The network for 'regulation of programmed cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

NameDescriptionProbabilityFunc Analog Organism
Mapk3mitogen activated protein kinase 30.870
Cd44Cd44 molecule0.865
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.831
Hspb1heat shock protein 10.808
Anxa4annexin A40.776
Socs3suppressor of cytokine signaling 30.772
Arandrogen receptor0.752
Klf4Kruppel-like factor 4 (gut)0.724
Arpc1bactin related protein 2/3 complex, subunit 1B0.673
Anxa5annexin A50.664
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.661
Pfkfb36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.657
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.656
Ptprcprotein tyrosine phosphatase, receptor type, C0.650
Anxa2annexin A20.647
RGD1564327similar to integrin alpha 80.635
Cd14CD14 molecule0.620
Cd4Cd4 molecule0.611
Itgamintegrin, alpha M0.607
Nr4a2nuclear receptor subfamily 4, group A, member 20.581
Errfi1ERBB receptor feedback inhibitor 10.570
Flt1FMS-related tyrosine kinase 10.558
Hspa1aheat shock 70kD protein 1A0.557
Ddr1discoidin domain receptor tyrosine kinase 10.550
Notch3Notch homolog 3 (Drosophila)0.549
St18suppression of tumorigenicity 180.534
Hspa5heat shock protein 50.522
FosFBJ osteosarcoma oncogene0.522
Agtr1aangiotensin II receptor, type 1a0.518
Dusp1dual specificity phosphatase 10.516
Cxcr5chemokine (C-X-C motif) receptor 50.510
Ahsgalpha-2-HS-glycoprotein0.505
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.501
Gjb3gap junction protein, beta 30.496
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.488
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.486
Albalbumin0.486
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.484
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.481
Fgfr2fibroblast growth factor receptor 20.477
Ngfnerve growth factor (beta polypeptide)0.474
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.473
Lgals3lectin, galactoside-binding, soluble, 30.470
Igfbp5insulin-like growth factor binding protein 50.459
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.458
Pdia4protein disulfide isomerase family A, member 40.456
Egr1early growth response 10.454
Slit3slit homolog 3 (Drosophila)0.449
Gzmbgranzyme B0.449
Hckhemopoietic cell kinase0.446
Hsph1heat shock 105/110 protein 10.446
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.440
Prlhrprolactin releasing hormone receptor0.436
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.435
Stip1stress-induced phosphoprotein 10.434
Impdh2IMP (inosine monophosphate) dehydrogenase 20.428
Ripk3receptor-interacting serine-threonine kinase 30.427
Fosl1fos-like antigen 10.426
Vipvasoactive intestinal peptide0.424
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.420
Lmnalamin A0.419
Ctrcchymotrypsin C (caldecrin)0.409
Txnrd1thioredoxin reductase 10.407
Tp53tumor protein p530.405
Unc5bunc-5 homolog B (C. elegans)0.401
Il8rainterleukin 8 receptor, alpha0.400
Thbdthrombomodulin0.399
Hspd1heat shock protein 1 (chaperonin)0.396
Cgm4carcinoembryonic antigen gene family 40.391
Hand2heart and neural crest derivatives expressed 20.391
Tcf4transcription factor 40.389
Runx1runt-related transcription factor 10.388
Nr4a3nuclear receptor subfamily 4, group A, member 30.388
Fgd4FYVE, RhoGEF and PH domain containing 40.365
Elk3ELK3, ETS-domain protein0.362
Adora2aadenosine A2a receptor0.360
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.360
Ccr3chemokine (C-C motif) receptor 30.356
Gabarapl2GABA(A) receptor-associated protein like 20.356
Mdm2Mdm2 p53 binding protein homolog (mouse)0.355
Klf2Kruppel-like factor 2 (lung)0.354
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.354
Dnase1l3deoxyribonuclease 1-like 30.354
Vegfavascular endothelial growth factor A0.352
Ifitm3interferon induced transmembrane protein 30.352
Egr2early growth response 20.351
Jak2Janus kinase 20.350
Nrg1neuregulin 10.348
Timp3TIMP metallopeptidase inhibitor 30.345
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.345
Ctsl1cathepsin L10.344
AxlAxl receptor tyrosine kinase0.344
Nek9NIMA (never in mitosis gene a)- related kinase 90.343
Vimvimentin0.343
Leprleptin receptor0.342
Vat1vesicle amine transport protein 1 homolog (T californica)0.341
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.339
Ftlferritin, light polypeptide0.339
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.339
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.337
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.541
bar-1Protein BAR-10.393
mat-3Protein MAT-30.245
sma-6Protein SMA-60.194
hcp-3Protein HCP-30.162
cam-1Protein CAM-10.158
ceh-20Protein CEH-200.149
trim-9Protein TRIM-90.141
nhr-45Protein NHR-450.139
hsp-1Protein HSP-10.134
mab-31Protein MAB-310.117
egl-46Protein EGL-460.116
par-5Protein PAR-50.113
F36D4.5Protein F36D4.50.112
glp-1Protein GLP-10.111
vav-1Protein VAV-10.104
inx-3Protein INX-30.101
F39B2.1Protein F39B2.10.101
egl-44Protein EGL-440.101
nhr-67Protein NHR-670.097
egl-30Protein EGL-300.097
vab-3Protein VAB-30.090
hum-6Protein HUM-60.087
ceh-44Protein CEH-440.086
flt-1Protein FLT-10.078
pha-4Protein PHA-40.078
F31C3.2Protein F31C3.20.078
egl-13Protein EGL-130.076
soc-2Protein SOC-20.071
drp-1Protein DRP-10.071
ifp-1Protein IFP-10.070
CELE_F14E5.2Protein F14E5.20.069
sax-7Protein SAX-70.068
hum-5Protein HUM-50.067
pat-12Protein PAT-120.065
F58B3.6Protein F58B3.60.065
egl-5Protein EGL-50.065
H24G06.1Protein H24G06.10.062
inx-13Protein INX-130.062
crt-1Protein CRT-10.062
eor-1Protein EOR-10.059
CELE_C12D8.1Protein C12D8.10.058
pal-1Protein PAL-10.058
ras-1Protein RAS-10.058
sel-12Protein SEL-120.056
unc-53Protein UNC-530.056
let-60Protein LET-600.055
acdh-3Protein ACDH-30.055
xbp-1Protein XBP-10.055
sos-1Protein SOS-10.054
ifg-1Protein IFG-10.054
egl-36Protein EGL-360.054
rla-0Protein RLA-00.053
sem-5Protein SEM-50.053
F36A2.13Protein F36A2.130.052
arf-3Protein ARF-30.052
clic-1Protein CLIC-10.052
pry-1Protein PRY-10.052
daf-1Protein DAF-10.052
nhr-2Protein NHR-20.051
tag-320Protein TAG-3200.051
unc-43Protein UNC-430.050
pdfr-1Protein PDFR-10.048
unc-85Protein UNC-850.048
atg-18Protein ATG-180.047
unc-52Protein UNC-520.047
unc-37Protein UNC-370.046
C35C5.3Protein C35C5.30.045
R74.8Protein R74.80.045
F48A11.4Protein F48A11.40.045
mel-11Protein MEL-110.044
rilp-1Protein RILP-10.044
hlh-14Protein HLH-140.043
vha-13Protein VHA-130.043
zip-7Protein ZIP-70.043
svh-2Protein SVH-20.043
ceh-27Protein CEH-270.042
imp-2Protein IMP-20.042
cfim-2Protein CFIM-20.042
egl-8Protein EGL-80.042
rpt-3Protein RPT-30.042
bre-1Protein BRE-10.042
lin-29Protein LIN-290.041
tct-1Protein TCT-10.041
egl-23Protein EGL-230.041
dlc-1Protein DLC-10.041
rars-1Protein RARS-10.041
zyg-1Protein ZYG-10.041
T28C6.7Protein T28C6.70.040
F55C12.5Protein F55C12.50.040
sel-10Protein SEL-100.039
CELE_W02F12.4Protein W02F12.40.039
exc-5Protein EXC-50.038
ahcy-1Protein AHCY-10.038
rnr-2Protein RNR-20.038
htz-1Protein HTZ-10.038
sac-1Protein SAC-10.037
C27A12.7Protein C27A12.70.037
eat-6Protein EAT-60.037
cdc-6Protein CDC-60.036
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.852
osr1odd-skipped related 1 (Drosophila)0.845
bmp2bbone morphogenetic protein 2b0.818
fgf8afibroblast growth factor 8 a0.755
pax2apaired box gene 2a0.722
hand2heart and neural crest derivatives expressed transcript 20.692
tal1T-cell acute lymphocytic leukemia 10.681
rad21RAD21 homolog (S. pombe)0.581
kdrlkinase insert domain receptor like0.574
ptf1apancreas specific transcription factor, 1a0.554
chdchordin0.535
baxabcl2-associated X protein, a0.529
gscgoosecoid0.527
rargaretinoic acid receptor gamma a0.516
tbx20T-box 200.492
gata3GATA-binding protein 30.485
cmybtranscription factor cmyb0.470
piwil2piwi-like 2 (Drosophila)0.467
tp53tumor protein p530.460
efnb2aephrin B2a0.455
evx1even-skipped homeobox 10.443
myod1myogenic differentiation 10.421
sema3aasemaphorin 3aa0.417
tgfb3transforming growth factor, beta 30.413
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.405
fgfr1afibroblast growth factor receptor 1a0.402
brd4bromodomain containing 40.386
fgfr3fibroblast growth factor receptor 30.380
fgf3fibroblast growth factor 30.370
tnfrsfatumor necrosis factor receptor superfamily, member a0.354
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.339
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.336
alcambactivated leukocyte cell adhesion molecule b0.336
dmddystrophin0.324
shhasonic hedgehog a0.319
wt1awilms tumor 1a0.312
aplnrbapelin receptor b0.306
raraaretinoic acid receptor, alpha a0.303
plcg1phospholipase C, gamma 10.301
fn1fibronectin 10.288
tp63tumor protein p630.285
runx2brunt-related transcription factor 2b0.275
egr2bearly growth response 2b0.270
wnt4awingless-type MMTV integration site family, member 4a0.262
nadl1.2neural adhesion molecule L1.20.254
wnt2bbwingless-type MMTV integration site family, member 2Bb0.253
sox11bSRY-box containing gene 11b0.251
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.248
hspa5heat shock protein 50.248
hhiphedgehog interacting protein0.245
foxo3bforkhead box O3b0.243
rag1recombination activating gene 10.241
dlddeltaD0.229
fstafollistatin a0.227
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.227
nrg2aneuregulin 2a0.225
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.224
sox32SRY-box containing gene 320.223
hey1hairy/enhancer-of-split related with YRPW motif 10.222
gpr126G protein-coupled receptor 1260.221
lef1lymphocyte enhancer binding factor 10.220
tuba1tubulin, alpha 10.218
sulf2lsulfatase 2, like0.217
ef1aelongation factor 1-alpha0.208
csnk1dacasein kinase 1, delta a0.208
tshbthyroid stimulating hormone, beta subunit0.207
thtyrosine hydroxylase0.206
bactin2bactin20.201
msxcmuscle segment homeobox C0.200
mcl1amyeloid cell leukemia sequence 1a0.200
ube2iubiquitin-conjugating enzyme E2I0.197
dlx6adistal-less homeobox gene 6a0.196
nrp1aneuropilin 1a0.194
wu:fv91b12wu:fv91b120.193
pax6bpaired box gene 6b0.193
pkd2polycystic kidney disease 20.192
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.190
notch1anotch homolog 1a0.187
cdh1cadherin 1, epithelial0.187
six3bsine oculis homeobox homolog 3b0.185
trpm7transient receptor potential cation channel, subfamily M, member 70.185
rargbretinoic acid receptor, gamma b0.185
eml2echinoderm microtubule associated protein like 20.185
LOC797832similar to signal peptide, CUB domain, EGF-like 10.182
btg2B-cell translocation gene 20.178
nkx2.3NK2 transcription factor related 30.177
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.176
id3inhibitor of DNA binding 30.175
rnd3aRho family GTPase 3a0.173
mibmind bomb0.173
bbc3BCL2 binding component 30.171
wnt1wingless-type MMTV integration site family, member 10.170
eve1even-skipped-like10.167
pcdh18bprotocadherin 18b0.163
bocbrother of CDO0.163
gng5guanine nucleotide binding protein (G protein), gamma 50.162
rhoabras homolog gene family, member Ab0.161
fzd7afrizzled homolog 7a0.160
her9hairy-related 90.157
barx1BarH-like homeobox 10.157
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
nejnejire0.988
CG11347CG11347 gene product from transcript CG11347-RE0.986
Ras85DRas oncogene at 85D0.980
kaykayak0.976
Akt1CG4006 gene product from transcript CG4006-RA0.945
exexpanded0.941
Pi3K92ECG4141 gene product from transcript CG4141-RB0.919
cicubitus interruptus0.894
Atg1Autophagy-specific gene 10.857
dmdiminutive0.835
rprreaper0.811
PakPAK-kinase0.810
MoeMoesin0.796
CaMKIICalcium/calmodulin-dependent protein kinase II0.794
Src42ASrc oncogene at 42A0.787
RbfRetinoblastoma-family protein0.782
G-salpha60AG protein salpha 60A0.775
alpha-Catalpha Catenin0.767
giggigas0.749
tsrtwinstar0.747
MhcMyosin heavy chain0.733
hephemipterous0.728
crolcrooked legs0.696
Nop60BNucleolar protein at 60B0.691
Rac1CG2248 gene product from transcript CG2248-RA0.673
slmbsupernumerary limbs0.650
putpunt0.645
shnschnurri0.639
drkdownstream of receptor kinase0.628
wgwingless0.626
ik2IkappaB kinase-like 20.622
DabDisabled0.620
Dcp-1Death caspase-10.611
dshdishevelled0.587
EcREcdysone receptor0.571
lealeak0.560
EgfrEpidermal growth factor receptor0.551
rapretina aberrant in pattern0.546
tkvthickveins0.543
S6kRPS6-p70-protein kinase0.531
UbxUltrabithorax0.519
rstroughest0.514
nkdnaked cuticle0.514
Aos1CG12276 gene product from transcript CG12276-RA0.512
Tsc1CG6147 gene product from transcript CG6147-RA0.512
CSN5COP9 complex homolog subunit 50.495
PtenCG5671 gene product from transcript CG5671-RB0.494
tintinman0.489
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE0.485
ecdecdysoneless0.476
MadMothers against dpp0.465
AntpAntennapedia0.465
Rac2CG8556 gene product from transcript CG8556-RA0.448
elavembryonic lethal abnormal vision0.442
rdxroadkill0.425
Adf1Adh transcription factor 10.414
uspultraspiracle0.397
Eip74EFEcdysone-induced protein 74EF0.396
stysprouty0.395
AtpalphaNa pump alpha subunit0.388
NetBNetrin-B0.388
atoatonal0.387
NrgNeuroglian0.387
p120ctnAdherens junction protein p1200.386
Int6Int6 homologue0.381
HHairless0.372
DpDP transcription factor0.371
spensplit ends0.368
Eip93FCG18389 gene product from transcript CG18389-RB0.366
Su(H)Suppressor of Hairless0.356
bibifid0.348
X11LCG5675 gene product from transcript CG5675-RB0.347
InRInsulin-like receptor0.345
bazbazooka0.345
Snr1Snf5-related 10.338
cutletCG33122 gene product from transcript CG33122-RA0.335
Tak1TGF-beta activated kinase 10.332
debcldeath executioner Bcl-2 homologue0.331
ptcpatched0.325
RASSF8CG5053 gene product from transcript CG5053-RA0.324
ththread0.324
MtlMig-2-like0.320
CG7998CG7998 gene product from transcript CG7998-RA0.315
mrnmarionette0.312
slp1sloppy paired 10.311
Rab11Rab-protein 110.309
weeCG4488 gene product from transcript CG4488-RA0.309
eyeyeless0.307
jarjaguar0.306
lolalongitudinals lacking0.304
CG14869CG14869 gene product from transcript CG14869-RB0.301
rictorrapamycin-insensitive companion of Tor0.300
SoxNSoxNeuro0.299
dncdunce0.299
slislit0.297
RelRelish0.295
CG9772CG9772 gene product from transcript CG9772-RB0.295
l(2)gllethal (2) giant larvae0.295
btszbitesize0.290
LamCLamin C0.287
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
BMH1Bmh1p0.020
SLT2Slt2p0.019
STI1Sti1p0.017
CDC34Cdc34p0.013
PIL1Pil1p0.012