The network for 'limb development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

limb development

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Pitx2paired-like homeodomain transcription factor 21.000
Pax2paired box gene 21.000
Msx2homeobox, msh-like 21.000
Tcfap2atranscription factor AP-2, alpha1.000
Pax3paired box gene 31.000
Gli2GLI-Kruppel family member GLI21.000
Rargretinoic acid receptor, gamma1.000
Otx2orthodenticle homolog 2 (Drosophila)0.999
Hand1heart and neural crest derivatives expressed transcript 10.999
Fgfr1fibroblast growth factor receptor 10.999
Foxc1forkhead box C10.999
Hoxa10homeobox A100.999
Tbx3T-box 30.999
Dlx5distal-less homeobox 50.999
Pitx1paired-like homeodomain transcription factor 10.999
Alx4aristaless-like homeobox 40.999
Wnt5awingless-related MMTV integration site 5A0.999
Bmp7bone morphogenetic protein 70.999
Pax6paired box gene 60.998
Ror2receptor tyrosine kinase-like orphan receptor 20.998
Hoxa11homeobox A110.997
Prrx1paired related homeobox 10.997
Ptenphosphatase and tensin homolog0.997
Hoxd13homeobox D130.997
Bmp4bone morphogenetic protein 40.996
Runx2runt related transcription factor 20.996
Lef1lymphoid enhancer binding factor 10.996
Hoxa13homeobox A130.996
Nodalnodal0.995
Sox9SRY-box containing gene 90.995
Fgf8fibroblast growth factor 80.994
Rararetinoic acid receptor, alpha0.993
Tbx15T-box 150.993
Lhx1LIM homeobox protein 10.992
Foxc2forkhead box C20.992
Chrdchordin0.991
Rxraretinoid X receptor alpha0.990
Pkd1polycystic kidney disease 1 homolog0.989
Hand2heart and neural crest derivatives expressed transcript 20.989
Fgf10fibroblast growth factor 100.989
Prrx2paired related homeobox 20.987
Pcsk5proprotein convertase subtilisin/kexin type 50.986
Tgfbr2transforming growth factor, beta receptor II0.985
Smosmoothened homolog (Drosophila)0.984
Isl1ISL1 transcription factor, LIM/homeodomain0.981
En1engrailed 10.980
Sall4sal-like 4 (Drosophila)0.979
Rarbretinoic acid receptor, beta0.972
Gscgoosecoid homeobox0.969
Msx1homeobox, msh-like 10.968
Wnt3awingless-related MMTV integration site 3A0.965
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.965
Fgfr3fibroblast growth factor receptor 30.964
Hoxd11homeobox D110.961
Pax8paired box gene 80.960
Hoxd10homeobox D100.959
Thrathyroid hormone receptor alpha0.955
Fuzfuzzy homolog (Drosophila)0.953
Gdf5growth differentiation factor 50.952
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.951
Tgfb2transforming growth factor, beta 20.949
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.945
Twist1twist homolog 1 (Drosophila)0.945
Fbn1fibrillin 10.943
Sox2SRY-box containing gene 20.941
Pax9paired box gene 90.937
Pou3f3POU domain, class 3, transcription factor 30.935
Zic3zinc finger protein of the cerebellum 30.933
Neurog3neurogenin 30.930
Hoxa9homeobox A90.928
Tbx4T-box 40.926
Foxd3forkhead box D30.922
Dkk1dickkopf homolog 1 (Xenopus laevis)0.920
Nognoggin0.917
Twist2twist homolog 2 (Drosophila)0.917
Trp63transformation related protein 630.904
Wnt6wingless-related MMTV integration site 60.901
Nr5a1nuclear receptor subfamily 5, group A, member 10.892
Tbx5T-box 50.877
Dlx1distal-less homeobox 10.876
Sox10SRY-box containing gene 100.870
Tbx1T-box 10.870
Ascl1achaete-scute complex homolog 1 (Drosophila)0.867
Acvr1activin A receptor, type 10.860
Lhx9LIM homeobox protein 90.855
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.854
Tcf15transcription factor 150.854
Col1a1collagen, type I, alpha 10.847
Fzd2frizzled homolog 2 (Drosophila)0.846
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.845
Alx3aristaless-like homeobox 30.841
Foxh1forkhead box H10.839
Notch1Notch gene homolog 1 (Drosophila)0.838
Foxf1aforkhead box F1a0.834
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.832
Pbx1pre B-cell leukemia transcription factor 10.831
Eya1eyes absent 1 homolog (Drosophila)0.826
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.975
wnt5bwingless-type MMTV integration site family, member 5b0.602
dlx2adistal-less homeobox gene 2a0.583
dlx5adistal-less homeobox gene 5a0.523
fgf24fibroblast growth factor 240.483
shhasonic hedgehog a0.429
hoxa9bhomeo box A9b0.419
hoxd13ahomeo box D13a0.313
hoxa11bhomeo box A11b0.300
osr2odd-skipped related 2 (Drosophila)0.257
hand2heart and neural crest derivatives expressed transcript 20.253
hoxa13bhomeo box A13b0.238
gli2aGLI-Kruppel family member GLI2a0.221
hoxd11ahomeo box D11a0.203
hoxa11ahomeo box A11a0.203
msxdmuscle segment homeobox D0.193
sox9aSRY-box containing gene 9a0.186
gbx2gastrulation brain homeo box 20.173
chdchordin0.162
tbx18T-box 180.134
bmp4bone morphogenetic protein 40.124
msxcmuscle segment homeobox C0.119
fgf10afibroblast growth factor 10a0.118
gscgoosecoid0.117
neo1neogenin 10.110
aldh1a2aldehyde dehydrogenase 1 family, member A20.107
prrx1apaired related homeobox 1a0.105
hoxa9ahomeo box A9a0.092
hoxa10bhomeo box A10b0.092
robo3roundabout homolog 30.085
fgf8afibroblast growth factor 8 a0.081
pax9paired box gene 90.072
bmp2abone morphogenetic protein 2a0.071
hoxd10ahomeo box D10a0.066
hoxd12ahomeo box D12a0.065
msxbmuscle segment homeobox B0.063
mibmind bomb0.062
msxemuscle segment homeobox E0.062
hoxd9ahomeo box D9a0.053
fgf3fibroblast growth factor 30.051
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.050
dlx3bdistal-less homeobox gene 3b0.050
hoxa13ahomeo box A13a0.047
col2a1acollagen type II, alpha-1a0.047
dusp6dual specificity phosphatase 60.047
hoxc6ahomeo box C6a0.045
pcdh8protocadherin 80.041
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.039
snai1asnail homolog 1a (Drosophila)0.039
dlx4bdistal-less homeobox gene 4b0.038
tfap2atranscription factor AP-2 alpha0.038
vcanbversican b0.038
tbx2bT-box 2b0.037
tbx2aT-box gene 2a0.035
wnt11wingless-type MMTV integration site family, member 110.034
spry4sprouty (Drosophila) homolog 40.032
lef1lymphocyte enhancer binding factor 10.032
notch1anotch homolog 1a0.031
vcanaversican a0.031
osr1odd-skipped related 1 (Drosophila)0.031
prdm16PR domain containing 160.030
hey1hairy/enhancer-of-split related with YRPW motif 10.030
col1a1acollagen, type I, alpha 1a0.030
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.029
twist3twist30.029
dkk1bdickkopf 1b0.028
barx2BarH-like homeobox 20.028
meis3myeloid ecotropic viral integration site 30.027
tbx16T-box gene 160.027
pea3ETS-domain transcription factor pea30.026
eya1eyes absent homolog 10.025
tcf7transcription factor 7 (T-cell specific, HMG-box)0.024
sox9bSRY-box containing gene 9b0.024
gli3GLI-Kruppel family member GLI30.024
aldh1a3aldehyde dehydrogenase 1 family, member A30.023
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.023
pitx3paired-like homeodomain transcription factor 30.022
tbx5aT-box 5a0.022
sparcsecreted acidic cysteine rich glycoprotein0.022
ihhaIndian hedgehog homolog a0.021
and1actinodin10.021
si:ch211-173o4.2si:ch211-173o4.20.021
notch3notch homolog 30.021
smad9MAD homolog 9 (Drosophila)0.021
runx2brunt-related transcription factor 2b0.020
ascl1aachaete-scute complex-like 1a (Drosophila)0.020
fgf17fibroblast growth factor 170.020
crabp2bcellular retinoic acid binding protein 2, b0.020
rxraaretinoid X receptor, alpha a0.020
hoxb1bhomeo box B1b0.019
znf503zinc finger protein 5030.019
smosmoothened homolog (Drosophila)0.019
etv5bets variant 5b0.019
eve1even-skipped-like10.019
tbx15T-box 150.019
tcf12transcription factor 120.018
prrx1bpaired related homeobox 1b0.018
nkx2.5NK2 transcription factor related 50.018
dccdeleted in colorectal carcinoma0.018
pcsk5bproprotein convertase subtilisin/kexin type 5b0.018
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wgwingless0.949
enengrailed0.629
dallydivision abnormally delayed0.461
cicubitus interruptus0.447
fngfringe0.361
vvlventral veins lacking0.340
dppdecapentaplegic0.321
knknot0.306
EgfrEpidermal growth factor receptor0.293
slp1sloppy paired 10.261
araaraucan0.245
hhhedgehog0.227
sogshort gastrulation0.227
DllDistal-less0.220
oddodd skipped0.217
tldtolloid0.204
alaristaless0.199
nkdnaked cuticle0.197
shgshotgun0.196
panpangolin0.189
dshdishevelled0.183
Doc2Dorsocross20.178
bibifid0.171
mirrmirror0.162
gcmglial cells missing0.159
esgescargot0.159
tintinman0.154
amosabsent MD neurons and olfactory sensilla0.151
SerSerrate0.142
acj6abnormal chemosensory jump 60.141
Cdk4Cyclin-dependent kinase 40.137
ininturned0.130
kniknirps0.127
lolallola like0.126
argosCG4531 gene product from transcript CG4531-RA0.125
twitwist0.125
DadDaughters against dpp0.107
shnschnurri0.103
UbxUltrabithorax0.100
Wnt2Wnt oncogene analog 20.096
tkvthickveins0.095
ifinflated0.094
rkrickets0.091
O-fut1O-fucosyltransferase 10.089
drmdrumstick0.088
bnlbranchless0.088
edechinoid0.087
Ptp69DProtein tyrosine phosphatase 69D0.086
E(spl)Enhancer of split0.085
opaodd paired0.084
cswcorkscrew0.083
18w18 wheeler0.082
fasfaint sausage0.082
fzfrizzled0.081
dapdacapo0.080
fz2frizzled 20.078
pnrpannier0.075
Lim3CG10699 gene product from transcript CG10699-RB0.074
slmbsupernumerary limbs0.072
hbshibris0.071
dsfdissatisfaction0.070
elBelbow B0.070
spdosanpodo0.069
CG32372CG32372 gene product from transcript CG32372-RA0.069
ckcrinkled0.068
rprreaper0.068
dvedefective proventriculus0.068
porporcupine0.067
midmidline0.064
pbproboscipedia0.064
scascabrous0.063
lblladybird late0.062
emsempty spiracles0.060
PliPellino0.059
lablabial0.059
eveeven skipped0.059
nompCno mechanoreceptor potential C0.058
slislit0.058
btlbreathless0.057
NotumCG13076 gene product from transcript CG13076-RB0.057
painpainless0.057
putpunt0.056
discodisconnected0.056
srstripe0.056
kluklumpfuss0.055
CG32556CG32556 gene product from transcript CG32556-RB0.055
tshteashirt0.055
grhgrainy head0.055
Btk29ABtk family kinase at 29A0.054
Myd88CG2078 gene product from transcript CG2078-RA0.054
sdscalloped0.052
PoxnPox neuro0.052
tsgtwisted gastrulation0.051
TolloCG6890 gene product from transcript CG6890-RA0.051
smosmoothened0.051
hthhomothorax0.050
Su(var)3-7Suppressor of variegation 3-70.050
atoatonal0.050
nubnubbin0.049
rempAreduced mechanoreceptor potential A0.049
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.991
FHL2four and a half LIM domains 20.970
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.555
ZNF43zinc finger protein 430.542
JAG1jagged 10.535
FN1fibronectin 10.507
PAX3paired box 30.437
SMAD3SMAD family member 30.434
ZFYVE9zinc finger, FYVE domain containing 90.380
TGFB1transforming growth factor, beta 10.361
ZNF253zinc finger protein 2530.336
APPamyloid beta (A4) precursor protein0.315
ENGendoglin0.258
ZNF273zinc finger protein 2730.215
COL1A1collagen, type I, alpha 10.207
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.196
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.192
BMP2bone morphogenetic protein 20.178
MEIS1Meis homeobox 10.136
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.134
ZNF675zinc finger protein 6750.132
SUFUsuppressor of fused homolog (Drosophila)0.130
FLNBfilamin B, beta0.123
FKBP1AFK506 binding protein 1A, 12kDa0.114
SMOsmoothened homolog (Drosophila)0.111
PMLpromyelocytic leukemia0.102
CHD7chromodomain helicase DNA binding protein 70.098
ELL2elongation factor, RNA polymerase II, 20.096
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.095
HOXA10homeobox A100.093
SMAD2SMAD family member 20.086
ARRB1arrestin, beta 10.080
THBS1thrombospondin 10.077
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.076
COL2A1collagen, type II, alpha 10.065
SETD8SET domain containing (lysine methyltransferase) 80.064
SKILSKI-like oncogene0.057
SIN3ASIN3 homolog A, transcription regulator (yeast)0.057
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.054
ZNF430zinc finger protein 4300.052
EIF2C2eukaryotic translation initiation factor 2C, 20.052
FBLN1fibulin 10.052
MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.052
BMPR1Abone morphogenetic protein receptor, type IA0.052
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.049
SOX2SRY (sex determining region Y)-box 20.048
HOXD13homeobox D130.048
ZNF254zinc finger protein 2540.048
FSTL1follistatin-like 10.047
GATA4GATA binding protein 40.047
HTThuntingtin0.046
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.046
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.045
TLN1talin 10.044
TJP1tight junction protein 1 (zona occludens 1)0.044
MDFIMyoD family inhibitor0.044
YY1YY1 transcription factor0.044
MMP14matrix metallopeptidase 14 (membrane-inserted)0.042
ZNF117zinc finger protein 1170.042
FGF1fibroblast growth factor 1 (acidic)0.041
MEIS2Meis homeobox 20.040
BAK1BCL2-antagonist/killer 10.039
ZNF708zinc finger protein 7080.038
SMAD4SMAD family member 40.038
FGF18fibroblast growth factor 180.038
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.038
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.037
EIF2C1eukaryotic translation initiation factor 2C, 10.036
MDM2Mdm2 p53 binding protein homolog (mouse)0.036
MMP11matrix metallopeptidase 11 (stromelysin 3)0.035
HOXC8homeobox C80.035
FOXF2forkhead box F20.033
FOXC1forkhead box C10.033
PSEN1presenilin 10.032
BMP4bone morphogenetic protein 40.032
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.032
PDZD11PDZ domain containing 110.032
TGFB3transforming growth factor, beta 30.031
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.031
DLX4distal-less homeobox 40.030
HDAC1histone deacetylase 10.030
ACANaggrecan0.029
ZNF93zinc finger protein 930.029
BCL2L11BCL2-like 11 (apoptosis facilitator)0.029
HOXD9homeobox D90.029
SFRP1secreted frizzled-related protein 10.029
COL17A1collagen, type XVII, alpha 10.028
HOXD11homeobox D110.028
MSX2msh homeobox 20.027
NRP1neuropilin 10.027
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.027
ITGB4integrin, beta 40.027
ZNF680zinc finger protein 6800.027
LRP6low density lipoprotein receptor-related protein 60.026
FLNAfilamin A, alpha0.026
CDH3cadherin 3, type 1, P-cadherin (placental)0.026
HOXC6homeobox C60.026
COL1A2collagen, type I, alpha 20.026
RARGretinoic acid receptor, gamma0.026
COL11A1collagen, type XI, alpha 10.025
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Glg1golgi apparatus protein 10.057
Col12a1collagen, type XII, alpha 10.056
Nfibnuclear factor I/B0.048
Igfbp5insulin-like growth factor binding protein 50.046
Nkd1naked cuticle homolog 1 (Drosophila)0.043
Msx1msh homeobox 10.037
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.035
Cald1caldesmon 10.031
Mmp13matrix metallopeptidase 130.029
Shox2short stature homeobox 20.027
Fgf7fibroblast growth factor 70.024
Fgfr2fibroblast growth factor receptor 20.022
Tacr1tachykinin receptor 10.020
Itpr3inositol 1,4,5-triphosphate receptor, type 30.020
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.018
Nedd4neural precursor cell expressed, developmentally down-regulated 40.017
Lef1lymphoid enhancer binding factor 10.015
Jak1Janus kinase 10.014
Bmp4bone morphogenetic protein 40.014
Tgfb2transforming growth factor, beta 20.013
MrgprfMAS-related GPR, member F0.011
Ptpn14protein tyrosine phosphatase, non-receptor type 140.011
Ubtfupstream binding transcription factor, RNA polymerase I0.011
Ccna1cyclin A10.011
Phexphosphate regulating endopeptidase homolog, X-linked0.010
Snrpd2small nuclear ribonucleoprotein D2 polypeptide0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism