The network for 'porphyrin containing compound metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

porphyrin containing compound metabolic process

The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hmbshydroxymethylbilane synthase0.688
Mdh1malate dehydrogenase 1, NAD (soluble)0.549
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.510
Oaz1ornithine decarboxylase antizyme 10.437
Aladaminolevulinate, delta-, dehydratase0.401
Mpstmercaptopyruvate sulfurtransferase0.314
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.213
Grhprglyoxylate reductase/hydroxypyruvate reductase0.207
Akr7a2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.185
Trap1TNF receptor-associated protein 10.165
Fechferrochelatase0.107
Mosc2MOCO sulphurase C-terminal domain containing 20.100
Tstthiosulfate sulfurtransferase0.099
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.097
Ccscopper chaperone for superoxide dismutase0.095
Atp5g3ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)0.089
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.078
ApehN-acylaminoacyl-peptide hydrolase0.077
Hspd1heat shock protein 1 (chaperonin)0.066
Nr5a2nuclear receptor subfamily 5, group A, member 20.057
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.046
DdtD-dopachrome tautomerase0.044
Idh2isocitrate dehydrogenase 2 (NADP+), mitochondrial0.039
Apobapolipoprotein B0.038
Mri1methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)0.038
Mipepmitochondrial intermediate peptidase0.036
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.035
Fabp1fatty acid binding protein 1, liver0.035
Uroduroporphyrinogen decarboxylase0.034
Mt2Ametallothionein 2A0.033
Prdx1peroxiredoxin 10.033
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.031
Crisp2cysteine-rich secretory protein 20.031
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.029
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.028
Sordsorbitol dehydrogenase0.025
Fgafibrinogen alpha chain0.025
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.025
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.025
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.023
Pecrperoxisomal trans-2-enoyl-CoA reductase0.023
Tmem205transmembrane protein 2050.023
Ciao1cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)0.022
Klk1c10T-kininogenase0.022
Acracrosin0.021
Kng1kininogen 10.020
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.018
Esr2estrogen receptor 2 (ER beta)0.018
Cryabcrystallin, alpha B0.018
Gpx4glutathione peroxidase 40.017
A1i3alpha-1-inhibitor III0.017
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.016
Gamtguanidinoacetate N-methyltransferase0.016
Agxtalanine-glyoxylate aminotransferase0.016
Gsta4glutathione S-transferase alpha 40.016
LOC293989cytochrome P450-like0.016
Prb1proline-rich protein BstNI subfamily 10.016
Tsta3tissue specific transplantation antigen P35B0.015
Bola1bolA homolog 1 (E. coli)0.015
Litaflipopolysaccharide-induced TNF factor0.015
Hspa8heat shock protein 80.015
Sephs2selenophosphate synthetase 20.014
Msmbmicroseminoprotein, beta0.014
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.014
Got1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.014
Dmgdhdimethylglycine dehydrogenase0.014
Cyp4f6cytochrome P450, family 4, subfamily f, polypeptide 60.014
Sftpbsurfactant protein B0.014
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.013
RGD1311605similar to apoptosis related protein APR-3; p18 protein0.013
Alkbh7alkB, alkylation repair homolog 7 (E. coli)0.012
Acox2acyl-Coenzyme A oxidase 2, branched chain0.012
RGD1308134similar to RIKEN cDNA 1110020A230.012
Tmem49transmembrane protein 490.012
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.012
Gjb2gap junction protein, beta 20.012
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.012
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.012
Nqo1NAD(P)H dehydrogenase, quinone 10.011
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.011
Nr0b2nuclear receptor subfamily 0, group B, member 20.011
Guca2aguanylate cyclase activator 2a (guanylin)0.011
Grik3glutamate receptor, ionotropic, kainate 30.011
Ccl17chemokine (C-C motif) ligand 170.011
Akr7a3aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)0.011
Orm1orosomucoid 10.011
LOC100363671hypothetical protein LOC1003636710.011
Bckdhbbranched chain keto acid dehydrogenase E1, beta polypeptide0.010
Fdxrferredoxin reductase0.010
Slc22a7solute carrier family 22 (organic anion transporter), member 70.010
Fbp1fructose-1,6-bisphosphatase 10.010
Cela2achymotrypsin-like elastase family, member 2A0.010
RGD1311910similar to hypothetical p38 protein0.010
Plaurplasminogen activator, urokinase receptor0.010
Sycp1synaptonemal complex protein 10.010
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.010
Amhanti-Mullerian hormone0.010
Acp2acid phosphatase 2, lysosomal0.010
Hnf1aHNF1 homeobox A0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tfr1atransferrin receptor 1a0.977
urosuroporphyrinogen III synthase0.878
fechferrochelatase0.759
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.752
gata1aGATA binding protein 1a0.660
slc25a37solute carrier family 25, member 370.449
ppoxprotoporphyrinogen oxidase0.215
slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.174
slc4a1asolute carrier family 4, anion exchanger, member 1a0.172
alas2aminolevulinate, delta-, synthetase 20.130
aco1aconitase 1, soluble0.105
iba57IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)0.083
tal1T-cell acute lymphocytic leukemia 10.078
uroduroporphyrinogen decarboxylase0.065
glrx5glutaredoxin 5 homolog (S. cerevisiae)0.058
adipor2adiponectin receptor 20.053
hbbe3hemoglobin beta embryonic-30.045
cmybtranscription factor cmyb0.044
slc25a39solute carrier family 25, member 390.040
zgc:153921zgc:1539210.038
LOC100151531zinc finger protein Gfi-1b-like0.037
rnf17ring finger protein 170.035
tmem14ctransmembrane protein 14C0.034
echdc2enoyl CoA hydratase domain containing 20.032
hmbsbhydroxymethylbilane synthase, b0.031
zgc:110231zgc:1102310.030
kbpkif1-binding protein0.028
abca12ATP-binding cassette, sub-family A (ABC1), member 120.028
hbbe2hemoglobin beta embryonic-20.024
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.023
trpm7transient receptor potential cation channel, subfamily M, member 70.022
frem2aFras1 related extracellular matrix protein 2a0.021
oip5opa interacting protein 50.021
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.020
cyp2k22cytochrome P450, family 2, subfamily K, polypeptide 220.019
hibadha3-hydroxyisobutyrate dehydrogenase a0.019
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.019
mchr1amelanin-concentrating hormone receptor 1a0.018
cnpy1canopy10.018
eif2s2eukaryotic translation initiation factor 2, subunit 2 beta0.018
hint2histidine triad nucleotide binding protein 20.017
ctszcathepsin Z0.017
bdh23-hydroxybutyrate dehydrogenase, type 20.017
snrk1SNF related kinase 10.017
zgc:112089zgc:1120890.017
upp2uridine phosphorylase 20.017
znhit1zinc finger, HIT-type containing 10.017
zgc:66313zgc:663130.017
procprotein C (inactivator of coagulation factors Va and VIIIa)0.017
npsnlnephrosin-like0.017
atxn7l3ataxin 7-like 30.017
smchd1structural maintenance of chromosomes flexible hinge domain containing 10.016
si:dkey-246k9.1si:dkey-246k9.10.016
tspotranslocator protein0.016
lmo2LIM domain only 2 (rhombotin-like 1)0.015
zgc:136874zgc:1368740.015
map2k4amitogen-activated protein kinase kinase 4a0.015
dync2i1dynein, cytoplasmic 2, intermediate chain 10.015
glipr2GLI pathogenesis-related 20.015
hbbe1.1hemoglobin beta embryonic-1.10.014
si:ch211-217g15.2si:ch211-217g15.20.014
hdrhematopoietic death receptor0.014
cpa4carboxypeptidase A40.014
aladaminolevulinate dehydratase0.013
atp7aATPase, Cu++ transporting, alpha polypeptide0.013
cry2bcryptochrome 2b0.013
igfbp1binsulin-like growth factor binding protein 1b0.013
trim2atripartite motif-containing 2a0.013
zgc:73070zgc:730700.013
znfl2azinc finger-like gene 2a0.013
tsc1atuberous sclerosis 1a0.013
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.013
masp2mannan-binding lectin serine peptidase 20.013
mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.012
wu:fd61a05wu:fd61a050.012
zgc:114097zgc:1140970.012
atg12ATG12 autophagy related 12 homolog (S. cerevisiae)0.012
zgc:158288zgc:1582880.012
serpinb1l3serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 30.012
cyp2v2cytochrome P450, family 2, subfamily V, polypeptide 20.012
tie2endothelium-specific receptor tyrosine kinase 20.012
gpx1aglutathione peroxidase 1a0.012
lmnl3lamin L30.012
si:ch211-233e16.1si:ch211-233e16.10.012
rab20RAB20, member RAS oncogene family0.012
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.012
nit1nitrilase 10.011
adh8aalcohol dehydrogenase 8a0.011
glcci1glucocorticoid induced transcript 10.011
selpselectin P0.011
gstt1bglutathione S-transferase theta 1b0.011
cx32.3connexin 32.30.011
csnk1g2acasein kinase 1, gamma 2a0.011
caprin2caprin family member 20.011
klfdKruppel-like factor d0.011
si:ch211-57k11.10si:ch211-57k11.100.011
st3gal4ST3 beta-galactoside alpha-2,3-sialyltransferase 40.011
pdap1pdgfa associated protein 10.010
im:6908224im:69082240.010
cmascytidine monophosphate N-acetylneuraminic acid synthetase0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SPTBspectrin, beta, erythrocytic0.991
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.730
ANK1ankyrin 1, erythrocytic0.482
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.360
EEF2eukaryotic translation elongation factor 20.208
RHAGRh-associated glycoprotein0.131
EIF3Keukaryotic translation initiation factor 3, subunit K0.127
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.062
FAF1Fas (TNFRSF6) associated factor 10.053
QARSglutaminyl-tRNA synthetase0.043
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.043
EIF3Deukaryotic translation initiation factor 3, subunit D0.034
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.021
PCBD2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 20.018
TTNtitin0.016
GRHPRglyoxylate reductase/hydroxypyruvate reductase0.015
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.015
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.015
URODuroporphyrinogen decarboxylase0.012
TALDO1transaldolase 10.011
TOLLIPtoll interacting protein0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hmbshydroxymethylbilane synthase0.736
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.675
Mup5major urinary protein 50.674
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.667
Spna1spectrin alpha 10.653
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.611
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.569
CrpC-reactive protein, pentraxin-related0.548
Spnb1spectrin beta 10.528
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.518
Exoc6exocyst complex component 60.469
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.404
G6pcglucose-6-phosphatase, catalytic0.348
Akr1c6aldo-keto reductase family 1, member C60.333
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.327
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.319
Cps1carbamoyl-phosphate synthetase 10.298
F9coagulation factor IX0.287
Ank1ankyrin 1, erythroid0.277
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.271
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.269
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.258
Keg1kidney expressed gene 10.237
Slc22a1solute carrier family 22 (organic cation transporter), member 10.234
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.234
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.220
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.212
Fechferrochelatase0.196
Otcornithine transcarbamylase0.163
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.156
Acot12acyl-CoA thioesterase 120.150
Pklrpyruvate kinase liver and red blood cell0.139
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.139
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.135
Dmgdhdimethylglycine dehydrogenase precursor0.135
Aadacarylacetamide deacetylase (esterase)0.135
Tattyrosine aminotransferase0.126
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.124
BC089597cDNA sequence BC0895970.122
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.116
Apoc4apolipoprotein C-IV0.114
Urosuroporphyrinogen III synthase0.114
Tdo2tryptophan 2,3-dioxygenase0.114
Azgp1alpha-2-glycoprotein 1, zinc0.111
Slc22a18solute carrier family 22 (organic cation transporter), member 180.108
Timd2T-cell immunoglobulin and mucin domain containing 20.107
Hrghistidine-rich glycoprotein0.104
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.102
Cfhr1complement factor H-related 10.100
