The network for 'regulation of signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

NameDescriptionProbabilityFunc Analog Organism
Cd14CD14 molecule0.808
Itgamintegrin, alpha M0.796
Fgfr2fibroblast growth factor receptor 20.739
Dlg4discs, large homolog 4 (Drosophila)0.710
Dlgap1discs, large (Drosophila) homolog-associated protein 10.709
Leprleptin receptor0.648
Hoxa1homeo box A10.647
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.622
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.622
Ptafrplatelet-activating factor receptor0.604
Utrnutrophin0.579
Jak2Janus kinase 20.575
Prkchprotein kinase C, eta0.571
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.570
Metmet proto-oncogene0.565
Ncr1natural cytotoxicity triggering receptor 10.564
Gzmbgranzyme B0.561
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.558
Folh1folate hydrolase 10.554
Fgfr1Fibroblast growth factor receptor 10.540
Icam1intercellular adhesion molecule 10.521
Calcrlcalcitonin receptor-like0.515
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.508
Epn2epsin 20.503
Bcl2B-cell CLL/lymphoma 20.502
Runx1runt-related transcription factor 10.501
Tgfbr2transforming growth factor, beta receptor II0.495
Ptger2prostaglandin E receptor 2 (subtype EP2)0.487
RGD1564327similar to integrin alpha 80.481
Rararetinoic acid receptor, alpha0.475
Myh9myosin, heavy chain 9, non-muscle0.472
Slco2b1solute carrier organic anion transporter family, member 2b10.471
Cugbp2CUG triplet repeat, RNA binding protein 20.469
Flt1FMS-related tyrosine kinase 10.463
Ccl2chemokine (C-C motif) ligand 20.463
Fgf7fibroblast growth factor 70.457
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.453
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.447
Il1r1interleukin 1 receptor, type I0.446
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.439
Agtr1aangiotensin II receptor, type 1a0.434
RhagRh-associated glycoprotein0.429
Adora2aadenosine A2a receptor0.427
Syt8synaptotagmin VIII0.426
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.426
Adarb2adenosine deaminase, RNA-specific, B20.417
Cd8aCD8a molecule0.411
Dchs1dachsous 1 (Drosophila)0.404
Jak1Janus kinase 10.401
Vav1vav 1 guanine nucleotide exchange factor0.401
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.400
Nrxn3neurexin 30.399
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.398
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.397
Sirpasignal-regulatory protein alpha0.393
Oprm1opioid receptor, mu 10.393
Gfra2GDNF family receptor alpha 20.387
Homer1homer homolog 1 (Drosophila)0.387
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.380
Adam2ADAM metallopeptidase domain 20.380
Dlg3discs, large homolog 3 (Drosophila)0.379
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.377
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.376
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.375
Ddr1discoidin domain receptor tyrosine kinase 10.374
Pld2phospholipase D20.371
Lgals5lectin, galactose binding, soluble 50.371
Tpc1808tropic 18080.371
Sgk1serum/glucocorticoid regulated kinase 10.367
Nrxn1neurexin 10.367
SnrkSNF related kinase0.365
Pnlippancreatic lipase0.364
Neurog3neurogenin 30.354
Creb1cAMP responsive element binding protein 10.354
Dlg1discs, large homolog 1 (Drosophila)0.352
Ciitaclass II, major histocompatibility complex, transactivator0.349
Myo1bmyosin Ib0.349
Cmklr1chemokine-like receptor 10.349
P2ry2purinergic receptor P2Y, G-protein coupled, 20.347
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.346
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.343
Lphn2latrophilin 20.342
Gdnfglial cell derived neurotrophic factor0.342
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.341
Nek9NIMA (never in mitosis gene a)- related kinase 90.341
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.340
Nedd4neural precursor cell expressed, developmentally down-regulated 40.340
Shox2short stature homeobox 20.339
Gria1glutamate receptor, ionotropic, AMPA 10.337
S1pr2sphingosine-1-phosphate receptor 20.335
Cxcl10chemokine (C-X-C motif) ligand 100.333
Il10rainterleukin 10 receptor, alpha0.332
Unc5aunc-5 homolog A (C. elegans)0.331
Glt25d1glycosyltransferase 25 domain containing 10.331
Fosl1fos-like antigen 10.329
Acmsdaminocarboxymuconate semialdehyde decarboxylase0.329
Robo1roundabout homolog 1 (Drosophila)0.327
KitlgKIT ligand0.326
Lnpepleucyl/cystinyl aminopeptidase0.326
Il9rinterleukin 9 receptor0.324
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.928
egl-18Protein EGL-180.868
atn-1Protein ATN-10.748
mig-5Protein MIG-50.744
par-5Protein PAR-50.715
bar-1Protein BAR-10.636
goa-1Protein GOA-10.579
K10D6.4Protein K10D6.40.576
mpz-2Protein MPZ-20.515
imb-2Protein IMB-20.493
npp-7Protein NPP-70.493
lin-25Protein LIN-250.458
akt-1Protein AKT-10.449
mec-2Protein MEC-20.439
unc-108Protein UNC-1080.420
egl-30Protein EGL-300.403
eor-2Protein EOR-20.388
sma-6Protein SMA-60.388
unc-62Protein UNC-620.381
ida-1Protein IDA-10.378
lin-45Protein LIN-450.372
eps-8Protein EPS-80.371
daf-11Protein DAF-110.370
plc-1Protein PLC-10.347
daf-6Protein DAF-60.340
sem-5Protein SEM-50.340
let-60Protein LET-600.334
shn-1Protein SHN-10.333
lin-36Protein LIN-360.322
pha-4Protein PHA-40.317
egl-8Protein EGL-80.317
pxf-1Protein PXF-10.312
osm-5Protein OSM-50.298
elt-6Protein ELT-60.293
pry-1Protein PRY-10.291
ZK686.3Protein ZK686.30.287
pmk-1Protein PMK-10.285
etr-1Protein ETR-10.281
nhr-67Protein NHR-670.273
gld-1Protein GLD-10.265
abl-1Protein ABL-10.265
hda-3Protein HDA-30.262
che-3Protein CHE-30.262
lag-1Protein LAG-10.256
trim-9Protein TRIM-90.253
imp-2Protein IMP-20.251
daf-14Protein DAF-140.246
ptr-14Protein PTR-140.240
lin-17Protein LIN-170.238
T04C9.1Protein T04C9.10.233
scd-1Protein SCD-10.231
mei-2Protein MEI-20.231
jnk-1Protein JNK-10.226
csn-5Protein CSN-50.221
CELE_F47G4.4Protein F47G4.40.220
mes-3Protein MES-30.213
inx-13Protein INX-130.212
CELE_C12D8.1Protein C12D8.10.206
nhr-34Protein NHR-340.203
sax-7Protein SAX-70.203
egl-27Protein EGL-270.200
pmp-3Protein PMP-30.200
lit-1Protein LIT-10.200
eef-1A.1Protein EEF-1A.10.197
npp-22Protein NPP-220.195
jmjd-1.2Protein JMJD-1.20.193
sax-3Protein SAX-30.193
daf-21Protein DAF-210.190
unc-40Protein UNC-400.190
nhr-6Protein NHR-60.190
unc-7Protein UNC-70.189
faah-1Protein FAAH-10.184
vav-1Protein VAV-10.183
arf-3Protein ARF-30.177
grk-2Protein GRK-20.177
ztf-4Protein ZTF-40.176
Y48G1A.2Protein Y48G1A.20.175
unc-104Protein UNC-1040.173
pal-1Protein PAL-10.169
mat-3Protein MAT-30.168
klp-7Protein KLP-70.168
rgl-1Protein RGL-10.168
zfp-3Protein ZFP-30.167
uig-1Protein UIG-10.165
let-607Protein LET-6070.164
che-2Protein CHE-20.164
dpy-31Protein DPY-310.163
irx-1Protein IRX-10.162
pkg-1Protein PKG-10.161
ceh-44Protein CEH-440.160
evl-14Protein EVL-140.160
abts-1Protein ABTS-10.159
atg-2Protein ATG-20.159
hgrs-1Protein HGRS-10.157
ykt-6Protein YKT-60.156
unc-32Protein UNC-320.156
T11G6.4Protein T11G6.40.153
msp-78Protein MSP-780.150
R90.1Protein R90.10.148
csnk-1Protein CSNK-10.148
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.999
tbx1T-box 10.997
ntlano tail a0.997
shhasonic hedgehog a0.987
fgf8afibroblast growth factor 8 a0.984
wnt5bwingless-type MMTV integration site family, member 5b0.983
gli2aGLI-Kruppel family member GLI2a0.977
notch1anotch homolog 1a0.959
bmp2bbone morphogenetic protein 2b0.940
sox2SRY-box containing gene 20.932
wnt11wingless-type MMTV integration site family, member 110.929
gli1GLI-Kruppel family member 10.929
fgf3fibroblast growth factor 30.923
acvr1lactivin A receptor, type I like0.913
tp53tumor protein p530.910
flt4fms-related tyrosine kinase 40.910
dlddeltaD0.902
rarabretinoic acid receptor, alpha b0.888
flhfloating head0.884
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.875
dusp6dual specificity phosphatase 60.865
frem3Fras1 related extracellular matrix 30.850
ptch1patched 10.837
kdrlkinase insert domain receptor like0.836
epb4.1l4erythrocyte protein band 4.1-like 40.827
lft1lefty10.822
tie1endothelium-specific receptor tyrosine kinase 10.812
pkd2polycystic kidney disease 20.804
nrp2bneuropilin 2b0.802
wnt2bbwingless-type MMTV integration site family, member 2Bb0.801
tal1T-cell acute lymphocytic leukemia 10.789
tnfrsfatumor necrosis factor receptor superfamily, member a0.787
yap1Yes-associated protein 10.779
pou5f1POU domain, class 5, transcription factor 10.766
dccdeleted in colorectal carcinoma0.752
tcf7transcription factor 7 (T-cell specific, HMG-box)0.750
brd4bromodomain containing 40.735
restRE1-silencing transcription factor0.723
etv5bets variant 5b0.717
igf1rbinsulin-like growth factor 1b receptor0.714
lmx1b.1LIM homeobox transcription factor 1, beta 10.703
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.692
efnb2aephrin B2a0.690
furinafurin (paired basic amino acid cleaving enzyme) a0.686
rag1recombination activating gene 10.684
nrp1aneuropilin 1a0.678
lhx2bLIM homeobox 2b0.677
gro2groucho 20.669
bmp4bone morphogenetic protein 40.667
plcg1phospholipase C, gamma 10.663
lef1lymphocyte enhancer binding factor 10.660
gdf6agrowth differentiation factor 6a0.660
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.659
gata3GATA-binding protein 30.652
sox9bSRY-box containing gene 9b0.643
ext2exostoses (multiple) 20.639
tbx16T-box gene 160.635
fzd10frizzled homolog 100.635
foxi1forkhead box I10.634
tyrtyrosinase0.630
sox9aSRY-box containing gene 9a0.625
evx1even-skipped homeobox 10.621
wu:fv91b12wu:fv91b120.615
pcdh18bprotocadherin 18b0.610
hoxd4ahomeo box D4a0.605
dkk1bdickkopf 1b0.604
bmp2abone morphogenetic protein 2a0.603
smad5MAD homolog 5 (Drosophila)0.601
robo3roundabout homolog 30.597
fzd5frizzled homolog 50.594
bbc3BCL2 binding component 30.589
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.585
lhx1aLIM homeobox 1a0.583
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.582
ptprkprotein tyrosine phosphatase, receptor type, K0.582
six3bsine oculis homeobox homolog 3b0.582
cdh5cadherin 50.580
tp53bp2tumor protein p53 binding protein, 20.575
runx2brunt-related transcription factor 2b0.575
twist3twist30.567
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.566
nanos3nanos homolog 30.564
wnt11rwingless-type MMTV integration site family, member 11, related0.562
fgfr1bfibroblast growth factor receptor 1b0.559
zbtb4zinc finger and BTB domain containing 40.557
esr2aestrogen receptor 2a0.556
spry4sprouty (Drosophila) homolog 40.548
smosmoothened homolog (Drosophila)0.546
vegfcvascular endothelial growth factor c0.540
pitx3paired-like homeodomain transcription factor 30.537
cmybtranscription factor cmyb0.535
pdlim3bPDZ and LIM domain 3b0.534
oepone-eyed pinhead0.534
cdh2cadherin 2, neuronal0.533
sox32SRY-box containing gene 320.530
sox19aSRY-box containing gene 19a0.530
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.530
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.518
lmnalamin A0.510
ntn1bnetrin 1b0.503
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CLA4Cla4p0.949
FAR1Far1p0.785
VPS64Vps64p0.696
SHO1Sho1p0.686
STE20Ste20p0.653
PPH21Pph21p0.651
CRZ1Crz1p0.650
CDC55Cdc55p0.624
FAR11Far11p0.622
TPK2Tpk2p0.600
RRI1Rri1p0.585
HOG1Hog1p0.576
PBS2Pbs2p0.567
ERP4Erp4p0.565
ROM2Rom2p0.525
CDC34Cdc34p0.507
SSK2Ssk2p0.429
PTC1Ptc1p0.400
TPK1Tpk1p0.399
BOI1Boi1p0.370
STE4Ste4p0.364
RHO1Rho1p0.350
CDC24Cdc24p0.346
AKL1Akl1p0.345
YOL087Chypothetical protein0.344
STE5Ste5p0.336
MON1Mon1p0.326
NBP2Nbp2p0.324
BEM1Bem1p0.316
MSG5Msg5p0.309
PRB1Prb1p0.298
ENA5Ena5p0.297
STI1Sti1p0.285
KSS1Kss1p0.277
GSC2Gsc2p0.268
KOG1Kog1p0.266
GYL1Gyl1p0.266
ZDS1Zds1p0.258
PPH22Pph22p0.254
MSN2Msn2p0.252
SLA2Sla2p0.246
PMT2Pmt2p0.242
CCR4Ccr4p0.240
STE7Ste7p0.240
STE50Ste50p0.238
SLT2Slt2p0.235
MKK1Mkk1p0.234
TOR1Tor1p0.234
RUD3Rud3p0.231
FUS3Fus3p0.223
SOK1Sok1p0.222
PRK1Prk1p0.218
YGL036Whypothetical protein0.214
HSP60Hsp60p0.212
TSC11Tsc11p0.212
GCN20Gcn20p0.210
PIK1Pik1p0.208
SSK22Ssk22p0.206
ICE2Ice2p0.205
BNI1Bni1p0.197
PCI8Pci8p0.197
HST1Hst1p0.192
AHP1Ahp1p0.192
MKT1Mkt1p0.190
VPS36Vps36p0.184
PPZ1Ppz1p0.182
RPT3Rpt3p0.177
STE2Ste2p0.177
ERP2Erp2p0.175
YAK1Yak1p0.173
FAR3Far3p0.172
STE11Ste11p0.172
PKC1Pkc1p0.170
ULA1Ula1p0.166
TPS1Tps1p0.165
SSN8Ssn8p0.162
ADR1Adr1p0.154
SRO7Sro7p0.152
MYO5Myo5p0.151
SPA2Spa2p0.150
HOS4Hos4p0.146
SEC7Sec7p0.143
PEP5Pep5p0.142
IME2Ime2p0.142
IZH4Izh4p0.142
ARC35Arc35p0.142
SLM2Slm2p0.141
VPS41Vps41p0.140
BCK2Bck2p0.139
VPS20Vps20p0.139
CHC1Chc1p0.137
KSP1Ksp1p0.131
MDS3Mds3p0.131
SNF8Snf8p0.130
UBC4Ubc4p0.130
STE12Ste12p0.128
MKK2Mkk2p0.128
CNB1Cnb1p0.128
SET3Set3p0.128
UBP2Ubp2p0.128