The network for 'negative regulation of wnt signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of wnt signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
Pitx2paired-like homeodomain transcription factor 20.996
Vangl2vang-like 2 (van gogh, Drosophila)0.994
Fgf8fibroblast growth factor 80.993
Pitx1paired-like homeodomain transcription factor 10.978
Pax3paired box gene 30.977
Ctnnb1catenin (cadherin associated protein), beta 10.975
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.968
Fgfr2fibroblast growth factor receptor 20.957
Wnt3awingless-related MMTV integration site 3A0.952
Hand1heart and neural crest derivatives expressed transcript 10.933
Wnt5awingless-related MMTV integration site 5A0.926
Dvl2dishevelled 2, dsh homolog (Drosophila)0.898
Fgfr1fibroblast growth factor receptor 10.886
Tbx3T-box 30.874
Gli2GLI-Kruppel family member GLI20.865
Hes1hairy and enhancer of split 1 (Drosophila)0.853
Hoxa1homeobox A10.841
Lhx1LIM homeobox protein 10.817
Fgf10fibroblast growth factor 100.816
Dvl3dishevelled 3, dsh homolog (Drosophila)0.806
Fgf3fibroblast growth factor 30.791
Otx2orthodenticle homolog 2 (Drosophila)0.754
Pou3f3POU domain, class 3, transcription factor 30.753
Fzd8frizzled homolog 8 (Drosophila)0.751
Ror2receptor tyrosine kinase-like orphan receptor 20.734
Sox2SRY-box containing gene 20.734
Ntf3neurotrophin 30.724
Ror1receptor tyrosine kinase-like orphan receptor 10.703
Gli1GLI-Kruppel family member GLI10.703
Apcadenomatosis polyposis coli0.698
Leprleptin receptor0.692
Lef1lymphoid enhancer binding factor 10.673
Meox2mesenchyme homeobox 20.657
Mapk14mitogen-activated protein kinase 140.644
Prrx1paired related homeobox 10.637
Gli3GLI-Kruppel family member GLI30.631
Trp53transformation related protein 530.627
Cdk4cyclin-dependent kinase 40.616
Hoxa13homeobox A130.604
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.598
Vangl1vang-like 1 (van gogh, Drosophila)0.594
Smad6MAD homolog 6 (Drosophila)0.588
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.549
Lhx3LIM homeobox protein 30.527
Wnt4wingless-related MMTV integration site 40.525
Lmx1aLIM homeobox transcription factor 1 alpha0.519
Axin1axin 10.515
Hdac1histone deacetylase 10.491
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.489
Lrp2low density lipoprotein receptor-related protein 20.463
Hoxd13homeobox D130.454
Gsk3bglycogen synthase kinase 3 beta0.453
Rargretinoic acid receptor, gamma0.448
Pax2paired box gene 20.448
Sfrp2secreted frizzled-related protein 20.434
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.424
Egr1early growth response 10.415
Twist1twist homolog 1 (Drosophila)0.414
Msx1homeobox, msh-like 10.411
Notch1Notch gene homolog 1 (Drosophila)0.398
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.397
Tekendothelial-specific receptor tyrosine kinase0.391
Tcf15transcription factor 150.387
Bcl2B-cell leukemia/lymphoma 20.387
Sfrp1secreted frizzled-related protein 10.373
Nr5a1nuclear receptor subfamily 5, group A, member 10.372
Lrp6low density lipoprotein receptor-related protein 60.370
Emx2empty spiracles homolog 2 (Drosophila)0.366
Zic3zinc finger protein of the cerebellum 30.365
Bdnfbrain derived neurotrophic factor0.360
Phox2apaired-like homeobox 2a0.358
Lbx1ladybird homeobox homolog 1 (Drosophila)0.357
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.355
Gdnfglial cell line derived neurotrophic factor0.355
Gas1growth arrest specific 10.343
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.343
Arandrogen receptor0.336
Foxc2forkhead box C20.334
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.331
Smad3MAD homolog 3 (Drosophila)0.330
Vegfavascular endothelial growth factor A0.328
Retret proto-oncogene0.327
Ptgs2prostaglandin-endoperoxide synthase 20.321
Insm1insulinoma-associated 10.307
Snai1snail homolog 1 (Drosophila)0.303
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.301
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.288
Pax7paired box gene 70.284
Lama5laminin, alpha 50.280
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.279
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.275
Nf2neurofibromatosis 20.270
Tbx1T-box 10.269
Rarbretinoic acid receptor, beta0.268
Fgf18fibroblast growth factor 180.267
Stk4serine/threonine kinase 40.264
Gja5gap junction protein, alpha 50.262
Dkk1dickkopf homolog 1 (Xenopus laevis)0.262
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pry-1Protein PRY-10.894
egl-18Protein EGL-180.259
egl-30Protein EGL-300.211
bar-1Protein BAR-10.153
cst-1Protein CST-10.122
gsk-3Protein GSK-30.114
hlh-1Protein HLH-10.107
lin-17Protein LIN-170.095
osm-6Protein OSM-60.091
ncx-3Protein NCX-30.074
eor-1Protein EOR-10.057
trim-9Protein TRIM-90.056
pig-1Protein PIG-10.056
axl-1Protein AXL-10.054
pop-1Protein POP-10.053
sel-8Protein SEL-80.047
smp-1Protein SMP-10.043
dsh-1Protein DSH-10.043
F13C5.2Protein F13C5.20.041
gpb-1Protein GPB-10.040
wrm-1Protein WRM-10.039
elt-6Protein ELT-60.039
unc-5Protein UNC-50.038
sdn-1Protein SDN-10.038
R02D5.1Protein R02D5.10.037
F59E12.11Protein F59E12.110.032
T28F4.1Protein T28F4.10.032
daf-3Protein DAF-30.029
sur-2Protein SUR-20.027
let-60Protein LET-600.026
ldb-1Protein LDB-10.025
mec-2Protein MEC-20.025
R10E12.2Protein R10E12.20.025
pxd-1Protein PXD-10.025
pkn-1Protein PKN-10.024
kqt-1Protein KQT-10.023
bli-1Protein BLI-10.023
nhr-34Protein NHR-340.022
daf-12Protein DAF-120.021
madf-5Protein MADF-50.021
sax-3Protein SAX-30.019
dpy-22Protein DPY-220.018
sox-2Protein SOX-20.018
cin-4Protein CIN-40.017
hlh-2Protein HLH-20.017
nhr-67Protein NHR-670.017
grd-2Protein GRD-20.016
unc-57Protein UNC-570.016
lin-66Protein LIN-660.016
K10D6.4Protein K10D6.40.015
vab-2Protein VAB-20.015
inx-3Protein INX-30.014
igcm-4Protein IGCM-40.014
gon-2Protein GON-20.014
jbts-14Protein JBTS-140.014
pqn-87Protein PQN-870.014
pad-1Protein PAD-10.014
ten-1Protein TEN-10.014
che-3Protein CHE-30.013
ima-3Protein IMA-30.013
attf-4Protein ATTF-40.013
hmr-1Protein HMR-10.012
lit-1Protein LIT-10.012
swsn-7Protein SWSN-70.012
T24B8.3Protein T24B8.30.012
xpo-1Protein XPO-10.011
mec-8Protein MEC-80.011
guk-1Protein GUK-10.011
vang-1Protein VANG-10.011
osm-8Protein OSM-80.011
ain-1Protein AIN-10.011
F10G8.8Protein F10G8.80.011
fox-1Protein FOX-10.011
inx-4Protein INX-40.010
T28B11.1Protein T28B11.10.010
cutl-20Protein CUTL-200.010
K04B12.2Protein K04B12.20.010
lsy-22Protein LSY-220.010
F55C12.5Protein F55C12.50.010
hda-1Protein HDA-10.010
gmeb-1Protein GMEB-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt5bwingless-type MMTV integration site family, member 5b0.844
nog1noggin 10.633
ptch2patched 20.542
wnt4awingless-type MMTV integration site family, member 4a0.537
tbx1T-box 10.519
fn1fibronectin 10.493
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.458
wnt3awingless-type MMTV integration site family, member 3A0.457
gli1GLI-Kruppel family member 10.448
pea3ETS-domain transcription factor pea30.427
bmp4bone morphogenetic protein 40.398
fzd7afrizzled homolog 7a0.393
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.392
ndr2nodal-related 20.343
sulf1sulfatase 10.294
notum3notum 30.292
flhfloating head0.290
wnt2bbwingless-type MMTV integration site family, member 2Bb0.284
fzd5frizzled homolog 50.281
wnt9awingless-type MMTV integration site family, member 9A0.279
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.277
dusp6dual specificity phosphatase 60.251
wlswntless homolog (Drosophila)0.246
wnt11wingless-type MMTV integration site family, member 110.243
fzd10frizzled homolog 100.221
sox2SRY-box containing gene 20.219
wnt8bwingless-type MMTV integration site family, member 8b0.219
per3period homolog 3 (Drosophila)0.205
rasl11bRAS-like, family 11, member B0.190
wnt10awingless-type MMTV integration site family, member 10a0.186
spns2spinster homolog 2 (Drosophila)0.186
etv5bets variant 5b0.183
lrp2low density lipoprotein-related protein 20.181
foxa2forkhead box A20.177
id1inhibitor of DNA binding 10.174
shhbsonic hedgehog b0.174
tp63tumor protein p630.173
rykreceptor-like tyrosine kinase0.173
frzbfrizzled-related protein0.157
zbtb4zinc finger and BTB domain containing 40.141
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.135
map2k4amitogen-activated protein kinase kinase 4a0.130
kctd12.1potassium channel tetramerisation domain containing 12.10.124
nhsl1bNHS-like 1b0.124
mapk1mitogen-activated protein kinase 10.122
wnt9bwingless-type MMTV integration site family, member 9B0.122
foxd5forkhead box D50.117
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.116
pnxposterior neuron-specific homeobox0.113
sfrp1asecreted frizzled-related protein 1a0.111
tbx16T-box gene 160.111
col11a2collagen type XI alpha-20.110
spry4sprouty (Drosophila) homolog 40.109
lfnglunatic fringe homolog0.109
axin2axin 2 (conductin, axil)0.107
vsx1visual system homeobox 1 homolog, chx10-like0.102
lhx2bLIM homeobox 2b0.097
znf503zinc finger protein 5030.095
sox9bSRY-box containing gene 9b0.095
per2period homolog 2 (Drosophila)0.094
cacnb4acalcium channel, voltage-dependent, beta 4a subunit0.089
yap1Yes-associated protein 10.087
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.084
wnt10bwingless-type MMTV integration site family, member 10b0.083
shhasonic hedgehog a0.082
bmp2abone morphogenetic protein 2a0.082
ext1aexostoses (multiple) 1a0.081
foxj1aforkhead box J1a0.081
six1bsine oculis homeobox homolog 1b0.081
robo2roundabout homolog 20.081
sulf2lsulfatase 2, like0.079
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.079
appaamyloid beta (A4) precursor protein a0.078
gli2aGLI-Kruppel family member GLI2a0.078
klf2aKruppel-like factor 2a0.077
ptch1patched 10.076
gpc4glypican 40.073
runx2brunt-related transcription factor 2b0.073
has2hyaluronan synthase 20.072
csnk1dbcasein kinase 1, delta b0.072
wnt3wingless-type MMTV integration site family, member 30.070
snai1asnail homolog 1a (Drosophila)0.070
adcyap1aadenylate cyclase activating polypeptide 1a0.069
aplnrbapelin receptor b0.068
efnb2aephrin B2a0.066
ephb4beph receptor B4b0.066
arl13bADP-ribosylation factor-like 13b0.066
tpm4tropomyosin 40.066
otx2orthodenticle homolog 20.063
admpanti-dorsalizing morphogenic protein0.063
rx3retinal homeobox gene 30.062
spry2sprouty homolog 20.061
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.796
Akt1CG4006 gene product from transcript CG4006-RA0.748
Pi3K92ECG4141 gene product from transcript CG4141-RB0.660
nkdnaked cuticle0.499
dallydivision abnormally delayed0.453
EcREcdysone receptor0.412
aopanterior open0.411
hipkhomeodomain interacting protein kinase0.273
Zyx102EFCG32018 gene product from transcript CG32018-RA0.212
EgfrEpidermal growth factor receptor0.204
phlpole hole0.178
Wnt4Wnt oncogene analog 40.164
MadMothers against dpp0.150
RbfRetinoblastoma-family protein0.138
Klp64DKinesin-like protein at 64D0.135
eyaeyes absent0.126
Ras85DRas oncogene at 85D0.120
Caf1Chromatin assembly factor 1 subunit0.116
CycACyclin A0.110
Bj1Bj1 protein0.099
fwdfour wheel drive0.096
TorTarget of rapamycin0.082
Cdk4Cyclin-dependent kinase 40.074
NotumCG13076 gene product from transcript CG13076-RB0.071
Usp7ubiquitin-specific protease 70.066
l(2)gllethal (2) giant larvae0.061
Tak1TGF-beta activated kinase 10.056
CG6234CG6234 gene product from transcript CG6234-RA0.055
toytwin of eyeless0.055
Rac1CG2248 gene product from transcript CG2248-RA0.053
aPKCatypical protein kinase C0.053
CycECyclin E0.052
ftz-f1ftz transcription factor 10.049
slmbsupernumerary limbs0.047
snostrawberry notch0.046
opaodd paired0.045
Mes2CG11100 gene product from transcript CG11100-RB0.044
SceSex combs extra0.044
CG17273CG17273 gene product from transcript CG17273-RA0.043
l(2)05510lethal (2) 055100.043
Traf4TNF-receptor-associated factor 40.042
S6kRPS6-p70-protein kinase0.041
CG5794CG5794 gene product from transcript CG5794-RB0.041
cdicenter divider0.040
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.999
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.998
AXIN1axin 10.993
SMAD3SMAD family member 30.982
CREBBPCREB binding protein0.971
ZFYVE9zinc finger, FYVE domain containing 90.953
PPP6Cprotein phosphatase 6, catalytic subunit0.953
SMAD7SMAD family member 70.950
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.944
LRP6low density lipoprotein receptor-related protein 60.938
GSK3Bglycogen synthase kinase 3 beta0.922
STK3serine/threonine kinase 30.912
PPP6R2protein phosphatase 6, regulatory subunit 20.888
BTRCbeta-transducin repeat containing0.876
HDAC1histone deacetylase 10.848
PSEN1presenilin 10.839
SUFUsuppressor of fused homolog (Drosophila)0.839
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.836
AFF1AF4/FMR2 family, member 10.830
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.825
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.811
SKP1S-phase kinase-associated protein 10.791
APCadenomatous polyposis coli0.791
HIPK3homeodomain interacting protein kinase 30.773
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.757
STK4serine/threonine kinase 40.751
IGF1Rinsulin-like growth factor 1 receptor0.739
SMAD4SMAD family member 40.669
PTPN1protein tyrosine phosphatase, non-receptor type 10.653
ARandrogen receptor0.632
SMAD2SMAD family member 20.623
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.611
INSRinsulin receptor0.606
EGFRepidermal growth factor receptor0.582
UHRF2ubiquitin-like with PHD and ring finger domains 20.563
YAP1Yes-associated protein 10.562
PPP6R1protein phosphatase 6, regulatory subunit 10.543
FBXW11F-box and WD repeat domain containing 110.542
ANKRD28ankyrin repeat domain 280.539
JUPjunction plakoglobin0.522
PTPRJprotein tyrosine phosphatase, receptor type, J0.519
FZD1frizzled homolog 1 (Drosophila)0.519
DVL3dishevelled, dsh homolog 3 (Drosophila)0.502
POU3F2POU class 3 homeobox 20.497
WNT3Awingless-type MMTV integration site family, member 3A0.485
SNAI1snail homolog 1 (Drosophila)0.479
ARHGAP1Rho GTPase activating protein 10.460
SKIv-ski sarcoma viral oncogene homolog (avian)0.429
CTNND1catenin (cadherin-associated protein), delta 10.426
BMP7bone morphogenetic protein 70.422
GIPC1GIPC PDZ domain containing family, member 10.420
BTBD2BTB (POZ) domain containing 20.419
BMPR1Abone morphogenetic protein receptor, type IA0.416
LEF1lymphoid enhancer-binding factor 10.397
BBS10Bardet-Biedl syndrome 100.397
CDK6cyclin-dependent kinase 60.396
CSNK1Ecasein kinase 1, epsilon0.389
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)0.382
ATXN1ataxin 10.373
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.367
TCF4transcription factor 40.362
PAX3paired box 30.359
FOXD3forkhead box D30.323
JUBjub, ajuba homolog (Xenopus laevis)0.310
FSTL1follistatin-like 10.309
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.290
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.286
USP6ubiquitin specific peptidase 6 (Tre-2 oncogene)0.286
TBX5T-box 50.275
VHLvon Hippel-Lindau tumor suppressor0.274
SFRP1secreted frizzled-related protein 10.270
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.268
CTNNBIP1catenin, beta interacting protein 10.251
ZNF512Bzinc finger protein 512B0.245
NCOR1nuclear receptor corepressor 10.245
ERBB2IPerbb2 interacting protein0.243
GLIS2GLIS family zinc finger 20.242
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.241
MARK3MAP/microtubule affinity-regulating kinase 30.239
GATA4GATA binding protein 40.218
IRS2insulin receptor substrate 20.214
TSC1tuberous sclerosis 10.207
SAV1salvador homolog 1 (Drosophila)0.200
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.197
PPARAperoxisome proliferator-activated receptor alpha0.194
RUNX1runt-related transcription factor 10.193
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.191
STK38Lserine/threonine kinase 38 like0.185
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.184
TP73tumor protein p730.181
IRS1insulin receptor substrate 10.178
EPHB1EPH receptor B10.178
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.172
ANAPC11anaphase promoting complex subunit 110.153
WNT5Awingless-type MMTV integration site family, member 5A0.145
MYO6myosin VI0.143
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.141
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a1nuclear receptor subfamily 4, group A, member 10.154
Btg2BTG family, member 20.077
Dusp6dual specificity phosphatase 60.077
Egr2early growth response 20.025
Gpc3glypican 30.022
Dlg1discs, large homolog 1 (Drosophila)0.021
FosFBJ osteosarcoma oncogene0.017
A4galtalpha 1,4-galactosyltransferase0.017
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.016
Plagl1pleiomorphic adenoma gene-like 10.015
Ier2immediate early response 20.014
Dock1dedicator of cyto-kinesis 10.013
Bmp7bone morphogenetic protein 70.013
Capn6calpain 60.012
Dchs1dachsous 1 (Drosophila)0.011
Ltbp1latent transforming growth factor beta binding protein 10.011
Sfrp2secreted frizzled-related protein 20.011
Tcf3transcription factor 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism