The network for 'autophagic vacuole assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

autophagic vacuole assembly

The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.

NameDescriptionProbabilityFunc Analog Organism
Notch2Notch gene homolog 2 (Drosophila)0.979
Atg12autophagy-related 12 (yeast)0.959
Ulk1Unc-51 like kinase 1 (C. elegans)0.892
Ncstnnicastrin0.768
Mtormechanistic target of rapamycin (serine/threonine kinase)0.747
Grb10growth factor receptor bound protein 100.744
Atg3autophagy-related 3 (yeast)0.724
Atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.682
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.573
Sqstm1sequestosome 10.525
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.418
Igf2rinsulin-like growth factor 2 receptor0.309
Notch1Notch gene homolog 1 (Drosophila)0.293
Atg7autophagy-related 7 (yeast)0.248
Sesn2sestrin 20.231
Trp53inp2transformation related protein 53 inducible nuclear protein 20.215
Wbp2WW domain binding protein 20.163
Appamyloid beta (A4) precursor protein0.149
Ift57intraflagellar transport 57 homolog (Chlamydomonas)0.121
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.117
Pld3phospholipase D family, member 30.116
Igf2insulin-like growth factor 20.100
Ctsbcathepsin B0.099
Kif3akinesin family member 3A0.097
Atg2aATG2 autophagy related 2 homolog A (S. cerevisiae)0.091
Pef1penta-EF hand domain containing 10.085
Mks1Meckel syndrome, type 10.084
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.077
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.076
Agtr1aangiotensin II receptor, type 1a0.072
Glis2GLIS family zinc finger 20.072
Irs2insulin receptor substrate 20.071
Irs1insulin receptor substrate 10.065
Erlin2ER lipid raft associated 20.062
Bsgbasigin0.057
Psapprosaposin0.056
Rb1cc1RB1-inducible coiled-coil 10.051
Cdkn1bcyclin-dependent kinase inhibitor 1B0.051
D19Wsu162eDNA segment, Chr 19, Wayne State University 162, expressed0.050
Tecrtrans-2,3-enoyl-CoA reductase0.047
Sirt2sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)0.046
Vamp4vesicle-associated membrane protein 40.044
Ppargperoxisome proliferator activated receptor gamma0.042
Abtb1ankyrin repeat and BTB (POZ) domain containing 10.039
Atg5autophagy-related 5 (yeast)0.035
Mapre3microtubule-associated protein, RP/EB family, member 30.035
Gabarapgamma-aminobutyric acid receptor associated protein0.033
Mib1mindbomb homolog 1 (Drosophila)0.033
Gsk3bglycogen synthase kinase 3 beta0.032
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.031
Mapkap1mitogen-activated protein kinase associated protein 10.028
Sik3SIK family kinase 30.028
Rnf167ring finger protein 1670.028
Leprleptin receptor0.027
Ubl7ubiquitin-like 7 (bone marrow stromal cell-derived)0.027
Atg10autophagy-related 10 (yeast)0.027
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.026
Rnf103ring finger protein 1030.026
Ift81intraflagellar transport 81 homolog (Chlamydomonas)0.026
Mark4MAP/microtubule affinity-regulating kinase 40.026
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.026
Pex5peroxisomal biogenesis factor 50.026
Aesamino-terminal enhancer of split0.025
Ptpn9protein tyrosine phosphatase, non-receptor type 90.025
Mapk9mitogen-activated protein kinase 90.025
Vps35vacuolar protein sorting 350.024
Criptcysteine-rich PDZ-binding protein0.024
Bet1blocked early in transport 1 homolog (S. cerevisiae)0.023
Uso1USO1 homolog, vesicle docking protein (yeast)0.023
Agtr2angiotensin II receptor, type 20.022
Cav1caveolin 1, caveolae protein0.022
Pnpla2patatin-like phospholipase domain containing 20.022
Wbp1WW domain binding protein 10.022
Mlst8MTOR associated protein, LST8 homolog (S. cerevisiae)0.022
Eif2ak1eukaryotic translation initiation factor 2 alpha kinase 10.021
Rbl2retinoblastoma-like 20.021
Foxg1forkhead box G10.021
Syvn1synovial apoptosis inhibitor 1, synoviolin0.020
Chmp1bchromatin modifying protein 1B0.019
Dll1delta-like 1 (Drosophila)0.018
Ubap1ubiquitin-associated protein 10.018
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.017
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.017
Gabarapl1gamma-aminobutyric acid (GABA) A receptor-associated protein-like 10.017
2510006D16RikRIKEN cDNA 2510006D16 gene0.017
Dgcr2DiGeorge syndrome critical region gene 20.017
Lamp2lysosomal-associated membrane protein 20.017
Dctn1dynactin 10.016
Lrp6low density lipoprotein receptor-related protein 60.016
Slc25a10solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 100.016
Asb8ankyrin repeat and SOCS box-containing 80.016
Ap2b1adaptor-related protein complex 2, beta 1 subunit0.016
Ypel3yippee-like 3 (Drosophila)0.015
Zfp40zinc finger protein 400.015
Rab33bRAB33B, member of RAS oncogene family0.015
Dcaf11DDB1 and CUL4 associated factor 110.015
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.014
Psenenpresenilin enhancer 2 homolog (C. elegans)0.014
Pex19peroxisomal biogenesis factor 190.014
Lipelipase, hormone sensitive0.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB1.000
Atg1Autophagy-specific gene 11.000
RhebCG1081 gene product from transcript CG1081-RA0.998
Akt1CG4006 gene product from transcript CG4006-RA0.989
Atg18Autophagy-specific gene 180.989
Pi3K59FPhosphotidylinositol 3 kinase 59F0.954
PtenCG5671 gene product from transcript CG5671-RB0.892
giggigas0.836
Atg2Autophagy-specific gene 20.794
Atg8aAutophagy-specific gene 8a0.783
Atg4Autophagy-specific gene 40.764
bskbasket0.644
Atg9Autophagy-specific gene 90.638
hephemipterous0.567
Atg7Autophagy-specific gene 70.519
Ras85DRas oncogene at 85D0.460
RagACG11968 gene product from transcript CG11968-RA0.449
dmdiminutive0.437
Atg6Autophagy-specific gene 60.354
CG11877CG11877 gene product from transcript CG11877-RA0.333
rlrolled0.304
ird1immune response deficient 10.263
IdeInsulin degrading metalloproteinase0.206
CG31033CG31033 gene product from transcript CG31033-RC0.184
foxoforkhead box, sub-group O0.184
polyCG9829 gene product from transcript CG9829-RB0.176
CG8974CG8974 gene product from transcript CG8974-RD0.171
TorTarget of rapamycin0.168
usnpubisnap0.150
ThorCG8846 gene product from transcript CG8846-RA0.149
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.146
savsalvador0.139
Pka-C1cAMP-dependent protein kinase 10.125
trpmltransient receptor potential mucolipin0.124
atlatlastin0.123
Rab5Rab-protein 50.112
CG7220CG7220 gene product from transcript CG7220-RD0.101
Rab7Rab-protein 70.096
keykenny0.087
drprdraper0.084
S6kRPS6-p70-protein kinase0.082
SybSynaptobrevin0.082
p38bCG7393 gene product from transcript CG7393-RA0.079
CG1599CG1599 gene product from transcript CG1599-RA0.079
chicoCG5686 gene product from transcript CG5686-RB0.076
Aut1CG6877 gene product from transcript CG6877-RA0.073
Atg13Autophagy-specific gene 130.069
Syx17Syntaxin 170.068
vrivrille0.066
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.065
Rac2CG8556 gene product from transcript CG8556-RA0.065
Rab4Rab-protein 40.064
PcafCG4107 gene product from transcript CG4107-RA0.063
Vps20Vacuolar protein sorting 200.061
l(2)37Bblethal (2) 37Bb0.061
gbbglass bottom boat0.057
pixpixie0.055
CG11009CG11009 gene product from transcript CG11009-RB0.055
kcckazachoc0.054
hppyhappyhour0.054
Rab14Rab-protein 140.054
Vps4Vacuolar protein sorting 40.053
krzkurtz0.052
Rab-RP4Rab-related protein 40.052
Rab2Rab-protein 20.049
CspCysteine string protein0.049
WASpCG1520 gene product from transcript CG1520-RA0.049
Tom34Translocase of outer membrane 340.048
gammaCopgamma-coatomer protein0.047
mtsmicrotubule star0.047
StamSignal transducing adaptor molecule0.047
CG6116CG6116 gene product from transcript CG6116-RA0.046
TBPHCG10327 gene product from transcript CG10327-RC0.046
CG30344CG30344 gene product from transcript CG30344-RA0.046
RfabgRetinoid- and fatty acid-binding glycoprotein0.046
Syx5Syntaxin 50.045
ash2absent, small, or homeotic discs 20.045
Klp64DKinesin-like protein at 64D0.045
WnkCG7177 gene product from transcript CG7177-RA0.044
M6CG7540 gene product from transcript CG7540-RA0.044
Snap25Synapse protein 250.043
egreiger0.042
ecdecdysoneless0.042
Eip74EFEcdysone-induced protein 74EF0.041
Ilp2Insulin-like peptide 20.041
prelpreli-like0.040
CG10673CG10673 gene product from transcript CG10673-RA0.040
CG8678CG8678 gene product from transcript CG8678-RA0.039
CG15309CG15309 gene product from transcript CG15309-RA0.039
drddrop dead0.039
SnapSoluble NSF attachment protein0.038
Ent1Equilibrative nucleoside transporter 10.037
wtswarts0.036
G-salpha60AG protein salpha 60A0.036
captcapulet0.035
ninaEneither inactivation nor afterpotential E0.034
Hsc70-4Heat shock protein cognate 40.034
EgmEnigma0.034
CG15012CG15012 gene product from transcript CG15012-RB0.034
bambag of marbles0.033
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.999
GABARAPGABA(A) receptor-associated protein0.997
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.996
GABARAPL2GABA(A) receptor-associated protein-like 20.995
ULK1unc-51-like kinase 1 (C. elegans)0.994
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.982
SQSTM1sequestosome 10.974
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.923
NBR1neighbor of BRCA1 gene 10.826
ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)0.713
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.689
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.590
BECN1beclin 1, autophagy related0.576
RB1CC1RB1-inducible coiled-coil 10.367
GRB10growth factor receptor-bound protein 100.358
GOLGA2golgin A20.355
GABARAPL1GABA(A) receptor-associated protein like 10.350
PTPN23protein tyrosine phosphatase, non-receptor type 230.334
SESN2sestrin 20.327
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.268
RRAGARas-related GTP binding A0.246
ATG4BATG4 autophagy related 4 homolog B (S. cerevisiae)0.242
C12orf44chromosome 12 open reading frame 440.234
FUNDC2FUN14 domain containing 20.195
CTSAcathepsin A0.194
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.184
AMBRA1autophagy/beclin-1 regulator 10.130
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.100
NRBF2nuclear receptor binding factor 20.090
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.057
UVRAGUV radiation resistance associated gene0.056
PDCD6programmed cell death 60.052
ATG9AATG9 autophagy related 9 homolog A (S. cerevisiae)0.052
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.051
PIK3C3phosphoinositide-3-kinase, class 30.050
ZFYVE1zinc finger, FYVE domain containing 10.050
ULK2unc-51-like kinase 2 (C. elegans)0.046
WDFY3WD repeat and FYVE domain containing 30.046
IRS2insulin receptor substrate 20.039
ATG10ATG10 autophagy related 10 homolog (S. cerevisiae)0.037
FLNBfilamin B, beta0.037
RUSC2RUN and SH3 domain containing 20.036
EIF1Beukaryotic translation initiation factor 1B0.035
UFD1Lubiquitin fusion degradation 1 like (yeast)0.034
MKRN1makorin ring finger protein 10.033
PKP4plakophilin 40.032
GHRgrowth hormone receptor0.032
RAB2ARAB2A, member RAS oncogene family0.032
UBXN6UBX domain protein 60.032
NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)0.030
PINK1PTEN induced putative kinase 10.029
CSKc-src tyrosine kinase0.029
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.029
IRS1insulin receptor substrate 10.029
FYCO1FYVE and coiled-coil domain containing 10.028
DNM2dynamin 20.027
UBXN2AUBX domain protein 2A0.027
PSEN2presenilin 2 (Alzheimer disease 4)0.025
OCRLoculocerebrorenal syndrome of Lowe0.024
COASYCoA synthase0.023
DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 360.023
SH3GL2SH3-domain GRB2-like 20.021
RAB6ARAB6A, member RAS oncogene family0.021
CLTBclathrin, light chain B0.020
SCFD1sec1 family domain containing 10.020
INSRinsulin receptor0.018
ABHD16Aabhydrolase domain containing 16A0.018
TSG101tumor susceptibility gene 1010.018
DERL1Der1-like domain family, member 10.018
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.017
SPAG9sperm associated antigen 90.017
ZNRF1zinc and ring finger 10.017
MTORmechanistic target of rapamycin (serine/threonine kinase)0.016
PSAPprosaposin0.016
PIK3R4phosphoinositide-3-kinase, regulatory subunit 40.016
STX4syntaxin 40.015
UBE2E2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)0.015
SH3KBP1SH3-domain kinase binding protein 10.015
EXOC4exocyst complex component 40.015
STX5syntaxin 50.015
APPamyloid beta (A4) precursor protein0.014
STRN4striatin, calmodulin binding protein 40.014
RPS19BP1ribosomal protein S19 binding protein 10.014
WASH1WAS protein family homolog 10.014
CLTAclathrin, light chain A0.014
PDCD6IPprogrammed cell death 6 interacting protein0.014
WBP2WW domain binding protein 20.013
ARFGAP2ADP-ribosylation factor GTPase activating protein 20.013
SPAG7sperm associated antigen 70.013
TMEM11transmembrane protein 110.013
UBQLN1ubiquilin 10.013
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.013
LGALS7lectin, galactoside-binding, soluble, 70.012
ATXN3ataxin 30.012
MAPK8mitogen-activated protein kinase 80.012
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.012
ATP6V0A1ATPase, H+ transporting, lysosomal V0 subunit a10.012
FHOD1formin homology 2 domain containing 10.012
PXNpaxillin0.011
EMDemerin0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.017
Psapprosaposin0.013
Arf1ADP-ribosylation factor 10.012
Tmbim6transmembrane BAX inhibitor motif containing 60.011
Nucb1nucleobindin 10.010
Gna12guanine nucleotide binding protein (G protein) alpha 120.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ATG11Atg11p0.822
ATG13Atg13p0.809
ATG9Atg9p0.728
ATG29Atg29p0.513
ATG1Atg1p0.494
ATG4Atg4p0.487
VPS30Vps30p0.425
ATG3Atg3p0.370
ATG7Atg7p0.356
ATG21Atg21p0.336
ATG14Atg14p0.323
CIS1Cis1p0.237
ATG20Atg20p0.195
ATG23Atg23p0.195
VPS15Vps15p0.186
NPR2Npr2p0.166
SNX4Snx4p0.155
HSV2Hsv2p0.143
ATG16Atg16p0.132
ATG26Atg26p0.124
VPS38Vps38p0.113
ATG2Atg2p0.096
ATG10Atg10p0.066
SEC4Sec4p0.064
VPS41Vps41p0.059
NPL4Npl4p0.055
ATG5Atg5p0.055
UFD2Ufd2p0.053
ATG12Atg12p0.050
PEP5Pep5p0.045
ATG18Atg18p0.045
SPG3Spg3p0.040
PEP12Pep12p0.040
SEC2Sec2p0.039
COT1Cot1p0.035
VPS51Vps51p0.034
BRO1Bro1p0.033
YLR211Chypothetical protein0.033
CDC48Cdc48p0.029
YPT52Ypt52p0.028
VPS21Vps21p0.028
SEC10Sec10p0.027
FMP48Fmp48p0.027
SRD1Srd1p0.027
CDC55Cdc55p0.026
YNL058Chypothetical protein0.026
ARE2Are2p0.026
LAP4Lap4p0.025
HSP33Hsp33p0.024
YAR068Whypothetical protein0.024
IML1Iml1p0.024
LEU2Leu2p0.023
YOL038C-Ahypothetical protein0.023
YLR264C-Ahypothetical protein0.022
ARP10Arp10p0.022
YLR162Whypothetical protein0.021
VPS17Vps17p0.020
ICS2Ics2p0.020
KSP1Ksp1p0.020
GPR1Gpr1p0.020
SPL2Spl2p0.020
VAM7Vam7p0.020
MER1Mer1p0.020
CHA1Cha1p0.019
SFT1Sft1p0.019
HSP32Hsp32p0.019
ZPS1Zps1p0.019
OPT2Opt2p0.018
HPF1Hpf1p0.018
PHO81Pho81p0.018
ATP6Atp6p0.018
VPS53Vps53p0.018
HXT3Hxt3p0.018
PEP3Pep3p0.017
CUP1-1Cup1-1p0.017
CRP1Crp1p0.017
SFB2Sfb2p0.017
YBR013Chypothetical protein0.017
YIL151Chypothetical protein0.017
YAR066Whypothetical protein0.017
HDA2Hda2p0.017
YPR157Whypothetical protein0.017
REE1Ree1p0.017
RPN2Rpn2p0.017
SSP1Ssp1p0.016
TLG2Tlg2p0.016
MFM1Mfm1p0.016
DOP1Dop1p0.016
GDI1Gdi1p0.016
HAP2Hap2p0.016
YLR042Chypothetical protein0.016
FIS1Fis1p0.016
YIL165Chypothetical protein0.016
ARG8Arg8p0.016
SEC20Sec20p0.016
YIR035Chypothetical protein0.016
MON2Mon2p0.016
CPD1Cpd1p0.016
FMT1Fmt1p0.016
TYE7Tye7p0.015