The network for 'type i interferon biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

type i interferon biosynthetic process

The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.868
Ticam1toll-like receptor adaptor molecule 10.832
Stat1signal transducer and activator of transcription 10.812
Ikbkginhibitor of kappaB kinase gamma0.743
Ikbkbinhibitor of kappaB kinase beta0.730
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.592
Myd88myeloid differentiation primary response gene 880.531
Chukconserved helix-loop-helix ubiquitous kinase0.486
Ifnar2interferon (alpha and beta) receptor 20.276
Ccr2chemokine (C-C motif) receptor 20.259
CblbCasitas B-lineage lymphoma b0.131
Unc93b1unc-93 homolog B1 (C. elegans)0.128
Birc3baculoviral IAP repeat-containing 30.121
Sfpi1SFFV proviral integration 10.118
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.097
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.071
Irf1interferon regulatory factor 10.058
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.052
Ccl2chemokine (C-C motif) ligand 20.051
Irak4interleukin-1 receptor-associated kinase 40.050
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.047
Tnftumor necrosis factor0.046
Stat2signal transducer and activator of transcription 20.045
Casp4caspase 4, apoptosis-related cysteine peptidase0.044
Traf6TNF receptor-associated factor 60.043
Ifngr1interferon gamma receptor 10.043
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.042
Stat6signal transducer and activator of transcription 60.041
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.041
Ifnar1interferon (alpha and beta) receptor 10.039
Irf5interferon regulatory factor 50.038
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.032
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.032
Uba7ubiquitin-like modifier activating enzyme 70.031
Usp18ubiquitin specific peptidase 180.031
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.029
Lyz2lysozyme 20.028
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.028
Map3k14mitogen-activated protein kinase kinase kinase 140.026
Il1r1interleukin 1 receptor, type I0.026
Sykbspleen tyrosine kinase0.025
Stat3signal transducer and activator of transcription 30.025
Tor3atorsin family 3, member A0.025
Irf8interferon regulatory factor 80.024
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.023
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.023
Map3k7mitogen-activated protein kinase kinase kinase 70.023
Ifit1interferon-induced protein with tetratricopeptide repeats 10.022
Tlr2toll-like receptor 20.021
Mavsmitochondrial antiviral signaling protein0.020
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.018
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.018
Rnf31ring finger protein 310.018
Ifit3interferon-induced protein with tetratricopeptide repeats 30.018
Dock2dedicator of cyto-kinesis 20.018
FasFas (TNF receptor superfamily member 6)0.018
Isg15ISG15 ubiquitin-like modifier0.018
1810019J16RikRIKEN cDNA 1810019J16 gene0.017
Sfnstratifin0.016
Mmp9matrix metallopeptidase 90.016
Igtpinterferon gamma induced GTPase0.015
TankTRAF family member-associated Nf-kappa B activator0.015
Irgm1immunity-related GTPase family M member 10.014
Rtp4receptor transporter protein 40.014
Parp10poly (ADP-ribose) polymerase family, member 100.014
Gbp3guanylate binding protein 30.014
C3complement component 30.014
Rsad2radical S-adenosyl methionine domain containing 20.014
Ptpn6protein tyrosine phosphatase, non-receptor type 60.014
Parp14poly (ADP-ribose) polymerase family, member 140.014
Itga4integrin alpha 40.013
Tlr5toll-like receptor 50.013
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.013
Mx2myxovirus (influenza virus) resistance 20.013
Pyhin1pyrin and HIN domain family, member 10.013
Cxcl10chemokine (C-X-C motif) ligand 100.013
Vav1vav 1 oncogene0.013
Cd14CD14 antigen0.012
Il10rainterleukin 10 receptor, alpha0.012
Ikzf1IKAROS family zinc finger 10.012
Map3k8mitogen-activated protein kinase kinase kinase 80.012
Irf7interferon regulatory factor 70.012
Irgm2immunity-related GTPase family M member 20.011
Pmlpromyelocytic leukemia0.011
Spp1secreted phosphoprotein 10.011
Ncoa3nuclear receptor coactivator 30.010
Sp100nuclear antigen Sp1000.010
Irf4interferon regulatory factor 40.010
Tgfb1transforming growth factor, beta 10.010
Irak1interleukin-1 receptor-associated kinase 10.010
Trim21tripartite motif-containing 210.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
LOC100003330melanocortin-2 receptor accessory protein 2-like0.108
stat1bsignal transducer and activator of transcription 1b0.066
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.039
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.026
LOC100534776toll-like receptor 7-like0.023
nos2anitric oxide synthase 2a, inducible0.021
clint1clathrin interactor 10.021
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.020
b2mbeta-2-microglobulin0.020
isg15ISG15 ubiquitin-like modifier0.017
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.017
tlr18toll-like receptor 180.017
terttelomerase reverse transcriptase0.016
junbjun B proto-oncogene0.016
zgc:123068zgc:1230680.015
grn1granulin 10.014
adrb2aadrenergic receptor, beta 2a0.014
lgmnlegumain0.013
LOC792676similar to N-myc-interactor (Nmi) (N-myc and STAT interactor)0.013
traf6TNF receptor-associated factor 60.013
ccnhcyclin H0.013
nr3c2nuclear receptor subfamily 3, group C, member 20.012
tlr20ftoll-like receptor 20f0.011
il22interleukin 220.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MYD88myeloid differentiation primary response gene (88)0.970
IRF7interferon regulatory factor 70.785
IRAK1interleukin-1 receptor-associated kinase 10.782
STAT2signal transducer and activator of transcription 2, 113kDa0.742
TICAM2toll-like receptor adaptor molecule 20.731
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.624
IRAK2interleukin-1 receptor-associated kinase 20.350
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.165
PIAS4protein inhibitor of activated STAT, 40.131
AZI25-azacytidine induced 20.130
IFNAR2interferon (alpha, beta and omega) receptor 20.113
TRIM21tripartite motif containing 210.088
TANKTRAF family member-associated NFKB activator0.067
TLR2toll-like receptor 20.064
LY96lymphocyte antigen 960.059
TNIP1TNFAIP3 interacting protein 10.051
IFNAR1interferon (alpha, beta and omega) receptor 10.049
IRF1interferon regulatory factor 10.039
STAT1signal transducer and activator of transcription 1, 91kDa0.039
CALCOCO2calcium binding and coiled-coil domain 20.027
STAP2signal transducing adaptor family member 20.026
TLR1toll-like receptor 10.025
MAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.024
TBK1TANK-binding kinase 10.022
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.020
OPTNoptineurin0.018
BTKBruton agammaglobulinemia tyrosine kinase0.016
HTThuntingtin0.015
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.015
ISG20interferon stimulated exonuclease gene 20kDa0.015
TLR4toll-like receptor 40.014
IFI35interferon-induced protein 350.013
MX2myxovirus (influenza virus) resistance 2 (mouse)0.013
MIB1mindbomb homolog 1 (Drosophila)0.013
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.013
VNN2vanin 20.011
LRP10low density lipoprotein receptor-related protein 100.011
CYLDcylindromatosis (turban tumor syndrome)0.011
IRAK4interleukin-1 receptor-associated kinase 40.010
ADARadenosine deaminase, RNA-specific0.010
LY86lymphocyte antigen 860.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism