The network for 'regulation of nitric oxide synthase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of nitric oxide synthase activity

Any process that modulates the activity of the enzyme nitric-oxide synthase.

Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.588
Sub1SUB1 homolog (S. cerevisiae)0.586
Dynll1dynein light chain LC8-type 10.577
Ptp4a2protein tyrosine phosphatase 4a20.237
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.199
Fkbp1aFK506 binding protein 1a0.149
Calm1calmodulin 10.131
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.119
Calm2calmodulin 20.094
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.089
Arf5ADP-ribosylation factor 50.076
Actr2ARP2 actin-related protein 2 homolog (yeast)0.074
Clcn3chloride channel 30.060
Mlf2myeloid leukemia factor 20.058
Smad3SMAD family member 30.048
Mapk3mitogen activated protein kinase 30.046
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.044
Uhmk1U2AF homology motif (UHM) kinase 10.042
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.037
Pgam1phosphoglycerate mutase 1 (brain)0.036
Tuba1ctubulin, alpha 1C0.036
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.034
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.032
Stmn1stathmin 10.032
Ccnd2cyclin D20.032
Tubb2atubulin, beta 2a0.032
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.031
KitlgKIT ligand0.026
Rab4aRAB4A, member RAS oncogene family0.024
Tuba4atubulin, alpha 4A0.024
Map2k2mitogen activated protein kinase kinase 20.024
Pgpphosphoglycolate phosphatase0.022
Slc15a2solute carrier family 15 (H+/peptide transporter), member 20.022
Ptmsparathymosin0.020
Actn4actinin alpha 40.020
Aif1lallograft inflammatory factor 1-like0.020
BokBCL2-related ovarian killer0.019
Mapk6mitogen-activated protein kinase 60.019
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.018
Pcbd1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.018
Sirpasignal-regulatory protein alpha0.018
Rhocras homolog gene family, member C0.018
Hk1hexokinase 10.018
Mmdmonocyte to macrophage differentiation-associated0.017
Ccnd3cyclin D30.017
Rab1bRAB1B, member RAS oncogene family0.017
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.017
Rab8bRAB8B, member RAS oncogene family0.016
Efhd2EF-hand domain family, member D20.016
Rgs14regulator of G-protein signaling 140.016
Prss35protease, serine, 350.016
Hn1hematological and neurological expressed 10.015
Atxn3ataxin 30.015
Prnpprion protein0.015
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.014
Scn3asodium channel, voltage-gated, type III, alpha0.014
Prrx1paired related homeobox 10.014
Tsc22d1TSC22 domain family, member 10.014
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.013
Cfl1cofilin 1, non-muscle0.013
Slc22a2solute carrier family 22 (organic cation transporter), member 20.013
Ube2mubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)0.012
Metmet proto-oncogene0.012
Mrfap1Mof4 family associated protein 10.012
Sepw1selenoprotein W, 10.012
Gsk3bglycogen synthase kinase 3 beta0.012
Wdr7WD repeat domain 70.012
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.012
Arpc1aactin related protein 2/3 complex, subunit 1A0.012
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.012
Pfkmphosphofructokinase, muscle0.012
Irs1insulin receptor substrate 10.012
Mmp7matrix metallopeptidase 70.012
RGD1562618similar to RIKEN cDNA 6030419C18 gene0.012
Pde5aphosphodiesterase 5A, cGMP-specific0.011
Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 30.011
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.011
Cdc42cell division cycle 42 (GTP binding protein)0.011
Hpgdhydroxyprostaglandin dehydrogenase 15 (NAD)0.011
Wsb2WD repeat and SOCS box-containing 20.011
Hspa8heat shock protein 80.011
Cd55Cd55 molecule0.011
Arrb2arrestin, beta 20.011
LOC100365339hypothetical protein LOC1003653390.011
Gadd45gip1growth arrest and DNA-damage-inducible, gamma interacting protein 10.010
Hist1h2bahistone cluster 1, H2ba0.010
Myo9amyosin IXA0.010
St6galnac3ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 30.010
Cftrcystic fibrosis transmembrane conductance regulator homolog (human)0.010
Maoamonoamine oxidase A0.010
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.982
ESR1estrogen receptor 10.714
EGFRepidermal growth factor receptor0.698
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.117
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.099
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.086
HPhaptoglobin0.066
PTK2BPTK2B protein tyrosine kinase 2 beta0.061
NOXA1NADPH oxidase activator 10.054
PPP5Cprotein phosphatase 5, catalytic subunit0.053
MAPTmicrotubule-associated protein tau0.049
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.041
APOC1apolipoprotein C-I0.039
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.031
A2Malpha-2-macroglobulin0.025
FYNFYN oncogene related to SRC, FGR, YES0.020
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.019
CDCP1CUB domain containing protein 10.018
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.018
CDC37cell division cycle 37 homolog (S. cerevisiae)0.016
MYLK2myosin light chain kinase 20.016
APOC3apolipoprotein C-III0.015
CALCAcalcitonin-related polypeptide alpha0.015
APPamyloid beta (A4) precursor protein0.015
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.012
ARRDC3arrestin domain containing 30.011
ESR2estrogen receptor 2 (ER beta)0.011
ADAM15ADAM metallopeptidase domain 150.011
MBNL1muscleblind-like (Drosophila)0.011
DLG2discs, large homolog 2 (Drosophila)0.011
INSRinsulin receptor0.011
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.972
Nos3nitric oxide synthase 3, endothelial cell0.601
Ppargperoxisome proliferator activated receptor gamma0.579
Nos1nitric oxide synthase 1, neuronal0.539
Tgfbr2transforming growth factor, beta receptor II0.379
Tgfb1transforming growth factor, beta 10.265
Lepleptin0.217
Nr3c1nuclear receptor subfamily 3, group C, member 10.151
Ghrgrowth hormone receptor0.091
Ren1renin 1 structural0.074
Agtr1aangiotensin II receptor, type 1a0.065
Ptpn11protein tyrosine phosphatase, non-receptor type 110.060
Smad4MAD homolog 4 (Drosophila)0.056
Fshrfollicle stimulating hormone receptor0.055
Lrp1low density lipoprotein receptor-related protein 10.054
Ldlrlow density lipoprotein receptor0.049
Ptgs2prostaglandin-endoperoxide synthase 20.046
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.040
Ptenphosphatase and tensin homolog0.037
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.037
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.037
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.034
Kitkit oncogene0.032
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.031
Nodalnodal0.030
SrcRous sarcoma oncogene0.028
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.026
Smad3MAD homolog 3 (Drosophila)0.025
Bcar1breast cancer anti-estrogen resistance 10.025
Vdrvitamin D receptor0.024
Dmddystrophin, muscular dystrophy0.024
Nos2nitric oxide synthase 2, inducible0.024
Arandrogen receptor0.023
Pgrprogesterone receptor0.023
Itgb1integrin beta 1 (fibronectin receptor beta)0.022
Npy1rneuropeptide Y receptor Y10.022
Ptrfpolymerase I and transcript release factor0.021
Acvrl1activin A receptor, type II-like 10.019
Cav1caveolin 1, caveolae protein0.019
Esr2estrogen receptor 2 (beta)0.018
Apcadenomatosis polyposis coli0.017
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.016
Agtrapangiotensin II, type I receptor-associated protein0.015
Clcn5chloride channel 50.015
Npc1Niemann Pick type C10.015
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.014
Mstnmyostatin0.013
Prkceprotein kinase C, epsilon0.013
Hif1ahypoxia inducible factor 1, alpha subunit0.013
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.013
Insrinsulin receptor0.013
Cdkn1bcyclin-dependent kinase inhibitor 1B0.011
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.011
Esr1estrogen receptor 1 (alpha)0.011
Igf1insulin-like growth factor 10.010
Smad2MAD homolog 2 (Drosophila)0.010
Tlr2toll-like receptor 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism