The network for 'mitotic dna damage checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic dna damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage.

NameDescriptionProbabilityFunc Analog Organism
Gpiglucose phosphate isomerase0.114
Pkm2pyruvate kinase, muscle0.104
Slc25a4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 40.079
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.059
Ldhalactate dehydrogenase A0.054
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.051
Zfand5zinc finger, AN1-type domain 50.048
Top2atopoisomerase (DNA) II alpha0.040
Bnip3lBCL2/adenovirus E1B interacting protein 3-like0.032
Cdk4cyclin-dependent kinase 40.029
Zfand6zinc finger, AN1-type domain 60.029
Tcp11l2t-complex 11 (mouse) like 20.028
Ptbp1polypyrimidine tract binding protein 10.027
Stxbp3syntaxin binding protein 30.026
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.026
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.025
Rpa2replication protein A20.025
Cdc42cell division cycle 42 (GTP binding protein)0.024
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.022
Cdca7cell division cycle associated 70.022
Mcm6minichromosome maintenance complex component 60.022
Acyp2acylphosphatase 2, muscle type0.022
Tpi1triosephosphate isomerase 10.020
GnasGNAS complex locus0.019
Mcm3minichromosome maintenance complex component 30.019
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.019
Rbbp7retinoblastoma binding protein 70.018
Usp9xubiquitin specific peptidase 9, X-linked0.017
Capza2capping protein (actin filament) muscle Z-line, alpha 20.017
Cops2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.016
Pgk1phosphoglycerate kinase 10.016
Ccnb1cyclin B10.016
Mcm5minichromosome maintenance complex component 50.016
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.016
Cdca4cell division cycle associated 40.015
Eno1enolase 1, (alpha)0.015
Ppp1r2protein phosphatase 1, regulatory (inhibitor) subunit 20.015
Ube2cubiquitin-conjugating enzyme E2C0.015
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.015
Pcmt1protein-L-isoaspartate (D-aspartate) O-methyltransferase 10.014
Brms1lbreast cancer metastasis-suppressor 1-like0.014
Metap2methionyl aminopeptidase 20.014
Serinc1serine incorporator 10.014
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.014
Cul3cullin 30.014
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.014
Melkmaternal embryonic leucine zipper kinase0.013
Bnip3BCL2/adenovirus E1B interacting protein 30.013
Clns1achloride channel, nucleotide-sensitive, 1A0.013
Ns5atp9NS5A (hepatitis C virus) transactivated protein 90.013
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.013
Cbfbcore-binding factor, beta subunit0.013
Ptp4a1protein tyrosine phosphatase type IVA, member 10.013
Ccnb2cyclin B20.013
Paip2poly(A) binding protein interacting protein 20.013
Lsm14aLSM14A, SCD6 homolog A (S. cerevisiae)0.013
Gabarapl2GABA(A) receptor-associated protein like 20.012
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.012
Gcs1glucosidase 10.012
Mdm2Mdm2 p53 binding protein homolog (mouse)0.012
Ppm1bprotein phosphatase 1B, magnesium dependent, beta isoform0.012
Tob1transducer of ErbB-2.10.012
Zhx1zinc fingers and homeoboxes 10.012
Klhl9kelch-like 9 (Drosophila)0.012
Adrbk1adrenergic, beta, receptor kinase 10.012
Rbm18RNA binding motif protein 180.012
Mcm2minichromosome maintenance complex component 20.012
Mxi1MAX interactor 10.012
Racgap1Rac GTPase-activating protein 10.012
Sdc1syndecan 10.012
Stag2stromal antigen 20.012
Ccng1cyclin G10.012
Blmhbleomycin hydrolase0.012
Supt16hsuppressor of Ty 16 homolog (S. cerevisiae)0.011
Fam21cfamily with sequence similarity 21, member C0.011
Kifc1kinesin family member C10.011
Ckbcreatine kinase, brain0.011
Pttg1pituitary tumor-transforming 10.011
Sh3yl1SH3 domain containing, Ysc84-like 1 (S. cerevisiae)0.011
Tp53tumor protein p530.011
Mapk6mitogen-activated protein kinase 60.011
Pdcd4programmed cell death 40.011
Sesn1sestrin 10.011
Hmgb2high mobility group box 20.011
Adam10ADAM metallopeptidase domain 100.011
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.010
Prkd3protein kinase D30.010
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.010
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.010
Fcho2FCH domain only 20.010
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.010
Mat2bmethionine adenosyltransferase II, beta0.010
Adaradenosine deaminase, RNA-specific0.010
Brp16brain protein 160.010
Ccdc132coiled-coil domain containing 1320.010
Leprotleptin receptor overlapping transcript0.010
Smad2SMAD family member 20.010
Tmco3transmembrane and coiled-coil domains 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.666
ccnd1cyclin D10.634
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.634
unguracil-DNA glycosylase0.529
zff9zinc finger protein 90.405
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.402
pcnaproliferating cell nuclear antigen0.390
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.360
tfamtranscription factor A, mitochondrial0.271
mab21l1mab-21-like 10.266
atp1b3aATPase, Na+/K+ transporting, beta 3a polypeptide0.213
cul3acullin 3a0.210
chek1CHK1 checkpoint homolog (S. pombe)0.210
nudcd2NudC domain containing 20.189
stilTAL1 (SCL) interrupting locus0.178
cand1cullin-associated and neddylation-dissociated 10.159
snrpd1small nuclear ribonucleoprotein D1 polypeptide0.154
brd2abromodomain-containing 2a0.143
nup43nucleoporin 430.138
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.130
sae1SUMO1 activating enzyme subunit 10.129
cct5chaperonin containing TCP1, subunit 5 (epsilon)0.127
naa15bN(alpha)-acetyltransferase 15, NatA auxiliary subunit b0.125
pld1aphospholipase D1a0.123
ddb2damage-specific DNA binding protein 20.119
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.117
cdk8cyclin-dependent kinase 80.113
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.113
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.113
fanciFanconi anemia, complementation group I0.112
lsm8LSM8 homolog, U6 small nuclear RNA associated0.106
caprin1acell cycle associated protein 1a0.105
cry5cryptochrome 50.103
crip2cysteine-rich protein 20.103
zc3h13zinc finger CCCH-type containing 130.100
cxcr4bchemokine (C-X-C motif), receptor 4b0.097
msh6mutS homolog 6 (E. coli)0.092
lrwd1leucine-rich repeats and WD repeat domain containing 10.092
ccnecyclin E0.091
mycl1av-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a0.091
ints6integrator complex subunit 60.089
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.088
rhoabras homolog gene family, member Ab0.088
ccng1cyclin G10.087
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.086
chaf1bchromatin assembly factor 1, subunit B0.085
fen1flap structure-specific endonuclease 10.084
c20orf11c20orf11 homolog (H. sapiens)0.084
skp2S-phase kinase-associated protein 2 (p45)0.084
smc1alstructural maintenance of chromosomes 1A, like0.083
hat1histone acetyltransferase 10.083
mycamyelocytomatosis oncogene a0.083
aggf1angiogenic factor with G patch and FHA domains 10.082
ubinataxin-1 ubiquitin-like interacting protein0.082
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.081
snrpcsmall nuclear ribonucleoprotein polypeptide C0.080
wdr76WD repeat domain 760.078
rpa1replication protein A10.078
dnmt5DNA (cytosine-5-)-methyltransferase 50.078
usp4ubiquitin specific protease 4 (proto-oncogene)0.076
snrpesmall nuclear ribonucleoprotein polypeptide E0.076
rasl11bRAS-like, family 11, member B0.075
g2e3G2/M-phase specific E3 ubiquitin ligase0.073
tbc1d23TBC1 domain family, member 230.073
ctcfCCCTC-binding factor (zinc finger protein)0.073
palb2partner and localizer of BRCA20.073
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.072
abcf1ATP-binding cassette, sub-family F (GCN20), member 10.072
orc6origin recognition complex, subunit 60.072
naspnuclear autoantigenic sperm protein (histone-binding)0.072
sass6spindle assembly 6 homolog (C. elegans)0.072
esco2establishment of cohesion 1 homolog 20.071
ptpn21protein tyrosine phosphatase, non-receptor type 210.070
trip13thyroid hormone receptor interactor 130.069
wdr18WD repeat domain 180.069
ppp2r5ebprotein phosphatase 2, regulatory subunit B', epsilon isoform b0.068
eif2deukaryotic translation initiation factor 2D0.068
dda1DET1 and DDB1 associated 10.067
gins3GINS complex subunit 30.066
pola2polymerase (DNA directed), alpha 20.066
hhiphedgehog interacting protein0.066
cops3COP9 constitutive photomorphogenic homolog subunit 30.065
ck2bcasein kinase 2 beta0.064
gins2GINS complex subunit 20.064
psma5proteasome (prosome, macropain) subunit, alpha type,50.064
prim1primase polypeptide 10.063
rnf40ring finger protein 400.063
ube2g2ubiquitin-conjugating enzyme E2G 20.063
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.063
arhgap11aRho GTPase activating protein 11A0.062
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.061
fhlafour and a half LIM domains a0.061
znf143zinc finger protein 1430.059
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus205mutagen-sensitive 2050.984
Brca2Breast cancer 2, early onset homolog0.969
Rcd1Reduction in Cnn dots 10.948
rad50CG6339 gene product from transcript CG6339-RD0.948
p53CG33336 gene product from transcript CG33336-RB0.920
CSN4COP9 complex homolog subunit 40.882
DNApol-etaCG7143 gene product from transcript CG7143-RA0.875
Cdk4Cyclin-dependent kinase 40.861
mus101mutagen-sensitive 1010.859
CSN5COP9 complex homolog subunit 50.846
tefutelomere fusion0.833
MAGECG10059 gene product from transcript CG10059-RA0.811
mus209mutagen-sensitive 2090.808
CDC45LCG3658 gene product from transcript CG3658-RA0.804
mus304mutagen-sensitive 3040.782
mre11meiotic recombination 110.772
CG5524CG5524 gene product from transcript CG5524-RA0.767
IswiImitation SWI0.758
cdc2cCG10498 gene product from transcript CG10498-RC0.753
CSN3COP9 complex homolog subunit 30.730
mei-9meiotic 90.723
DrefDNA replication-related element factor0.719
RPA2Replication protein A20.698
MED6Mediator complex subunit 60.688
BRWD3CG31132 gene product from transcript CG31132-RA0.687
dre4CG1828 gene product from transcript CG1828-RB0.681
Vap-33-1CG5014 gene product from transcript CG5014-RB0.671
Rpd3CG7471 gene product from transcript CG7471-RA0.655
His2AvHistone H2A variant0.631
CG6066CG6066 gene product from transcript CG6066-RA0.604
piepineapple eye0.588
Mcm3Minichromosome maintenance 30.580
CG10414CG10414 gene product from transcript CG10414-RA0.575
mus201mutagen-sensitive 2010.564
mus301mutagen-sensitive 3010.547
eIF4AIIICG7483 gene product from transcript CG7483-RA0.536
spn-Bspindle B0.505
MED17Mediator complex subunit 170.502
Cdc37CG12019 gene product from transcript CG12019-RA0.483
spn-Aspindle A0.429
mus312mutagen-sensitive 3120.409
mus308mutagen-sensitive 3080.399
SuURSuppressor of Under-Replication0.375
Smc5CG32438 gene product from transcript CG32438-RE0.372
CycCCyclin C0.360
imdimmune deficiency0.359
CG10139CG10139 gene product from transcript CG10139-RA0.352
nbsCG6754 gene product from transcript CG6754-RC0.349
IrbpInverted repeat-binding protein0.349
Rev1CG12189 gene product from transcript CG12189-RA0.347
CSN7COP9 complex homolog subunit 70.340
Snr1Snf5-related 10.339
PcafCG4107 gene product from transcript CG4107-RA0.332
Caf1Chromatin assembly factor 1 subunit0.325
Bap55Brahma associated protein 55kD0.322
CG13298CG13298 gene product from transcript CG13298-RA0.319
c(3)Gcrossover suppressor on 3 of Gowen0.315
CycDCyclin D0.312
CG10754CG10754 gene product from transcript CG10754-RA0.303
MBD-R2CG10042 gene product from transcript CG10042-RB0.303
Nup50Nucleoporin 500.302
sxcsuper sex combs0.300
smt3CG4494 gene product from transcript CG4494-RA0.296
RecQ5homolog of RecQ0.292
polyCG9829 gene product from transcript CG9829-RB0.290
Cap-GCG34438 gene product from transcript CG34438-RF0.285
skpACG16983 gene product from transcript CG16983-RD0.276
mus309mutagen-sensitive 3090.271
waplwings apart-like0.265
CG9715CG9715 gene product from transcript CG9715-RA0.249
eIF5CG9177 gene product from transcript CG9177-RE0.246
Chrac-14CG13399 gene product from transcript CG13399-RA0.245
RpS17Ribosomal protein S170.244
CG9915CG9915 gene product from transcript CG9915-RB0.237
RanGapRan GTPase activating protein0.235
l(2)NC136lethal (2) NC1360.233
CG14641CG14641 gene product from transcript CG14641-RA0.230
Ge-1CG6181 gene product from transcript CG6181-RA0.230
Hdac3Histone deacetylase 30.224
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.221
U2af50U2 small nuclear riboprotein auxiliary factor 500.220
Nedd8CG10679 gene product from transcript CG10679-RA0.213
Mcm7Minichromosome maintenance 70.212
CG4699CG4699 gene product from transcript CG4699-RJ0.212
RASSF8CG5053 gene product from transcript CG5053-RA0.210
StimStromal interaction molecule0.206
RnrLRibonucleoside diphosphate reductase large subunit0.198
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RB1retinoblastoma 11.000
TP53tumor protein p531.000
BRCA1breast cancer 1, early onset1.000
MDM2Mdm2 p53 binding protein homolog (mouse)0.999
CASP8caspase 8, apoptosis-related cysteine peptidase0.990
CDK2cyclin-dependent kinase 20.990
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.989
CHEK1CHK1 checkpoint homolog (S. pombe)0.974
E2F1E2F transcription factor 10.964
XIAPX-linked inhibitor of apoptosis0.953
PARP1poly (ADP-ribose) polymerase 10.836
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.832
RAD50RAD50 homolog (S. cerevisiae)0.818
CDK8cyclin-dependent kinase 80.816
CASP3caspase 3, apoptosis-related cysteine peptidase0.810
CUL4Acullin 4A0.759
CHEK2CHK2 checkpoint homolog (S. pombe)0.748
MCM7minichromosome maintenance complex component 70.736
BLMBloom syndrome, RecQ helicase-like0.722
RBL1retinoblastoma-like 1 (p107)0.650
H2AFXH2A histone family, member X0.635
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.626
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.579
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.566
FASFas (TNF receptor superfamily, member 6)0.563
PCNAproliferating cell nuclear antigen0.560
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.551
ATMataxia telangiectasia mutated0.540
MDM4Mdm4 p53 binding protein homolog (mouse)0.534
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.505
MCM2minichromosome maintenance complex component 20.488
CUL1cullin 10.486
DDB1damage-specific DNA binding protein 1, 127kDa0.481
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.471
SKP2S-phase kinase-associated protein 2 (p45)0.469
CCND1cyclin D10.468
CDK6cyclin-dependent kinase 60.426
PLK1polo-like kinase 10.398
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.387
CNOT8CCR4-NOT transcription complex, subunit 80.387
FADDFas (TNFRSF6)-associated via death domain0.383
RFWD2ring finger and WD repeat domain 20.383
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.381
RBL2retinoblastoma-like 2 (p130)0.366
COPS3COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)0.343
CDC6cell division cycle 6 homolog (S. cerevisiae)0.341
RBBP8retinoblastoma binding protein 80.332
CASP10caspase 10, apoptosis-related cysteine peptidase0.323
TOPBP1topoisomerase (DNA) II binding protein 10.305
GFERgrowth factor, augmenter of liver regeneration0.298
FOSFBJ murine osteosarcoma viral oncogene homolog0.296
MSH6mutS homolog 6 (E. coli)0.291
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.288
RPA2replication protein A2, 32kDa0.282
CCNA2cyclin A20.272
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.264
DDB2damage-specific DNA binding protein 2, 48kDa0.262
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.248
APAF1apoptotic peptidase activating factor 10.241
CNOT6CCR4-NOT transcription complex, subunit 60.226
CFLARCASP8 and FADD-like apoptosis regulator0.217
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.216
MDC1mediator of DNA-damage checkpoint 10.211
ATRXalpha thalassemia/mental retardation syndrome X-linked0.210
DAXXdeath-domain associated protein0.197
CCND3cyclin D30.197
MED1mediator complex subunit 10.196
MED28mediator complex subunit 280.188
UBA1ubiquitin-like modifier activating enzyme 10.183
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.178
FANCD2Fanconi anemia, complementation group D20.172
FANCAFanconi anemia, complementation group A0.172
WWOXWW domain containing oxidoreductase0.165
CNOT1CCR4-NOT transcription complex, subunit 10.158
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.151
CDC45cell division cycle 45 homolog (S. cerevisiae)0.136
GPS1G protein pathway suppressor 10.135
CNOT3CCR4-NOT transcription complex, subunit 30.135
CCNE1cyclin E10.132
CDC25Acell division cycle 25 homolog A (S. pombe)0.126
HDAC1histone deacetylase 10.125
SMAD7SMAD family member 70.122
MED23mediator complex subunit 230.122
TNRC6Btrinucleotide repeat containing 6B0.115
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.114
PRMT6protein arginine methyltransferase 60.110
CHAF1Achromatin assembly factor 1, subunit A (p150)0.110
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.108
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.107
TFDP1transcription factor Dp-10.100
UHRF2ubiquitin-like with PHD and ring finger domains 20.098
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.097
MCM6minichromosome maintenance complex component 60.096
WWP2WW domain containing E3 ubiquitin protein ligase 20.093
MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor)0.093
CDK4cyclin-dependent kinase 40.091
BTG1B-cell translocation gene 1, anti-proliferative0.086
CASP8AP2caspase 8 associated protein 20.084
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YOR060Chypothetical protein0.011