The network for 'positive regulation of bone mineralization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of bone mineralization

Any process that activates or increases the frequency, rate or extent of bone mineralization.

NameDescriptionProbabilityFunc Analog Organism
Cd44Cd44 molecule0.154
Fgfr2fibroblast growth factor receptor 20.145
Myh9myosin, heavy chain 9, non-muscle0.141
Tgfbr2transforming growth factor, beta receptor II0.072
Znf503zinc finger protein 5030.071
Akt1v-akt murine thymoma viral oncogene homolog 10.065
Fgfr1Fibroblast growth factor receptor 10.054
Edn1endothelin 10.049
Prkchprotein kinase C, eta0.047
Smad7SMAD family member 70.043
Ptpn14protein tyrosine phosphatase, non-receptor type 140.043
Irs1insulin receptor substrate 10.042
Ehfets homologous factor0.038
Rararetinoic acid receptor, alpha0.036
Stat6signal transducer and activator of transcription 60.034
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.034
Usp25ubiquitin specific peptidase 250.034
Cpsf2cleavage and polyadenylation specific factor 20.034
Jak1Janus kinase 10.033
Mmp23matrix metallopeptidase 230.032
Rnf111ring finger protein 1110.032
Jak2Janus kinase 20.032
Ntn1netrin 10.031
Klf2Kruppel-like factor 2 (lung)0.030
Tgfb2transforming growth factor, beta 20.029
RbpmsRNA binding protein with multiple splicing0.027
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.026
Cd14CD14 molecule0.026
Socs3suppressor of cytokine signaling 30.026
Padi1peptidyl arginine deiminase, type I0.026
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.025
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.024
Emp1epithelial membrane protein 10.024
Efnb1ephrin B10.024
Ptgs1prostaglandin-endoperoxide synthase 10.024
Efemp2EGF-containing fibulin-like extracellular matrix protein 20.023
Ubtfupstream binding transcription factor, RNA polymerase I0.023
Slco2a1solute carrier organic anion transporter family, member 2a10.023
Lamc1laminin, gamma 10.022
Cysscystatin S0.022
Jdp2Jun dimerization protein 20.021
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.021
Col18a1collagen, type XVIII, alpha 10.021
RestRE1-silencing transcription factor0.021
Jubjub, ajuba homolog (Xenopus laevis)0.021
Casp3caspase 30.020
GperG protein-coupled estrogen receptor 10.020
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.020
Elk3ELK3, ETS-domain protein0.020
Soat1sterol O-acyltransferase 10.019
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.019
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.019
Klf3Kruppel-like factor 3 (basic)0.019
Crtapcartilage associated protein0.019
Syt8synaptotagmin VIII0.018
Itpr2inositol 1,4,5-triphosphate receptor, type 20.018
Ptk7PTK7 protein tyrosine kinase 70.018
Gata6GATA binding protein 60.018
Nfianuclear factor I/A0.018
CdonCdon homolog (mouse)0.017
Lama5laminin, alpha 50.017
Ptger4prostaglandin E receptor 4 (subtype EP4)0.017
Fam198bfamily with sequence similarity 198, member B0.017
Sod3superoxide dismutase 3, extracellular0.017
Sox4SRY (sex determining region Y)-box 40.017
P22k15cystatin related protein 20.017
Nbl1neuroblastoma, suppression of tumorigenicity 10.017
Gna15guanine nucleotide binding protein, alpha 150.016
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.016
Wdr26WD repeat domain 260.016
Tgfbr1transforming growth factor, beta receptor 10.016
Pde4dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)0.015
Adarb2adenosine deaminase, RNA-specific, B20.015
Metap2methionyl aminopeptidase 20.015
Pdlim5PDZ and LIM domain 50.015
Mpripmyosin phosphatase Rho interacting protein0.015
Pias2protein inhibitor of activated STAT, 20.015
Arhgap42Rho GTPase activating protein 420.015
Socs2suppressor of cytokine signaling 20.015
Klf4Kruppel-like factor 4 (gut)0.014
Ccnd3cyclin D30.014
Acvr1activin A receptor, type I0.014
Clcn1chloride channel 10.014
Fzd2frizzled homolog 2 (Drosophila)0.014
Agtr1aangiotensin II receptor, type 1a0.014
Ece1endothelin converting enzyme 10.014
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.014
Rasa1RAS p21 protein activator (GTPase activating protein) 10.014
Unc50unc-50 homolog (C. elegans)0.014
Timp3TIMP metallopeptidase inhibitor 30.014
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.014
Il1rapinterleukin 1 receptor accessory protein0.014
Cand1cullin-associated and neddylation-dissociated 10.014
A4galtalpha 1,4-galactosyltransferase0.014
Sp1Sp1 transcription factor0.013
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.996
FKBP1AFK506 binding protein 1A, 12kDa0.976
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.856
BMPR1Bbone morphogenetic protein receptor, type IB0.758
FSTL1follistatin-like 10.619
TGFB1transforming growth factor, beta 10.604
SMAD7SMAD family member 70.539
TGFB3transforming growth factor, beta 30.430
SMAD2SMAD family member 20.370
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.292
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.284
GDF5growth differentiation factor 50.211
GFI1Bgrowth factor independent 1B transcription repressor0.190
FGF21fibroblast growth factor 210.110
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.105
NRP1neuropilin 10.087
HDAC4histone deacetylase 40.074
EP300E1A binding protein p3000.069
ARRDC3arrestin domain containing 30.067
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.064
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.060
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.059
ZFYVE9zinc finger, FYVE domain containing 90.059
ACVR2Bactivin A receptor, type IIB0.058
FGF18fibroblast growth factor 180.047
BMP4bone morphogenetic protein 40.046
TGFBR1transforming growth factor, beta receptor 10.044
PRKG1protein kinase, cGMP-dependent, type I0.041
FGF4fibroblast growth factor 40.041
SH3BP4SH3-domain binding protein 40.036
WIF1WNT inhibitory factor 10.035
HDAC9histone deacetylase 90.029
MEF2Amyocyte enhancer factor 2A0.023
NELL1NEL-like 1 (chicken)0.021
TGFBR3transforming growth factor, beta receptor III0.021
DLX4distal-less homeobox 40.021
MMP11matrix metallopeptidase 11 (stromelysin 3)0.020
HIPK2homeodomain interacting protein kinase 20.020
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.020
COL2A1collagen, type II, alpha 10.018
JAG2jagged 20.017
SFRP1secreted frizzled-related protein 10.016
SMAD4SMAD family member 40.016
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.016
BMP2bone morphogenetic protein 20.014
HOXB1homeobox B10.014
TBC1D10ATBC1 domain family, member 10A0.014
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.014
FOXF2forkhead box F20.014
AHRaryl hydrocarbon receptor0.013
PTPN21protein tyrosine phosphatase, non-receptor type 210.013
FOXB1forkhead box B10.013
SPTBN1spectrin, beta, non-erythrocytic 10.013
IHHIndian hedgehog0.013
TGFB2transforming growth factor, beta 20.013
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.012
FOXD3forkhead box D30.012
AQP5aquaporin 50.012
WNT1wingless-type MMTV integration site family, member 10.012
FGF8fibroblast growth factor 8 (androgen-induced)0.011
INHBBinhibin, beta B0.011
FOXF1forkhead box F10.011
SNX9sorting nexin 90.010
CDH3cadherin 3, type 1, P-cadherin (placental)0.010
GDNFglial cell derived neurotrophic factor0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfb2transforming growth factor, beta 20.853
Gli3GLI-Kruppel family member GLI30.847
Fgfr2fibroblast growth factor receptor 20.820
Msx1homeobox, msh-like 10.799
Prrx2paired related homeobox 20.791
Tbx1T-box 10.762
Shhsonic hedgehog0.737
Prrx1paired related homeobox 10.693
Lhx1LIM homeobox protein 10.673
Sox9SRY-box containing gene 90.645
Smosmoothened homolog (Drosophila)0.640
Fgfr1fibroblast growth factor receptor 10.554
Gli2GLI-Kruppel family member GLI20.511
Ror2receptor tyrosine kinase-like orphan receptor 20.482
Bmp4bone morphogenetic protein 40.475
Pthlhparathyroid hormone-like peptide0.417
Fgf8fibroblast growth factor 80.389
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.380
Foxc1forkhead box C10.371
Runx2runt related transcription factor 20.352
Fgfr3fibroblast growth factor receptor 30.299
Bmp7bone morphogenetic protein 70.266
Acvr1activin A receptor, type 10.243
Bmp2bone morphogenetic protein 20.193
Hand1heart and neural crest derivatives expressed transcript 10.141
Ctnnb1catenin (cadherin associated protein), beta 10.132
Hand2heart and neural crest derivatives expressed transcript 20.129
Col1a1collagen, type I, alpha 10.123
Tgfbr2transforming growth factor, beta receptor II0.120
Dlx5distal-less homeobox 50.110
Msx2homeobox, msh-like 20.109
Rspo2R-spondin 2 homolog (Xenopus laevis)0.100
Smad4MAD homolog 4 (Drosophila)0.094
Cd80CD80 antigen0.084
Pax3paired box gene 30.082
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.082
Alx4aristaless-like homeobox 40.078
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.073
Gata4GATA binding protein 40.073
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.072
Smad6MAD homolog 6 (Drosophila)0.069
Gata6GATA binding protein 60.065
Fzd1frizzled homolog 1 (Drosophila)0.061
Hspg2perlecan (heparan sulfate proteoglycan 2)0.061
Dkk1dickkopf homolog 1 (Xenopus laevis)0.058
Vdrvitamin D receptor0.054
Wnt4wingless-related MMTV integration site 40.053
Pax9paired box gene 90.051
Alx3aristaless-like homeobox 30.051
ND6NADH dehydrogenase subunit 60.044
Ednraendothelin receptor type A0.043
Pnpla2patatin-like phospholipase domain containing 20.040
Tbx2T-box 20.039
Hdac4histone deacetylase 40.039
Ptch1patched homolog 10.039
Fgf5fibroblast growth factor 50.037
Rarbretinoic acid receptor, beta0.037
Sstr4somatostatin receptor 40.036
Fgf18fibroblast growth factor 180.036
Wnt7awingless-related MMTV integration site 7A0.036
Fgf23fibroblast growth factor 230.036
Foxc2forkhead box C20.034
Fzd2frizzled homolog 2 (Drosophila)0.034
Meox2mesenchyme homeobox 20.034
Dlx6distal-less homeobox 60.033
Twist1twist homolog 1 (Drosophila)0.033
Wnt10bwingless related MMTV integration site 10b0.033
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.032
Il6stinterleukin 6 signal transducer0.030
Adrb2adrenergic receptor, beta 20.030
Gdnfglial cell line derived neurotrophic factor0.030
En1engrailed 10.029
Ror1receptor tyrosine kinase-like orphan receptor 10.029
Hoxa2homeobox A20.029
Fzd8frizzled homolog 8 (Drosophila)0.027
Gpc3glypican 30.027
Gas1growth arrest specific 10.027
Mafavian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog0.027
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.025
Grid1glutamate receptor, ionotropic, delta 10.023
Wt1Wilms tumor 1 homolog0.023
Casrcalcium-sensing receptor0.023
Chrm1cholinergic receptor, muscarinic 1, CNS0.023
Rbl2retinoblastoma-like 20.023
Batf3basic leucine zipper transcription factor, ATF-like 30.022
Tbx15T-box 150.021
Smad2MAD homolog 2 (Drosophila)0.021
Hoxc5homeobox C50.021
Wnt3wingless-related MMTV integration site 30.020
Bnc1basonuclin 10.020
Emid2EMI domain containing 20.020
Sema3bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B0.019
Wnt3awingless-related MMTV integration site 3A0.019
Mmp2matrix metallopeptidase 20.019
Apcadenomatosis polyposis coli0.019
Pbx1pre B-cell leukemia transcription factor 10.019
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism