The network for 'regulation of chronic inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of chronic inflammatory response

Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.

NameDescriptionProbabilityFunc Analog Organism
Cd8aCD8a molecule0.219
Sellselectin L0.176
Ccr5chemokine (C-C motif) receptor 50.101
Ccl4chemokine (C-C motif) ligand 40.088
Cd247Cd247 molecule0.083
FaslgFas ligand (TNF superfamily, member 6)0.072
Pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.071
F2rl1coagulation factor II (thrombin) receptor-like 10.067
Krt34keratin 340.065
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.064
Ccl3chemokine (C-C motif) ligand 30.060
Cd5Cd5 molecule0.060
Il8rbinterleukin 8 receptor, beta0.058
Il1binterleukin 1 beta0.056
Gzmkgranzyme K0.054
Cd4Cd4 molecule0.054
Cnga3cyclic nucleotide gated channel alpha 30.054
Il1ainterleukin 1 alpha0.050
Fcnbficolin B0.050
Pax6paired box 60.049
Havcr1hepatitis A virus cellular receptor 10.047
Klrc2killer cell lectin-like receptor subfamily C, member 20.046
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.045
Itpr2inositol 1,4,5-triphosphate receptor, type 20.045
Grprgastrin releasing peptide receptor0.045
Il6interleukin 60.044
LOC300024similar to Ly6-B antigen gene0.042
Myl7myosin, light chain 7, regulatory0.041
Ccr2chemokine (C-C motif) receptor 20.040
Cxcl2chemokine (C-X-C motif) ligand 20.039
Zcwpw1zinc finger, CW-type with PWWP domain 10.038
Cd38CD38 molecule0.038
Il8rainterleukin 8 receptor, alpha0.038
Grip1glutamate receptor interacting protein 10.037
Ciitaclass II, major histocompatibility complex, transactivator0.036
LOC100361571keratin associated protein 1-3-like0.035
Clec9aC-type lectin domain family 9, member a0.035
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.035
Cd3eCD3 molecule, epsilon0.034
Il2rainterleukin 2 receptor, alpha0.033
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.033
Ccr3chemokine (C-C motif) receptor 30.032
Vcsa2variable coding sequence A20.030
Ptafrplatelet-activating factor receptor0.029
MefvMediterranean fever0.029
Il9rinterleukin 9 receptor0.029
Hrh2histamine receptor H 20.029
Adora3adenosine A3 receptor0.029
Dbc1deleted in bladder cancer 1 (human)0.029
Olr1496olfactory receptor 14960.028
Slc26a5solute carrier family 26, member 5 (prestin)0.028
Reg3gregenerating islet-derived 3 gamma0.027
Ptpreprotein tyrosine phosphatase, receptor type, E0.026
Klrd1killer cell lectin-like receptor, subfamily D, member 10.026
Arl5cADP-ribosylation factor-like 5C0.026
Gucy2dguanylate cyclase 2d0.025
Mmp8matrix metallopeptidase 80.024
Gpr37l1G protein-coupled receptor 37-like 10.024
Olr1278olfactory receptor 12780.024
Gpr6G protein-coupled receptor 60.024
Ptger2prostaglandin E receptor 2 (subtype EP2)0.023
Esr1estrogen receptor 10.023
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.023
Il1rl2interleukin 1 receptor-like 20.023
F2rl2coagulation factor II (thrombin) receptor-like 20.022
Cd8bCD8b molecule0.022
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.022
Plauplasminogen activator, urokinase0.021
Pvrl1poliovirus receptor-related 10.021
Neurog3neurogenin 30.021
Fgfr2fibroblast growth factor receptor 20.021
Nkg7natural killer cell group 7 sequence0.021
Notch3Notch homolog 3 (Drosophila)0.021
Slc10a2solute carrier family 10 (sodium/bile acid cotransporter family), member 20.021
Lin28lin-28 homolog (C. elegans)0.020
P2ry12purinergic receptor P2Y, G-protein coupled, 120.020
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.020
Igh-6immunoglobulin heavy chain 60.020
Sgp158proline-rich glycoprotein (sgp158)0.019
Samsn1SAM domain, SH3 domain and nuclear localization signals, 10.019
Tas2r126taste receptor, type 2, member 1260.019
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.018
Gna15guanine nucleotide binding protein, alpha 150.018
Sctsecretin0.018
Tnni3troponin I type 3 (cardiac)0.018
Tgfbr3transforming growth factor, beta receptor III0.018
Nr0b1nuclear receptor subfamily 0, group B, member 10.018
Ccdc102acoiled-coil domain containing 102A0.018
Fam108b1family with sequence similarity 108, member B10.017
Selpselectin P0.017
Rassf5Ras association (RalGDS/AF-6) domain family member 50.017
Mrgprx3MAS-related GPR, member X30.017
Tas2r118taste receptor, type 2, member 1180.017
Ppyr1pancreatic polypeptide receptor 10.017
Ccbp2chemokine binding protein 20.017
Ldb3LIM domain binding 30.017
Ptprcprotein tyrosine phosphatase, receptor type, C0.017
Klrc1killer cell lectin-like receptor subfamily C, member 10.017
Il2rbinterleukin 2 receptor, beta0.016
MrgprfMAS-related GPR, member F0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
lyzlysozyme0.820
mmp9matrix metalloproteinase 90.698
col12a1collagen, type XII, alpha 10.416
csf3rcolony stimulating factor 3 receptor (granulocyte)0.380
mpxmyeloid-specific peroxidase0.256
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.230
il1binterleukin 1, beta and interleukin 1, beta0.217
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.213
mmp13amatrix metalloproteinase 13a0.205
ctgfconnective tissue growth factor0.205
timp2btissue inhibitor of metalloproteinase 2b0.080
bactin1bactin10.078
si:ch211-212m21.5si:ch211-212m21.50.072
timp2atissue inhibitor of metalloproteinase 2a0.070
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.069
cnn2calponin 20.064
grnagranulin a0.064
sgk1serum/glucocorticoid regulated kinase 10.060
dusp6dual specificity phosphatase 60.059
si:dkey-12o15.1si:dkey-12o15.10.055
unc5bunc-5 homolog B (C. elegans)0.054
coro1acoronin, actin binding protein, 1A0.052
actn1actinin, alpha 10.050
ptgs2aprostaglandin-endoperoxide synthase 2a0.041
irf8interferon regulatory factor 80.040
ef1aelongation factor 1-alpha0.038
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.036
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.035
crhcorticotropin releasing hormone0.034
il8interleukin 80.030
npsnnephrosin0.030
ncf1neutrophil cytosolic factor 10.026
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.026
csf1racolony stimulating factor 1 receptor, a0.026
olfml3bolfactomedin-like 3b0.026
wlswntless homolog (Drosophila)0.023
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.022
ctsl1acathepsin L, 1 a0.022
hbbe1.1hemoglobin beta embryonic-1.10.022
bcl2B-cell leukemia/lymphoma 20.022
gcm2glial cells missing homolog 2 (Drosophila)0.021
dcndecorin0.019
igfbp1ainsulin-like growth factor binding protein 1a0.018
stc1lstanniocalcin 1, like0.018
grk7aG-protein-coupled receptor kinase 7a0.018
si:dkeyp-22b2.3si:dkeyp-22b2.30.018
dusp5dual specificity phosphatase 50.018
eporerythropoietin receptor0.017
scinlascinderin like a0.017
fgf20afibroblast growth factor 20a0.017
mmp14bmatrix metalloproteinase 14b (membrane-inserted)0.016
pcsk5bproprotein convertase subtilisin/kexin type 5b0.016
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.016
sat1aspermidine/spermine N1-acetyltransferase 1a0.015
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.015
odc1ornithine decarboxylase 10.014
pcsk9proprotein convertase subtilisin/kexin type 90.014
thraathyroid hormone receptor alpha a0.014
rhogbras homolog gene family, member Gb0.014
pth1aparathyroid hormone 1a0.014
acp5bacid phosphatase 5b, tartrate resistant0.013
tpm4tropomyosin 40.013
ahr2aryl hydrocarbon receptor 20.013
cd63Cd63 antigen0.012
mcoln1mucolipin 10.012
zgc:171802zgc:1718020.012
cd247CD247 antigen0.012
adh8aalcohol dehydrogenase 8a0.011
agtr2angiotensin II receptor, type 20.011
lta4hleukotriene A4 hydrolase0.011
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.011
copebcore promoter element binding protein0.011
yrkYes-related kinase0.011
rhcgbRhesus blood group, C glycoprotein b0.010
hspg2heparan sulfate proteoglycan 20.010
mmp15bmatrix metallopeptidase 15b0.010
limk2LIM domain kinase 20.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Ifnginterferon gamma0.939
Map3k14mitogen-activated protein kinase kinase kinase 140.629
Il10interleukin 100.611
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.609
Tlr4toll-like receptor 40.534
Ikzf1IKAROS family zinc finger 10.461
Lyz2lysozyme 20.379
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.304
Il4interleukin 40.265
Nos2nitric oxide synthase 2, inducible0.237
Il6interleukin 60.192
Ccl2chemokine (C-C motif) ligand 20.160
FasFas (TNF receptor superfamily member 6)0.134
Cd40CD40 antigen0.114
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.113
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.107
Il2interleukin 20.089
Ighimmunoglobulin heavy chain complex0.081
Ltalymphotoxin A0.074
Cd19CD19 antigen0.066
Ptgs2prostaglandin-endoperoxide synthase 20.061
Prf1perforin 1 (pore forming protein)0.052
Rag1recombination activating gene 10.041
Vdrvitamin D receptor0.033
Socs1suppressor of cytokine signaling 10.028
Il1r1interleukin 1 receptor, type I0.025
Cd44CD44 antigen0.023
TcraT-cell receptor alpha chain0.019
Mmp9matrix metallopeptidase 90.018
Myd88myeloid differentiation primary response gene 880.018
Nlrp3NLR family, pyrin domain containing 30.018
Toxthymocyte selection-associated high mobility group box0.015
FaslFas ligand (TNF superfamily, member 6)0.015
Cxcl13chemokine (C-X-C motif) ligand 130.012
Ltblymphotoxin B0.012
Ccr2chemokine (C-C motif) receptor 20.012
Il7interleukin 70.012
Traf6TNF receptor-associated factor 60.012
Ccl4chemokine (C-C motif) ligand 40.012
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.011
Smad3MAD homolog 3 (Drosophila)0.010
Cxcr5chemokine (C-X-C motif) receptor 50.010
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism