax3paired box gene 30.962
Eya1eyes absent 1 homolog (Drosophila)0.957
Ascl1achaete-scute complex homolog 1 (Drosophila)0.956
Meox2mesenchyme homeobox 20.946
Hspg2perlecan (heparan sulfate proteoglycan 2)0.940
Pdx1pancreatic and duodenal homeobox 10.937
Loxlysyl oxidase0.934
Col2a1collagen, type II, alpha 10.932
Hoxa11homeobox A110.929
Hand2heart and neural crest derivatives expressed transcript 20.929
Trp53transformation related protein 530.925
Lepleptin0.924
Thrathyroid hormone receptor alpha0.921
Mapk14mitogen-activated protein kinase 140.918
Gdnfglial cell line derived neurotrophic factor0.916
Irs2insulin receptor substrate 20.905
Twist1twist homolog 1 (Drosophila)0.904
Lhx3LIM homeobox protein 30.904
Twist2twist homolog 2 (Drosophila)0.900
Gas1growth arrest specific 10.900
Hoxa2homeobox A20.898
Ptf1apancreas specific transcription factor, 1a0.894
Sox11SRY-box containing gene 110.892
Hoxd11homeobox D110.892
Pou3f3POU domain, class 3, transcription factor 30.890
Nodalnodal0.888
Gbx2gastrulation brain homeobox 20.887
Nos3nitric oxide synthase 3, endothelial cell0.877
Fgf15fibroblast growth factor 150.876
Runx2runt related transcription factor 20.873
Foxc1forkhead box C10.871
Tgfb1transforming growth factor, beta 10.868
Col11a1collagen, type XI, alpha 10.868
Col3a1collagen, type III, alpha 10.868
Otx2orthodenticle homolog 2 (Drosophila)0.863
En1engrailed 10.858
Dkk1dickkopf homolog 1 (Xenopus laevis)0.857
Thbs1thrombospondin 10.846
Bcl2B-cell leukemia/lymphoma 20.840
Tgfb2transforming growth factor, beta 20.840
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.837
Smad4MAD homolog 4 (Drosophila)0.832
Col5a2collagen, type V, alpha 20.832
Elnelastin0.829
Ctnnb1catenin (cadherin associated protein), beta 10.824
Fgf9fibroblast growth factor 90.819
Hes1hairy and enhancer of split 1 (Drosophila)0.815
Bbs4Bardet-Biedl syndrome 4 (human)0.815
Foxc2forkhead box C20.813
Ltbp2latent transforming growth factor beta binding protein 20.811
Col1a2collagen, type I, alpha 20.811
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.810
Nognoggin0.800
Bgnbiglycan0.799
Hoxa1homeobox A10.797
Pax9paired box gene 90.795
Thbs2thrombospondin 20.789
Rararetinoic acid receptor, alpha0.786
Lrp5low density lipoprotein receptor-related protein 50.783
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.780
Sox2SRY-box containing gene 20.780
Itgb1integrin beta 1 (fibronectin receptor beta)0.770
Dlx5distal-less homeobox 50.765
Hand1heart and neural crest derivatives expressed transcript 10.764
Bmpr1abone morphogenetic protein receptor, type 1A0.762
Lhx1LIM homeobox protein 10.757
Smad2MAD homolog 2 (Drosophila)0.750
Tcfap2atranscription factor AP-2, alpha0.744
Nkx6-1NK6 homeobox 10.743
Zfp503zinc finger protein 5030.742
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.740
Fzd2frizzled homolog 2 (Drosophila)0.737
Snai1snail homolog 1 (Drosophila)0.731
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.998
sox9aSRY-box containing gene 9a0.991
foxi1forkhead box I10.983
disp1dispatched homolog 1 (Drosophila)0.981
brpf1bromodomain and PHD finger containing, 10.964
dlx2adistal-less homeobox gene 2a0.952
jag1bjagged 1b0.951
edn1endothelin 10.950
barx1BarH-like homeobox 10.946
bmp2abone morphogenetic protein 2a0.916
gli2aGLI-Kruppel family member GLI2a0.915
col1a1acollagen, type I, alpha 1a0.890
bocbrother of CDO0.889
wu:fv91b12wu:fv91b120.886
col5a1procollagen, type V, alpha 10.881
rargaretinoic acid receptor gamma a0.865
fn1fibronectin 10.851
pcsk5bproprotein convertase subtilisin/kexin type 5b0.848
bmp2bbone morphogenetic protein 2b0.838
tshbthyroid stimulating hormone, beta subunit0.832
furinafurin (paired basic amino acid cleaving enzyme) a0.823
gscgoosecoid0.803
eya1eyes absent homolog 10.790
zgc:158603zgc:1586030.763
foxd3forkhead box D30.731
fgf4fibroblast growth factor 40.719
pax9paired box gene 90.717
fgf10afibroblast growth factor 10a0.716
wnt5bwingless-type MMTV integration site family, member 5b0.709
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.688
brd4bromodomain containing 40.675
axin2axin 2 (conductin, axil)0.675
hapln1ahyaluronan and proteoglycan link protein 1a0.669
zgc:111821zgc:1118210.662
fli1afriend leukemia integration 1a0.647
sox2SRY-box containing gene 20.637
twist1atwist1a0.628
wnt9bwingless-type MMTV integration site family, member 9B0.623
chpfchondroitin polymerizing factor0.616
efnb2aephrin B2a0.611
twist3twist30.608
ndr2nodal-related 20.605
ecrg4aesophageal cancer related gene 4a0.601
hoxa13bhomeo box A13b0.591
fgf3fibroblast growth factor 30.575
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.566
chdchordin0.556
bmpr1aabone morphogenetic protein receptor, type 1aa0.555
eve1even-skipped-like10.549
sox32SRY-box containing gene 320.549
s1pr2sphingosine-1-phosphate receptor 20.541
tp63tumor protein p630.531
tbx16T-box gene 160.515
notch2notch homolog 20.513
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.504
csnk1a1casein kinase 1, alpha 10.501
notch3notch homolog 30.497
mbtps1membrane-bound transcription factor protease, site 10.483
col9a3collagen, type IX, alpha 30.481
fgf17fibroblast growth factor 170.474
wnt9awingless-type MMTV integration site family, member 9A0.463
fgfr2fibroblast growth factor receptor 20.460
LOC100000500sclerostin-like0.459
ptch1patched 10.457
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.456
myod1myogenic differentiation 10.441
foxd5forkhead box D50.439
fgfrl1bfibroblast growth factor receptor-like 1b0.430
dcndecorin0.427
sec24dSEC24 family, member D (S. cerevisiae)0.420
mef2camyocyte enhancer factor 2ca0.418
ctgfconnective tissue growth factor0.418
pkd2polycystic kidney disease 20.416
foxa3forkhead box A30.415
sarsseryl-tRNA synthetase0.412
dmrt2adoublesex and mab-3 related transcription factor 2a0.404
rxraaretinoid X receptor, alpha a0.403
nrp2aneuropilin 2a0.403
osr1odd-skipped related 1 (Drosophila)0.399
igf1rainsulin-like growth factor 1a receptor0.392
xylt1xylosyltransferase 10.391
bmp3bone morphogenetic protein 30.388
matn4matrilin 40.386
flhfloating head0.377
hey1hairy/enhancer-of-split related with YRPW motif 10.375
neo1neogenin 10.375
hoxa3ahomeo box A3a0.374
zic1zic family member 1 (odd-paired homolog, Drosophila)0.373
runx3runt-related transcription factor 30.371
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.370
nkx3.2NK3 homeobox 20.364
prdm1aPR domain containing 1a, with ZNF domain0.364
gli2bGLI-Kruppel family member GLI2b0.362
dlx3bdistal-less homeobox gene 3b0.361
postnperiostin, osteoblast specific factor0.355
raraaretinoic acid receptor, alpha a0.353
jag2jagged 20.352
pcdh8protocadherin 80.347
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.347
bmp1abone morphogenetic protein 1a0.343
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.965
dshdishevelled0.949
cicubitus interruptus0.912
wgwingless0.910
shnschnurri0.850
enengrailed0.771
tkvthickveins0.753
HLHmbetaE(spl) region transcript mbeta0.750
HLHm7E(spl) region transcript m70.740
apapterous0.731
hthhomothorax0.720
Fas2Fasciclin 20.709
tshteashirt0.663
E(spl)Enhancer of split0.644
LanB2Laminin B20.579
ifinflated0.563
Su(H)Suppressor of Hairless0.563
dppdecapentaplegic0.551
grngrain0.541
grogroucho0.541
bnlbranchless0.534
ushu-shaped0.520
HLHmgammaE(spl) region transcript mgamma0.511
ttvtout-velu0.501
EgfrEpidermal growth factor receptor0.501
bibifid0.474
Pi3K92ECG4141 gene product from transcript CG4141-RB0.454
fz2frizzled 20.443
htlheartless0.414
gbbglass bottom boat0.410
fngfringe0.408
HLHm3E(spl) region transcript m30.394
sosine oculis0.394
tintinman0.375
btdbuttonhead0.374
slouslouch0.373
nkdnaked cuticle0.358
sdscalloped0.357
DadDaughters against dpp0.346
srstripe0.335
MhcMyosin heavy chain0.331
drmdrumstick0.327
Cg25CCollagen type IV0.319
sqhspaghetti squash0.297
HLHmdeltaE(spl) region transcript mdelta0.292
MedMedea0.289
malphaE(spl) region transcript malpha0.286
HLHm5E(spl) region transcript m50.283
slp1sloppy paired 10.282
gsbgooseberry0.280
ssspineless0.265
norpAno receptor potential A0.263
arrarrow0.262
Mpk2CG5475 gene product from transcript CG5475-RB0.252
knknot0.240
lbeladybird early0.240
bowlbrother of odd with entrails limited0.235
putpunt0.231
brkbrinker0.221
eveeven skipped0.217
oddodd skipped0.213
SmoxSmad on X0.207
phlpole hole0.201
hhhedgehog0.199
alaristaless0.199
pashapartner of drosha0.196
dcodiscs overgrown0.192
eyaeyes absent0.185
vgvestigial0.183
ftfat0.180
eygeyegone0.180
Myo31DFMyosin 31DF0.180
myoglianinCG1838 gene product from transcript CG1838-RD0.180
SoxNSoxNeuro0.179
inscinscuteable0.177
18w18 wheeler0.176
TolloCG6890 gene product from transcript CG6890-RA0.174
CG5746CG5746 gene product from transcript CG5746-RB0.171
mskmoleskin0.165
tldtolloid0.163
CG8516CG8516 gene product from transcript CG8516-RA0.161
discodisconnected0.159
TigTiggrin0.158
foxoforkhead box, sub-group O0.158
nubnubbin0.157
kniknirps0.157
caupcaupolican0.154
emcextra macrochaetae0.154
lablabial0.153
GscGoosecoid0.148
stwlstonewall0.147
opaodd paired0.145
araaraucan0.143
mewmultiple edematous wings0.138
tuptailup0.136
kek5kekkon50.136
Bre1CG10542 gene product from transcript CG10542-RA0.134
TspThrombospondin0.134
UbxUltrabithorax0.132
osaCG7467 gene product from transcript CG7467-RD0.130
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.996
SMAD4SMAD family member 40.992
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.988
COL3A1collagen, type III, alpha 10.982
FGF1fibroblast growth factor 1 (acidic)0.975
SMAD3SMAD family member 30.968
FN1fibronectin 10.958
VEGFAvascular endothelial growth factor A0.958
COL1A1collagen, type I, alpha 10.902
ELNelastin0.894
CTGFconnective tissue growth factor0.894
SMAD7SMAD family member 70.884
MMP14matrix metallopeptidase 14 (membrane-inserted)0.866
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.865
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.861
FGFR1fibroblast growth factor receptor 10.855
COL6A1collagen, type VI, alpha 10.845
COL2A1collagen, type II, alpha 10.819
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.805
PAX3paired box 30.787
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.781
LTBP2latent transforming growth factor beta binding protein 20.773
NRP1neuropilin 10.773
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.763
ACTBactin, beta0.748
TGFB3transforming growth factor, beta 30.737
LOXlysyl oxidase0.718
ARandrogen receptor0.651
JAG1jagged 10.628
FBN1fibrillin 10.616
COL1A2collagen, type I, alpha 20.600
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.558
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.529
COL5A1collagen, type V, alpha 10.480
IGFBP5insulin-like growth factor binding protein 50.467
LOXL1lysyl oxidase-like 10.458
ACANaggrecan0.437
FBLN1fibulin 10.435
ENGendoglin0.422
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.410
BGNbiglycan0.405
RXRAretinoid X receptor, alpha0.399
FSTL1follistatin-like 10.395
NOTCH3notch 30.374
DCNdecorin0.373
BMP4bone morphogenetic protein 40.360
THBS1thrombospondin 10.352
POU3F2POU class 3 homeobox 20.351
HOXD9homeobox D90.342
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.325
BMP7bone morphogenetic protein 70.324
PKD2polycystic kidney disease 2 (autosomal dominant)0.323
COL6A2collagen, type VI, alpha 20.322
BMP1bone morphogenetic protein 10.313
ITGB4integrin, beta 40.308
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.302
SMAD1SMAD family member 10.300
DDR2discoidin domain receptor tyrosine kinase 20.299
SFRP4secreted frizzled-related protein 40.298
HDAC4histone deacetylase 40.291
TNCtenascin C0.290
MSX1msh homeobox 10.288
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.286
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.278
ACVR1activin A receptor, type I0.275
LZTS2leucine zipper, putative tumor suppressor 20.264
TGFB2transforming growth factor, beta 20.256
FGF8fibroblast growth factor 8 (androgen-induced)0.247
PRRX1paired related homeobox 10.245
BMPR1Bbone morphogenetic protein receptor, type IB0.241
FKBP1AFK506 binding protein 1A, 12kDa0.218
NCOR2nuclear receptor corepressor 20.218
RUNX1runt-related transcription factor 10.208
PARVAparvin, alpha0.204
CD248CD248 molecule, endosialin0.201
HMGA2high mobility group AT-hook 20.200
LUMlumican0.198
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.198
HOXB5homeobox B50.196
PLECplectin0.194
FGF2fibroblast growth factor 2 (basic)0.188
CYR61cysteine-rich, angiogenic inducer, 610.181
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.181
MMP11matrix metallopeptidase 11 (stromelysin 3)0.179
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.171
PTCH1patched 10.171
MSNmoesin0.169
FOXD3forkhead box D30.166
GDF5growth differentiation factor 50.160
SEC31ASEC31 homolog A (S. cerevisiae)0.159
TGFB1transforming growth factor, beta 10.149
POSTNperiostin, osteoblast specific factor0.148
TIMP3TIMP metallopeptidase inhibitor 30.144
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.143
HIPK2homeodomain interacting protein kinase 20.142
FGF10fibroblast growth factor 100.137
SOX2SRY (sex determining region Y)-box 20.136
FZD1frizzled homolog 1 (Drosophila)0.136
POU5F1POU class 5 homeobox 10.135
HOXA10homeobox A100.131
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.805
Col1a1collagen, type I, alpha 10.779
Col5a1collagen, type V, alpha 10.620
Col5a2collagen, type V, alpha 20.422
Col1a2collagen, type I, alpha 20.420
Hapln1hyaluronan and proteoglycan link protein 10.418
Col12a1collagen, type XII, alpha 10.375
Fstl1follistatin-like 10.370
Sqlesqualene epoxidase0.287
FosFBJ osteosarcoma oncogene0.279
C1qtnf6C1q and tumor necrosis factor related protein 60.251
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.236
Vimvimentin0.230
Egr2early growth response 20.203
Egr1early growth response 10.169
Idi1isopentenyl-diphosphate delta isomerase 10.169
Tnctenascin C0.152
Shox2short stature homeobox 20.150
Lamc1laminin, gamma 10.148
Fgfr2fibroblast growth factor receptor 20.142
Tgfbr2transforming growth factor, beta receptor II0.139
Junbjun B proto-oncogene0.133
Nr4a1nuclear receptor subfamily 4, group A, member 10.127
Myh9myosin, heavy chain 9, non-muscle0.110
Fn1fibronectin 10.109
Elnelastin0.102
Btg2BTG family, member 20.099
Anxa1annexin A10.091
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.080
Syn3synapsin III0.078
Col8a1collagen, type VIII, alpha 10.073
Zfp36zinc finger protein 360.072
Ralgdsral guanine nucleotide dissociation stimulator0.071
Lumlumican0.071
Arandrogen receptor0.069
Ncanneurocan0.067
Pou3f2POU class 3 homeobox 20.065
Cpzcarboxypeptidase Z0.063
Cercamcerebral endothelial cell adhesion molecule0.062
Sod3superoxide dismutase 3, extracellular0.062
Igfbp5insulin-like growth factor binding protein 50.062
Foxe3forkhead box E30.058
Calcrcalcitonin receptor0.058
Fgf10fibroblast growth factor 100.057
Fh1fumarate hydratase 10.057
Smad6SMAD family member 60.056
Zg16zymogen granule protein 160.054
Psen1presenilin 10.053
Loxl1lysyl oxidase-like 10.053
Myo1amyosin IA0.053
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.050
Pcolceprocollagen C-endopeptidase enhancer0.050
Col9a2collagen, type IX, alpha 20.049
Irs1insulin receptor substrate 10.049
Nr1d2nuclear receptor subfamily 1, group D, member 20.048
DbpD site of albumin promoter (albumin D-box) binding protein0.046
Slc12a4solute carrier family 12 (potassium/chloride transporters), member 40.045
Prrx1paired related homeobox 10.045
Col9a1collagen, type IX, alpha 10.045
Ccnd3cyclin D30.044
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.044
Barhl2BarH-like homeobox 20.044
Loxlysyl oxidase0.044
Cd44Cd44 molecule0.043
Cd80Cd80 molecule0.043
Kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.043
Fdft1farnesyl diphosphate farnesyl transferase 10.042
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.042
Hbg1hemoglobin, gamma A0.042
Esr2estrogen receptor 2 (ER beta)0.041
Aspnasporin0.041
Ntn1netrin 10.040
Gpr176G protein-coupled receptor 1760.039
F13a1coagulation factor XIII, A1 polypeptide0.039
Foxj1forkhead box J10.038
Myod1myogenic differentiation 10.038
Dab2disabled homolog 2 (Drosophila)0.038
Arhgap28Rho GTPase activating protein 280.038
Ece1endothelin converting enzyme 10.038
S100a6S100 calcium binding protein A60.038
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.038
Fbn1fibrillin 10.037
Lims1LIM and senescent cell antigen-like domains 10.037
Vcanversican0.036
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.036
Dusp6dual specificity phosphatase 60.036
Flnafilamin A, alpha0.036
Asgr2asialoglycoprotein receptor 20.036
Capn6calpain 60.036
Slc22a9solute carrier family 22 (organic anion transporter), member 90.036
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.035
Olfml2bolfactomedin-like 2B0.034
Emp1epithelial membrane protein 10.034
Tgfb3transforming growth factor, beta 30.033
Nr4a3nuclear receptor subfamily 4, group A, member 30.033
Atf3activating transcription factor 30.033
Nppcnatriuretic peptide precursor C0.033
Pxdnperoxidasin homolog (Drosophila)0.033
Ltb4rleukotriene B4 receptor0.032
Rhocras homolog gene family, member C0.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism