The network for 'protein desumoylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein desumoylation

The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.

NameDescriptionProbabilityFunc Analog Organism
Arrb1arrestin, beta 10.967
Arrb2arrestin, beta 20.943
Kpnb1karyopherin (importin) beta 10.677
Metap1methionyl aminopeptidase 10.375
Nsun2NOL1/NOP2/Sun domain family member 20.313
Ipo5importin 50.251
Nolc1nucleolar and coiled-body phosphoprotein 10.232
Kpna3karyopherin (importin) alpha 30.162
Ssrp1structure specific recognition protein 10.144
Gspt1G1 to S phase transition 10.144
Ftsj3FtsJ homolog 3 (E. coli)0.137
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.137
Caprin1cell cycle associated protein 10.130
Tfdp1transcription factor Dp 10.126
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.109
G3bp1Ras-GTPase-activating protein SH3-domain binding protein 10.107
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.095
Ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.082
Ipo9importin 90.082
Rcc2regulator of chromosome condensation 20.082
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.078
Ctpscytidine 5'-triphosphate synthase0.078
Etf1eukaryotic translation termination factor 10.077
Wdr77WD repeat domain 770.076
Kpna1karyopherin (importin) alpha 10.069
Psme3proteaseome (prosome, macropain) 28 subunit, 30.066
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.063
Srsf2serine/arginine-rich splicing factor 20.057
Foxm1forkhead box M10.056
Naa15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.054
Tcerg1transcription elongation regulator 1 (CA150)0.053
Xpo5exportin 50.052
Adssadenylosuccinate synthetase, non muscle0.050
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.049
Rad23bRAD23b homolog (S. cerevisiae)0.041
Sipa1signal-induced proliferation associated gene 10.038
Eif3beukaryotic translation initiation factor 3, subunit B0.037
Rqcd1rcd1 (required for cell differentiation) homolog 1 (S. pombe)0.034
Kif2akinesin family member 2A0.033
Foxk2forkhead box K20.031
Sdccag3serologically defined colon cancer antigen 30.030
Larp1La ribonucleoprotein domain family, member 10.030
Hcfc1host cell factor C10.030
Pprc1peroxisome proliferative activated receptor, gamma, coactivator-related 10.028
2610027L16RikRIKEN cDNA 2610027L16 gene0.027
Pa2g4proliferation-associated 2G40.026
Add1adducin 1 (alpha)0.026
Coro1acoronin, actin binding protein 1A0.025
Pwp1PWP1 homolog (S. cerevisiae)0.023
Tmem48transmembrane protein 480.022
Bzw1basic leucine zipper and W2 domains 10.021
Karslysyl-tRNA synthetase0.021
Mdm2transformed mouse 3T3 cell double minute 20.020
Pkd1polycystic kidney disease 1 homolog0.019
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.019
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.018
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.018
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.017
Nup50nucleoporin 500.017
Eif2s3xeukaryotic translation initiation factor 2, subunit 3, structural gene X-linked0.016
Stip1stress-induced phosphoprotein 10.015
Mkl1MKL (megakaryoblastic leukemia)/myocardin-like 10.015
Nupl1nucleoporin like 10.015
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.015
Pabpc4poly(A) binding protein, cytoplasmic 40.015
Nop14NOP14 nucleolar protein homolog (yeast)0.013
Pitpnm1phosphatidylinositol transfer protein, membrane-associated 10.013
Adrbk1adrenergic receptor kinase, beta 10.013
Parp1poly (ADP-ribose) polymerase family, member 10.013
Rrm1ribonucleotide reductase M10.012
Gm2223predicted pseudogene 22230.012
Grk6G protein-coupled receptor kinase 60.012
Cerkceramide kinase0.012
Ythdf1YTH domain family 10.011
Plxnd1plexin D10.011
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.011
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.011
4632428N05RikRIKEN cDNA 4632428N05 gene0.010
Zbed4zinc finger, BED domain containing 40.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.313
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.118
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.102
rbp4lretinol binding protein 4, like0.092
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.061
nrp2aneuropilin 2a0.045
hdac1histone deacetylase 10.043
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.041
smc3structural maintenance of chromosomes 30.041
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.040
guk1guanylate kinase 10.031
h3f3aH3 histone, family 3A0.029
guca1cguanylate cyclase activator 1C0.028
gc3guanylyl cyclase 30.025
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.025
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.024
nucks1anuclear casein kinase and cyclin-dependent kinase substrate 1a0.022
nrp1bneuropilin 1b0.021
gngt1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 10.018
slc25a3asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a0.016
znf143zinc finger protein 1430.016
arl4aaADP-ribosylation factor-like 4aa0.015
srsf1aserine/arginine-rich splicing factor 1a0.015
fkbp1aaFK506 binding protein 1Aa0.014
grk7aG-protein-coupled receptor kinase 7a0.013
rpe65aretinal pigment epithelium-specific protein 65a0.012
txnrd3thioredoxin reductase 30.012
nr2e3nuclear receptor subfamily 2, group E, member 30.012
foxg1bforkhead box G1b0.012
irbpinterphotoreceptor retinoid-binding protein0.011
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.011
aanat2arylalkylamine N-acetyltransferase0.011
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.011
usp7ubiquitin specific peptidase 7 (herpes virus-associated)0.011
anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.011
mcm3MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.836
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.554
USPL1ubiquitin specific peptidase like 10.530
SENP1SUMO1/sentrin specific peptidase 10.438
PELP1proline, glutamate and leucine rich protein 10.143
SAE1SUMO1 activating enzyme subunit 10.117
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.107
PIAS4protein inhibitor of activated STAT, 40.077
RANBP2RAN binding protein 20.071
RANRAN, member RAS oncogene family0.059
ZNF496zinc finger protein 4960.033
RANGAP1Ran GTPase activating protein 10.028
PFDN1prefoldin subunit 10.019
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.017
NUP153nucleoporin 153kDa0.016
TEX10testis expressed 100.015
SP100SP100 nuclear antigen0.015
LAS1LLAS1-like (S. cerevisiae)0.012
IPO7importin 70.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism