The network for 'activation of protein kinase b activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of protein kinase b activity

Any process that initiates the activity of the inactive enzyme protein kinase B.

NameDescriptionProbabilityFunc Analog Organism
Sirpasignal-regulatory protein alpha0.206
Fmnl1formin-like 10.142
Gna12guanine nucleotide binding protein (G protein) alpha 120.141
Ptprcprotein tyrosine phosphatase, receptor type, C0.081
Fam70bfamily with sequence similarity 70, member B0.081
Dock8dedicator of cytokinesis 80.079
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.077
Eef2eukaryotic translation elongation factor 20.077
Rab1bRAB1B, member RAS oncogene family0.077
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.071
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.069
Fgfr1Fibroblast growth factor receptor 10.066
Adaradenosine deaminase, RNA-specific0.062
Inpp5dinositol polyphosphate-5-phosphatase D0.058
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.058
Hist1h1ahistone cluster 1, H1a0.049
Tgfb1transforming growth factor, beta 10.044
Il1binterleukin 1 beta0.041
Nrasneuroblastoma ras oncogene0.041
Syngr2synaptogyrin 20.041
Il2rbinterleukin 2 receptor, beta0.041
Hk1hexokinase 10.040
Stat6signal transducer and activator of transcription 60.040
Cd247Cd247 molecule0.037
Cd83CD83 molecule0.037
Il18interleukin 180.035
Cd37CD37 molecule0.035
Ptafrplatelet-activating factor receptor0.034
Smad7SMAD family member 70.034
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.032
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.031
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.031
Vav1vav 1 guanine nucleotide exchange factor0.030
Ptproprotein tyrosine phosphatase, receptor type, O0.030
Usf2upstream transcription factor 2, c-fos interacting0.030
Gja1gap junction protein, alpha 10.029
Slc4a1solute carrier family 4 (anion exchanger), member 10.029
Mpripmyosin phosphatase Rho interacting protein0.029
Myh9myosin, heavy chain 9, non-muscle0.029
Sptbn2spectrin, beta, non-erythrocytic 20.029
BokBCL2-related ovarian killer0.028
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.028
Sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.027
Epn2epsin 20.027
Rgs14regulator of G-protein signaling 140.027
Cx3cl1chemokine (C-X3-C motif) ligand 10.027
Arf5ADP-ribosylation factor 50.027
Cyfip2cytoplasmic FMR1 interacting protein 20.026
Olr1469olfactory receptor Olr14690.026
Lphn1latrophilin 10.026
Fgfr2fibroblast growth factor receptor 20.025
Casp1caspase 10.024
Prkcdprotein kinase C, delta0.024
Icosinducible T-cell co-stimulator0.024
Csnk1g2casein kinase 1, gamma 20.024
RGD1311493similar to CG13379-PA0.024
Cd4Cd4 molecule0.024
Itpr3inositol 1,4,5-triphosphate receptor, type 30.023
Oclnoccludin0.023
Cyth1cytohesin 10.023
Il2rginterleukin 2 receptor, gamma0.023
Ly86lymphocyte antigen 860.022
Rassf5Ras association (RalGDS/AF-6) domain family member 50.022
Foxg1forkhead box G10.022
Tgfbr2transforming growth factor, beta receptor II0.022
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.022
Sema6bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B0.022
Ptpn6protein tyrosine phosphatase, non-receptor type 60.022
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.022
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.022
Ddr1discoidin domain receptor tyrosine kinase 10.022
LOC100364500RT1 class I, locus CE11-like0.022
Olr857olfactory receptor 8570.021
Hckhemopoietic cell kinase0.021
Faahfatty acid amide hydrolase0.021
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.021
BidBH3 interacting domain death agonist0.021
Cnksr2connector enhancer of kinase suppressor of Ras 20.021
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.020
Myo1gmyosin IG0.020
Sykspleen tyrosine kinase0.020
Ttc3tetratricopeptide repeat domain 30.020
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.020
Cgaglycoprotein hormones, alpha polypeptide0.020
Ccnd3cyclin D30.020
Olr1701olfactory receptor 17010.019
Ptk2bPTK2B protein tyrosine kinase 2 beta0.019
Arl5cADP-ribosylation factor-like 5C0.019
Fusip1FUS interacting protein (serine-arginine rich) 10.019
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.019
Sbk1SH3-binding domain kinase 10.019
Adrbk1adrenergic, beta, receptor kinase 10.019
Arhgap27Rho GTPase activating protein 270.019
Cfpcomplement factor properdin0.019
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.018
Irs1insulin receptor substrate 10.018
Rasa2RAS p21 protein activator 20.018
Calcrlcalcitonin receptor-like0.018
Cd3gCD3 molecule, gamma0.018
Lmo2LIM domain only 20.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.989
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.961
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.861
NTRK1neurotrophic tyrosine kinase, receptor, type 10.845
VEGFAvascular endothelial growth factor A0.836
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.764
EGFRepidermal growth factor receptor0.751
MPDZmultiple PDZ domain protein0.660
NRP1neuropilin 10.469
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.396
FAF1Fas (TNFRSF6) associated factor 10.373
INSRinsulin receptor0.330
AXLAXL receptor tyrosine kinase0.321
IGF1Rinsulin-like growth factor 1 receptor0.288
ANGangiogenin, ribonuclease, RNase A family, 50.271
CAV1caveolin 1, caveolae protein, 22kDa0.267
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.253
RNASE4ribonuclease, RNase A family, 40.199
PLCG1phospholipase C, gamma 10.186
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.184
IRS1insulin receptor substrate 10.160
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.119
GRB2growth factor receptor-bound protein 20.112
PDGFCplatelet derived growth factor C0.091
GRB10growth factor receptor-bound protein 100.075
FZD1frizzled homolog 1 (Drosophila)0.055
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.055
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.054
IRS2insulin receptor substrate 20.047
PGFplacental growth factor0.041
NGFnerve growth factor (beta polypeptide)0.040
ITGB1BP3integrin beta 1 binding protein 30.033
GHRgrowth hormone receptor0.031
BCAR1breast cancer anti-estrogen resistance 10.029
ARRDC3arrestin domain containing 30.028
CARD11caspase recruitment domain family, member 110.027
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.024
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.023
COL6A1collagen, type VI, alpha 10.023
PDGFAplatelet-derived growth factor alpha polypeptide0.021
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.020
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.019
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.018
NTRK3neurotrophic tyrosine kinase, receptor, type 30.018
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.018
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.017
FGFR1fibroblast growth factor receptor 10.017
SHC3SHC (Src homology 2 domain containing) transforming protein 30.016
IGF2Rinsulin-like growth factor 2 receptor0.015
LATlinker for activation of T cells0.015
NTF3neurotrophin 30.014
NGFRnerve growth factor receptor0.013
TBX5T-box 50.013
PTENphosphatase and tensin homolog0.012
EPORerythropoietin receptor0.011
COL5A1collagen, type V, alpha 10.011
C1orf93chromosome 1 open reading frame 930.010
AKT1v-akt murine thymoma viral oncogene homolog 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism