The network for 'cholesterol metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E1.000
Ldlrlow density lipoprotein receptor1.000
Apoa1apolipoprotein A-I0.999
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.996
Sqlesqualene epoxidase0.996
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.963
Lsslanosterol synthase0.960
Lrp1low density lipoprotein receptor-related protein 10.957
Npc1Niemann Pick type C10.956
Prnpprion protein0.953
Mvdmevalonate (diphospho) decarboxylase0.952
Scd1stearoyl-Coenzyme A desaturase 10.943
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.929
Ahsgalpha-2-HS-glycoprotein0.909
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.908
Dhcr77-dehydrocholesterol reductase0.907
Ambpalpha 1 microglobulin/bikunin0.870
Fggfibrinogen gamma chain0.850
Ppargperoxisome proliferator activated receptor gamma0.805
Cyp51cytochrome P450, family 510.792
Dhcr2424-dehydrocholesterol reductase0.776
Fgafibrinogen alpha chain0.773
Dab1disabled homolog 1 (Drosophila)0.771
Fasnfatty acid synthase0.745
Il1r1interleukin 1 receptor, type I0.694
Stat3signal transducer and activator of transcription 30.683
Lcatlecithin cholesterol acyltransferase0.681
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.638
C3complement component 30.636
Lpin1lipin 10.627
Sc4molsterol-C4-methyl oxidase-like0.627
Ghrgrowth hormone receptor0.617
Apobapolipoprotein B0.605
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.600
Leprleptin receptor0.539
Serpina3mserine (or cysteine) peptidase inhibitor, clade A, member 3M0.534
Apoc4apolipoprotein C-IV0.531
Foxa2forkhead box A20.519
Lepleptin0.494
F2coagulation factor II0.490
Apoa5apolipoprotein A-V0.478
Abhd5abhydrolase domain containing 50.464
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.460
Hnf4ahepatic nuclear factor 4, alpha0.456
Aacsacetoacetyl-CoA synthetase0.441
Siglec5sialic acid binding Ig-like lectin 50.431
Sc5dsterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)0.391
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.390
Itih4inter alpha-trypsin inhibitor, heavy chain 40.385
C4bcomplement component 4B (Childo blood group)0.379
F9coagulation factor IX0.375
AclyATP citrate lyase0.367
Selpselectin, platelet0.350
Acat2acetyl-Coenzyme A acetyltransferase 20.341
Idi1isopentenyl-diphosphate delta isomerase0.302
Apoa2apolipoprotein A-II0.299
Cav1caveolin 1, caveolae protein0.289
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.286
Aldobaldolase B, fructose-bisphosphate0.286
Asgr1asialoglycoprotein receptor 10.258
Cideccell death-inducing DFFA-like effector c0.255
Tm7sf2transmembrane 7 superfamily member 20.253
Hphaptoglobin0.252
Adra1badrenergic receptor, alpha 1b0.248
Itih3inter-alpha trypsin inhibitor, heavy chain 30.248
Pnpla2patatin-like phospholipase domain containing 20.244
Srebf2sterol regulatory element binding factor 20.237
Agtr1aangiotensin II receptor, type 1a0.237
Ccl2chemokine (C-C motif) ligand 20.235
Ifnginterferon gamma0.232
Gcgroup specific component0.228
Fdpsfarnesyl diphosphate synthetase0.223
Apoc2apolipoprotein C-II0.221
Tbx3T-box 30.220
Hpxhemopexin0.219
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.216
Kitkit oncogene0.207
Scd2stearoyl-Coenzyme A desaturase 20.206
Rdh8retinol dehydrogenase 80.202
Srebf1sterol regulatory element binding transcription factor 10.200
Slc25a1solute carrier family 25 (mitochondrial carrier, citrate transporter), member 10.199
Plin1perilipin 10.192
Clstn1calsyntenin 10.189
1100001G20RikRIKEN cDNA 1100001G20 gene0.188
Plgplasminogen0.187
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.183
Vnn3vanin 30.181
Aco1aconitase 10.176
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.174
Pltpphospholipid transfer protein0.174
Mup3major urinary protein 30.174
Psen1presenilin 10.173
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.170
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.167
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.166
Nr1h4nuclear receptor subfamily 1, group H, member 40.166
Serpina1bserine (or cysteine) preptidase inhibitor, clade A, member 1B0.164
Scp2sterol carrier protein 2, liver0.164
Angptl4angiopoietin-like 40.164
Mgst1microsomal glutathione S-transferase 10.163
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.983
INSIG1insulin induced gene 10.904
SREBF2sterol regulatory element binding transcription factor 20.851
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.836
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.729
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.700
SC4MOLsterol-C4-methyl oxidase-like0.696
DHCR77-dehydrocholesterol reductase0.695
SQLEsqualene epoxidase0.588
FGF1fibroblast growth factor 1 (acidic)0.571
FDFT1farnesyl-diphosphate farnesyltransferase 10.544
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.526
IDI1isopentenyl-diphosphate delta isomerase 10.399
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.361
IL4Rinterleukin 4 receptor0.353
LDLRlow density lipoprotein receptor0.342
HPhaptoglobin0.340
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.311
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.293
FGAfibrinogen alpha chain0.266
LRP1low density lipoprotein receptor-related protein 10.244
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.222
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.171
A2Malpha-2-macroglobulin0.144
C14orf1chromosome 14 open reading frame 10.140
FGFR1fibroblast growth factor receptor 10.125
FDPSfarnesyl diphosphate synthase0.113
MVDmevalonate (diphospho) decarboxylase0.112
LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.105
NSDHLNAD(P) dependent steroid dehydrogenase-like0.096
CRPC-reactive protein, pentraxin-related0.096
DHCR2424-dehydrocholesterol reductase0.078
FRS2fibroblast growth factor receptor substrate 20.072
SLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 10.071
APOA1apolipoprotein A-I0.066
APOC1apolipoprotein C-I0.058
APOEapolipoprotein E0.053
PGRMC1progesterone receptor membrane component 10.053
APOA2apolipoprotein A-II0.053
LCATlecithin-cholesterol acyltransferase0.048
PDIA3protein disulfide isomerase family A, member 30.048
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.047
APOC3apolipoprotein C-III0.047
FADS1fatty acid desaturase 10.044
STARD4StAR-related lipid transfer (START) domain containing 40.036
ACAA1acetyl-CoA acyltransferase 10.036
PDZK1PDZ domain containing 10.035
APPamyloid beta (A4) precursor protein0.033
HNF4Ahepatocyte nuclear factor 4, alpha0.032
MVKmevalonate kinase0.031
FASNfatty acid synthase0.031
PGDphosphogluconate dehydrogenase0.030
CANXcalnexin0.027
SMAD3SMAD family member 30.027
MBL2mannose-binding lectin (protein C) 2, soluble0.026
FGF10fibroblast growth factor 100.026
MED15mediator complex subunit 150.026
FGF8fibroblast growth factor 8 (androgen-induced)0.026
CAPRIN2caprin family member 20.025
PRMT2protein arginine methyltransferase 20.025
SC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.024
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.023
SREBF1sterol regulatory element binding transcription factor 10.022
COX6Ccytochrome c oxidase subunit VIc0.022
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase0.021
CRYABcrystallin, alpha B0.019
CABIN1calcineurin binding protein 10.018
BACE1beta-site APP-cleaving enzyme 10.018
TMBIM6transmembrane BAX inhibitor motif containing 60.018
ACACAacetyl-CoA carboxylase alpha0.018
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.017
HSD17B4hydroxysteroid (17-beta) dehydrogenase 40.017
FGBfibrinogen beta chain0.017
MPZL1myelin protein zero-like 10.017
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.017
GPLD1glycosylphosphatidylinositol specific phospholipase D10.016
PORP450 (cytochrome) oxidoreductase0.016
HSPB1heat shock 27kDa protein 10.016
PCSK9proprotein convertase subtilisin/kexin type 90.016
MASP2mannan-binding lectin serine peptidase 20.016
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.015
C8Acomplement component 8, alpha polypeptide0.014
CTSDcathepsin D0.014
STX12syntaxin 120.014
CCNG2cyclin G20.014
TKTtransketolase0.014
DEDDdeath effector domain containing0.014
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.014
EPHX1epoxide hydrolase 1, microsomal (xenobiotic)0.014
APOC2apolipoprotein C-II0.014
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.013
PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)0.013
IDH1isocitrate dehydrogenase 1 (NADP+), soluble0.013
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.013
APOBapolipoprotein B (including Ag(x) antigen)0.013
APCSamyloid P component, serum0.012
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.012
ABCG1ATP-binding cassette, sub-family G (WHITE), member 10.012
FGF3fibroblast growth factor 30.012
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp51cytochrome P450, family 510.996
Sc4molsterol-C4-methyl oxidase-like0.990
Acat3acetyl-Coenzyme A acetyltransferase 30.931
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.921
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.898
Lsslanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.788
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.781
Idi1isopentenyl-diphosphate delta isomerase 10.763
Sqlesqualene epoxidase0.689
Insig1insulin induced gene 10.508
Fdft1farnesyl diphosphate farnesyl transferase 10.493
DbpD site of albumin promoter (albumin D-box) binding protein0.389
Dhcr77-dehydrocholesterol reductase0.291
Hsd17b7hydroxysteroid (17-beta) dehydrogenase 70.278
Dhcr2424-dehydrocholesterol reductase0.245
Fasnfatty acid synthase0.217
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.077
NsdhlNAD(P) dependent steroid dehydrogenase-like0.075
Tm7sf2transmembrane 7 superfamily member 20.053
Sc5dlsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.041
Mvkmevalonate kinase0.028
Slc25a10solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 100.028
Fads1fatty acid desaturase 10.022
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.022
Aacsacetoacetyl-CoA synthetase0.019
Scd1stearoyl-Coenzyme A desaturase 10.017
Slc25a20solute carrier family 25 (carnitine/acylcarnitine translocase), member 200.017
Rxraretinoid X receptor alpha0.016
Fut1fucosyltransferase 10.016
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.014
Sptan1spectrin, alpha, non-erythrocytic 10.014
Acss2acyl-CoA synthetase short-chain family member 20.013
Crhbpcorticotropin releasing hormone binding protein0.013
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.013
Hadhbhydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit0.012
Prlprolactin0.012
Aqp8aquaporin 80.011
Acaa2acetyl-Coenzyme A acyltransferase 20.011
Gulogulonolactone (L-) oxidase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism