The network for 'regulation of platelet activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of platelet activation

Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.

NameDescriptionProbabilityFunc Analog Organism
Cd44Cd44 molecule0.110
Gja1gap junction protein, alpha 10.079
Icam1intercellular adhesion molecule 10.070
Ddr2discoidin domain receptor tyrosine kinase 20.061
Olr1500olfactory receptor 15000.054
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.052
Bst1bone marrow stromal cell antigen 10.051
Ccl4chemokine (C-C motif) ligand 40.048
AxlAxl receptor tyrosine kinase0.044
Itgb7integrin, beta 70.042
Casp1caspase 10.040
RorbRAR-related orphan receptor B0.040
Edn1endothelin 10.039
Inpp5dinositol polyphosphate-5-phosphatase D0.038
Ptafrplatelet-activating factor receptor0.038
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.038
Arl11ADP-ribosylation factor-like 110.037
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.037
Phkg1phosphorylase kinase, gamma 10.034
Pmp22peripheral myelin protein 220.034
Pla1aphospholipase A1 member A0.034
Fgf14fibroblast growth factor 140.033
Plauplasminogen activator, urokinase0.033
Ccl3chemokine (C-C motif) ligand 30.032
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.032
Colec12collectin sub-family member 120.030
Cma1chymase 1, mast cell0.030
Gpc3glypican 30.030
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.029
Gna15guanine nucleotide binding protein, alpha 150.029
Fn1fibronectin 10.029
Hckhemopoietic cell kinase0.028
Rassf5Ras association (RalGDS/AF-6) domain family member 50.027
Gucy2fguanylate cyclase 2F0.027
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.026
Cd37CD37 molecule0.026
Wipf1WAS/WASL interacting protein family, member 10.026
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.026
Fshbfollicle stimulating hormone, beta polypeptide0.026
Pecam1platelet/endothelial cell adhesion molecule 10.025
Aebp1AE binding protein 10.025
Gja4gap junction protein, alpha 40.025
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.024
Pthparathyroid hormone0.024
Cd83CD83 molecule0.024
Ltbp3latent transforming growth factor beta binding protein 30.023
Agtr1aangiotensin II receptor, type 1a0.023
Runx1runt-related transcription factor 10.023
Mmp12matrix metallopeptidase 120.023
Ednrbendothelin receptor type B0.023
Gpr88G-protein coupled receptor 880.023
Homer3homer homolog 3 (Drosophila)0.023
RGD1564664similar to LOC387763 protein0.022
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.022
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.022
Il7interleukin 70.022
Il1rapinterleukin 1 receptor accessory protein0.022
Cd247Cd247 molecule0.021
Slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.021
Gria4glutamate receptor, ionotrophic, AMPA 40.021
Ly86lymphocyte antigen 860.021
Tpsb2tryptase beta 20.021
Crhbpcorticotropin releasing hormone binding protein0.021
Csrnp2cysteine-serine-rich nuclear protein 20.020
Fat3FAT tumor suppressor homolog 3 (Drosophila)0.020
Npy5rneuropeptide Y receptor Y50.020
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.020
Ctrcchymotrypsin C (caldecrin)0.020
Kcnk13potassium channel, subfamily K, member 130.020
Cd5Cd5 molecule0.020
C5ar1complement component 5a receptor 10.020
Ripk3receptor-interacting serine-threonine kinase 30.020
LOC60591calcium-activated potassium channel beta subunit0.020
Olr287olfactory receptor 2870.020
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.020
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.020
Dock8dedicator of cytokinesis 80.020
Fgf7fibroblast growth factor 70.019
Lst1leukocyte specific transcript 10.019
Kalrnkalirin, RhoGEF kinase0.019
Lamc1laminin, gamma 10.019
Prrx1paired related homeobox 10.019
Il6interleukin 60.019
Olr1523olfactory receptor 15230.019
Gad2glutamate decarboxylase 20.019
Adam17ADAM metallopeptidase domain 170.019
Mmp9matrix metallopeptidase 90.019
Rhojras homolog gene family, member J0.019
Athl1ATH1, acid trehalase-like 1 (yeast)0.019
Tal1T-cell acute lymphocytic leukemia 10.018
Cxcl2chemokine (C-X-C motif) ligand 20.018
Crygecrystallin, gamma E0.018
Il1binterleukin 1 beta0.018
Arnt2aryl hydrocarbon receptor nuclear translocator 20.018
S1pr2sphingosine-1-phosphate receptor 20.018
Slasrc-like adaptor0.018
A3galt2alpha 1,3-galactosyltransferase 20.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.812
NCF1neutrophil cytosolic factor 10.750
C1QAcomplement component 1, q subcomponent, A chain0.690
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.646
VEGFAvascular endothelial growth factor A0.473
PLCG1phospholipase C, gamma 10.395
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.221
NRP1neuropilin 10.173
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.168
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.149
SYKspleen tyrosine kinase0.087
C1QCcomplement component 1, q subcomponent, C chain0.064
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.060
CTNND1catenin (cadherin-associated protein), delta 10.050
EGFRepidermal growth factor receptor0.049
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.046
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.041
LATlinker for activation of T cells0.038
FASLGFas ligand (TNF superfamily, member 6)0.035
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.029
C1QBcomplement component 1, q subcomponent, B chain0.028
GAB1GRB2-associated binding protein 10.027
LCKlymphocyte-specific protein tyrosine kinase0.025
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.022
CDH5cadherin 5, type 2 (vascular endothelium)0.021
PGFplacental growth factor0.019
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.017
APOC1apolipoprotein C-I0.015
LY96lymphocyte antigen 960.014
LCATlecithin-cholesterol acyltransferase0.014
PDGFAplatelet-derived growth factor alpha polypeptide0.013
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.012
BTKBruton agammaglobulinemia tyrosine kinase0.012
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.011
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.011
ZNF746zinc finger protein 7460.011
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.010
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.010
KITLGKIT ligand0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lcklymphocyte protein tyrosine kinase0.910
Ldb3LIM domain binding 30.887
Ptprcprotein tyrosine phosphatase, receptor type, C0.832
FasFas (TNF receptor superfamily member 6)0.622
Selpselectin, platelet0.579
Prkceprotein kinase C, epsilon0.446
Latlinker for activation of T cells0.444
Il2rginterleukin 2 receptor, gamma chain0.399
BlnkB-cell linker0.373
Lyz2lysozyme 20.358
FynFyn proto-oncogene0.342
Ikzf1IKAROS family zinc finger 10.312
Rag2recombination activating gene 20.302
Cd28CD28 antigen0.246
Nos3nitric oxide synthase 3, endothelial cell0.238
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.222
Cd19CD19 antigen0.212
TcraT-cell receptor alpha chain0.174
Ccr2chemokine (C-C motif) receptor 20.171
Sykbspleen tyrosine kinase0.138
Ighimmunoglobulin heavy chain complex0.124
Ush1gUsher syndrome 1G homolog (human)0.116
SrcRous sarcoma oncogene0.112
Itgb3integrin beta 30.095
Lcp1lymphocyte cytosolic protein 10.083
Zap70zeta-chain (TCR) associated protein kinase0.079
Ush1cUsher syndrome 1C homolog (human)0.078
Ppargperoxisome proliferator activated receptor gamma0.076
Seleselectin, endothelial cell0.075
Actn2actinin alpha 20.070
Prkcbprotein kinase C, beta0.069
Cdh5cadherin 50.066
Sellselectin, lymphocyte0.065
Tnftumor necrosis factor0.065
Alox5aparachidonate 5-lipoxygenase activating protein0.062
WasWiskott-Aldrich syndrome homolog (human)0.062
FybFYN binding protein0.059
Mmp9matrix metallopeptidase 90.059
Ptpreprotein tyrosine phosphatase, receptor type, E0.058
Orai1ORAI calcium release-activated calcium modulator 10.057
Bcl2B-cell leukemia/lymphoma 20.057
Il7rinterleukin 7 receptor0.057
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.055
Nfam1Nfat activating molecule with ITAM motif 10.054
Grxcr1glutaredoxin, cysteine rich 10.053
Sirpasignal-regulatory protein alpha0.051
Ptk2bPTK2 protein tyrosine kinase 2 beta0.051
CblCasitas B-lineage lymphoma0.050
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.049
Plcd1phospholipase C, delta 10.049
Ptenphosphatase and tensin homolog0.049
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.049
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.048
Cd4CD4 antigen0.048
Ptk2PTK2 protein tyrosine kinase 20.047
Cd14CD14 antigen0.047
Vhlvon Hippel-Lindau tumor suppressor0.042
Grb2growth factor receptor bound protein 20.042
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.042
Myo6myosin VI0.041
Ticam1toll-like receptor adaptor molecule 10.038
Ncoa3nuclear receptor coactivator 30.036
ND6NADH dehydrogenase subunit 60.036
Cx3cr1chemokine (C-X3-C) receptor 10.035
Rasgrp1RAS guanyl releasing protein 10.034
Rag1recombination activating gene 10.034
Cd22CD22 antigen0.034
BlkB lymphoid kinase0.033
Slasrc-like adaptor0.033
Rgs14regulator of G-protein signaling 140.033
Notch2Notch gene homolog 2 (Drosophila)0.033
Itgb2integrin beta 20.033
Csf1colony stimulating factor 1 (macrophage)0.032
Il2rbinterleukin 2 receptor, beta chain0.032
LOC100503041PDZ domain-containing protein 7-like0.031
Foxn1forkhead box N10.030
ItkIL2-inducible T-cell kinase0.030
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.029
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.028
Inpp5dinositol polyphosphate-5-phosphatase D0.028
Akt1thymoma viral proto-oncogene 10.028
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.026
Asprv1aspartic peptidase, retroviral-like 10.025
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.025
Ccl4chemokine (C-C motif) ligand 40.025
Cd247CD247 antigen0.025
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.024
Cd40CD40 antigen0.023
Fcgr1Fc receptor, IgG, high affinity I0.023
Fbxw7F-box and WD-40 domain protein 70.022
Myo7amyosin VIIA0.022
Lair1leukocyte-associated Ig-like receptor 10.022
Cmklr1chemokine-like receptor 10.022
Hcsthematopoietic cell signal transducer0.021
Fam65bfamily with sequence similarity 65, member B0.021
Nfibnuclear factor I/B0.021
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.021
Itga2bintegrin alpha 2b0.020
Myo15myosin XV0.020
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism