The network for 'protein refolding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein refolding

The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

NameDescriptionProbabilityFunc Analog Organism
Hspa8heat shock protein 81.000
Hsph1heat shock 105kDa/110kDa protein 11.000
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 11.000
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 11.000
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 11.000
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.998
Cacybpcalcyclin binding protein0.998
Iqcb1IQ calmodulin-binding motif containing 10.989
Stip1stress-induced phosphoprotein 10.972
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.961
Rpgrip1lRpgrip1-like0.924
Hspd1heat shock protein 1 (chaperonin)0.837
Hspa5heat shock protein 50.767
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.715
Hsp90b1heat shock protein 90, beta (Grp94), member 10.678
Hspa1bheat shock protein 1B0.662
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.627
Hspe1heat shock protein 1 (chaperonin 10)0.623
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.618
Hspa4heat shock protein 40.495
Pno1partner of NOB1 homolog (S. cerevisiae)0.471
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.385
H2-K1histocompatibility 2, K1, K region0.385
Hspa1aheat shock protein 1A0.350
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.309
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.308
Hspa9heat shock protein 90.306
Hspa4lheat shock protein 4 like0.297
Ncbp2nuclear cap binding protein subunit 20.290
Lrpprcleucine-rich PPR-motif containing0.281
H2-D1histocompatibility 2, D region locus 10.280
Ahsa1AHA1, activator of heat shock protein ATPase homolog 1 (yeast)0.274
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.228
Tra2btransformer 2 beta homolog (Drosophila)0.220
Skp1aS-phase kinase-associated protein 1A0.219
Hnrnpcheterogeneous nuclear ribonucleoprotein C0.203
Ahi1Abelson helper integration site 10.197
Fam98afamily with sequence similarity 98, member A0.184
Mrfap1Morf4 family associated protein 10.184
Dnajb4DnaJ (Hsp40) homolog, subfamily B, member 40.182
Pcbp1poly(rC) binding protein 10.182
Ahsa2AHA1, activator of heat shock protein ATPase homolog 2 (yeast)0.176
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.174
Eedembryonic ectoderm development0.173
Pfdn2prefoldin 20.172
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.169
Tcp1t-complex protein 10.167
St13suppression of tumorigenicity 130.164
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.158
Fkbp4FK506 binding protein 40.148
Tmem33transmembrane protein 330.144
Serbp1serpine1 mRNA binding protein 10.140
Dnajb2DnaJ (Hsp40) homolog, subfamily B, member 20.129
Cfhcomplement component factor h0.116
Ubqln1ubiquilin 10.113
Tomm70atranslocase of outer mitochondrial membrane 70 homolog A (yeast)0.108
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.099
Canxcalnexin0.099
Bag3BCL2-associated athanogene 30.093
Lamp3lysosomal-associated membrane protein 30.077
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.075
Caprin1cell cycle associated protein 10.066
Mks1Meckel syndrome, type 10.066
Vcpvalosin containing protein0.059
Cct8chaperonin containing Tcp1, subunit 8 (theta)0.058
Dynll1dynein light chain LC8-type 10.058
Pole4polymerase (DNA-directed), epsilon 4 (p12 subunit)0.057
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.057
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.053
Ptges3prostaglandin E synthase 3 (cytosolic)0.052
Eprsglutamyl-prolyl-tRNA synthetase0.050
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.049
Eif3jeukaryotic translation initiation factor 3, subunit J0.049
Hnrnph3heterogeneous nuclear ribonucleoprotein H30.046
Nclnucleolin0.045
Impa1inositol (myo)-1(or 4)-monophosphatase 10.044
Smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.042
Paf1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.042
Ccdc117coiled-coil domain containing 1170.041
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.040
Dnaja3DnaJ (Hsp40) homolog, subfamily A, member 30.039
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.038
H2-Q7histocompatibility 2, Q region locus 70.037
Gtpbp4GTP binding protein 40.034
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.032
Rp2hretinitis pigmentosa 2 homolog (human)0.031
Cct2chaperonin containing Tcp1, subunit 2 (beta)0.031
Mat2amethionine adenosyltransferase II, alpha0.031
Ddit3DNA-damage inducible transcript 30.030
Pcmt1protein-L-isoaspartate (D-aspartate) O-methyltransferase 10.030
Tbcatubulin cofactor A0.030
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.030
Syf2SYF2 homolog, RNA splicing factor (S. cerevisiae)0.030
Eif2c2eukaryotic translation initiation factor 2C, 20.029
Bag2BCL2-associated athanogene 20.028
Nxf1nuclear RNA export factor 1 homolog (S. cerevisiae)0.028
RhebRas homolog enriched in brain0.028
Psma1proteasome (prosome, macropain) subunit, alpha type 10.027
Vps4avacuolar protein sorting 4a (yeast)0.027
Mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.027
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
fkb-6Protein FKB-60.881
CELE_C01G10.8Protein C01G10.80.261
hsp-1Protein HSP-10.231
cct-6Protein CCT-60.176
D2085.3Protein D2085.30.075
sti-1Protein STI-10.071
C30C11.4Protein C30C11.40.070
ttll-12Protein TTLL-120.060
ZC395.10Protein ZC395.100.056
nra-2Protein NRA-20.054
eef-1A.1Protein EEF-1A.10.046
hel-1Protein HEL-10.044
prp-8Protein PRP-80.028
icd-1Protein ICD-10.024
pas-6Protein PAS-60.022
par-5Protein PAR-50.020
gst-1Protein GST-10.020
rpn-3Protein RPN-30.019
dnj-12Protein DNJ-120.019
cdc-48.2Protein CDC-48.20.018
tomm-40Protein TOMM-400.018
tbb-2Protein TBB-20.018
CELE_C23G10.7Protein C23G10.70.018
coq-8Protein COQ-80.017
hsp-4Protein HSP-40.017
ubh-4Protein UBH-40.017
cct-7Protein CCT-70.016
rsp-7Protein RSP-70.015
CELE_B0280.9Protein B0280.90.014
chp-1Protein CHP-10.014
mrpl-51Protein MRPL-510.014
cct-4Protein CCT-40.014
tars-1Protein TARS-10.013
npl-4.2Protein NPL-4.20.013
cct-2Protein CCT-20.013
mars-1Protein MARS-10.012
metr-1Protein METR-10.012
R05D11.5Protein R05D11.50.012
rpt-3Protein RPT-30.012
adr-1Protein ADR-10.012
orc-3Protein ORC-30.012
mrps-17Protein MRPS-170.012
fkb-2Protein FKB-20.011
cyn-7Protein CYN-70.011
guk-1Protein GUK-10.011
qars-1Protein QARS-10.011
CELE_K08F4.2Protein K08F4.20.010
rpt-5Protein RPT-50.010
lbp-9Protein LBP-90.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSPA8heat shock 70kDa protein 81.000
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 11.000
HSPH1heat shock 105kDa/110kDa protein 11.000
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 11.000
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 11.000
STIP1stress-induced-phosphoprotein 11.000
PPIDpeptidylprolyl isomerase D1.000
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)1.000
HSPA1Bheat shock 70kDa protein 1B1.000
HSPA4heat shock 70kDa protein 40.999
HSPA9heat shock 70kDa protein 9 (mortalin)0.998
HSPD1heat shock 60kDa protein 1 (chaperonin)0.998
BAG3BCL2-associated athanogene 30.997
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.996
FKBP4FK506 binding protein 4, 59kDa0.996
HSPA1Aheat shock 70kDa protein 1A0.994
BAG2BCL2-associated athanogene 20.992
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.991
BAG1BCL2-associated athanogene0.856
PPP5Cprotein phosphatase 5, catalytic subunit0.815
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.669
DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 60.589
TCP1t-complex 10.462
PTGES3prostaglandin E synthase 3 (cytosolic)0.199
DNAJA2DnaJ (Hsp40) homolog, subfamily A, member 20.161
CCDC117coiled-coil domain containing 1170.090
CDC37cell division cycle 37 homolog (S. cerevisiae)0.085
HFEhemochromatosis0.069
BAG4BCL2-associated athanogene 40.061
HDAC11histone deacetylase 110.056
HSPB1heat shock 27kDa protein 10.053
CACYBPcalcyclin binding protein0.049
EIF5eukaryotic translation initiation factor 50.048
RIPK3receptor-interacting serine-threonine kinase 30.047
HSPB8heat shock 22kDa protein 80.044
C4orf14chromosome 4 open reading frame 140.043
VCPvalosin containing protein0.043
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.034
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.033
HLA-Amajor histocompatibility complex, class I, A0.032
ITM2Bintegral membrane protein 2B0.030
MARSmethionyl-tRNA synthetase0.030
TGFBR1transforming growth factor, beta receptor 10.028
VDAC1voltage-dependent anion channel 10.026
PRSS23protease, serine, 230.026
MAP3K3mitogen-activated protein kinase kinase kinase 30.024
FKBP5FK506 binding protein 50.022
NCLnucleolin0.018
CYCScytochrome c, somatic0.017
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.016
MEOX2mesenchyme homeobox 20.016
TMX2thioredoxin-related transmembrane protein 20.016
LDHAlactate dehydrogenase A0.016
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.015
TOMM34translocase of outer mitochondrial membrane 340.015
DNAJC7DnaJ (Hsp40) homolog, subfamily C, member 70.015
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)0.015
G3BP2GTPase activating protein (SH3 domain) binding protein 20.014
AARSalanyl-tRNA synthetase0.014
SMAD9SMAD family member 90.013
LONP1lon peptidase 1, mitochondrial0.013
TM4SF1transmembrane 4 L six family member 10.013
CDC37L1cell division cycle 37 homolog (S. cerevisiae)-like 10.013
TBK1TANK-binding kinase 10.012
DNAJA4DnaJ (Hsp40) homolog, subfamily A, member 40.012
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.012
FTH1ferritin, heavy polypeptide 10.011
ETF1eukaryotic translation termination factor 10.011
TARS2threonyl-tRNA synthetase 2, mitochondrial (putative)0.011
ANTXR2anthrax toxin receptor 20.011
WIPI2WD repeat domain, phosphoinositide interacting 20.011
GCLMglutamate-cysteine ligase, modifier subunit0.010
TRAF3IP1TNF receptor-associated factor 3 interacting protein 10.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsph1heat shock 105/110 protein 11.000
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 11.000
Hspd1heat shock protein 1 (chaperonin)1.000
Hspa8heat shock protein 81.000
Stip1stress-induced phosphoprotein 11.000
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.999
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.999
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.952
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.859
Hspa1aheat shock 70kD protein 1A0.821
Hspa5heat shock protein 50.784
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.690
St13suppression of tumorigenicity 130.634
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.599
Ubbubiquitin B0.476
Ppidpeptidylprolyl isomerase D (cyclophilin D)0.267
Ptges3prostaglandin E synthase 3 (cytosolic)0.253
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.252
Canxcalnexin0.192
Nudcnuclear distribution gene C homolog (A. nidulans)0.191
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.175
P4ha1prolyl 4-hydroxylase, alpha polypeptide I0.160
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.137
Fkbp4FK506 binding protein 40.137
Ybx1Y box binding protein 10.116
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.112
Tcp1t-complex 10.107
CnbpCCHC-type zinc finger, nucleic acid binding protein0.102
Cct2chaperonin containing TCP1, subunit 2 (beta)0.099
Hnrnpcheterogeneous nuclear ribonucleoprotein C (C1/C2)0.085
Pcnaproliferating cell nuclear antigen0.083
Glrx3glutaredoxin 30.074
Ddit3DNA-damage inducible transcript 30.055
Cacybpcalcyclin binding protein0.053
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.048
Ubqln1ubiquilin 10.042
SsbSjogren syndrome antigen B0.041
Hspb1heat shock protein 10.041
Sod2superoxide dismutase 2, mitochondrial0.037
Snx6sorting nexin 60.036
Hspa4heat shock protein 40.036
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.032
Utp3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)0.031
Odc1ornithine decarboxylase 10.029
Uspl1ubiquitin specific peptidase like 10.028
Hprt1hypoxanthine phosphoribosyltransferase 10.026
Pias2protein inhibitor of activated STAT, 20.025
COX1cytochrome c oxidase subunit 10.025
Hsp90b1heat shock protein 90, beta, member 10.025
Psmd5proteasome (prosome, macropain) 26S subunit, non-ATPase, 50.025
LOC100360150eukaryotic translation elongation factor 1 alpha 20.024
Snx16sorting nexin 160.024
Ubcubiquitin C0.024
RT1-CE12RT1 class I, locus CE120.022
Hsd17b8hydroxysteroid (17-beta) dehydrogenase 80.021
Criptcysteine-rich PDZ-binding protein0.021
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.021
Mapk1mitogen activated protein kinase 10.019
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.019
Skp1S-phase kinase-associated protein 10.018
Dynll1dynein light chain LC8-type 10.018
Mat2amethionine adenosyltransferase II, alpha0.018
Pex12peroxisomal biogenesis factor 120.018
Rnf34ring finger protein 340.017
Tomm70atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)0.016
Prdx6peroxiredoxin 60.016
Ipo5importin 50.016
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.016
Cds1CDP-diacylglycerol synthase 10.015
Usp10ubiquitin specific peptidase 100.015
Homer1homer homolog 1 (Drosophila)0.015
Mgst1microsomal glutathione S-transferase 10.015
Zrsr1zinc finger (CCCH type), RNA binding motif and serine/arginine rich 10.015
Ppatphosphoribosyl pyrophosphate amidotransferase0.014
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.014
Alas1aminolevulinate, delta-, synthase 10.014
Smndc1survival motor neuron domain containing 10.014
Mrpl45mitochondrial ribosomal protein L450.013
Cnn3calponin 3, acidic0.013
Irgqimmunity-related GTPase family, Q0.013
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.013
Cd48Cd48 molecule0.013
Rad23bRAD23 homolog B (S. cerevisiae)0.013
Camkk1calcium/calmodulin-dependent protein kinase kinase 1, alpha0.013
Mapk3mitogen activated protein kinase 30.013
Eml2echinoderm microtubule associated protein like 20.013
Tfamtranscription factor A, mitochondrial0.013
Dph5DPH5 homolog (S. cerevisiae)0.012
Atg3ATG3 autophagy related 3 homolog (S. cerevisiae)0.012
Rab10RAB10, member RAS oncogene family0.012
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.012
Rhot2ras homolog gene family, member T20.011
Habp4hyaluronan binding protein 40.011
Psma1proteasome (prosome, macropain) subunit, alpha type 10.011
Zc3h15zinc finger CCCH-type containing 150.011
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.011
Rangap1RAN GTPase activating protein 10.011
Fth1ferritin, heavy polypeptide 10.011
Sv2bsynaptic vesicle glycoprotein 2b0.011
Socs5suppressor of cytokine signaling 50.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
STI1Sti1p1.000
SIS1Sis1p0.997
SSA4Ssa4p0.992
AHA1Aha1p0.991
SSA1Ssa1p0.988
HSP82Hsp82p0.985
BTN2Btn2p0.982
SSA2Ssa2p0.976
YDJ1Ydj1p0.968
CPR6Cpr6p0.959
SSA3Ssa3p0.952
SGT2Sgt2p0.875
HSP60Hsp60p0.771
HSC82Hsc82p0.735
SSC1Ssc1p0.726
CUR1Cur1p0.679
SSE1Sse1p0.586
HSP78Hsp78p0.563
MDJ1Mdj1p0.537
KAR2Kar2p0.529
FES1Fes1p0.413
HSP104Hsp104p0.359
HCH1Hch1p0.257
HSP10Hsp10p0.190
APJ1Apj1p0.114
CPR7Cpr7p0.104
TIM44Tim44p0.052
YHB1Yhb1p0.048
UBA1Uba1p0.041
PIM1Pim1p0.031
HSP42Hsp42p0.030
NTG1Ntg1p0.029
YLR264C-Ahypothetical protein0.026
SRD1Srd1p0.025
ADR1Adr1p0.022
YFR016Chypothetical protein0.021
NAM9Nam9p0.021
LEU2Leu2p0.021
MBF1Mbf1p0.020
PTC5Ptc5p0.020
BDH1Bdh1p0.020
MIA40Mia40p0.020
YLR162Whypothetical protein0.020
YDR186Chypothetical protein0.019
YOL038C-Ahypothetical protein0.019
ALT2Alt2p0.018
YLR042Chypothetical protein0.018
ARP10Arp10p0.018
BAT2Bat2p0.017
TFC7Tfc7p0.017
CDC37Cdc37p0.016
BFR1Bfr1p0.016
CUP1-1Cup1-1p0.016
MER1Mer1p0.016
YAR068Whypothetical protein0.015
NTA1Nta1p0.015
SPL2Spl2p0.015
URA3Ura3p0.015
FAS2Fas2p0.014
HOHop0.014
COA3Coa3p0.014
HPF1Hpf1p0.014
HSP26Hsp26p0.014
ATP6Atp6p0.014
YIR035Chypothetical protein0.014
YBR013Chypothetical protein0.013
ABP140Abp140p0.013
GIP2Gip2p0.013
ARG8Arg8p0.013
TYE7Tye7p0.013
SWC7Swc7p0.013
CAR1Car1p0.012
GYL1Gyl1p0.012
ADH2Adh2p0.012
YPR157Whypothetical protein0.012
YLF2Ylf2p0.012
ICS2Ics2p0.012
YKR075Chypothetical protein0.011
LHS1Lhs1p0.011
UPS3Ups3p0.011
YIR042Chypothetical protein0.011
SRT1Srt1p0.011
AUA1Aua1p0.011
BSC1Bsc1p0.011
YLR108Chypothetical protein0.011
SOV1Sov1p0.011
HOR2Hor2p0.011
YIL151Chypothetical protein0.011
FMT1Fmt1p0.011
CAM1Cam1p0.011
MF(ALPHA)2Mf(alpha)2p0.011
YOL013W-Ahypothetical protein0.010
JEM1Jem1p0.010
PNT1Pnt1p0.010
ZPS1Zps1p0.010