The network for 'protein homotetramerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein homotetramerization

The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.

NameDescriptionProbabilityFunc Analog Organism
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.770
Gpiglucose phosphate isomerase0.422
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.407
Acadvlacyl-Coenzyme A dehydrogenase, very long chain0.265
Pkm2pyruvate kinase, muscle0.262
Acaa2acetyl-Coenzyme A acyltransferase 20.247
Etfdhelectron-transferring-flavoprotein dehydrogenase0.192
Etfaelectron-transfer-flavoprotein, alpha polypeptide0.148
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.132
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.095
Acat1acetyl-coenzyme A acetyltransferase 10.089
Adkadenosine kinase0.076
Hpd4-hydroxyphenylpyruvate dioxygenase0.075
Suclg2succinate-CoA ligase, GDP-forming, beta subunit0.074
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.073
CnbpCCHC-type zinc finger, nucleic acid binding protein0.069
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.063
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.062
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.062
Gsta3glutathione S-transferase A30.061
Akap1A kinase (PRKA) anchor protein 10.057
Exoc5exocyst complex component 50.056
Pgm1phosphoglucomutase 10.053
Nckap1NCK-associated protein 10.047
Slc25a20solute carrier family 25 (carnitine/acylcarnitine translocase), member 200.046
Gcdhglutaryl-Coenzyme A dehydrogenase0.046
Eef1a2eukaryotic translation elongation factor 1 alpha 20.042
Pygmphosphorylase, glycogen, muscle0.041
Oplah5-oxoprolinase (ATP-hydrolysing)0.039
Acox1acyl-Coenzyme A oxidase 1, palmitoyl0.037
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.035
Cpt2carnitine palmitoyltransferase 20.033
Aldh9a1aldehyde dehydrogenase 9 family, member A10.031
Hspa9heat shock protein 90.031
Gabrb2gamma-aminobutyric acid (GABA) A receptor, beta 20.030
Ivdisovaleryl coenzyme A dehydrogenase0.029
Tfrctransferrin receptor0.028
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.028
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.028
Trim23tripartite motif-containing 230.028
Neu2sialidase 2 (cytosolic sialidase)0.027
Tmem38atransmembrane protein 38a0.026
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.024
Dmddystrophin0.024
Fkbp4FK506 binding protein 40.024
Vat1vesicle amine transport protein 1 homolog (T californica)0.023
Ldhdlactate dehydrogenase D0.022
Sec31aSEC31 homolog A (S. cerevisiae)0.022
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.022
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.021
Abhd14babhydrolase domain containing 14b0.021
Ahcyadenosylhomocysteinase0.021
UncxUNC homeobox0.021
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.021
Cdk5rap1CDK5 regulatory subunit associated protein 10.021
Aldh4a1aldehyde dehydrogenase 4 family, member A10.021
RGD1309501hypothetical LOC3055520.021
Eci1enoyl-Coenzyme A delta isomerase 10.020
Bckdhbbranched chain keto acid dehydrogenase E1, beta polypeptide0.020
Khkketohexokinase0.020
Eci2enoyl-Coenzyme A delta isomerase 20.020
Ddcdopa decarboxylase (aromatic L-amino acid decarboxylase)0.019
Snrpnsmall nuclear ribonucleoprotein polypeptide N0.019
DdtD-dopachrome tautomerase0.019
Mgst1microsomal glutathione S-transferase 10.019
Agtpbp1ATP/GTP binding protein 10.018
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.018
Car5acarbonic anhydrase 5a, mitochondrial0.018
Eno1enolase 1, (alpha)0.018
Ambpalpha-1-microglobulin/bikunin precursor0.018
Tmem218transmembrane protein 2180.018
Phka1phosphorylase kinase, alpha 10.018
Fgf14fibroblast growth factor 140.018
Ppp3r2protein phosphatase 3, regulatory subunit B, beta isoform0.017
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.017
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.017
GnasGNAS complex locus0.017
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.016
Upb1ureidopropionase, beta0.016
Cabp1calcium binding protein 10.016
Gnmtglycine N-methyltransferase0.016
Akr1c18aldo-keto reductase family 1, member C180.015
Dpysdihydropyrimidinase0.015
Slc30a2solute carrier family 30 (zinc transporter), member 20.015
Uoxurate oxidase0.015
Dlg1discs, large homolog 1 (Drosophila)0.015
Haao3-hydroxyanthranilate 3,4-dioxygenase0.015
Tpi1triosephosphate isomerase 10.015
RGD1311612similar to hypothetical protein FLJ121180.015
