The network for 'ensheathment of neurons' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ensheathment of neurons

The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.

NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.692
Plp1proteolipid protein 10.686
Mbpmyelin basic protein0.475
Timp3TIMP metallopeptidase inhibitor 30.341
Gatmglycine amidinotransferase (L-arginine:glycine amidinotransferase)0.253
Mpzmyelin protein zero0.246
Usf2upstream transcription factor 2, c-fos interacting0.216
Ddr1discoidin domain receptor tyrosine kinase 10.200
Epn1Epsin 10.200
Lpar1lysophosphatidic acid receptor 10.188
S100a6S100 calcium binding protein A60.169
Tmod2tropomodulin 20.161
Anxa5annexin A50.131
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.125
Srebf1sterol regulatory element binding transcription factor 10.124
Slco2a1solute carrier organic anion transporter family, member 2a10.110
Plcl1phospholipase C-like 10.108
Nr1d2nuclear receptor subfamily 1, group D, member 20.106
Arnt2aryl hydrocarbon receptor nuclear translocator 20.106
Platplasminogen activator, tissue0.105
Fgd4FYVE, RhoGEF and PH domain containing 40.103
Pllpplasma membrane proteolipid (plasmolipin)0.096
Serinc5serine incorporator 50.094
Cd9CD9 molecule0.093
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.091
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.089
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.089
Scn7asodium channel, voltage-gated, type VII, alpha0.085
Nptx1neuronal pentraxin 10.080
Akt1s1AKT1 substrate 1 (proline-rich)0.079
Apodapolipoprotein D0.079
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.078
Nr3c2nuclear receptor subfamily 3, group C, member 20.077
Unc13cunc-13 homolog C (C. elegans)0.074
Csf1colony stimulating factor 1 (macrophage)0.072
Eif2b1eukaryotic translation initiation factor 2B, subunit 1 alpha0.068
Syngr2synaptogyrin 20.068
Ehd2EH-domain containing 20.067
Atrnattractin0.065
Krt15keratin 150.065
Fasnfatty acid synthase0.063
Hpnhepsin0.062
Rabep1rabaptin, RAB GTPase binding effector protein 10.062
Oprl1opiate receptor-like 10.061
Hspb2heat shock protein beta 20.061
Sycp1synaptonemal complex protein 10.059
Smad3SMAD family member 30.058
Notch3Notch homolog 3 (Drosophila)0.058
Gria2glutamate receptor, ionotropic, AMPA 20.058
Fgfr2fibroblast growth factor receptor 20.057
Dgkbdiacylglycerol kinase, beta0.057
Prtfdc1phosphoribosyl transferase domain containing 10.057
Tcp11l2t-complex 11 (mouse) like 20.057
Pcyox1prenylcysteine oxidase 10.056
Aesamino-terminal enhancer of split0.056
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.055
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.055
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.055
Vsnl1visinin-like 10.054
Cav1caveolin 1, caveolae protein0.053
Syt3synaptotagmin III0.053
Olr1271olfactory receptor 12710.053
Cplx2complexin 20.053
Neurod2neurogenic differentiation 20.051
Epha5EphA50.051
Bcl2B-cell CLL/lymphoma 20.049
Scdstearoyl-CoA desaturase (delta-9-desaturase)0.048
Tm4sf1transmembrane 4 L six family member 10.048
Gata6GATA binding protein 60.047
Pdpnpodoplanin0.047
Ctf1cardiotrophin 10.047
Scn3asodium channel, voltage-gated, type III, alpha0.047
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.047
Trim47tripartite motif-containing 470.047
Gpr150G protein-coupled receptor 1500.046
Lphn3latrophilin 30.046
Tgfbr2transforming growth factor, beta receptor II0.046
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.046
Taf6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.045
Stat6signal transducer and activator of transcription 60.045
Dchs1dachsous 1 (Drosophila)0.045
CadpsCa++-dependent secretion activator0.044
Kcng1potassium voltage-gated channel, subfamily G, member 10.043
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.043
Slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.043
Dpy19l1dpy-19-like 1 (C. elegans)0.043
Ppt2palmitoyl-protein thioesterase 20.043
Gdf10growth differentiation factor 100.043
Col9a1collagen, type IX, alpha 10.043
Orai1ORAI calcium release-activated calcium modulator 10.042
Papss13'-phosphoadenosine 5'-phosphosulfate synthase 10.042
Sox10SRY (sex determining region Y)-box 100.042
Tspan2tetraspanin 20.041
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.041
Zmym4zinc finger, MYM-type 40.041
Ugt8UDP glycosyltransferase 80.040
Pctk1PCTAIRE protein kinase 10.040
Gnb4guanine nucleotide binding protein (G protein), beta polypeptide 40.039
Odz2odz, odd Oz/ten-m homolog 2 (Drosophila)0.039
Sfrp4secreted frizzled-related protein 40.039
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.944
sox10SRY-box containing gene 100.898
notch1anotch homolog 1a0.580
bnc2basonuclin 20.514
tuba8l3tubulin, alpha 8 like 30.480
eya1eyes absent homolog 10.444
six3bsine oculis homeobox homolog 3b0.389
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.366
rx3retinal homeobox gene 30.346
ascl1aachaete-scute complex-like 1a (Drosophila)0.330
egr1early growth response 10.321
plp1aproteolipid protein 1a0.299
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.249
egr2bearly growth response 2b0.240
nf1aneurofibromin 1a0.225
gpm6abglycoprotein M6Ab0.217
gpm6baglycoprotein M6Ba0.215
hey1hairy/enhancer-of-split related with YRPW motif 10.206
notch3notch homolog 30.178
fabp7afatty acid binding protein 7, brain, a0.173
her12hairy-related 120.151
dzip1DAZ interacting protein 10.146
tnctenascin C0.141
mbpmyelin basic protein0.138
ptmaaprothymosin, alpha a0.134
zgc:114181zgc:1141810.132
gpm6aaglycoprotein M6Aa0.122
dlcdeltaC0.112
crb2acrumbs homolog 2a0.111
pou3f3bPOU class 3 homeobox 3b0.110
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.107
six3asine oculis homeobox homolog 3a0.103
dladeltaA0.102
pax6apaired box gene 6a0.101
her15.1hairy and enhancer of split-related 15.10.099
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.098
foxa3forkhead box A30.096
dnmt6DNA (cytosine-5-)-methyltransferase 60.089
sox19aSRY-box containing gene 19a0.087
neurodneurogenic differentiation0.083
kbpkif1-binding protein0.083
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.075
dpysl5adihydropyrimidinase-like 5a0.069
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.068
nr2e1nuclear receptor subfamily 2, group E, member 10.067
pcdh10aprotocadherin 10a0.067
lmx1b.1LIM homeobox transcription factor 1, beta 10.067
cdh1cadherin 1, epithelial0.066
mdkamidkine-related growth factor0.065
hmx3homeo box (H6 family) 30.063
foxi3aforkhead box I3a0.062
spry4sprouty (Drosophila) homolog 40.062
dlbdeltaB0.062
six2asine oculis-related homeobox 2a0.060
nr2e3nuclear receptor subfamily 2, group E, member 30.055
eya2eyes absent homolog 2 (Drosophila)0.054
plp1bproteolipid protein 1b0.053
robo2roundabout homolog 20.052
dnmt8DNA (cytosine-5-)-methyltransferase 80.052
traf4atnf receptor-associated factor 4a0.051
slc4a4bsolute carrier family 4, sodium bicarbonate cotransporter, member 4b0.046
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.046
rx2retinal homeobox gene 20.045
rtn1breticulon 1b0.044
gpm6bbglycoprotein M6Bb0.044
otx2orthodenticle homolog 20.043
thrbthyroid hormone receptor beta0.043
hoxd3ahomeo box D3a0.043
cldn5aclaudin 5a0.043
mmp2matrix metalloproteinase 20.043
dmrta2doublesex and mab-3 related transcription factor like family A20.042
col2a1acollagen type II, alpha-1a0.041
fzd7bfrizzled homolog 7b0.041
lgi1aleucine-rich, glioma inactivated 1a0.041
zic6zic family member 60.040
rhoubras homolog gene family, member Ub0.040
irx4biroquois homeobox protein 4b0.040
nrarpanotch-regulated ankyrin repeat protein a0.039
edn1endothelin 10.039
rxrgaretinoid x receptor, gamma a0.039
rcv1recoverin0.039
ripk2receptor-interacting serine-threonine kinase 20.038
dachadachshund a0.037
olfm2olfactomedin 20.037
slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.037
lfnglunatic fringe homolog0.036
nrg1neuregulin 10.036
tuba1tubulin, alpha 10.035
her9hairy-related 90.034
cntn1acontactin 1a0.034
vcanbversican b0.033
hs3st1l2heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 20.033
nhsl1aNHS-like 1a0.033
prnprs3prion protein, related sequence 30.033
lama2laminin, alpha 20.033
lrrc4.1leucine rich repeat containing 4.10.032
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.032
gnalguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type0.031
her11hairy-related 110.030
vat1vesicle amine transport protein 1 homolog (T californica)0.030
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HLHmdeltaE(spl) region transcript mdelta0.542
armarmadillo0.540
norpAno receptor potential A0.499
G-oalpha47AG protein oalpha 47A0.495
HLHmgammaE(spl) region transcript mgamma0.347
HLHm7E(spl) region transcript m70.294
Ras85DRas oncogene at 85D0.238
MadMothers against dpp0.173
malphaE(spl) region transcript malpha0.170
stysprouty0.155
rhorhomboid0.127
WnkCG7177 gene product from transcript CG7177-RA0.122
HLHmbetaE(spl) region transcript mbeta0.122
NrgNeuroglian0.099
E(spl)Enhancer of split0.094
bibbig brain0.092
NrtNeurotactin0.086
beta-Specbeta Spectrin0.085
CG4020CG4020 gene product from transcript CG4020-RA0.084
Tak1TGF-beta activated kinase 10.081
McrMacroglobulin complement-related0.077
inscinscuteable0.063
m2E(spl) region transcript m20.059
Ggamma1G protein gamma 10.059
Cdk4Cyclin-dependent kinase 40.057
HLHm5E(spl) region transcript m50.054
pntpointed0.051
sdscalloped0.051
HLHm3E(spl) region transcript m30.050
stumpsCG31317 gene product from transcript CG31317-RC0.050
rawCG12437 gene product from transcript CG12437-RB0.047
prosprospero0.046
eloFelongase F0.046
kuzkuzbanian0.045
spispitz0.044
cicubitus interruptus0.042
emcextra macrochaetae0.042
ttktramtrack0.041
shnschnurri0.040
Syx1ASyntaxin 1A0.038
nrv2nervana 20.037
m4E(spl) region transcript m40.036
crbcrumbs0.035
CycJCyclin J0.035
howheld out wings0.034
tkvthickveins0.034
cnocanoe0.033
myoglianinCG1838 gene product from transcript CG1838-RD0.031
vvlventral veins lacking0.029
witwishful thinking0.027
EndoGIEndonuclease G inhibitor0.027
SNF1ASNF1A/AMP-activated protein kinase0.026
RglRal guanine nucleotide exchange factor0.023
pckpickel0.023
PRL-1CG4993 gene product from transcript CG4993-RB0.022
btlbreathless0.022
twstwins0.020
TomTwin of m40.019
IdeInsulin degrading metalloproteinase0.019
rheaCG6831 gene product from transcript CG6831-RA0.019
vrivrille0.019
Src42ASrc oncogene at 42A0.018
Xe7CG2179 gene product from transcript CG2179-RA0.017
Applbeta amyloid protein precursor-like0.017
ewgerect wing0.017
smi35Asmell impaired 35A0.017
sdtstardust0.016
Fas3Fasciclin 30.016
elavembryonic lethal abnormal vision0.016
Rya-r44FRyanodine receptor 44F0.016
scscute0.016
CG1553CG1553 gene product from transcript CG1553-RA0.016
Gcn2CG1609 gene product from transcript CG1609-RA0.016
Atg1Autophagy-specific gene 10.016
HmgsHMG Coenzyme A synthase0.016
PpnPapilin0.015
sec10CG6159 gene product from transcript CG6159-RA0.015
hipkhomeodomain interacting protein kinase0.015
mysmyospheroid0.015
dvedefective proventriculus0.015
Su(z)2Suppressor of zeste 20.015
Tre1trapped in endoderm-10.015
twitwist0.015
Nrx-IVNeurexin IV0.014
ftz-f1ftz transcription factor 10.014
Syx18Syntaxin 180.014
rostrolling stone0.014
spensplit ends0.014
rprreaper0.014
sdaslamdance0.014
DabDisabled0.013
TspThrombospondin0.013
kcckazachoc0.013
comtcomatose0.013
MaxCG9648 gene product from transcript CG9648-RA0.013
CG7337CG7337 gene product from transcript CG7337-RA0.013
CdsACDP diglyceride synthetase0.012
Snap25Synapse protein 250.012
pyrpyramus0.012
Plc21CPhospholipase C at 21C0.012
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha0.961
EGFRepidermal growth factor receptor0.478
MED25mediator complex subunit 250.289
RXRAretinoid X receptor, alpha0.271
YAP1Yes-associated protein 10.194
CAB39calcium binding protein 390.188
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.175
NCOA1nuclear receptor coactivator 10.117
TSC2tuberous sclerosis 20.063
TRAF2TNF receptor-associated factor 20.059
SOX10SRY (sex determining region Y)-box 100.050
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.050
ZMYND11zinc finger, MYND-type containing 110.040
INADLInaD-like (Drosophila)0.039
TRAF5TNF receptor-associated factor 50.036
APPamyloid beta (A4) precursor protein0.027
EXOSC10exosome component 100.026
JAM2junctional adhesion molecule 20.024
PAX3paired box 30.022
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.020
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.019
RXRBretinoid X receptor, beta0.018
EGR1early growth response 10.017
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.015
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.015
EIF2B4eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa0.013
USP22ubiquitin specific peptidase 220.012
FSTL1follistatin-like 10.011
JUPjunction plakoglobin0.011
FGF1fibroblast growth factor 1 (acidic)0.010
TP53BP2tumor protein p53 binding protein, 20.010
CD81CD81 molecule0.010
BTRCbeta-transducin repeat containing0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.996
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.994
Egr2early growth response 20.992
Tjp1tight junction protein 10.985
Ptpn11protein tyrosine phosphatase, non-receptor type 110.983
Ctnnb1catenin (cadherin associated protein), beta 10.953
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.951
Isl1ISL1 transcription factor, LIM/homeodomain0.949
Otx2orthodenticle homolog 2 (Drosophila)0.944
Ptenphosphatase and tensin homolog0.926
Emx1empty spiracles homolog 1 (Drosophila)0.917
Ltalymphotoxin A0.911
Mpdzmultiple PDZ domain protein0.903
Lef1lymphoid enhancer binding factor 10.894
Ntf3neurotrophin 30.881
Klk1b21kallikrein 1-related peptidase b210.871
Pax8paired box gene 80.864
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.852
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.848
Map3k14mitogen-activated protein kinase kinase kinase 140.835
Klk1b5kallikrein 1-related peptidase b50.828
Tgfb1transforming growth factor, beta 10.811
Id3inhibitor of DNA binding 30.804
Pax6paired box gene 60.795
Prnpprion protein0.773
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.770
Ugt8aUDP galactosyltransferase 8A0.756
Plp1proteolipid protein (myelin) 10.745
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.744
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.742
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.736
Lhx1LIM homeobox protein 10.735
Sox2SRY-box containing gene 20.727
Shhsonic hedgehog0.723
Id1inhibitor of DNA binding 10.714
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.709
Lin7clin-7 homolog C (C. elegans)0.699
Fgf8fibroblast growth factor 80.688
Ccr2chemokine (C-C motif) receptor 20.679
Emx2empty spiracles homolog 2 (Drosophila)0.675
Mobpmyelin-associated oligodendrocytic basic protein0.665
Hrhairless0.648
Itgb1integrin beta 1 (fibronectin receptor beta)0.635
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.622
Klk1b26kallikrein 1-related petidase b260.621
Appamyloid beta (A4) precursor protein0.611
Lhx3LIM homeobox protein 30.604
Slc12a2solute carrier family 12, member 20.576
Klk6kallikrein related-peptidase 60.571
Bdnfbrain derived neurotrophic factor0.568
Rargretinoic acid receptor, gamma0.563
Apoeapolipoprotein E0.547
Retret proto-oncogene0.539
Pou3f2POU domain, class 3, transcription factor 20.537
Olig2oligodendrocyte transcription factor 20.530
Dccdeleted in colorectal carcinoma0.519
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.517
Ltblymphotoxin B0.503
Sstr4somatostatin receptor 40.501
2210010C04RikRIKEN cDNA 2210010C04 gene0.501
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.500
Nab2Ngfi-A binding protein 20.492
Ptgs2prostaglandin-endoperoxide synthase 20.486
Tbx1T-box 10.486
Sox9SRY-box containing gene 90.473
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.472
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.467
Klk1b11kallikrein 1-related peptidase b110.460
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.452
Dlg4discs, large homolog 4 (Drosophila)0.444
Rxraretinoid X receptor alpha0.444
Tff2trefoil factor 2 (spasmolytic protein 1)0.436
Phox2bpaired-like homeobox 2b0.436
KelKell blood group0.431
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.429
Insm1insulinoma-associated 10.429
Pdx1pancreatic and duodenal homeobox 10.427
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.426
Cdx1caudal type homeobox 10.425
Gjd3gap junction protein, delta 30.423
Ctrb1chymotrypsinogen B10.416
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.411
Mogmyelin oligodendrocyte glycoprotein0.400
Id4inhibitor of DNA binding 40.397
Ptprz1protein tyrosine phosphatase, receptor type Z, polypeptide 10.396
Scn5asodium channel, voltage-gated, type V, alpha0.396
Chd7chromodomain helicase DNA binding protein 70.391
Nos1nitric oxide synthase 1, neuronal0.383
Nognoggin0.376
Cuzd1CUB and zona pellucida-like domains 10.373
Hes1hairy and enhancer of split 1 (Drosophila)0.373
Klk1kallikrein 10.371
Thrbthyroid hormone receptor beta0.371
Pitx2paired-like homeodomain transcription factor 20.370
Lepleptin0.370
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.369
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.362
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.362
Pick1protein interacting with C kinase 10.361
Tgfb2transforming growth factor, beta 20.360
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism