The network for 'regulation of cholesterol metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cholesterol metabolic process

Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp51cytochrome P450, family 510.886
Sc4molsterol-C4-methyl oxidase-like0.750
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.476
Sqlesqualene epoxidase0.437
Idi1isopentenyl-diphosphate delta isomerase 10.256
Fdft1farnesyl diphosphate farnesyl transferase 10.209
Acaa2acetyl-Coenzyme A acyltransferase 20.182
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.181
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.180
Insig1insulin induced gene 10.157
Cpt2carnitine palmitoyltransferase 20.123
Lsslanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.093
Acat3acetyl-Coenzyme A acetyltransferase 30.092
Fasnfatty acid synthase0.081
Etfdhelectron-transferring-flavoprotein dehydrogenase0.078
Acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.055
Hadhbhydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit0.050
Mvdmevalonate (diphospho) decarboxylase0.050
Dhcr2424-dehydrocholesterol reductase0.037
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.037
Ddr1discoidin domain receptor tyrosine kinase 10.033
Slc25a20solute carrier family 25 (carnitine/acylcarnitine translocase), member 200.032
Eci2enoyl-Coenzyme A delta isomerase 20.027
DbpD site of albumin promoter (albumin D-box) binding protein0.026
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.022
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.020
Mvkmevalonate kinase0.017
Retsatretinol saturase (all trans retinol 13,14 reductase)0.013
Sc5dlsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.011
NsdhlNAD(P) dependent steroid dehydrogenase-like0.011
Slc25a1solute carrier family 25 (mitochondrial carrier, citrate transporter), member 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGFR1fibroblast growth factor receptor 10.996
FGF1fibroblast growth factor 1 (acidic)0.992
HPhaptoglobin0.873
A2Malpha-2-macroglobulin0.759
FGF10fibroblast growth factor 100.588
APOC1apolipoprotein C-I0.588
ALBalbumin0.402
MED15mediator complex subunit 150.369
FGFR3fibroblast growth factor receptor 30.350
PRDX1peroxiredoxin 10.233
LCATlecithin-cholesterol acyltransferase0.221
APOA2apolipoprotein A-II0.176
APOA1apolipoprotein A-I0.111
ACAA1acetyl-CoA acyltransferase 10.108
FGF8fibroblast growth factor 8 (androgen-induced)0.098
TXNthioredoxin0.080
FGAfibrinogen alpha chain0.075
CTGFconnective tissue growth factor0.075
SREBF2sterol regulatory element binding transcription factor 20.068
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.066
COX6Ccytochrome c oxidase subunit VIc0.061
FGF7fibroblast growth factor 70.059
ECH1enoyl CoA hydratase 1, peroxisomal0.052
TTRtransthyretin0.052
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.047
MED12mediator complex subunit 120.045
PEX19peroxisomal biogenesis factor 190.041
LDLRlow density lipoprotein receptor0.040
TRIM11tripartite motif containing 110.034
ILVBLilvB (bacterial acetolactate synthase)-like0.034
FRS2fibroblast growth factor receptor substrate 20.032
PLTPphospholipid transfer protein0.032
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)0.031
C14orf1chromosome 14 open reading frame 10.030
SRP14signal recognition particle 14kDa (homologous Alu RNA binding protein)0.030
CREBBPCREB binding protein0.027
FAM83Cfamily with sequence similarity 83, member C0.027
PDCD4programmed cell death 4 (neoplastic transformation inhibitor)0.025
PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)0.024
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.024
FGFBP1fibroblast growth factor binding protein 10.023
BAG1BCL2-associated athanogene0.023
LOXL4lysyl oxidase-like 40.022
SLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 10.021
PLCG1phospholipase C, gamma 10.021
ATG9AATG9 autophagy related 9 homolog A (S. cerevisiae)0.020
APOEapolipoprotein E0.020
FGF2fibroblast growth factor 2 (basic)0.019
DCTN1dynactin 10.019
C11orf2chromosome 11 open reading frame 20.019
UQCRBubiquinol-cytochrome c reductase binding protein0.018
COASYCoA synthase0.018
BAG3BCL2-associated athanogene 30.018
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.018
ECSITECSIT homolog (Drosophila)0.017
NOSTRINnitric oxide synthase trafficker0.017
ARandrogen receptor0.017
ANXA7annexin A70.017
FAM82Bfamily with sequence similarity 82, member B0.017
WDR13WD repeat domain 130.016
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.016
SYPL1synaptophysin-like 10.016
PEX14peroxisomal biogenesis factor 140.016
TMEM115transmembrane protein 1150.016
DGAT1diacylglycerol O-acyltransferase 10.016
FGF19fibroblast growth factor 190.016
KRT1keratin 10.016
SEC24CSEC24 family, member C (S. cerevisiae)0.015
ABCG1ATP-binding cassette, sub-family G (WHITE), member 10.015
KAL1Kallmann syndrome 1 sequence0.015
AKT2v-akt murine thymoma viral oncogene homolog 20.015
EAPPE2F-associated phosphoprotein0.014
BRP44brain protein 440.014
APOBapolipoprotein B (including Ag(x) antigen)0.014
TMCC2transmembrane and coiled-coil domain family 20.014
PEX13peroxisomal biogenesis factor 130.014
PRDX6peroxiredoxin 60.014
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.014
KRT16keratin 160.014
CLEC4GC-type lectin domain family 4, member G0.013
F7coagulation factor VII (serum prothrombin conversion accelerator)0.013
PTHparathyroid hormone0.013
CPceruloplasmin (ferroxidase)0.013
NEDD4neural precursor cell expressed, developmentally down-regulated 40.013
ECHDC2enoyl CoA hydratase domain containing 20.013
LIPClipase, hepatic0.013
KIFAP3kinesin-associated protein 30.013
TOLLIPtoll interacting protein0.013
SMG5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)0.013
LRP1low density lipoprotein receptor-related protein 10.013
PGRprogesterone receptor0.013
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.013
GPLD1glycosylphosphatidylinositol specific phospholipase D10.013
TWIST2twist homolog 2 (Drosophila)0.013
FGF3fibroblast growth factor 30.013
FGF4fibroblast growth factor 40.013
HOXB7homeobox B70.013
SCAPSREBF chaperone0.013
MOGSmannosyl-oligosaccharide glucosidase0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.998
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.994
Apoa1apolipoprotein A-I0.976
Ldlrlow density lipoprotein receptor0.935
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.864
Agtr1aangiotensin II receptor, type 1a0.845
Leprleptin receptor0.831
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.765
Fgafibrinogen alpha chain0.750
Ahsgalpha-2-HS-glycoprotein0.537
Serpina1bserine (or cysteine) preptidase inhibitor, clade A, member 1B0.479
Npc1Niemann Pick type C10.467
Lcatlecithin cholesterol acyltransferase0.454
Lpin1lipin 10.454
Dhcr77-dehydrocholesterol reductase0.293
Fggfibrinogen gamma chain0.257
Otcornithine transcarbamylase0.257
Abhd5abhydrolase domain containing 50.252
F9coagulation factor IX0.251
Egfrepidermal growth factor receptor0.251
CrpC-reactive protein, pentraxin-related0.238
Fasnfatty acid synthase0.228
Kng1kininogen 10.194
LOC100503041PDZ domain-containing protein 7-like0.194
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.193
Apohapolipoprotein H0.184
Albalbumin0.182
Akr1c6aldo-keto reductase family 1, member C60.181
C3complement component 30.175
Plgplasminogen0.174
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.173
Serpina1aserine (or cysteine) peptidase inhibitor, clade A, member 1A0.154
Scd1stearoyl-Coenzyme A desaturase 10.152
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.151
Hpxhemopexin0.147
Tdo2tryptophan 2,3-dioxygenase0.144
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.138
F2coagulation factor II0.131
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.127
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.126
Itih3inter-alpha trypsin inhibitor, heavy chain 30.114
Thrathyroid hormone receptor alpha0.113
Hrghistidine-rich glycoprotein0.112
Bckdhabranched chain ketoacid dehydrogenase E1, alpha polypeptide0.112
Ppargperoxisome proliferator activated receptor gamma0.110
Apofapolipoprotein F0.109
Ren1renin 1 structural0.109
Aldobaldolase B, fructose-bisphosphate0.105
Dmgdhdimethylglycine dehydrogenase precursor0.104
Apobapolipoprotein B0.102
Il1r1interleukin 1 receptor, type I0.101
Srfserum response factor0.099
Ttrtransthyretin0.087
Hamphepcidin antimicrobial peptide0.086
Itih4inter alpha-trypsin inhibitor, heavy chain 40.085
Ptpn11protein tyrosine phosphatase, non-receptor type 110.085
1100001G20RikRIKEN cDNA 1100001G20 gene0.083
Serpina3cserine (or cysteine) peptidase inhibitor, clade A, member 3C0.082
Pahphenylalanine hydroxylase0.081
C4bcomplement component 4B (Childo blood group)0.079
Etfaelectron transferring flavoprotein, alpha polypeptide0.076
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.075
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.073
Gcgroup specific component0.070
Serpina3mserine (or cysteine) peptidase inhibitor, clade A, member 3M0.070
Pzppregnancy zone protein0.070
Cps1carbamoyl-phosphate synthetase 10.069
Apoc4apolipoprotein C-IV0.068
Fgbfibrinogen beta chain0.067
Ambpalpha 1 microglobulin/bikunin0.066
Prlrprolactin receptor0.064
Serpina1eserine (or cysteine) peptidase inhibitor, clade A, member 1E0.060
Fabp1fatty acid binding protein 1, liver0.058
Azgp1alpha-2-glycoprotein 1, zinc0.057
Pax8paired box gene 80.051
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.050
Scarb1scavenger receptor class B, member 10.050
Mup3major urinary protein 30.048
Acox1acyl-Coenzyme A oxidase 1, palmitoyl0.048
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.048
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.044
C9complement component 90.044
Pcnxl3pecanex-like 3 (Drosophila)0.044
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.043
Ebag9estrogen receptor-binding fragment-associated gene 90.043
C2complement component 2 (within H-2S)0.042
Rxraretinoid X receptor alpha0.041
Pcxpyruvate carboxylase0.041
Gjb2gap junction protein, beta 20.041
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.041
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.040
Grhprglyoxylate reductase/hydroxypyruvate reductase0.039
Mvdmevalonate (diphospho) decarboxylase0.038
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.038
Slc25a1solute carrier family 25 (mitochondrial carrier, citrate transporter), member 10.037
Vegfavascular endothelial growth factor A0.037
Ces3acarboxylesterase 3A0.037
Reep6receptor accessory protein 60.035
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.035
Smpd2sphingomyelin phosphodiesterase 2, neutral0.035
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism