The network for 'leukocyte activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte activation involved in immune response

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Ccr2chemokine (C-C motif) receptor 20.998
Cd40CD40 antigen0.997
FynFyn proto-oncogene0.986
Il2rginterleukin 2 receptor, gamma chain0.983
Lyz2lysozyme 20.982
Inpp5dinositol polyphosphate-5-phosphatase D0.976
Leprleptin receptor0.971
Ptprcprotein tyrosine phosphatase, receptor type, C0.962
Ptk2PTK2 protein tyrosine kinase 20.954
Casp4caspase 4, apoptosis-related cysteine peptidase0.950
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.950
Il10interleukin 100.950
Ikzf1IKAROS family zinc finger 10.940
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.930
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.924
Il10rainterleukin 10 receptor, alpha0.920
FaslFas ligand (TNF superfamily, member 6)0.907
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.904
Tlr4toll-like receptor 40.900
Il4interleukin 40.897
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.895
Runx1runt related transcription factor 10.881
Ccr1chemokine (C-C motif) receptor 10.871
Stat6signal transducer and activator of transcription 60.871
Pyhin1pyrin and HIN domain family, member 10.869
Il1binterleukin 1 beta0.861
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.850
Il18rapinterleukin 18 receptor accessory protein0.847
Prf1perforin 1 (pore forming protein)0.839
Il2interleukin 20.839
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.836
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.821
Map3k14mitogen-activated protein kinase kinase kinase 140.812
Casp1caspase 10.811
Prdm1PR domain containing 1, with ZNF domain0.807
Irf5interferon regulatory factor 50.804
Socs1suppressor of cytokine signaling 10.789
Stat5bsignal transducer and activator of transcription 5B0.777
Hckhemopoietic cell kinase0.773
Ccl4chemokine (C-C motif) ligand 40.770
Bcl6B-cell leukemia/lymphoma 60.769
Slamf1signaling lymphocytic activation molecule family member 10.769
Fgf10fibroblast growth factor 100.763
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.761
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.756
Cd28CD28 antigen0.745
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.739
Ccl2chemokine (C-C motif) ligand 20.729
Itgalintegrin alpha L0.728
Klrd1killer cell lectin-like receptor, subfamily D, member 10.721
FasFas (TNF receptor superfamily member 6)0.721
Ltblymphotoxin B0.711
Batfbasic leucine zipper transcription factor, ATF-like0.700
Sfpi1SFFV proviral integration 10.700
Il2rbinterleukin 2 receptor, beta chain0.697
Ptenphosphatase and tensin homolog0.696
Ncr1natural cytotoxicity triggering receptor 10.695
Ccr5chemokine (C-C motif) receptor 50.689
Cd7CD7 antigen0.677
Il4rainterleukin 4 receptor, alpha0.674
Nlrp3NLR family, pyrin domain containing 30.668
AF251705cDNA sequence AF2517050.666
Atmataxia telangiectasia mutated homolog (human)0.661
Jak2Janus kinase 20.661
Cd14CD14 antigen0.658
Ifnginterferon gamma0.657
Ccr7chemokine (C-C motif) receptor 70.657
Clec4dC-type lectin domain family 4, member d0.655
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.648
Lilrb3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.646
Trp53transformation related protein 530.643
Selpselectin, platelet0.639
Bmp5bone morphogenetic protein 50.638
Pitx1paired-like homeodomain transcription factor 10.633
Ctswcathepsin W0.629
Ldb3LIM domain binding 30.627
Cxcr5chemokine (C-X-C motif) receptor 50.623
Ccr6chemokine (C-C motif) receptor 60.622
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.615
Il18r1interleukin 18 receptor 10.608
Tlr2toll-like receptor 20.607
Lcp2lymphocyte cytosolic protein 20.605
Cd86CD86 antigen0.603
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.602
Cxcr4chemokine (C-X-C motif) receptor 40.599
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.593
Pdcd1programmed cell death 10.593
Zeb1zinc finger E-box binding homeobox 10.592
Nos2nitric oxide synthase 2, inducible0.592
ItkIL2-inducible T-cell kinase0.584
Cd247CD247 antigen0.583
Gzmkgranzyme K0.576
Cishcytokine inducible SH2-containing protein0.572
Gpr132G protein-coupled receptor 1320.567
Cd160CD160 antigen0.565
B2mbeta-2 microglobulin0.564
Msr1macrophage scavenger receptor 10.562
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.560
Tbx3T-box 30.557
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.996
FHL2four and a half LIM domains 20.973
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.782
SYKspleen tyrosine kinase0.753
IL4Rinterleukin 4 receptor0.616
CCR5chemokine (C-C motif) receptor 50.506
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.494
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.440
CXCL2chemokine (C-X-C motif) ligand 20.436
TGIF1TGFB-induced factor homeobox 10.385
CCL4chemokine (C-C motif) ligand 40.379
PTPRCprotein tyrosine phosphatase, receptor type, C0.355
SNAP23synaptosomal-associated protein, 23kDa0.350
BLNKB-cell linker0.289
SHC2SHC (Src homology 2 domain containing) transforming protein 20.287
SOCS3suppressor of cytokine signaling 30.282
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.265
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.263
APLFaprataxin and PNKP like factor0.252
IL2RGinterleukin 2 receptor, gamma0.237
CD80CD80 molecule0.234
CCR1chemokine (C-C motif) receptor 10.232
ICAM1intercellular adhesion molecule 10.228
CXCL9chemokine (C-X-C motif) ligand 90.226
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.223
BIRC3baculoviral IAP repeat containing 30.217
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.209
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.197
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.192
CCL2chemokine (C-C motif) ligand 20.185
HK3hexokinase 3 (white cell)0.182
CD33CD33 molecule0.172
LIN9lin-9 homolog (C. elegans)0.168
CCR7chemokine (C-C motif) receptor 70.167
CD63CD63 molecule0.167
BRCA1breast cancer 1, early onset0.162
CCR2chemokine (C-C motif) receptor 20.155
TICAM2toll-like receptor adaptor molecule 20.144
PTPN6protein tyrosine phosphatase, non-receptor type 60.144
MDC1mediator of DNA-damage checkpoint 10.134
RAD50RAD50 homolog (S. cerevisiae)0.126
PECAM1platelet/endothelial cell adhesion molecule0.120
CTLA4cytotoxic T-lymphocyte-associated protein 40.117
PSEN2presenilin 2 (Alzheimer disease 4)0.116
CCL22chemokine (C-C motif) ligand 220.114
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.110
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.110
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.110
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.106
NR0B1nuclear receptor subfamily 0, group B, member 10.104
NLRP3NLR family, pyrin domain containing 30.103
NLRC4NLR family, CARD domain containing 40.100
IL7Rinterleukin 7 receptor0.099
CD84CD84 molecule0.098
CLEC10AC-type lectin domain family 10, member A0.098
SIGLEC7sialic acid binding Ig-like lectin 70.093
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.091
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.090
ESR1estrogen receptor 10.085
RBBP8retinoblastoma binding protein 80.085
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.084
RXRAretinoid X receptor, alpha0.080
GBAglucosidase, beta, acid0.077
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.077
VCAM1vascular cell adhesion molecule 10.074
TFF1trefoil factor 10.073
CD2CD2 molecule0.072
TLR2toll-like receptor 20.071
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.071
EMR1egf-like module containing, mucin-like, hormone receptor-like 10.070
IL23Ainterleukin 23, alpha subunit p190.068
ZNF830zinc finger protein 8300.068
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.067
TP53BP1tumor protein p53 binding protein 10.066
HCKhemopoietic cell kinase0.066
LATlinker for activation of T cells0.066
IRF4interferon regulatory factor 40.065
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.064
IL1Binterleukin 1, beta0.064
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.063
CDH5cadherin 5, type 2 (vascular endothelium)0.063
PILRApaired immunoglobin-like type 2 receptor alpha0.063
IL8interleukin 80.063
MSH6mutS homolog 6 (E. coli)0.062
SLAMF1signaling lymphocytic activation molecule family member 10.062
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi10.061
CYBBcytochrome b-245, beta polypeptide0.061
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.061
CD48CD48 molecule0.060
CD86CD86 molecule0.060
ARandrogen receptor0.060
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.059
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.058
IL2RBinterleukin 2 receptor, beta0.057
CCL5chemokine (C-C motif) ligand 50.056
CAV1caveolin 1, caveolae protein, 22kDa0.055
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.054
NCOR2nuclear receptor corepressor 20.054
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hckhemopoietic cell kinase0.626
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.589
Ptprcprotein tyrosine phosphatase, receptor type, C0.547
Ptafrplatelet-activating factor receptor0.340
Il2rbinterleukin 2 receptor, beta0.335
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.324
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.262
Cd4Cd4 molecule0.258
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.237
Cybbcytochrome b-245, beta polypeptide0.237
Cd247Cd247 molecule0.216
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.210
Vav1vav 1 guanine nucleotide exchange factor0.191
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.169
Calm1calmodulin 10.146
Ctsecathepsin E0.140
Mmp12matrix metallopeptidase 120.139
Il1binterleukin 1 beta0.122
Il2rginterleukin 2 receptor, gamma0.114
Itpr2inositol 1,4,5-triphosphate receptor, type 20.107
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.102
Cd38CD38 molecule0.097
Tgfbr3transforming growth factor, beta receptor III0.094
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.089
Morf4l2mortality factor 4 like 20.085
Clec4a3C-type lectin domain family 4, member a30.082
Pgam1phosphoglycerate mutase 1 (brain)0.079
RGD1304644similar to RIKEN cDNA 2310046K010.078
Inpp5dinositol polyphosphate-5-phosphatase D0.076
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.076
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.075
Casp1caspase 10.074
Mef2dmyocyte enhancer factor 2D0.073
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.071
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.069
Neurl3neuralized homolog 3 (Drosophila)0.068
Igsf6immunoglobulin superfamily, member 60.067
Pde3aphosphodiesterase 3A, cGMP inhibited0.067
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.066
Ptger2prostaglandin E receptor 2 (subtype EP2)0.062
Tgfbr2transforming growth factor, beta receptor II0.061
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.061
Cd53Cd53 molecule0.060
Ccr5chemokine (C-C motif) receptor 50.060
Tbxas1thromboxane A synthase 1, platelet0.059
Ptpn6protein tyrosine phosphatase, non-receptor type 60.059
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.058
Sirpasignal-regulatory protein alpha0.058
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.057
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.056
C5ar1complement component 5a receptor 10.055
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.054
Icam1intercellular adhesion molecule 10.053
Il9rinterleukin 9 receptor0.052
Ltalymphotoxin alpha (TNF superfamily, member 1)0.051
Wdr1WD repeat domain 10.048
Padi3peptidyl arginine deiminase, type III0.047
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.047
Ciitaclass II, major histocompatibility complex, transactivator0.047
Tlr4toll-like receptor 40.047
Actr3ARP3 actin-related protein 3 homolog (yeast)0.047
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.045
Cd8bCD8b molecule0.044
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.044
Cd3gCD3 molecule, gamma0.043
Klhl6kelch-like 6 (Drosophila)0.043
Ptpn1protein tyrosine phosphatase, non-receptor type 10.043
Olr1496olfactory receptor 14960.039
Gzmkgranzyme K0.039
Cxcr3chemokine (C-X-C motif) receptor 30.038
Psd4pleckstrin and Sec7 domain containing 40.038
Prlhrprolactin releasing hormone receptor0.037
Cd68Cd68 molecule0.037
Ripk3receptor-interacting serine-threonine kinase 30.037
Hpgdshematopoietic prostaglandin D synthase0.035
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.034
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.034
Slc15a3solute carrier family 15, member 30.034
Ccl3chemokine (C-C motif) ligand 30.033
Hspa8heat shock protein 80.033
Olr1469olfactory receptor Olr14690.033
Folr2folate receptor 2 (fetal)0.033
Batf3basic leucine zipper transcription factor, ATF-like 30.032
Csf1colony stimulating factor 1 (macrophage)0.032
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.032
Cpa3carboxypeptidase A3, mast cell0.031
Hdac7histone deacetylase 70.031
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.031
Ugt2b7UDP glucuronosyltransferase 2 family, polypeptide B70.031
NrarpNotch-regulated ankyrin repeat protein0.031
Arl11ADP-ribosylation factor-like 110.031
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.030
Sellselectin L0.029
Cx3cr1chemokine (C-X3-C motif) receptor 10.029
Icosinducible T-cell co-stimulator0.029
Laptm5lysosomal protein transmembrane 50.029
Stat3signal transducer and activator of transcription 30.028
Cd86CD86 molecule0.028
Tlr7toll-like receptor 70.027
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism