The network for 'protein sumoylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein sumoylation

The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.

Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apcadenomatosis polyposis coli0.851
Ptenphosphatase and tensin homolog0.686
Rnf2ring finger protein 20.664
Clockcircadian locomotor output cycles kaput0.315
Egr2early growth response 20.312
Pcgf2polycomb group ring finger 20.239
Per2period homolog 2 (Drosophila)0.237
Mef2dmyocyte enhancer factor 2D0.188
Bmi1Bmi1 polycomb ring finger oncogene0.187
Cry1cryptochrome 1 (photolyase-like)0.163
Sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.125
Arntaryl hydrocarbon receptor nuclear translocator0.096
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.093
Hif1ahypoxia inducible factor 1, alpha subunit0.092
Cry2cryptochrome 2 (photolyase-like)0.092
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.081
Rbbp7retinoblastoma binding protein 70.072
Ncoa3nuclear receptor coactivator 30.068
Ahraryl-hydrocarbon receptor0.065
Kdm2blysine (K)-specific demethylase 2B0.063
Ring1ring finger protein 10.061
SharpinSHANK-associated RH domain interacting protein0.059
Setdb1SET domain, bifurcated 10.049
Trp53transformation related protein 530.048
Phc2polyhomeotic-like 2 (Drosophila)0.046
Tcf3transcription factor 30.044
Sap18Sin3-associated polypeptide 180.041
Fgfr2fibroblast growth factor receptor 20.038
Ctbp2C-terminal binding protein 20.038
Cnbpcellular nucleic acid binding protein0.035
Sufusuppressor of fused homolog (Drosophila)0.034
Iqcb1IQ calmodulin-binding motif containing 10.032
Npas2neuronal PAS domain protein 20.030
6330577E15RikRIKEN cDNA 6330577E15 gene0.028
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.028
FosFBJ osteosarcoma oncogene0.027
Cbx5chromobox homolog 5 (Drosophila HP1a)0.027
Matr3matrin 30.026
Nae1NEDD8 activating enzyme E1 subunit 10.026
Sox2SRY-box containing gene 20.023
Pbx2pre B-cell leukemia transcription factor 20.023
Axin1axin 10.022
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.022
Arhgap1Rho GTPase activating protein 10.020
Ifit1interferon-induced protein with tetratricopeptide repeats 10.020
Rpa1replication protein A10.020
Ikzf1IKAROS family zinc finger 10.019
Per3period homolog 3 (Drosophila)0.018
Ttc7tetratricopeptide repeat domain 70.018
Ctbp1C-terminal binding protein 10.018
Cul1cullin 10.018
Cbfbcore binding factor beta0.017
Cdkn1bcyclin-dependent kinase inhibitor 1B0.016
Kiss1KiSS-1 metastasis-suppressor0.016
Nr4a1nuclear receptor subfamily 4, group A, member 10.016
Sim1single-minded homolog 1 (Drosophila)0.016
Rnf19aring finger protein 19A0.016
Hnrpllheterogeneous nuclear ribonucleoprotein L-like0.015
Nup153nucleoporin 1530.015
Ehmt2euchromatic histone lysine N-methyltransferase 20.015
Morf4l2mortality factor 4 like 20.015
Nononon-POU-domain-containing, octamer binding protein0.015
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.014
Ptgs2prostaglandin-endoperoxide synthase 20.014
Smad4MAD homolog 4 (Drosophila)0.014
Bcl7aB-cell CLL/lymphoma 7A0.013
Vhlvon Hippel-Lindau tumor suppressor0.013
Casp8ap2caspase 8 associated protein 20.013
Rspo2R-spondin 2 homolog (Xenopus laevis)0.012
Hmgn1high mobility group nucleosomal binding domain 10.012
Ilkintegrin linked kinase0.012
Fkbp1aFK506 binding protein 1a0.012
Lhcgrluteinizing hormone/choriogonadotropin receptor0.012
Per1period homolog 1 (Drosophila)0.012
Tbx1T-box 10.011
Gm12372predicted gene 123720.011
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.011
Ctslcathepsin L0.011
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.011
Hmx3H6 homeobox 30.011
Esr1estrogen receptor 1 (alpha)0.011
Srsf9serine/arginine-rich splicing factor 90.011
Tbx10T-box 100.011
Rnpc3RNA-binding region (RNP1, RRM) containing 30.011
Gli3GLI-Kruppel family member GLI30.011
Nr3c1nuclear receptor subfamily 3, group C, member 10.011
Arandrogen receptor0.011
TbpTATA box binding protein0.011
Tuba1btubulin, alpha 1B0.011
Fgf13fibroblast growth factor 130.011
Lbrlamin B receptor0.011
Gtf2igeneral transcription factor II I0.010
Numa1nuclear mitotic apparatus protein 10.010
Foxo1forkhead box O10.010
Vangl2vang-like 2 (van gogh, Drosophila)0.010
Mph1macrophage antigen 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.408
sumo2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.344
sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.143
hmga1ahigh mobility group AT-hook 1a0.080
zgc:158409zgc:1584090.066
nrp2aneuropilin 2a0.038
ube2iubiquitin-conjugating enzyme E2I0.037
nrp1bneuropilin 1b0.036
h2afvH2A histone family, member V0.031
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.029
zgc:111986zgc:1119860.028
sox9aSRY-box containing gene 9a0.028
rbmxRNA binding motif protein, X-linked0.028
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.027
narno arches0.023
mifmacrophage migration inhibitory factor0.022
h3f3aH3 histone, family 3A0.022
hmgb2bhigh-mobility group box 2b0.020
smad1MAD homolog 1 (Drosophila)0.019
rbb4lretinoblastoma binding protein 4, like0.018
cdc42cell division cycle 420.018
pop7processing of precursor 7, ribonuclease P family0.018
tbpTATA box binding protein0.017
smc3structural maintenance of chromosomes 30.017
psen1presenilin 10.017
marcksbmyristoylated alanine rich protein kinase C substrate b0.016
rplp1ribosomal protein, large, P10.016
si:ch211-57k11.10si:ch211-57k11.100.016
nucks1anuclear casein kinase and cyclin-dependent kinase substrate 1a0.016
rhoabras homolog gene family, member Ab0.016
pbx2pre-B-cell leukemia transcription factor 20.015
twist1atwist1a0.015
hmgb2ahigh-mobility group box 2a0.015
zgc:66100zgc:661000.014
acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.014
jag2jagged 20.014
rhogcras homolog gene family, member Gc0.014
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.014
srsf1aserine/arginine-rich splicing factor 1a0.013
arvcfbarmadillo repeat gene deleted in velocardiofacial syndrome b0.013
si:dkey-250d21.1si:dkey-250d21.10.013
supt3hsuppressor of Ty 3 homolog (S. cerevisiae)0.013
ssbp4single stranded DNA binding protein 40.013
cnnm2acyclin M2a0.013
ck2bcasein kinase 2 beta0.012
egr2aearly growth response 2a0.012
fkbp1aaFK506 binding protein 1Aa0.012
znf711zinc finger protein 7110.012
cnot8CCR4-NOT transcription complex, subunit 80.012
snrpcsmall nuclear ribonucleoprotein polypeptide C0.012
ctnnd2acatenin (cadherin-associated protein), delta 2a0.012
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.012
zgc:112425zgc:1124250.012
mapk3mitogen-activated protein kinase 30.012
sox11bSRY-box containing gene 11b0.012
chrna4cholinergic receptor, nicotinic, alpha 40.012
rltprRGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing0.012
wnt9awingless-type MMTV integration site family, member 9A0.012
zgc:123194zgc:1231940.011
LOC565106novel protein similar to vertebrate calpain 1 (CAPN1)0.011
nlgn4bneuroligin 4b0.011
hsbp1heat shock factor binding protein 10.011
tmietransmembrane inner ear0.011
capn1acalpain 1, (mu/I) large subunit a0.011
lzts2aleucine zipper, putative tumor suppressor 2a0.011
ppp6r3protein phosphatase 6, regulatory subunit 30.011
brpf1bromodomain and PHD finger containing, 10.011
mettl3methyltransferase like 30.011
pbx4pre-B-cell leukemia transcription factor 40.011
smarcb1bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b0.011
ythdf1YTH domain family, member 10.010
cyp2ad2cytochrome P450, family 2, subfamily AD, polypeptide 20.010
cdc16cell division cycle 16 homolog (S. cerevisiae)0.010
ctnnd1catenin (cadherin-associated protein), delta 10.010
wacaWW domain containing adaptor with coiled-coil a0.010
tfectranscription factor EC0.010
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.010
wrbtryptophan rich basic protein0.010
rabifRAB interacting factor0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)1.000
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)1.000
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.984
TP53tumor protein p530.963
DAXXdeath-domain associated protein0.937
EGR1early growth response 10.884
RANGAP1Ran GTPase activating protein 10.839
PIAS4protein inhibitor of activated STAT, 40.826
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.800
HIPK2homeodomain interacting protein kinase 20.681
MBD1methyl-CpG binding domain protein 10.667
NAP1L5nucleosome assembly protein 1-like 50.635
HDAC3histone deacetylase 30.600
CTAG1Bcancer/testis antigen 1B0.470
SMAD4SMAD family member 40.465
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.372
MAP3K3mitogen-activated protein kinase kinase kinase 30.355
UBA1ubiquitin-like modifier activating enzyme 10.333
USPL1ubiquitin specific peptidase like 10.328
SP100SP100 nuclear antigen0.307
SIN3ASIN3 homolog A, transcription regulator (yeast)0.291
MEF2Cmyocyte enhancer factor 2C0.291
EID2EP300 interacting inhibitor of differentiation 20.253
PMLpromyelocytic leukemia0.229
EGR3early growth response 30.229
EGR2early growth response 20.223
MAGEA2melanoma antigen family A, 20.215
NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae)0.204
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.204
MAGEA3melanoma antigen family A, 30.181
ELK1ELK1, member of ETS oncogene family0.159
MAGEA6melanoma antigen family A, 60.158
EID2BEP300 interacting inhibitor of differentiation 2B0.136
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.129
UBA2ubiquitin-like modifier activating enzyme 20.119
MAGEA12melanoma antigen family A, 120.106
EID3EP300 interacting inhibitor of differentiation 30.104
PRKD2protein kinase D20.097
TRIM25tripartite motif containing 250.096
HDAC4histone deacetylase 40.094
NCOR1nuclear receptor corepressor 10.091
TTNtitin0.082
ZNF420zinc finger protein 4200.080
PIAS2protein inhibitor of activated STAT, 20.078
EID1EP300 interacting inhibitor of differentiation 10.075
CBX5chromobox homolog 50.075
SATB1SATB homeobox 10.073
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.068
TRIM63tripartite motif containing 630.067
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.066
TRIM69tripartite motif containing 690.066
MAGEA5melanoma antigen family A, 50.066
BCL6B-cell CLL/lymphoma 60.065
CAPNS1calpain, small subunit 10.064
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.058
SENP1SUMO1/sentrin specific peptidase 10.057
SFNstratifin0.056
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.055
PJA1praja ring finger 10.052
SMAD2SMAD family member 20.052
TRIM27tripartite motif containing 270.051
EIF2C2eukaryotic translation initiation factor 2C, 20.048
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.047
PIAS1protein inhibitor of activated STAT, 10.047
EIF2C1eukaryotic translation initiation factor 2C, 10.046
ZC3HAV1zinc finger CCCH-type, antiviral 10.042
SKILSKI-like oncogene0.041
SMAD1SMAD family member 10.040
MAGEA1melanoma antigen family A, 1 (directs expression of antigen MZ2-E)0.037
MOAP1modulator of apoptosis 10.037
CTNND1catenin (cadherin-associated protein), delta 10.037
HIPK1homeodomain interacting protein kinase 10.036
RANBP2RAN binding protein 20.036
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.035
SETDB1SET domain, bifurcated 10.033
MUL1mitochondrial E3 ubiquitin protein ligase 10.033
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.032
DVL3dishevelled, dsh homolog 3 (Drosophila)0.032
MEF2Amyocyte enhancer factor 2A0.031
SP1Sp1 transcription factor0.030
APCadenomatous polyposis coli0.029
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.029
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.028
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.027
HERC5hect domain and RLD 50.027
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.026
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.026
BTBD2BTB (POZ) domain containing 20.026
TNRC6Atrinucleotide repeat containing 6A0.025
IPO13importin 130.025
SNIP1Smad nuclear interacting protein 10.024
NCOR2nuclear receptor corepressor 20.024
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.024
MYH10myosin, heavy chain 10, non-muscle0.023
MAGEA4melanoma antigen family A, 40.023
PHC1polyhomeotic homolog 1 (Drosophila)0.022
SNAI1snail homolog 1 (Drosophila)0.022
TRIM33tripartite motif containing 330.022
FOXP3forkhead box P30.022
IKZF3IKAROS family zinc finger 3 (Aiolos)0.021
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a1nuclear receptor subfamily 4, group A, member 10.347
Btg2BTG family, member 20.178
Egr2early growth response 20.145
Hprt1hypoxanthine phosphoribosyltransferase 10.108
FosFBJ osteosarcoma oncogene0.103
Junbjun B proto-oncogene0.080
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.059
Ier2immediate early response 20.035
Clns1achloride channel, nucleotide-sensitive, 1A0.032
Dusp1dual specificity phosphatase 10.028
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.028
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.027
Eif4heukaryotic translation initiation factor 4H0.023
Dusp6dual specificity phosphatase 60.020
Psma3proteasome (prosome, macropain) subunit, alpha type 30.019
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.019
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.019
Nr4a3nuclear receptor subfamily 4, group A, member 30.018
Rnps1ribonucleic acid binding protein S10.018
Cdc42cell division cycle 42 (GTP binding protein)0.016
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.015
Snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.015
CnbpCCHC-type zinc finger, nucleic acid binding protein0.015
Pdcd10programmed cell death 100.015
Mapk6mitogen-activated protein kinase 60.014
Sumo3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.014
RGD1311703similar to sid2057p0.014
Hnrnplheterogeneous nuclear ribonucleoprotein L0.013
Bat1HLA-B associated transcript 10.013
Rbbp7retinoblastoma binding protein 70.013
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.012
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.012
Cdk7cyclin-dependent kinase 70.012
Uba2ubiquitin-like modifier activating enzyme 20.012
Arrdc1arrestin domain containing 10.011
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.011
Psma1proteasome (prosome, macropain) subunit, alpha type 10.011
Gtf2igeneral transcription factor II I0.011
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.011
Rpa2replication protein A20.011
Tgfbr2transforming growth factor, beta receptor II0.011
Uba1ubiquitin-like modifier activating enzyme 10.011
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.011
Jtbjumping translocation breakpoint0.011
Csnk2a2casein kinase 2, alpha prime polypeptide0.010
Puf60poly-U binding splicing factor 600.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SLX8Slx8p0.618
MMS21Mms21p0.488
ECM11Ecm11p0.435
RED1Red1p0.321
SGS1Sgs1p0.205
SLX5Slx5p0.184
HFM1Hfm1p0.105
MSH4Msh4p0.083
WSS1Wss1p0.059
KAP114Kap114p0.057
UBA2Uba2p0.054
PCH2Pch2p0.053
HOP1Hop1p0.046
LIN1Lin1p0.045
ULS1Uls1p0.042
RAD52Rad52p0.042
SIZ1Siz1p0.034
NFI1Nfi1p0.034
ESC2Esc2p0.030
ESC1Esc1p0.029
SRD1Srd1p0.029
PDS5Pds5p0.028
YAR068Whypothetical protein0.027
ARP10Arp10p0.027
SPO22Spo22p0.027
YLR264C-Ahypothetical protein0.026
MMS1Mms1p0.026
LEU2Leu2p0.026
VMA4Vma4p0.025
YGR126Whypothetical protein0.025
SHS1Shs1p0.025
YLR162Whypothetical protein0.025
HDA2Hda2p0.024
YOL038C-Ahypothetical protein0.024
MER1Mer1p0.024
RAD55Rad55p0.023
AHC1Ahc1p0.023
LHS1Lhs1p0.022
VMA13Vma13p0.022
ARG8Arg8p0.022
YKR075Chypothetical protein0.022
MND1Mnd1p0.021
SPL2Spl2p0.021
YLR042Chypothetical protein0.021
TYE7Tye7p0.020
LRS4Lrs4p0.020
ATP6Atp6p0.020
ZPS1Zps1p0.020
CRP1Crp1p0.020
YBR013Chypothetical protein0.020
SMC4Smc4p0.020
GIS3Gis3p0.020
URA3Ura3p0.019
HPF1Hpf1p0.019
YAR066Whypothetical protein0.019
SGT2Sgt2p0.018
YPR157Whypothetical protein0.018
YML053Chypothetical protein0.018
YGR017Whypothetical protein0.018
SRC1Src1p0.018
FMT1Fmt1p0.018
DIC1Dic1p0.018
HMRA1Hmra1p0.017
AUA1Aua1p0.017
OPT2Opt2p0.017
TFA2Tfa2p0.017
RNP1Rnp1p0.017
MF(ALPHA)2Mf(alpha)2p0.017
SCM4Scm4p0.017
CUP1-1Cup1-1p0.017
CPD1Cpd1p0.017
BSC1Bsc1p0.016
YOL013W-Ahypothetical protein0.016
PRS2Prs2p0.016
THP3Thp3p0.016
LCL1Lcl1p0.016
COS12Cos12p0.016
YIR035Chypothetical protein0.016
MGR3Mgr3p0.016
MET8Met8p0.016
UBC4Ubc4p0.016
UPS3Ups3p0.016
CHA1Cha1p0.016
AAD6Aad6p0.016
HOHop0.016
PHD1Phd1p0.016
NUT2Nut2p0.016
YBL044Whypothetical protein0.015
YER064Chypothetical protein0.015
BSC2Bsc2p0.015
SSP1Ssp1p0.015
YJL213Whypothetical protein0.015
SAE2Sae2p0.015
AAD15Aad15p0.015
ALT2Alt2p0.015
MEI4Mei4p0.015
CAR1Car1p0.015
HXT3Hxt3p0.015
BNA4Bna4p0.015
YPR096Chypothetical protein0.015