Gsta4glutathione S-transferase alpha 40.015
Cntn4contactin 40.015
Nefhneurofilament, heavy polypeptide0.015
Qarsglutaminyl-tRNA synthetase0.014
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.014
Rpl3lribosomal protein L3-like0.014
Calm4calmodulin 40.014
Acsm3acyl-CoA synthetase medium-chain family member 30.014
LOC56764dnaj-like protein0.013
Lipalipase A, lysosomal acid, cholesterol esterase0.013
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ncdnon-claret disjunctional0.012
CG17597CG17597 gene product from transcript CG17597-RA0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha0.797
LIN7Blin-7 homolog B (C. elegans)0.571
HLCSholocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)0.478
NME1non-metastatic cells 1, protein (NM23A) expressed in0.466
SMN1survival of motor neuron 1, telomeric0.408
PEX19peroxisomal biogenesis factor 190.292
PEX14peroxisomal biogenesis factor 140.255
ETFDHelectron-transferring-flavoprotein dehydrogenase0.231
MED25mediator complex subunit 250.206
HADHhydroxyacyl-CoA dehydrogenase0.188
PEX5peroxisomal biogenesis factor 50.179
WDYHV1WDYHV motif containing 10.137
ZYXzyxin0.115
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.111
PEX12peroxisomal biogenesis factor 120.106
RTCD1RNA terminal phosphate cyclase domain 10.098
EPT1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)0.097
PRTFDC1phosphoribosyl transferase domain containing 10.094
PEMTphosphatidylethanolamine N-methyltransferase0.093
CCL3chemokine (C-C motif) ligand 30.091
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.090
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase0.089
MYOZ1myozenin 10.089
FLNAfilamin A, alpha0.083
WWOXWW domain containing oxidoreductase0.076
NCOA1nuclear receptor coactivator 10.075
HMMRhyaluronan-mediated motility receptor (RHAMM)0.068
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.066
PROX1prospero homeobox 10.062
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.062
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.062
SPOPspeckle-type POZ protein0.057
ARRB1arrestin, beta 10.054
PDLIM1PDZ and LIM domain 10.053
HSD17B4hydroxysteroid (17-beta) dehydrogenase 40.048
AGLamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase0.046
FAF1Fas (TNFRSF6) associated factor 10.045
TRIP13thyroid hormone receptor interactor 130.042
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.040
FAM46Afamily with sequence similarity 46, member A0.040
KRT5keratin 50.039
ABCD3ATP-binding cassette, sub-family D (ALD), member 30.038
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.037
HIBCH3-hydroxyisobutyryl-CoA hydrolase0.037
STRA13stimulated by retinoic acid 13 homolog (mouse)0.036
NR0B2nuclear receptor subfamily 0, group B, member 20.035
SATB2SATB homeobox 20.035
RXRAretinoid X receptor, alpha0.034
SKIV2L2superkiller viralicidic activity 2-like 2 (S. cerevisiae)0.034
IDH1isocitrate dehydrogenase 1 (NADP+), soluble0.034
SGK3serum/glucocorticoid regulated kinase family, member 30.033
ECI2enoyl-CoA delta isomerase 20.031
ACADSBacyl-CoA dehydrogenase, short/branched chain0.029
RBBP8retinoblastoma binding protein 80.029
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.029
PXMP2peroxisomal membrane protein 2, 22kDa0.028
OSBPoxysterol binding protein0.028
PEX13peroxisomal biogenesis factor 130.027
ECHS1enoyl CoA hydratase, short chain, 1, mitochondrial0.027
POLR2Ipolymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa0.025
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.025
MYH9myosin, heavy chain 9, non-muscle0.025
NIPSNAP1nipsnap homolog 1 (C. elegans)0.024
ECH1enoyl CoA hydratase 1, peroxisomal0.023
YAP1Yes-associated protein 10.023
SREBF2sterol regulatory element binding transcription factor 20.023
TTNtitin0.023
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.021
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.021
NDUFS8NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)0.021
PHYHphytanoyl-CoA 2-hydroxylase0.021
ADH5alcohol dehydrogenase 5 (class III), chi polypeptide0.020
PEX3peroxisomal biogenesis factor 30.020
LASP1LIM and SH3 protein 10.020
TMEM97transmembrane protein 970.019
GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase0.019
NEDD9neural precursor cell expressed, developmentally down-regulated 90.019
HSD17B14hydroxysteroid (17-beta) dehydrogenase 140.019
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.019
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.018
PCTPphosphatidylcholine transfer protein0.018
TJP1tight junction protein 1 (zona occludens 1)0.018
YLPM1YLP motif containing 10.018
BRAPBRCA1 associated protein0.017
MYD88myeloid differentiation primary response gene (88)0.017
DHRS4dehydrogenase/reductase (SDR family) member 40.017
KCNJ16potassium inwardly-rectifying channel, subfamily J, member 160.017
TRIM63tripartite motif containing 630.017
HIPK3homeodomain interacting protein kinase 30.017
ALDH6A1aldehyde dehydrogenase 6 family, member A10.016
VASPvasodilator-stimulated phosphoprotein0.016
GCDHglutaryl-CoA dehydrogenase0.016
C6orf108chromosome 6 open reading frame 1080.016
NAMPTnicotinamide phosphoribosyltransferase0.016
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.016
ANXA7annexin A70.016
KRT6Ckeratin 6C0.016
PPP1R13Bprotein phosphatase 1, regulatory (inhibitor) subunit 13B0.015
CD81CD81 molecule0.015
ATP5G1ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hint2histidine triad nucleotide binding protein 20.152
Acaa2acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)0.067
Akr7a5aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)0.067
Pgls6-phosphogluconolactonase0.052
Eci1enoyl-Coenzyme A delta isomerase 10.051
DdtD-dopachrome tautomerase0.040
Mceemethylmalonyl CoA epimerase0.039
Etfaelectron transferring flavoprotein, alpha polypeptide0.034
Phyhphytanoyl-CoA hydroxylase0.033
Nudt1nudix (nucleoside diphosphate linked moiety X)-type motif 10.023
0610007C21RikRIKEN cDNA 0610007C21 gene0.022
Aldoaaldolase A, fructose-bisphosphate0.022
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.021
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.018
Ldb3LIM domain binding 30.018
Pex7peroxisomal biogenesis factor 70.017
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.017
Eci2enoyl-Coenzyme A delta isomerase 20.015
Pkm2pyruvate kinase, muscle0.014
Srebf1sterol regulatory element binding transcription factor 10.013
Cbr4carbonyl reductase 40.012
Hrchistidine rich calcium binding protein0.012
Clyblcitrate lyase beta like0.011
Gstk1glutathione S-transferase kappa 10.011
Hsdl2hydroxysteroid dehydrogenase like 20.011
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.011
Pgk1phosphoglycerate kinase 10.011
Tpi1triosephosphate isomerase 10.011
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.011
Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
DCS2Dcs2p0.051
ALD3Ald3p0.039
GCY1Gcy1p0.030
ACC1Acc1p0.029
PEX2Pex2p0.027
PEX1Pex1p0.025
FAS1Fas1p0.023
URA2Ura2p0.023
YLR264C-Ahypothetical protein0.021
ALD2Ald2p0.020
SRD1Srd1p0.020
LEU2Leu2p0.019
DCI1Dci1p0.019
LAP3Lap3p0.019
YAR068Whypothetical protein0.018
YOL038C-Ahypothetical protein0.018
YLR162Whypothetical protein0.018
ECI1Eci1p0.018
GSP2Gsp2p0.018
ARP10Arp10p0.017
HOR7Hor7p0.017
URA3Ura3p0.016
MER1Mer1p0.016
PEX5Pex5p0.016
FAA2Faa2p0.016
CUP1-1Cup1-1p0.016
HXT3Hxt3p0.016
ARG8Arg8p0.015
BRN1Brn1p0.015
NUD1Nud1p0.015
ATP6Atp6p0.015
YPR157Whypothetical protein0.015
SPL2Spl2p0.014
YAR066Whypothetical protein0.014
YJL218Whypothetical protein0.014
CRP1Crp1p0.014
ZPS1Zps1p0.014
SMC4Smc4p0.014
HPF1Hpf1p0.014
YMR160Whypothetical protein0.014
MNN4Mnn4p0.014
HOHop0.014
DUR1,2Dur1,2p0.014
SAM2Sam2p0.014
YKR075Chypothetical protein0.014
YBR013Chypothetical protein0.013
YLR042Chypothetical protein0.013
CPD1Cpd1p0.013
FAA1Faa1p0.013
PEX11Pex11p0.013
YEL073Chypothetical protein0.013
FMT1Fmt1p0.013
NCE103Nce103p0.013
TKL2Tkl2p0.013
ICS2Ics2p0.013
OPT2Opt2p0.013
AUA1Aua1p0.013
YIR035Chypothetical protein0.013
YIL151Chypothetical protein0.013
CDD1Cdd1p0.013
YHB1Yhb1p0.013
YOL013W-Ahypothetical protein0.013
GAD1Gad1p0.013
TYE7Tye7p0.012
DIC1Dic1p0.012
FAS2Fas2p0.012
AQY2Aqy2p0.012
VAB2Vab2p0.012
PNS1Pns1p0.012
MF(ALPHA)2Mf(alpha)2p0.012
ALD4Ald4p0.012
ADH2Adh2p0.012
SGO1Sgo1p0.012
YLR040Chypothetical protein0.012
YPL066Whypothetical protein0.012
REE1Ree1p0.012
YAL037C-Ahypothetical protein0.012
PEX12Pex12p0.012
BAT2Bat2p0.012
YMR317Whypothetical protein0.012
CHA1Cha1p0.012
YPL168Whypothetical protein0.012
SPG3Spg3p0.012
HOR2Hor2p0.012
ATO3Ato3p0.012
BSC1Bsc1p0.012
ALT2Alt2p0.012
BIO2Bio2p0.012
MET8Met8p0.011
PEX10Pex10p0.011
PEX15Pex15p0.011
IZH4Izh4p0.011
CAR1Car1p0.011
YOL014Whypothetical protein0.011
MFA2Mfa2p0.011
YPR096Chypothetical protein0.011
AGC1Agc1p0.011
YAL064Whypothetical protein0.011
AAP1Aap1p0.011
YJL181Whypothetical protein0.011