The network for 'positive regulation of ion transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of ion transport

Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NameDescriptionProbabilityFunc Analog Organism
Magmyelin-associated glycoprotein0.596
S100a10S100 calcium binding protein A100.518
Grm7glutamate receptor, metabotropic 70.476
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.400
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.394
Oprk1opioid receptor, kappa 10.361
Gng7guanine nucleotide binding protein (G protein), gamma 70.358
Aqp4aquaporin 40.345
Tff1trefoil factor 10.342
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.304
Chrna7cholinergic receptor, nicotinic, alpha 70.290
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.280
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.238
Trhrthyrotropin releasing hormone receptor0.228
Dlg4discs, large homolog 4 (Drosophila)0.205
Cx3cr1chemokine (C-X3-C motif) receptor 10.204
Calcrlcalcitonin receptor-like0.204
Fgf14fibroblast growth factor 140.200
Gabra6gamma-aminobutyric acid (GABA) A receptor, alpha 60.199
Ccl4chemokine (C-C motif) ligand 40.198
Lim2lens intrinsic membrane protein 20.195
Adam2ADAM metallopeptidase domain 20.191
Pax6paired box 60.189
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.188
Dlgap1discs, large (Drosophila) homolog-associated protein 10.183
Pitx3paired-like homeodomain 30.183
Rgs8regulator of G-protein signaling 80.178
S100a8S100 calcium binding protein A80.177
S100a9S100 calcium binding protein A90.175
Gpr6G protein-coupled receptor 60.161
Rftn2raftlin family member 20.157
Rab20RAB20, member RAS oncogene family0.156
Htr75-hydroxytryptamine (serotonin) receptor 70.153
RorbRAR-related orphan receptor B0.146
Cxcl10chemokine (C-X-C motif) ligand 100.145
Atxn1ataxin 10.143
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.138
Dock8dedicator of cytokinesis 80.137
Phkg1phosphorylase kinase, gamma 10.136
Pthparathyroid hormone0.135
LOC60591calcium-activated potassium channel beta subunit0.135
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.133
Aif1lallograft inflammatory factor 1-like0.133
Ppyr1pancreatic polypeptide receptor 10.130
Pnma1paraneoplastic antigen MA10.129
Cntfrciliary neurotrophic factor receptor0.127
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.127
Hist1h2aahistone cluster 1, H2aa0.126
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.125
Gja1gap junction protein, alpha 10.123
Atp7bATPase, Cu++ transporting, beta polypeptide0.123
Ccl2chemokine (C-C motif) ligand 20.122
Neu2sialidase 2 (cytosolic sialidase)0.121
Gja6gap junction protein, alpha 60.118
Vom2r53vomeronasal 2 receptor, 530.116
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.116
Neurl3neuralized homolog 3 (Drosophila)0.116
Drd1adopamine receptor D1A0.115
Plp2proteolipid protein 2 (colonic epithelium-enriched)0.114
Hoxa2homeo box A20.110
Agtr1aangiotensin II receptor, type 1a0.108
Gzmkgranzyme K0.107
Anxa2annexin A20.106
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.106
Map2microtubule-associated protein 20.106
Ctsjcathepsin J0.105
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.105
Dccdeleted in colorectal carcinoma0.103
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.103
Itgamintegrin, alpha M0.103
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.102
Pgcprogastricsin (pepsinogen C)0.101
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.100
Prss1protease, serine, 1 (trypsin 1)0.100
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.100
Kcnt1potassium channel, subfamily T, member 10.100
Slc22a25solute carrier family 22, member 250.099
Csrnp2cysteine-serine-rich nuclear protein 20.098
Celcarboxyl ester lipase0.097
Fgf2fibroblast growth factor 20.096
Gucy1a2guanylate cyclase 1, soluble, alpha 20.096
Vipvasoactive intestinal peptide0.096
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.095
Pla2g2cphospholipase A2, group IIC0.094
Ccr5chemokine (C-C motif) receptor 50.094
Slc14a2solute carrier family 14 (urea transporter), member 20.094
Tmem171transmembrane protein 1710.093
Tnni1troponin I type 1 (skeletal, slow)0.093
Dio3deiodinase, iodothyronine, type III0.092
Grid2glutamate receptor, ionotropic, delta 20.092
Nxph4neurexophilin 40.092
Anxa1annexin A10.091
Catsper2cation channel, sperm associated 20.091
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.090
Hrh4histamine receptor H40.090
Atp2a3ATPase, Ca++ transporting, ubiquitous0.089
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
gpb-1Protein GPB-10.463
nlg-1Protein NLG-10.331
goa-1Protein GOA-10.154
pkg-1Protein PKG-10.128
rpm-1Protein RPM-10.113
T14B1.1Protein T14B1.10.104
itr-1Protein ITR-10.095
ntl-4Protein NTL-40.090
R90.1Protein R90.10.085
gar-3Protein GAR-30.085
F53F10.2Protein F53F10.20.077
ist-1Protein IST-10.073
mpz-2Protein MPZ-20.062
csnk-1Protein CSNK-10.060
kin-20Protein KIN-200.055
unc-10Protein UNC-100.052
egl-30Protein EGL-300.049
F32B5.7Protein F32B5.70.049
grk-2Protein GRK-20.048
ZK287.1Protein ZK287.10.047
daf-5Protein DAF-50.046
cmd-1Protein CMD-10.046
gpr-1Protein GPR-10.042
pdl-1Protein PDL-10.039
dop-5Protein DOP-50.037
kin-19Protein KIN-190.036
rab-11.1Protein RAB-11.10.030
apg-1Protein APG-10.030
vav-1Protein VAV-10.030
eat-6Protein EAT-60.029
zyg-11Protein ZYG-110.026
CELE_F59C6.11Protein F59C6.110.025
sea-2Protein SEA-20.023
pde-4Protein PDE-40.023
unc-31Protein UNC-310.022
T23F11.1Protein T23F11.10.020
hrg-4Protein HRG-40.019
lim-9Protein LIM-90.018
R03G8.3Protein R03G8.30.017
frm-3Protein FRM-30.017
Y25C1A.5Protein Y25C1A.50.017
C55F2.1Protein C55F2.10.016
camt-1Protein CAMT-10.016
CELE_Y67A10A.9Protein Y67A10A.90.016
mltn-1Protein MLTN-10.016
grk-1Protein GRK-10.015
H18N23.2Protein H18N23.20.014
nhr-1Protein NHR-10.014
pkn-1Protein PKN-10.014
F01G4.6Protein F01G4.60.014
unc-54Protein UNC-540.014
inx-1Protein INX-10.014
sol-1Protein SOL-10.014
CELE_T13H5.1Protein T13H5.10.014
T13H5.6Protein T13H5.60.014
slo-2Protein SLO-20.014
C28H8.1Protein C28H8.10.014
scm-1Protein SCM-10.013
mab-23Protein MAB-230.013
Y71F9AL.17Protein Y71F9AL.170.013
dpy-23Protein DPY-230.013
lin-10Protein LIN-100.013
npp-1Protein NPP-10.013
rhgf-2Protein RHGF-20.013
ajm-1Protein AJM-10.013
unc-38Protein UNC-380.012
T05G5.1Protein T05G5.10.012
sto-5Protein STO-50.012
mod-1Protein MOD-10.012
insc-1Protein INSC-10.012
R04E5.2Protein R04E5.20.012
cls-1Protein CLS-10.012
ell-1Protein ELL-10.012
svh-2Protein SVH-20.012
twk-35Protein TWK-350.012
egl-36Protein EGL-360.012
nrx-1Protein NRX-10.012
tfg-1Protein TFG-10.012
rig-3Protein RIG-30.011
F32A5.8Protein F32A5.80.011
gei-18Protein GEI-180.011
sli-1Protein SLI-10.011
tpa-1Protein TPA-10.011
smp-1Protein SMP-10.011
mec-18Protein MEC-180.011
let-23Protein LET-230.011
F39G3.5Protein F39G3.50.011
unc-29Protein UNC-290.011
CELE_Y53F4B.5Protein Y53F4B.50.011
ain-2Protein AIN-20.011
aak-2Protein AAK-20.011
twk-29Protein TWK-290.010
C15C8.3Protein C15C8.30.010
frm-2Protein FRM-20.010
ptp-1Protein PTP-10.010
rgef-1Protein RGEF-10.010
hum-6Protein HUM-60.010
F14B8.6Protein F14B8.60.010
tmc-2Protein TMC-20.010
ZC196.5Protein ZC196.50.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.999
GSTM1glutathione S-transferase mu 10.990
IL8interleukin 80.979
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.970
CCR5chemokine (C-C motif) receptor 50.965
S100BS100 calcium binding protein B0.962
CALM1calmodulin 1 (phosphorylase kinase, delta)0.960
GSTM2glutathione S-transferase mu 2 (muscle)0.938
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.937
DRD2dopamine receptor D20.885
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.849
CXCL3chemokine (C-X-C motif) ligand 30.836
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.832
ARRB1arrestin, beta 10.830
MPDZmultiple PDZ domain protein0.811
CXCL9chemokine (C-X-C motif) ligand 90.794
MAPTmicrotubule-associated protein tau0.791
GUCY2Cguanylate cyclase 2C (heat stable enterotoxin receptor)0.777
CCL2chemokine (C-C motif) ligand 20.761
MPZL2myelin protein zero-like 20.744
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.725
ADORA2Aadenosine A2a receptor0.719
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.706
TBX5T-box 50.690
CAV1caveolin 1, caveolae protein, 22kDa0.682
CCL5chemokine (C-C motif) ligand 50.657
CXCL2chemokine (C-X-C motif) ligand 20.652
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.651
MPZL3myelin protein zero-like 30.635
CALCOCO2calcium binding and coiled-coil domain 20.627
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.620
SORBS3sorbin and SH3 domain containing 30.563
CCL4chemokine (C-C motif) ligand 40.562
CXCL10chemokine (C-X-C motif) ligand 100.550
PLAUplasminogen activator, urokinase0.543
IL6interleukin 6 (interferon, beta 2)0.537
PTENphosphatase and tensin homolog0.535
GSTM4glutathione S-transferase mu 40.513
IFNGinterferon, gamma0.513
GDAguanine deaminase0.501
DLG4discs, large homolog 4 (Drosophila)0.500
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.498
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.497
CCL8chemokine (C-C motif) ligand 80.489
CCL20chemokine (C-C motif) ligand 200.482
IL2RBinterleukin 2 receptor, beta0.469
CCL19chemokine (C-C motif) ligand 190.466
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.449
CABP1calcium binding protein 10.444
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.377
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.377
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.369
BAK1BCL2-antagonist/killer 10.336
CXCL5chemokine (C-X-C motif) ligand 50.317
STIM1stromal interaction molecule 10.314
RPH3Arabphilin 3A homolog (mouse)0.311
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.311
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.311
CXCL11chemokine (C-X-C motif) ligand 110.307
DLG2discs, large homolog 2 (Drosophila)0.305
S100A6S100 calcium binding protein A60.298
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.297
DPP4dipeptidyl-peptidase 40.289
ARHGAP1Rho GTPase activating protein 10.289
CRHR1corticotropin releasing hormone receptor 10.281
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.270
VAC14Vac14 homolog (S. cerevisiae)0.270
RYR2ryanodine receptor 2 (cardiac)0.269
CXCL13chemokine (C-X-C motif) ligand 130.265
CCL13chemokine (C-C motif) ligand 130.263
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.260
CCR2chemokine (C-C motif) receptor 20.259
TRPC3transient receptor potential cation channel, subfamily C, member 30.254
SHC1SHC (Src homology 2 domain containing) transforming protein 10.253
SOD1superoxide dismutase 1, soluble0.251
ORAI1ORAI calcium release-activated calcium modulator 10.250
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.249
KLHL3kelch-like 3 (Drosophila)0.245
IL10interleukin 100.243
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.242
MAPK14mitogen-activated protein kinase 140.241
AKT1v-akt murine thymoma viral oncogene homolog 10.239
MAP2K4mitogen-activated protein kinase kinase 40.237
CCL7chemokine (C-C motif) ligand 70.234
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.231
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.230
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.227
PRKCGprotein kinase C, gamma0.224
CCL22chemokine (C-C motif) ligand 220.224
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.224
TRIM63tripartite motif containing 630.219
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.217
APOC1apolipoprotein C-I0.217
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.216
PKD1polycystic kidney disease 1 (autosomal dominant)0.214
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.998
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.915
Tnftumor necrosis factor0.900
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.862
Vegfavascular endothelial growth factor A0.843
Drd2dopamine receptor D20.842
Nos1nitric oxide synthase 1, neuronal0.809
Ifnginterferon gamma0.791
Map3k14mitogen-activated protein kinase kinase kinase 140.767
Dlg4discs, large homolog 4 (Drosophila)0.699
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.635
Homer1homer homolog 1 (Drosophila)0.604
Grm1glutamate receptor, metabotropic 10.599
Rac1RAS-related C3 botulinum substrate 10.597
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.477
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.451
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.430
Ltblymphotoxin B0.421
Mtap2microtubule-associated protein 20.418
Plcb1phospholipase C, beta 10.416
Cyldcylindromatosis (turban tumor syndrome)0.405
BtkBruton agammaglobulinemia tyrosine kinase0.397
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.385
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.368
Cd40CD40 antigen0.364
Lhx3LIM homeobox protein 30.353
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.352
Il1binterleukin 1 beta0.351
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.344
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.339
Ptenphosphatase and tensin homolog0.330
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.325
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.320
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.319
Dlgap1discs, large (Drosophila) homolog-associated protein 10.319
Ltalymphotoxin A0.315
CblCasitas B-lineage lymphoma0.290
Lrp1low density lipoprotein receptor-related protein 10.288
Inpp5dinositol polyphosphate-5-phosphatase D0.284
Dpp6dipeptidylpeptidase 60.274
Fgfr1fibroblast growth factor receptor 10.273
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.266
Srpk3serine/arginine-rich protein specific kinase 30.265
Prkceprotein kinase C, epsilon0.265
Nos3nitric oxide synthase 3, endothelial cell0.264
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.262
Camk2bcalcium/calmodulin-dependent protein kinase II, beta0.258
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.256
Prkccprotein kinase C, gamma0.249
Kdrkinase insert domain protein receptor0.245
Ldb3LIM domain binding 30.244
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.242
Rock2Rho-associated coiled-coil containing protein kinase 20.238
Ctnnb1catenin (cadherin associated protein), beta 10.237
Ikbkginhibitor of kappaB kinase gamma0.234
Itgb1integrin beta 1 (fibronectin receptor beta)0.231
Ikzf1IKAROS family zinc finger 10.221
Syt8synaptotagmin VIII0.217
RoraRAR-related orphan receptor alpha0.215
Apoeapolipoprotein E0.204
Plauplasminogen activator, urokinase0.203
Ppargperoxisome proliferator activated receptor gamma0.201
Tgfbr2transforming growth factor, beta receptor II0.200
Actn2actinin alpha 20.194
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.193
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.190
Per3period homolog 3 (Drosophila)0.189
Mapk14mitogen-activated protein kinase 140.187
Atoh7atonal homolog 7 (Drosophila)0.187
Cxcl13chemokine (C-X-C motif) ligand 130.186
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.185
Il7interleukin 70.185
Inpp5jinositol polyphosphate 5-phosphatase J0.182
Plcg1phospholipase C, gamma 10.179
Zp2zona pellucida glycoprotein 20.179
Itgaxintegrin alpha X0.179
Eya1eyes absent 1 homolog (Drosophila)0.178
Wnt6wingless-related MMTV integration site 60.176
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.170
Ednrbendothelin receptor type B0.167
Leprleptin receptor0.162
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.161
Hif3ahypoxia inducible factor 3, alpha subunit0.160
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.158
Ccl17chemokine (C-C motif) ligand 170.156
Sstr3somatostatin receptor 30.156
Sntb1syntrophin, basic 10.154
Htr75-hydroxytryptamine (serotonin) receptor 70.153
Usp9xubiquitin specific peptidase 9, X chromosome0.150
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.147
Slc12a2solute carrier family 12, member 20.147
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.147
Plp1proteolipid protein (myelin) 10.146
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.144
Shhsonic hedgehog0.143
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YOL036Whypothetical protein0.046
YKR075Chypothetical protein0.027
YPL014Whypothetical protein0.017
YGR125Whypothetical protein0.016
YPR157Whypothetical protein0.015
YHR033Whypothetical protein0.011
YKL187Chypothetical protein0.010