The network for 'marginal zone b cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

marginal zone b cell differentiation

The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).

NameDescriptionProbabilityFunc Analog Organism
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B1.000
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1051.000
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.677
Tnip1TNFAIP3 interacting protein 10.604
Bcar1breast cancer anti-estrogen resistance 10.597
Bcl3B-cell leukemia/lymphoma 30.529
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.513
Tnftumor necrosis factor0.402
JunbJun-B oncogene0.391
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.375
Cyldcylindromatosis (turban tumor syndrome)0.355
Stat3signal transducer and activator of transcription 30.330
Pxnpaxillin0.271
FasFas (TNF receptor superfamily member 6)0.219
SrcRous sarcoma oncogene0.215
Map3k14mitogen-activated protein kinase kinase kinase 140.190
Bcl6B-cell leukemia/lymphoma 60.167
Icam1intercellular adhesion molecule 10.139
Zfp36zinc finger protein 360.131
Socs3suppressor of cytokine signaling 30.125
Prkcdprotein kinase C, delta0.123
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.121
2010106G01RikRIKEN cDNA 2010106G01 gene0.110
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.080
FynFyn proto-oncogene0.072
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.061
Vav1vav 1 oncogene0.059
Supv3l1suppressor of var1, 3-like 1 (S. cerevisiae)0.056
Nfkbienuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.056
Birc3baculoviral IAP repeat-containing 30.049
Mvpmajor vault protein0.048
Il2rginterleukin 2 receptor, gamma chain0.044
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.040
Tnfaip3tumor necrosis factor, alpha-induced protein 30.034
Rnf19bring finger protein 19B0.034
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.034
Irf1interferon regulatory factor 10.033
Plcg2phospholipase C, gamma 20.031
Il4rainterleukin 4 receptor, alpha0.030
Myd88myeloid differentiation primary response gene 880.029
Ptpn1protein tyrosine phosphatase, non-receptor type 10.027
Ptenphosphatase and tensin homolog0.025
Ikbkeinhibitor of kappaB kinase epsilon0.025
Csf1colony stimulating factor 1 (macrophage)0.023
Ltblymphotoxin B0.022
BlnkB-cell linker0.020
Ptpn11protein tyrosine phosphatase, non-receptor type 110.020
Grb2growth factor receptor bound protein 20.020
Ighimmunoglobulin heavy chain complex0.019
Ubcubiquitin C0.018
Prkceprotein kinase C, epsilon0.018
Dok1docking protein 10.018
Cd40CD40 antigen0.018
Pim1proviral integration site 10.017
Mcl1myeloid cell leukemia sequence 10.017
Lcn2lipocalin 20.016
Arid5aAT rich interactive domain 5A (MRF1-like)0.016
Pou2af1POU domain, class 2, associating factor 10.016
Ikzf1IKAROS family zinc finger 10.016
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.015
Maffv-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)0.015
Sbno2strawberry notch homolog 2 (Drosophila)0.014
Jak3Janus kinase 30.014
Zc3h12azinc finger CCCH type containing 12A0.013
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.013
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.012
Stk4serine/threonine kinase 40.012
Traf3ip2TRAF3 interacting protein 20.012
Runx1runt related transcription factor 10.012
Csrnp1cysteine-serine-rich nuclear protein 10.011
Efhd2EF hand domain containing 20.011
Il17rainterleukin 17 receptor A0.011
Casp4caspase 4, apoptosis-related cysteine peptidase0.011
Sykbspleen tyrosine kinase0.011
Traf6TNF receptor-associated factor 60.011
Coro1acoronin, actin binding protein 1A0.010
Map3k8mitogen-activated protein kinase kinase kinase 80.010
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.010
Shisa5shisa homolog 5 (Xenopus laevis)0.010
Stat6signal transducer and activator of transcription 60.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
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Drosophila melanogaster
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism