The network for 'intrinsic apoptotic signaling pathway in response to dna damage' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intrinsic apoptotic signaling pathway in response to dna damage

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

NameDescriptionProbabilityFunc Analog Organism
RT1-Db1RT1 class II, locus Db10.277
RT1-BaRT1 class II, locus Ba0.179
Timp1TIMP metallopeptidase inhibitor 10.099
Plaurplasminogen activator, urokinase receptor0.058
PVRpoliovirus receptor0.058
RT1-DMaRT1 class II, locus DMa0.053
Icam1intercellular adhesion molecule 10.045
Ier3immediate early response 30.045
Lgals3lectin, galactoside-binding, soluble, 30.044
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.041
Txnrd1thioredoxin reductase 10.041
RT1-DMbRT1 class II, locus DMb0.039
Ripk3receptor-interacting serine-threonine kinase 30.036
RT1-DaRT1 class II, locus Da0.035
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.035
Ptbp1polypyrimidine tract binding protein 10.033
Hmox1heme oxygenase (decycling) 10.032
Ccl2chemokine (C-C motif) ligand 20.030
Tgfb1transforming growth factor, beta 10.029
Anxa2annexin A20.028
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.028
Atf3activating transcription factor 30.027
Mycmyelocytomatosis oncogene0.027
Litaflipopolysaccharide-induced TNF factor0.027
Socs3suppressor of cytokine signaling 30.026
S100a11S100 calcium binding protein A11 (calizzarin)0.025
Tp53tumor protein p530.024
Ifitm3interferon induced transmembrane protein 30.024
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.023
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.023
PorP450 (cytochrome) oxidoreductase0.023
Pcolceprocollagen C-endopeptidase enhancer0.022
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.022
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.021
Klf4Kruppel-like factor 4 (gut)0.021
Errfi1ERBB receptor feedback inhibitor 10.021
Klhl24kelch-like 24 (Drosophila)0.021
Cdkn1acyclin-dependent kinase inhibitor 1A0.021
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.021
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.020
Il6interleukin 60.020
Junbjun B proto-oncogene0.019
Stxbp3syntaxin binding protein 30.019
Nr1d2nuclear receptor subfamily 1, group D, member 20.019
Plaaphospholipase A2, activating protein0.019
Cnot1CCR4-NOT transcription complex, subunit 10.018
Lcn2lipocalin 20.018
Vcanversican0.018
Zc3h11azinc finger CCCH-type containing 11A0.018
Psme4proteasome (prosome, macropain) activator subunit 40.018
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.018
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.018
RT1-BbRT1 class II, locus Bb0.017
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.017
Csde1cold shock domain containing E1, RNA binding0.017
Mt2Ametallothionein 2A0.016
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.016
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.016
Stat3signal transducer and activator of transcription 30.016
Trim47tripartite motif-containing 470.015
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.015
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.015
Cd14CD14 molecule0.015
Zfp36zinc finger protein 360.015
Pelopelota homolog (Drosophila)0.015
Atl2atlastin GTPase 20.015
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.014
Admadrenomedullin0.014
Coro1acoronin, actin binding protein 1A0.014
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.014
Sfrs12splicing factor, arginine/serine-rich 120.014
Zfand5zinc finger, AN1-type domain 50.014
Nolc1nucleolar and coiled-body phosphoprotein 10.014
Phlda1pleckstrin homology-like domain, family A, member 10.014
Akr1b8aldo-keto reductase family 1, member B80.014
Pdlim1PDZ and LIM domain 10.014
RGD1565310similar to RIKEN cDNA 1110018J120.014
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.014
Zyxzyxin0.013
Mgpmatrix Gla protein0.013
Epn1Epsin 10.013
Runx1runt-related transcription factor 10.013
Mybl2myeloblastosis oncogene-like 20.013
Smad1SMAD family member 10.013
Plscr3phospholipid scramblase 30.013
Homer3homer homolog 3 (Drosophila)0.013
Mt1ametallothionein 1a0.013
Tcp11l2t-complex 11 (mouse) like 20.013
Dirc2disrupted in renal carcinoma 2 (human)0.013
Ppardperoxisome proliferator-activated receptor delta0.013
Klf6Kruppel-like factor 60.013
Daxxdeath-domain associated protein0.013
Rhocras homolog gene family, member C0.012
Ptpn1protein tyrosine phosphatase, non-receptor type 10.012
Sf3b4splicing factor 3b, subunit 40.012
Arhgap1Rho GTPase activating protein 10.012
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.012
JunJun oncogene0.012
Stag2stromal antigen 20.012
Mdm2Mdm2 p53 binding protein homolog (mouse)0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mlt-9Protein MLT-90.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
tefutelomere fusion0.981
p53CG33336 gene product from transcript CG33336-RB0.977
scylscylla0.765
Dcp-1Death caspase-10.740
Atg1Autophagy-specific gene 10.642
Sir2CG5216 gene product from transcript CG5216-RA0.392
lokloki0.342
mus205mutagen-sensitive 2050.306
rad50CG6339 gene product from transcript CG6339-RD0.281
ththread0.271
DrefDNA replication-related element factor0.261
ykiyorkie0.260
Brca2Breast cancer 2, early onset homolog0.230
mei-9meiotic 90.213
hephemipterous0.202
Tango7Transport and Golgi organization 70.185
DNApol-etaCG7143 gene product from transcript CG7143-RA0.168
panpangolin0.165
Mi-2CG8103 gene product from transcript CG8103-RA0.146
bskbasket0.139
mus101mutagen-sensitive 1010.137
mubmushroom-body expressed0.127
Ptp61FProtein tyrosine phosphatase 61F0.121
CtBPC-terminal Binding Protein0.114
MAGECG10059 gene product from transcript CG10059-RA0.113
Atg8aAutophagy-specific gene 8a0.110
Trf2TATA box binding protein-related factor 20.108
grogroucho0.108
Smg5CG8954 gene product from transcript CG8954-RA0.100
crolcrooked legs0.096
debcldeath executioner Bcl-2 homologue0.096
AGO2Argonaute 20.093
p120ctnAdherens junction protein p1200.092
CG5524CG5524 gene product from transcript CG5524-RA0.086
CG11347CG11347 gene product from transcript CG11347-RE0.084
PRL-1CG4993 gene product from transcript CG4993-RB0.079
RecQ5homolog of RecQ0.079
mus201mutagen-sensitive 2010.070
IswiImitation SWI0.065
bchsblue cheese0.063
alphalphabet0.055
Atx2Ataxin-20.053
okrokra0.051
chicoCG5686 gene product from transcript CG5686-RB0.050
kibrakibra ortholog0.049
pr-set7CG3307 gene product from transcript CG3307-RC0.049
CycGCyclin G0.046
spinspinster0.045
mus304mutagen-sensitive 3040.044
RnrLRibonucleoside diphosphate reductase large subunit0.044
Vap-33-1CG5014 gene product from transcript CG5014-RB0.044
CG5794CG5794 gene product from transcript CG5794-RB0.043
RASSF8CG5053 gene product from transcript CG5053-RA0.043
Mnn1Menin 10.042
mre11meiotic recombination 110.042
hipkhomeodomain interacting protein kinase0.039
mus301mutagen-sensitive 3010.039
parkparkin0.038
S6kRPS6-p70-protein kinase0.037
ImpL2Ecdysone-inducible gene L20.036
ns2nucleostemin 20.035
CG33936CG33936 gene product from transcript CG33936-RB0.034
Smc5CG32438 gene product from transcript CG32438-RE0.034
SdcSyndecan0.032
Chrac-14CG13399 gene product from transcript CG13399-RA0.032
HcfHost cell factor0.032
SseSeparase0.032
TER94CG2331 gene product from transcript CG2331-RA0.030
mtsmicrotubule star0.029
CG13350CG13350 gene product from transcript CG13350-RA0.029
hayhaywire0.028
X11LCG5675 gene product from transcript CG5675-RB0.027
par-1CG8201 gene product from transcript CG8201-RA0.027
Pka-C1cAMP-dependent protein kinase 10.027
Pp1-87BProtein phosphatase 1 at 87B0.027
CG10990CG10990 gene product from transcript CG10990-RB0.026
babobaboon0.025
CG4771CG4771 gene product from transcript CG4771-RA0.025
maelmaelstrom0.025
MED19Mediator complex subunit 190.024
rprreaper0.024
mei-41meiotic 410.023
chrbcharybde0.023
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.022
CG1317CG1317 gene product from transcript CG1317-RC0.022
spn-Aspindle A0.021
CG9425CG9425 gene product from transcript CG9425-RB0.021
Caf1Chromatin assembly factor 1 subunit0.021
mus308mutagen-sensitive 3080.021
uspultraspiracle0.020
GATAdCG5034 gene product from transcript CG5034-RA0.020
nbsCG6754 gene product from transcript CG6754-RC0.020
cathDCG1548 gene product from transcript CG1548-RA0.020
grimCG4345 gene product from transcript CG4345-RA0.020
cmetCENP-meta0.019
DabDisabled0.019
CG9772CG9772 gene product from transcript CG9772-RB0.019
AckCG14992 gene product from transcript CG14992-RA0.018
smsmooth0.018
HtrA2CG8464 gene product from transcript CG8464-RA0.018
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.998
RB1retinoblastoma 10.995
MDM2Mdm2 p53 binding protein homolog (mouse)0.992
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.986
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.982
CASP8caspase 8, apoptosis-related cysteine peptidase0.976
BCL2B-cell CLL/lymphoma 20.968
BCL2L1BCL2-like 10.963
BRCA1breast cancer 1, early onset0.956
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.940
E2F1E2F transcription factor 10.938
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.932
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.918
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.891
XIAPX-linked inhibitor of apoptosis0.876
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.862
TP53tumor protein p530.858
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.855
CHEK2CHK2 checkpoint homolog (S. pombe)0.844
RBL1retinoblastoma-like 1 (p107)0.840
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.816
BAXBCL2-associated X protein0.768
BCL2L11BCL2-like 11 (apoptosis facilitator)0.764
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.744
RBL2retinoblastoma-like 2 (p130)0.687
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.685
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.658
BIRC3baculoviral IAP repeat containing 30.655
FASFas (TNF receptor superfamily, member 6)0.619
CDK2cyclin-dependent kinase 20.595
MSH6mutS homolog 6 (E. coli)0.560
BIRC2baculoviral IAP repeat containing 20.529
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.516
IER3immediate early response 30.510
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.510
CFLARCASP8 and FADD-like apoptosis regulator0.504
RBBP8retinoblastoma binding protein 80.494
FADDFas (TNFRSF6)-associated via death domain0.483
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.459
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.454
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.441
CASP10caspase 10, apoptosis-related cysteine peptidase0.415
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.409
PCNAproliferating cell nuclear antigen0.408
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.400
CHUKconserved helix-loop-helix ubiquitous kinase0.400
RIPK2receptor-interacting serine-threonine kinase 20.395
NBNnibrin0.375
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.375
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.370
E2F4E2F transcription factor 4, p107/p130-binding0.367
TRAF2TNF receptor-associated factor 20.356
TP53BP2tumor protein p53 binding protein, 20.351
MDM4Mdm4 p53 binding protein homolog (mouse)0.348
BIDBH3 interacting domain death agonist0.330
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.330
BTRCbeta-transducin repeat containing0.312
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.303
EP300E1A binding protein p3000.296
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.276
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.270
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.264
NLRC4NLR family, CARD domain containing 40.260
HIPK2homeodomain interacting protein kinase 20.258
MAP3K8mitogen-activated protein kinase kinase kinase 80.257
FANCD2Fanconi anemia, complementation group D20.249
SNIP1Smad nuclear interacting protein 10.242
SIN3ASIN3 homolog A, transcription regulator (yeast)0.240
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.240
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.237
RAD18RAD18 homolog (S. cerevisiae)0.234
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.233
HDAC1histone deacetylase 10.209
APAF1apoptotic peptidase activating factor 10.208
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.203
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.201
TRAF1TNF receptor-associated factor 10.197
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.196
SFNstratifin0.190
YAP1Yes-associated protein 10.189
CHEK1CHK1 checkpoint homolog (S. pombe)0.186
ATMataxia telangiectasia mutated0.183
AKT1v-akt murine thymoma viral oncogene homolog 10.179
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.178
TNFtumor necrosis factor0.175
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.170
MSH3mutS homolog 3 (E. coli)0.165
LZTS2leucine zipper, putative tumor suppressor 20.163
DCAF7DDB1 and CUL4 associated factor 70.159
CDK6cyclin-dependent kinase 60.159
RYBPRING1 and YY1 binding protein0.159
IL8interleukin 80.158
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.153
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.150
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.143
BADBCL2-associated agonist of cell death0.140
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.131
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.131
TRADDTNFRSF1A-associated via death domain0.130
CASP3caspase 3, apoptosis-related cysteine peptidase0.127
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Tnftumor necrosis factor1.000
Mdm2transformed mouse 3T3 cell double minute 20.998
Ighimmunoglobulin heavy chain complex0.998
Rb1retinoblastoma 10.998
FasFas (TNF receptor superfamily member 6)0.998
Map3k14mitogen-activated protein kinase kinase kinase 140.996
Ltblymphotoxin B0.979
Ikzf1IKAROS family zinc finger 10.974
Ptenphosphatase and tensin homolog0.959
Brca1breast cancer 10.943
Ifnginterferon gamma0.942
SkilSKI-like0.893
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.874
Brca2breast cancer 20.867
Ltalymphotoxin A0.866
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.864
Cdkn1bcyclin-dependent kinase inhibitor 1B0.857
Ncoa3nuclear receptor coactivator 30.852
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.848
Mcl1myeloid cell leukemia sequence 10.839
Casp4caspase 4, apoptosis-related cysteine peptidase0.804
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.802
Bcl2l1BCL2-like 10.762
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.715
TcraT-cell receptor alpha chain0.697
Cd40CD40 antigen0.685
Socs1suppressor of cytokine signaling 10.678
Cd19CD19 antigen0.677
BaxBCL2-associated X protein0.652
Il2rginterleukin 2 receptor, gamma chain0.632
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.604
Pnp2purine-nucleoside phosphorylase 20.568
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.566
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.565
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.549
Tcf3transcription factor 30.538
Apcadenomatosis polyposis coli0.509
Kitkit oncogene0.501
Trp73transformation related protein 730.472
Card11caspase recruitment domain family, member 110.463
Bcl3B-cell leukemia/lymphoma 30.462
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.462
E2f1E2F transcription factor 10.451
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.450
Eif2c1eukaryotic translation initiation factor 2C, 10.448
Cyldcylindromatosis (turban tumor syndrome)0.434
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.428
Rbl1retinoblastoma-like 1 (p107)0.389
Ccnd1cyclin D10.368
Foxp3forkhead box P30.362
Casp1caspase 10.359
Traf3ip2TRAF3 interacting protein 20.353
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.348
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.343
BtkBruton agammaglobulinemia tyrosine kinase0.341
S100a6S100 calcium binding protein A6 (calcyclin)0.339
Gbp5guanylate binding protein 50.325
Irf1interferon regulatory factor 10.317
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.316
Ctnnb1catenin (cadherin associated protein), beta 10.309
Kdm2blysine (K)-specific demethylase 2B0.306
Notch1Notch gene homolog 1 (Drosophila)0.305
Kitlkit ligand0.299
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.261
Stk4serine/threonine kinase 40.260
Msh2mutS homolog 2 (E. coli)0.259
Nlrp3NLR family, pyrin domain containing 30.249
Mycmyelocytomatosis oncogene0.249
Socs3suppressor of cytokine signaling 30.243
Egr2early growth response 20.241
Cdk4cyclin-dependent kinase 40.241
Tnfaip3tumor necrosis factor, alpha-induced protein 30.238
Runx1runt related transcription factor 10.217
Map3k7mitogen-activated protein kinase kinase kinase 70.216
Nfe2l2nuclear factor, erythroid derived 2, like 20.215
Cxcl13chemokine (C-X-C motif) ligand 130.205
Rararetinoic acid receptor, alpha0.202
Cdkn2acyclin-dependent kinase inhibitor 2A0.198
Pax3paired box gene 30.197
Cxcr4chemokine (C-X-C motif) receptor 40.182
Timelesstimeless homolog (Drosophila)0.178
Bcl2B-cell leukemia/lymphoma 20.178
Il7interleukin 70.177
Ets1E26 avian leukemia oncogene 1, 5' domain0.173
Atmataxia telangiectasia mutated homolog (human)0.164
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.163
Il4interleukin 40.163
Traf2TNF receptor-associated factor 20.161
Nbnnibrin0.160
Mndalmyeloid nuclear differentiation antigen like0.160
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.158
Ikbkbinhibitor of kappaB kinase beta0.158
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.157
Prf1perforin 1 (pore forming protein)0.153
Birc3baculoviral IAP repeat-containing 30.153
Icam1intercellular adhesion molecule 10.144
Rhogras homolog gene family, member G0.141
Trp63transformation related protein 630.137
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism