The network for 'cellular response to unfolded protein' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to unfolded protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

NameDescriptionProbabilityFunc Analog Organism
Pdia3protein disulfide isomerase family A, member 30.108
Pdia6protein disulfide isomerase family A, member 60.090
Manfmesencephalic astrocyte-derived neurotrophic factor0.089
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.078
Pdia4protein disulfide isomerase family A, member 40.077
Hsph1heat shock 105/110 protein 10.048
Rpn1ribophorin I0.041
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.040
Hspd1heat shock protein 1 (chaperonin)0.040
Lrrc59leucine rich repeat containing 590.033
Sdf2l1stromal cell-derived factor 2-like 10.031
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.031
Hspa8heat shock protein 80.030
Ubxn4UBX domain protein 40.030
Uso1USO1 homolog, vesicle docking protein (yeast)0.030
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.030
Ddb1damage-specific DNA binding protein 10.026
Creld2cysteine-rich with EGF-like domains 20.026
Hsp90b1heat shock protein 90, beta, member 10.023
P4hbprolyl 4-hydroxylase, beta polypeptide0.023
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.021
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.021
Ddostdolichyl-diphosphooligosaccharide-protein glycosyltransferase0.021
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.020
Hspa5heat shock protein 50.019
Slc39a7solute carrier family 39 (zinc transporter), member 70.018
Sec24cSEC24 family, member C (S. cerevisiae)0.017
Hyou1hypoxia up-regulated 10.016
Herpud1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.016
Atf4activating transcription factor 4 (tax-responsive enhancer element B67)0.016
Lman2lectin, mannose-binding 20.015
Rpn2ribophorin II0.015
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.015
Lamp2lysosomal-associated membrane protein 20.014
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.014
Sec23bSec23 homolog B (S. cerevisiae)0.014
Tor1aip2torsin A interacting protein 20.014
Ap2a1adaptor-related protein complex 2, alpha 1 subunit0.014
Tarsthreonyl-tRNA synthetase0.014
Psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.013
Harshistidyl-tRNA synthetase0.013
Srprsignal recognition particle receptor ('docking protein')0.013
Wsb2WD repeat and SOCS box-containing 20.013
Surf4surfeit 40.013
Tmem66transmembrane protein 660.013
Rnf181ring finger protein 1810.012
Nsfl1cNSFL1 (p97) cofactor (p47)0.012
Narsasparaginyl-tRNA synthetase0.012
Snd1staphylococcal nuclease and tudor domain containing 10.012
Sil1SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)0.012
Plscr3phospholipid scramblase 30.012
Tmed9transmembrane emp24 protein transport domain containing 90.012
LOC100360501ribonuclease inhibitor-like0.012
Eif3ceukaryotic translation initiation factor 3, subunit C0.012
RalyRNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))0.012
Stip1stress-induced phosphoprotein 10.012
Slc35b1solute carrier family 35, member B10.012
Srprbsignal recognition particle receptor, B subunit0.012
Gorasp2golgi reassembly stacking protein 20.012
Aph1aanterior pharynx defective 1 homolog A (C. elegans)0.011
Psmd7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.011
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.011
Stat3signal transducer and activator of transcription 30.011
Twf1twinfilin, actin-binding protein, homolog 1 (Drosophila)0.011
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.011
Warstryptophanyl-tRNA synthetase0.011
Btg1B-cell translocation gene 1, anti-proliferative0.011
Marsmethionine-tRNA synthetase0.010
Mgat2mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.010
Capn1calpain 10.010
Tmem127transmembrane protein 1270.010
Pdrg1p53 and DNA damage regulated 10.010
Gcs1glucosidase 10.010
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.010
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
abu-15Protein ABU-150.992
tag-320Protein TAG-3200.981
abu-8Protein ABU-80.979
abu-11Protein ABU-110.965
hsp-16.2Protein HSP-16.20.957
hsp-16.1Protein HSP-16.10.921
hsp-16.41Protein HSP-16.410.883
hsp-70Protein HSP-700.855
abu-6Protein ABU-60.844
F44E5.4Protein F44E5.40.842
hsp-3Protein HSP-30.836
pqn-54Protein PQN-540.824
abu-14Protein ABU-140.746
pqn-74Protein PQN-740.659
abu-1Protein ABU-10.647
Y47D3B.6Protein Y47D3B.60.558
abu-10Protein ABU-100.498
hsp-16.48Protein HSP-16.480.485
Y19D2B.1Protein Y19D2B.10.458
CELE_F20G2.2Protein F20G2.20.448
CELE_T05E11.3Protein T05E11.30.433
dnj-7Protein DNJ-70.309
dct-18Protein DCT-180.303
pqn-63Protein PQN-630.296
CELE_C01G6.5Protein C01G6.50.278
unc-78Protein UNC-780.273
ckb-2Protein CKB-20.265
C29F3.7Protein C29F3.70.265
nhr-17Protein NHR-170.245
R03C1.1Protein R03C1.10.242
abu-9Protein ABU-90.242
ifd-1Protein IFD-10.241
CELE_T06E4.9Protein T06E4.90.239
dsc-4Protein DSC-40.221
stt-3Protein STT-30.216
trap-2Protein TRAP-20.215
imp-2Protein IMP-20.212
nipi-3Protein NIPI-30.210
pdi-3Protein PDI-30.208
sec-22Protein SEC-220.196
pdi-2Protein PDI-20.181
F41E6.11Protein F41E6.110.176
F54E2.1Protein F54E2.10.175
F13E6.5Protein F13E6.50.171
pqn-71Protein PQN-710.166
Y94H6A.7Protein Y94H6A.70.155
CELE_Y41C4A.11Protein Y41C4A.110.151
F13H6.1Protein F13H6.10.143
CELE_T06E4.8Protein T06E4.80.141
dnj-21Protein DNJ-210.139
CELE_Y39B6A.1Protein Y39B6A.10.134
gbh-1Protein GBH-10.130
crt-1Protein CRT-10.129
hsp-4Protein HSP-40.127
R05F9.6Protein R05F9.60.121
lig-4Protein LIG-40.121
pak-1Protein PAK-10.121
grl-7Protein GRL-70.120
rsbp-1Protein RSBP-10.119
T10B10.3Protein T10B10.30.119
haly-1Protein HALY-10.118
pqn-57Protein PQN-570.114
uig-1Protein UIG-10.113
CELE_F19B2.5Protein F19B2.50.110
tufm-1Protein TUFM-10.108
ser-3Protein SER-30.106
F40G12.5Protein F40G12.50.104
C18B2.4Protein C18B2.40.101
pkc-3Protein PKC-30.099
Y76B12C.3Protein Y76B12C.30.096
arf-1.1Protein ARF-1.10.095
T25E4.1Protein T25E4.10.095
cdc-48.2Protein CDC-48.20.095
hint-3Protein HINT-30.095
sgt-1Protein SGT-10.094
R02F11.1Protein R02F11.10.090
CELE_F54F7.6Protein F54F7.60.089
K02G10.1Protein K02G10.10.089
F53B3.3Protein F53B3.30.088
paa-1Protein PAA-10.087
C31E10.6Protein C31E10.60.086
F46G11.1Protein F46G11.10.086
dnj-29Protein DNJ-290.085
ZK662.2Protein ZK662.20.081
hke-4.2Protein HKE-4.20.081
eef-1A.1Protein EEF-1A.10.080
dim-1Protein DIM-10.079
gst-23Protein GST-230.079
col-127Protein COL-1270.078
cdf-1Protein CDF-10.078
comt-3Protein COMT-30.078
mtp-18Protein MTP-180.077
glod-4Protein GLOD-40.077
H40L08.1Protein H40L08.10.075
ztf-17Protein ZTF-170.074
C18B12.6Protein C18B12.60.073
cut-2Protein CUT-20.073
C09E9.1Protein C09E9.10.073
erv-46Protein ERV-460.073
ZK686.3Protein ZK686.30.072
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hsp90b1heat shock protein 90, beta (grp94), member 10.910
manfmesencephalic astrocyte-derived neurotrophic factor0.877
hspa5heat shock protein 50.856
hyou1hypoxia up-regulated 10.515
ccng1cyclin G10.481
pdia3protein disulfide isomerase family A, member 30.474
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.472
yarstyrosyl-tRNA synthetase0.416
calrcalreticulin and calreticulin0.405
dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.371
pdia4protein disulfide isomerase associated 40.351
pdip5protein disulfide isomerase-related protein (provisional)0.344
calrlcalreticulin like0.242
adra2badrenergic, alpha-2B-, receptor0.189
pvalb4parvalbumin 40.184
larsleucyl-tRNA synthetase0.142
mbnl2muscleblind-like 2 (Drosophila)0.127
tram1translocating chain-associating membrane protein 10.118
prkcshprotein kinase C substrate 80K-H0.113
sec61al2Sec61 alpha like 20.109
nme2b.2non-metastatic cells 2b.2, protein (NM23B) expressed in0.094
calrl2calreticulin, like 20.088
tmed9transmembrane emp24 protein transport domain containing 90.086
txnrd1thioredoxin reductase 10.084
hspa4aheat shock protein 4a0.084
slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.079
etf1eukaryotic translation termination factor 10.077
vmp1vacuole membrane protein 10.072
ttnatitin a0.070
papss2b3'-phosphoadenosine 5'-phosphosulfate synthase 2b0.067
atp2b4ATPase, Ca++ transporting, plasma membrane 40.063
vmhcventricular myosin heavy chain0.061
tuba8ltubulin, alpha 8 like0.059
herpud1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.056
gspt1lG1 to S phase transition 1, like0.052
mapkapk2amitogen-activated protein kinase-activated protein kinase 2a0.051
tmem38atransmembrane protein 38A0.050
ahcyS-adenosylhomocysteine hydrolase0.050
mylz3myosin, light polypeptide 3, skeletal muscle0.049
ddostdolichyl-diphosphooligosaccharide-protein glycosyltransferase0.048
cdv3carnitine deficiency-associated gene expressed in ventricle 30.042
ppibpeptidylprolyl isomerase B (cyclophilin B)0.042
ckmbcreatine kinase, muscle b0.041
tm9sf2transmembrane 9 superfamily member 20.040
tnnc2troponin C type 2 (fast)0.040
cyc1cytochrome c-10.040
eif4a1aeukaryotic translation initiation factor 4A, isoform 1A0.039
golt1bgolgi transport 1 homolog B (S. cerevisiae)0.039
mtdhametadherin a0.039
syvn1synovial apoptosis inhibitor 1, synoviolin0.038
adra2dbadrenergic, alpha-2D-, receptor b0.038
ppp1cabprotein phosphatase 1, catalytic subunit, alpha isoform b0.037
odc1ornithine decarboxylase 10.037
stat1asignal transduction and activation of transcription 1a0.037
pvalb7parvalbumin 70.037
defbl3defensin, beta-like 30.037
junjun proto-oncogene0.037
rnf128aring finger protein 128a0.035
ldb3bLIM domain binding 3b0.035
hspa8heat shock protein 80.035
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.035
mbnl3muscleblind-like 3 (Drosophila)0.034
pcsk5aproprotein convertase subtilisin/kexin type 5a0.034
cx52.6connexin 52.60.034
akap9A kinase (PRKA) anchor protein (yotiao) 90.033
pvalb2parvalbumin 20.033
cdkn1acyclin-dependent kinase inhibitor 1A0.033
tnnt3btroponin T3b, skeletal, fast0.032
pcsk1proprotein convertase subtilisin/kexin type 10.032
pyyapeptide YYa0.032
qarsglutaminyl-tRNA synthetase0.032
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.031
tmed2transmembrane emp24 domain trafficking protein 20.031
alg2asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)0.030
rer1RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)0.030
tm9sf3transmembrane 9 superfamily member 30.030
lonp1lon peptidase 1, mitochondrial0.030
LOC555713hypothetical LOC5557130.030
opn1mw2opsin 1 (cone pigments), medium-wave-sensitive, 20.030
psmb9aproteasome (prosome, macropain) subunit, beta type, 9a0.030
gria2bglutamate receptor, ionotropic, AMPA 2b0.030
adra2aadrenergic, alpha-2A-, receptor0.029
rad54bRAD54 homolog B (S. cerevisiae)0.029
rnf11ring finger protein 110.029
tomm34translocase of outer mitochondrial membrane 340.029
tnni2a.4troponin I, skeletal, fast 2a.40.029
ef1aelongation factor 1-alpha0.029
c20orf24c20orf24 homolog (H. sapiens)0.028
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.028
vipr2vasoactive intestinal peptide receptor 20.028
LOC100001008prepro-urotensin II-related peptide0.028
pcsk7proprotein convertase subtilisin/kexin type 70.028
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.028
zbtb22bzinc finger and BTB domain containing 22b0.028
nucb2bnucleobindin 2b0.027
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
imdimmune deficiency0.124
CG7830CG7830 gene product from transcript CG7830-RA0.120
HerpHomocysteine-induced endoplasmic reticulum protein0.119
SuURSuppressor of Under-Replication0.111
CG5484CG5484 gene product from transcript CG5484-RC0.080
Syx18Syntaxin 180.046
CG12404CG12404 gene product from transcript CG12404-RA0.042
CG3061CG3061 gene product from transcript CG3061-RA0.032
Vhlvon Hippel-Lindau0.032
Kr-h2Kruppel homolog 20.031
PdiProtein disulfide isomerase0.029
CaBP1CG5809 gene product from transcript CG5809-RA0.029
CG7371CG7371 gene product from transcript CG7371-RA0.028
CG9304CG9304 gene product from transcript CG9304-RA0.027
TRAMCG11642 gene product from transcript CG11642-RB0.026
CrebACyclic-AMP response element binding protein A0.025
Traf4TNF-receptor-associated factor 40.025
BG4CG12297 gene product from transcript CG12297-RA0.024
myoglianinCG1838 gene product from transcript CG1838-RD0.024
P58IPKCG8286 gene product from transcript CG8286-RA0.022
ird1immune response deficient 10.020
CG6191CG6191 gene product from transcript CG6191-RA0.019
Edc3Enhancer of decapping 30.019
CG11857CG11857 gene product from transcript CG11857-RA0.017
Gcn2CG1609 gene product from transcript CG1609-RA0.016
CG9318CG9318 gene product from transcript CG9318-RA0.015
CG3781CG3781 gene product from transcript CG3781-RA0.015
CG1418CG1418 gene product from transcript CG1418-RA0.014
JhI-1Juvenile hormone-inducible protein 10.014
CG5850CG5850 gene product from transcript CG5850-RC0.013
cwoclockwork orange0.013
SsRbetaSignal sequence receptor beta0.012
EDTPEgg-derived tyrosine phosphatase0.012
Ero1LEndoplasmic reticulum oxidoreductin-1-like0.012
RagACG11968 gene product from transcript CG11968-RA0.011
Srp54kSignal recognition particle protein 54k0.011
CG9590CG9590 gene product from transcript CG9590-RA0.011
flowerCG6151 gene product from transcript CG6151-RA0.010
Xbp1X box binding protein-10.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1.000
PDIA3protein disulfide isomerase family A, member 30.999
SYVN1synovial apoptosis inhibitor 1, synoviolin0.998
BCL2L1BCL2-like 10.912
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.899
DERL1Der1-like domain family, member 10.890
P4HBprolyl 4-hydroxylase, beta polypeptide0.876
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.859
GHRgrowth hormone receptor0.852
VCPvalosin containing protein0.753
BCL2L11BCL2-like 11 (apoptosis facilitator)0.538
STON2stonin 20.514
BCL2B-cell CLL/lymphoma 20.440
SELSselenoprotein S0.427
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 90.420
PDIA6protein disulfide isomerase family A, member 60.347
PDIA4protein disulfide isomerase family A, member 40.332
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.320
PPIBpeptidylprolyl isomerase B (cyclophilin B)0.310
BAK1BCL2-antagonist/killer 10.271
BAXBCL2-associated X protein0.189
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.160
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.158
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.157
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.155
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.147
MANFmesencephalic astrocyte-derived neurotrophic factor0.117
FOSFBJ murine osteosarcoma viral oncogene homolog0.108
HYOU1hypoxia up-regulated 10.105
HSPD1heat shock 60kDa protein 1 (chaperonin)0.091
UBE2J1ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)0.091
BADBCL2-associated agonist of cell death0.085
C4orf14chromosome 4 open reading frame 140.084
JUNDjun D proto-oncogene0.079
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.075
PLCG1phospholipase C, gamma 10.074
GANABglucosidase, alpha; neutral AB0.071
SOS1son of sevenless homolog 1 (Drosophila)0.069
WDR83WD repeat domain 830.066
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.062
ATF3activating transcription factor 30.055
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.055
CCND3cyclin D30.054
PTPRBprotein tyrosine phosphatase, receptor type, B0.052
CDK6cyclin-dependent kinase 60.050
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.047
NUCB2nucleobindin 20.045
RNF144Bring finger protein 144B0.044
ERN1endoplasmic reticulum to nucleus signaling 10.041
AMFRautocrine motility factor receptor0.040
SURF4surfeit 40.039
RABAC1Rab acceptor 1 (prenylated)0.038
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)0.038
RPN2ribophorin II0.036
ERO1LERO1-like (S. cerevisiae)0.035
CSRNP1cysteine-serine-rich nuclear protein 10.030
HM13histocompatibility (minor) 130.028
VDAC1voltage-dependent anion channel 10.028
DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 30.025
ATXN3ataxin 30.024
DDIT3DNA-damage-inducible transcript 30.024
RPN1ribophorin I0.022
IFIT1interferon-induced protein with tetratricopeptide repeats 10.022
UHRF2ubiquitin-like with PHD and ring finger domains 20.022
BHLHE40basic helix-loop-helix family, member e400.021
VAPAVAMP (vesicle-associated membrane protein)-associated protein A, 33kDa0.021
PTPN3protein tyrosine phosphatase, non-receptor type 30.021
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.021
STX8syntaxin 80.020
NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)0.020
HBP1HMG-box transcription factor 10.019
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.018
PDIA5protein disulfide isomerase family A, member 50.018
OSBPL9oxysterol binding protein-like 90.018
UBXN2AUBX domain protein 2A0.018
IL8interleukin 80.018
KDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 20.017
DBPD site of albumin promoter (albumin D-box) binding protein0.017
SLC3A2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.016
JUNjun proto-oncogene0.016
IFRD1interferon-related developmental regulator 10.016
NFIL3nuclear factor, interleukin 3 regulated0.016
EIF3CLeukaryotic translation initiation factor 3, subunit C-like0.015
SSR1signal sequence receptor, alpha0.015
STAT5Asignal transducer and activator of transcription 5A0.015
PTPN2protein tyrosine phosphatase, non-receptor type 20.015
KLF6Kruppel-like factor 60.015
IER2immediate early response 20.015
UBE4Bubiquitination factor E4B (UFD2 homolog, yeast)0.015
HSPB1heat shock 27kDa protein 10.015
DERL2Der1-like domain family, member 20.014
FKBP4FK506 binding protein 4, 59kDa0.014
SART1squamous cell carcinoma antigen recognized by T cells0.014
VEGFAvascular endothelial growth factor A0.014
KEAP1kelch-like ECH-associated protein 10.014
EIF1eukaryotic translation initiation factor 10.014
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YLR264C-Ahypothetical protein0.010
YHR162Whypothetical protein0.010