Hgdhomogentisate 1, 2-dioxygenase0.099
Rdh7retinol dehydrogenase 70.099
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.098
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.098
Pigrpolymeric immunoglobulin receptor0.096
Hbb-b2hemoglobin, beta adult minor chain0.095
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.093
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.091
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.089
Mup3major urinary protein 30.086
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.086
Slc4a1solute carrier family 4 (anion exchanger), member 10.084
Cyp2f2cytochrome P450, family 2, subfamily f, polypeptide 20.076
Epb4.1erythrocyte protein band 4.10.073
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.073
Hfehemochromatosis0.073
Pon1paraoxonase 10.072
Albalbumin0.070
Hbb-b1hemoglobin, beta adult major chain0.068
Ces3acarboxylesterase 3A0.066
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.064
Nr1i3nuclear receptor subfamily 1, group I, member 30.064
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.063
C9complement component 90.061
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.061
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.060
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.059
Apohapolipoprotein H0.058
Mbl2mannose-binding lectin (protein C) 20.057
Afmafamin0.056
Tfrctransferrin receptor0.055
Cyp2b13cytochrome P450, family 2, subfamily b, polypeptide 130.055
Hfe2hemochromatosis type 2 (juvenile) (human homolog)0.055
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.054
Krtap6-1keratin associated protein 6-10.053
Abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 40.052
Cml2camello-like 20.052
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.051
Glrx5glutaredoxin 5 homolog (S. cerevisiae)0.050
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.049
Catcatalase0.048
Sult1d1sulfotransferase family 1D, member 10.047
Bhmtbetaine-homocysteine methyltransferase0.047
F13bcoagulation factor XIII, beta subunit0.046
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.045
Inmtindolethylamine N-methyltransferase0.045
Taldo1transaldolase 10.045
Thbs1thrombospondin 10.044
Vnn3vanin 30.044
Cyp2c37cytochrome P450, family 2. subfamily c, polypeptide 370.043
Macf1microtubule-actin crosslinking factor 10.042
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
HEM2Hem2p0.575
HEM12Hem12p0.291
HEM3Hem3p0.078
COX18Cox18p0.061
MIR1Mir1p0.059
GLT1Glt1p0.057
YHR009Chypothetical protein0.053
PET9Pet9p0.051
SUL2Sul2p0.046
AIM38Aim38p0.042
MET16Met16p0.035
LEU5Leu5p0.034
PDI1Pdi1p0.033
PAN1Pan1p0.030
BAP3Bap3p0.029
YNL190Whypothetical protein0.029
THO1Tho1p0.028
ALE1Ale1p0.028
SRD1Srd1p0.028
ARG8Arg8p0.028
PMI40Pmi40p0.027
MNP1Mnp1p0.026
LEU2Leu2p0.026
DLD1Dld1p0.026
YLR177Whypothetical protein0.025
YLR264C-Ahypothetical protein0.024
LSC1Lsc1p0.024
MET2Met2p0.024
PUT4Put4p0.024
ANB1Anb1p0.023
COX4Cox4p0.023
YOL038C-Ahypothetical protein0.023
GAL83Gal83p0.023
PUS6Pus6p0.023
BIO2Bio2p0.023
COX2Cox2p0.023
SCM4Scm4p0.023
CAR1Car1p0.022
YLR162Whypothetical protein0.022
BCS1Bcs1p0.022
ARP10Arp10p0.021
CPD1Cpd1p0.021
MET10Met10p0.021
HOR2Hor2p0.021
HXT3Hxt3p0.021
MER1Mer1p0.021
NDE1Nde1p0.020
YDL241Whypothetical protein0.020
OPT2Opt2p0.020
YPR157Whypothetical protein0.020
SPL2Spl2p0.020
YCH1Ych1p0.019
MTM1Mtm1p0.019
YLR042Chypothetical protein0.019
ZPS1Zps1p0.019
URA6Ura6p0.018
CUP1-1Cup1-1p0.018
PDC6Pdc6p0.018
SWC7Swc7p0.018
SUC2Suc2p0.018
YJL107Chypothetical protein0.018
NAM8Nam8p0.018
RMD6Rmd6p0.018
SLC1Slc1p0.018
YAR068Whypothetical protein0.017
CYT1Cyt1p0.017
BSC1Bsc1p0.017
YBR013Chypothetical protein0.017
ADH2Adh2p0.017
YOL013W-Ahypothetical protein0.017
YJL218Whypothetical protein0.017
PET10Pet10p0.017
FMT1Fmt1p0.017
ICS2Ics2p0.017
HPF1Hpf1p0.017
UPS3Ups3p0.017
MET8Met8p0.016
YIR035Chypothetical protein0.016
AUA1Aua1p0.016
MFA2Mfa2p0.016
TIR3Tir3p0.016
MF(ALPHA)2Mf(alpha)2p0.016
MET6Met6p0.016
CTR2Ctr2p0.016
ARO10Aro10p0.016
NRG2Nrg2p0.016
ARO9Aro9p0.016
ALT2Alt2p0.016
PCP1Pcp1p0.015
GPD2Gpd2p0.015
DIC1Dic1p0.015
KNH1Knh1p0.015
YJR120Whypothetical protein0.015
YDL012Chypothetical protein0.015
COX5ACox5ap0.015
BNA5Bna5p0.015
MHT1Mht1p0.015
ERG9Erg9p0.015
ATP6Atp6p0.015
REE1Ree1p0.015