The network for 'fibroblast growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

fibroblast growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Grb2growth factor receptor bound protein 21.000
Fgf8fibroblast growth factor 80.998
Gata4GATA binding protein 40.997
Fgfr3fibroblast growth factor receptor 30.993
Gli3GLI-Kruppel family member GLI30.988
Lef1lymphoid enhancer binding factor 10.987
Pax3paired box gene 30.986
Dok1docking protein 10.980
CblCasitas B-lineage lymphoma0.978
Ptpn11protein tyrosine phosphatase, non-receptor type 110.976
Gli2GLI-Kruppel family member GLI20.975
Egfrepidermal growth factor receptor0.974
Pax2paired box gene 20.961
Inpp5dinositol polyphosphate-5-phosphatase D0.961
Shc1src homology 2 domain-containing transforming protein C10.951
Fgfr2fibroblast growth factor receptor 20.947
Fgf18fibroblast growth factor 180.942
Ntf3neurotrophin 30.935
Pitx2paired-like homeodomain transcription factor 20.933
Twist2twist homolog 2 (Drosophila)0.931
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.907
Gab2growth factor receptor bound protein 2-associated protein 20.899
Retret proto-oncogene0.866
Dkk1dickkopf homolog 1 (Xenopus laevis)0.856
Tgfb2transforming growth factor, beta 20.834
Msx2homeobox, msh-like 20.832
Lhx1LIM homeobox protein 10.810
Meox2mesenchyme homeobox 20.804
Gata6GATA binding protein 60.799
Foxc1forkhead box C10.792
Tbx3T-box 30.774
Hoxd11homeobox D110.717
Col1a1collagen, type I, alpha 10.713
Sox9SRY-box containing gene 90.698
Wnt3awingless-related MMTV integration site 3A0.696
Bmp4bone morphogenetic protein 40.692
Dok2docking protein 20.644
Usp8ubiquitin specific peptidase 80.644
En1engrailed 10.640
Csf1colony stimulating factor 1 (macrophage)0.636
Smpd3sphingomyelin phosphodiesterase 3, neutral0.630
Pthlhparathyroid hormone-like peptide0.621
Wnt10bwingless related MMTV integration site 10b0.617
Map4k1mitogen-activated protein kinase kinase kinase kinase 10.612
Nos3nitric oxide synthase 3, endothelial cell0.608
Ror2receptor tyrosine kinase-like orphan receptor 20.607
Rarbretinoic acid receptor, beta0.592
Spry4sprouty homolog 4 (Drosophila)0.588
Cd22CD22 antigen0.576
Fgf10fibroblast growth factor 100.564
Zfpm2zinc finger protein, multitype 20.552
Fzd8frizzled homolog 8 (Drosophila)0.520
Wnt5awingless-related MMTV integration site 5A0.508
Lrp2low density lipoprotein receptor-related protein 20.463
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.463
Lmx1aLIM homeobox transcription factor 1 alpha0.452
Spry2sprouty homolog 2 (Drosophila)0.439
Hoxa11homeobox A110.415
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.414
Rxraretinoid X receptor alpha0.409
Wnt4wingless-related MMTV integration site 40.402
Thbs2thrombospondin 20.384
Jag1jagged 10.383
Flt4FMS-like tyrosine kinase 40.375
Bmpr1abone morphogenetic protein receptor, type 1A0.371
Acvr1activin A receptor, type 10.371
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.361
Fbn1fibrillin 10.357
Tnctenascin C0.348
Fli1Friend leukemia integration 10.343
Hspg2perlecan (heparan sulfate proteoglycan 2)0.340
Sulf2sulfatase 20.336
Prrx1paired related homeobox 10.328
Klf3Kruppel-like factor 3 (basic)0.327
Zap70zeta-chain (TCR) associated protein kinase0.326
Pkdccprotein kinase domain containing, cytoplasmic0.308
Gata5GATA binding protein 50.305
Tbx15T-box 150.301
Otx1orthodenticle homolog 1 (Drosophila)0.298
Ctnnb1catenin (cadherin associated protein), beta 10.292
Trp53transformation related protein 530.291
Alx4aristaless-like homeobox 40.288
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.279
Gas1growth arrest specific 10.276
Ptk2PTK2 protein tyrosine kinase 20.268
SrcRous sarcoma oncogene0.267
Foxf1aforkhead box F1a0.267
Snai1snail homolog 1 (Drosophila)0.261
Fgfrl1fibroblast growth factor receptor-like 10.260
Vav1vav 1 oncogene0.258
Gli1GLI-Kruppel family member GLI10.256
Pou3f3POU domain, class 3, transcription factor 30.256
Gab1growth factor receptor bound protein 2-associated protein 10.253
Fgf2fibroblast growth factor 20.252
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
let-60Protein LET-600.749
pry-1Protein PRY-10.461
bar-1Protein BAR-10.168
egl-15Protein EGL-150.158
sos-1Protein SOS-10.050
mep-1Protein MEP-10.050
mef-2Protein MEF-20.046
gck-2Protein GCK-20.046
pxf-1Protein PXF-10.038
unc-40Protein UNC-400.031
sel-8Protein SEL-80.031
pop-1Protein POP-10.016
col-111Protein COL-1110.015
grd-2Protein GRD-20.015
hmg-1.2Protein HMG-1.20.014
dcap-2Protein DCAP-20.014
sma-6Protein SMA-60.014
T28B11.1Protein T28B11.10.014
F13B6.1Protein F13B6.10.013
C45G9.6Protein C45G9.60.012
let-756Protein LET-7560.012
nhr-67Protein NHR-670.012
F46G10.2Protein F46G10.20.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.879
wnt8bwingless-type MMTV integration site family, member 8b0.422
dlx5adistal-less homeobox gene 5a0.416
tbx1T-box 10.402
wnt4awingless-type MMTV integration site family, member 4a0.297
fgf17fibroblast growth factor 170.291
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.279
ptch2patched 20.278
robo3roundabout homolog 30.261
cdx1bcaudal type homeobox 1 b0.202
bmp4bone morphogenetic protein 40.179
spry4sprouty (Drosophila) homolog 40.176
dusp6dual specificity phosphatase 60.173
wnt1wingless-type MMTV integration site family, member 10.159
wnt10awingless-type MMTV integration site family, member 10a0.139
sulf1sulfatase 10.126
wnt5bwingless-type MMTV integration site family, member 5b0.115
bmp2abone morphogenetic protein 2a0.102
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.099
fzd7afrizzled homolog 7a0.099
bmp2bbone morphogenetic protein 2b0.097
ndr1nodal-related 10.095
foxa2forkhead box A20.093
flhfloating head0.091
spns2spinster homolog 2 (Drosophila)0.089
etv5aets variant 5a0.088
dkk1bdickkopf 1b0.086
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.086
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.083
wnt9awingless-type MMTV integration site family, member 9A0.078
smad9MAD homolog 9 (Drosophila)0.075
wnt3awingless-type MMTV integration site family, member 3A0.075
wif1wnt inhibitory factor 10.071
bmp1abone morphogenetic protein 1a0.066
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.065
pea3ETS-domain transcription factor pea30.061
tcf7transcription factor 7 (T-cell specific, HMG-box)0.059
fgf4fibroblast growth factor 40.059
zbtb4zinc finger and BTB domain containing 40.057
bonbonnie and clyde0.055
wnt10bwingless-type MMTV integration site family, member 10b0.053
ephb4beph receptor B4b0.052
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.051
tbx2bT-box 2b0.051
brd4bromodomain containing 40.049
shhasonic hedgehog a0.049
gata2aGATA-binding protein 2a0.047
slc30a7solute carrier family 30 (zinc transporter), member 70.044
smoxspermine oxidase0.044
sec24dSEC24 family, member D (S. cerevisiae)0.044
bmpr1aabone morphogenetic protein receptor, type 1aa0.044
fgf8afibroblast growth factor 8 a0.044
wnt2wingless-type MMTV integration site family member 20.043
foxd3forkhead box D30.043
emx3empty spiracles homeobox 30.042
fn1fibronectin 10.041
foxa1forkhead box A10.041
ihhaIndian hedgehog homolog a0.040
aplnrbapelin receptor b0.040
wnt3wingless-type MMTV integration site family, member 30.040
wnt7aawingless-type MMTV integration site family, member 7Aa0.039
nr2f1anuclear receptor subfamily 2, group F, member 1a0.039
lef1lymphocyte enhancer binding factor 10.038
sfrp1asecreted frizzled-related protein 1a0.038
runx2brunt-related transcription factor 2b0.037
mmp15bmatrix metallopeptidase 15b0.037
og9xOG9 homeobox gene0.037
bocbrother of CDO0.037
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.037
runx3runt-related transcription factor 30.036
wnt9bwingless-type MMTV integration site family, member 9B0.035
grhl2bgrainyhead-like 2b (Drosophila)0.035
frzbfrizzled-related protein0.035
pcdh8protocadherin 80.034
gli2aGLI-Kruppel family member GLI2a0.034
gpc4glypican 40.033
spon2aspondin 2a, extracellular matrix protein0.033
wnt5awingless-type MMTV integration site family, member 5a0.033
col5a1procollagen, type V, alpha 10.033
vax1ventral anterior homeobox 10.033
hey1hairy/enhancer-of-split related with YRPW motif 10.032
meis2.2myeloid ecotropic viral integration site 2.20.032
ntlano tail a0.031
hmx4H6 family homeobox 40.031
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.031
sulf2lsulfatase 2, like0.031
notum3notum 30.030
klf4Kruppel-like factor 40.030
sfrp5secreted frizzled-related protein 50.030
col11a2collagen type XI alpha-20.030
hoxd4ahomeo box D4a0.029
ventventral expressed homeobox0.029
wlswntless homolog (Drosophila)0.029
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
stumpsCG31317 gene product from transcript CG31317-RC0.745
ShcSHC-adaptor protein0.200
Ext2CG8433 gene product from transcript CG8433-RA0.198
hipkhomeodomain interacting protein kinase0.134
Hs6stHeparan sulfate 6-O-sulfotransferase0.127
CG12004CG12004 gene product from transcript CG12004-RC0.092
Rab2Rab-protein 20.090
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.050
botvbrother of tout-velu0.049
mbcmyoblast city0.043
plexBplexin B0.032
dosdaughter of sevenless0.030
frcfringe connection0.027
sogshort gastrulation0.024
kirrekin of irre0.021
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.020
StamSignal transducing adaptor molecule0.020
zfh2Zn finger homeodomain 20.016
EloAElongin A0.016
Spn77BaSerpin 77Ba0.015
ksrkinase suppressor of ras0.015
vvlventral veins lacking0.015
MrtfMyocardin-related transcription factor0.014
Dsor1Downstream of raf10.014
Ras64BRas oncogene at 64B0.014
svpseven up0.014
drkdownstream of receptor kinase0.013
CG9139CG9139 gene product from transcript CG9139-RA0.013
cnkconnector enhancer of ksr0.013
edlETS-domain lacking0.012
Ced-12CG5336 gene product from transcript CG5336-RA0.012
salmspalt major0.012
Cpsf160Cleavage and polyadenylation specificity factor 1600.012
Fas3Fasciclin 30.012
Rac2CG8556 gene product from transcript CG8556-RA0.012
nocno ocelli0.011
Klp64DKinesin-like protein at 64D0.011
TimpTissue inhibitor of metalloproteases0.011
opaodd paired0.010
Rab5Rab-protein 50.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGF1fibroblast growth factor 1 (acidic)0.999
FGFR1fibroblast growth factor receptor 10.997
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.996
STAMBPSTAM binding protein0.859
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.851
PLCG1phospholipase C, gamma 10.700
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.571
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.549
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.539
FGF10fibroblast growth factor 100.509
SH2D1ASH2 domain containing 1A0.485
SH3KBP1SH3-domain kinase binding protein 10.436
FGF2fibroblast growth factor 2 (basic)0.432
ZUFSPzinc finger with UFM1-specific peptidase domain0.427
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.391
GRB2growth factor receptor-bound protein 20.367
SHC1SHC (Src homology 2 domain containing) transforming protein 10.290
FRS2fibroblast growth factor receptor substrate 20.285
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.272
HDAC7histone deacetylase 70.243
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.239
TESK1testis-specific kinase 10.155
CTGFconnective tissue growth factor0.149
SPRY2sprouty homolog 2 (Drosophila)0.142
TGFB1transforming growth factor, beta 10.141
FGF8fibroblast growth factor 8 (androgen-induced)0.136
GLIS2GLIS family zinc finger 20.135
CYR61cysteine-rich, angiogenic inducer, 610.135
NEDD4neural precursor cell expressed, developmentally down-regulated 40.120
HIC1hypermethylated in cancer 10.120
EGFRepidermal growth factor receptor0.119
COL5A1collagen, type V, alpha 10.118
FN1fibronectin 10.114
EEA1early endosome antigen 10.105
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.097
FGF7fibroblast growth factor 70.095
STMN2stathmin-like 20.093
LIN28Blin-28 homolog B (C. elegans)0.081
ITSN1intersectin 1 (SH3 domain protein)0.080
APCadenomatous polyposis coli0.080
SNRNP70small nuclear ribonucleoprotein 70kDa (U1)0.079
JAK1Janus kinase 10.073
FERMT2fermitin family member 20.068
ATF2activating transcription factor 20.066
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.064
COL1A1collagen, type I, alpha 10.064
TSG101tumor susceptibility gene 1010.064
MARCKSmyristoylated alanine-rich protein kinase C substrate0.062
KLBklotho beta0.060
ERBB2IPerbb2 interacting protein0.055
ABI1abl-interactor 10.055
FYNFYN oncogene related to SRC, FGR, YES0.051
FGFR3fibroblast growth factor receptor 30.050
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.049
NCK1NCK adaptor protein 10.049
PTPN11protein tyrosine phosphatase, non-receptor type 110.047
GAB2GRB2-associated binding protein 20.047
PDGFCplatelet derived growth factor C0.046
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.042
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.041
AP1G1adaptor-related protein complex 1, gamma 1 subunit0.041
LATlinker for activation of T cells0.041
HGShepatocyte growth factor-regulated tyrosine kinase substrate0.039
SLAMF1signaling lymphocytic activation molecule family member 10.039
THBS1thrombospondin 10.038
UBR1ubiquitin protein ligase E3 component n-recognin 10.038
BMP7bone morphogenetic protein 70.035
FBLN1fibulin 10.035
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.034
PDGFAplatelet-derived growth factor alpha polypeptide0.034
SPRY1sprouty homolog 1, antagonist of FGF signaling (Drosophila)0.034
NRP1neuropilin 10.034
HSPG2heparan sulfate proteoglycan 20.033
EGR1early growth response 10.033
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.033
TIMP3TIMP metallopeptidase inhibitor 30.032
ACTN4actinin, alpha 40.031
GAB1GRB2-associated binding protein 10.030
COL2A1collagen, type II, alpha 10.030
COL4A1collagen, type IV, alpha 10.030
PECAM1platelet/endothelial cell adhesion molecule0.030
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.029
COL6A1collagen, type VI, alpha 10.029
TIMP2TIMP metallopeptidase inhibitor 20.029
TGFB3transforming growth factor, beta 30.028
PHLDA1pleckstrin homology-like domain, family A, member 10.027
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.027
CD33CD33 molecule0.026
EPS15epidermal growth factor receptor pathway substrate 150.026
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 10.026
OCRLoculocerebrorenal syndrome of Lowe0.026
SALL2sal-like 2 (Drosophila)0.025
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.025
RCC1regulator of chromosome condensation 10.025
FZD1frizzled homolog 1 (Drosophila)0.024
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.024
NGFnerve growth factor (beta polypeptide)0.024
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.068
Gna12guanine nucleotide binding protein (G protein) alpha 120.021
Fis1fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)0.020
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.018
Rab7aRAB7A, member RAS oncogene family0.016
Rab3il1RAB3A interacting protein (rabin3)-like 10.016
Gpx4glutathione peroxidase 40.015
Ucn2urocortin 20.013
Unc5bunc-5 homolog B (C. elegans)0.013
Cercamcerebral endothelial cell adhesion molecule0.012
Cxxc4CXXC finger 40.012
Gja3gap junction protein, alpha 30.011
S100a7aS100 calcium binding protein A7A0.011
Egfrepidermal growth factor receptor0.011
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.010
Usf1upstream transcription factor 10.010
Ndfip1Nedd4 family interacting protein 10.010
GperG protein-coupled estrogen receptor 10.010
Foxe3forkhead box E30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism