The network for 'intracellular signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

NameDescriptionProbabilityFunc Analog Organism
Socs3suppressor of cytokine signaling 30.830
Ncr1natural cytotoxicity triggering receptor 10.805
Jak2Janus kinase 20.793
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.773
Nckap1NCK-associated protein 10.771
Jak1Janus kinase 10.767
Rap1bRAP1B, member of RAS oncogene family0.759
Dlgap1discs, large (Drosophila) homolog-associated protein 10.729
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.721
Anxa2annexin A20.721
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.709
Gucy1a3guanylate cyclase 1, soluble, alpha 30.703
Tgfbr2transforming growth factor, beta receptor II0.682
Arpc1bactin related protein 2/3 complex, subunit 1B0.674
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.669
Cd14CD14 molecule0.651
Rxraretinoid X receptor alpha0.643
Shank2SH3 and multiple ankyrin repeat domains 20.614
Adora2aadenosine A2a receptor0.602
Map2microtubule-associated protein 20.599
Fgfr2fibroblast growth factor receptor 20.596
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.583
Nrxn1neurexin 10.580
Fgfr1Fibroblast growth factor receptor 10.572
Sdc3syndecan 30.572
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.571
Utrnutrophin0.564
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.563
Nedd4neural precursor cell expressed, developmentally down-regulated 40.554
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.546
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.544
Klf2Kruppel-like factor 2 (lung)0.544
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.541
Gria2glutamate receptor, ionotropic, AMPA 20.536
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.528
Notch1Notch homolog 1, translocation-associated (Drosophila)0.524
Lgals5lectin, galactose binding, soluble 50.522
Adarb2adenosine deaminase, RNA-specific, B20.517
Syn1synapsin I0.513
RT1-BaRT1 class II, locus Ba0.509
Cdh6cadherin 60.509
Grm5glutamate receptor, metabotropic 50.507
Ccr5chemokine (C-C motif) receptor 50.506
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.502
Trhthyrotropin releasing hormone0.500
Phox2apaired-like homeobox 2a0.500
Nos3nitric oxide synthase 3, endothelial cell0.498
Pfn1profilin 10.497
Gng7guanine nucleotide binding protein (G protein), gamma 70.491
Tsc1tuberous sclerosis 10.491
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.490
Nek9NIMA (never in mitosis gene a)- related kinase 90.489
Nptnneuroplastin0.486
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.484
Fkbp4FK506 binding protein 40.482
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.480
Vav1vav 1 guanine nucleotide exchange factor0.480
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.478
Trhrthyrotropin releasing hormone receptor0.477
Prl7a4prolactin family 7, subfamily a, member 40.474
Grb2growth factor receptor bound protein 20.472
Prkcgprotein kinase C, gamma0.472
Gria1glutamate receptor, ionotropic, AMPA 10.462
Nrp2neuropilin 20.458
Pde2aphosphodiesterase 2A, cGMP-stimulated0.457
Prrx1paired related homeobox 10.454
Ptger4prostaglandin E receptor 4 (subtype EP4)0.453
Arih1ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)0.453
Fgf7fibroblast growth factor 70.450
S1pr2sphingosine-1-phosphate receptor 20.447
Tbxa2rthromboxane A2 receptor0.446
Ptch1patched homolog 1 (Drosophila)0.444
Mapk9mitogen-activated protein kinase 90.442
Htr75-hydroxytryptamine (serotonin) receptor 70.441
Barhl2BarH-like homeobox 20.437
Gfra2GDNF family receptor alpha 20.436
Inpp5dinositol polyphosphate-5-phosphatase D0.433
Myo1emyosin IE0.431
Prdm2PR domain containing 2, with ZNF domain0.431
Flt1FMS-related tyrosine kinase 10.429
Grm7glutamate receptor, metabotropic 70.428
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.428
Bhlha15basic helix-loop-helix family, member a150.426
Pxnpaxillin0.423
Irs1insulin receptor substrate 10.419
Homer1homer homolog 1 (Drosophila)0.418
Gnrhrgonadotropin releasing hormone receptor0.418
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.416
Exoc5exocyst complex component 50.416
Neu2sialidase 2 (cytosolic sialidase)0.413
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.413
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.412
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.412
Ccl22chemokine (C-C motif) ligand 220.409
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.408
Mc4rmelanocortin 4 receptor0.406
Ptafrplatelet-activating factor receptor0.405
Nr5a2nuclear receptor subfamily 5, group A, member 20.404
Hivep2human immunodeficiency virus type I enhancer binding protein 20.404
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.404
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.853
glp-1Protein GLP-10.707
vab-3Protein VAB-30.567
bar-1Protein BAR-10.475
daf-19Protein DAF-190.469
tps-1Protein TPS-10.435
sem-5Protein SEM-50.431
lin-25Protein LIN-250.417
eor-2Protein EOR-20.417
sma-1Protein SMA-10.381
eor-1Protein EOR-10.366
hgrs-1Protein HGRS-10.331
pkg-1Protein PKG-10.326
ida-1Protein IDA-10.320
sma-6Protein SMA-60.309
csn-5Protein CSN-50.302
mat-3Protein MAT-30.301
pry-1Protein PRY-10.294
tam-1Protein TAM-10.291
abl-1Protein ABL-10.271
daf-12Protein DAF-120.269
elt-6Protein ELT-60.269
msp-77Protein MSP-770.265
plc-1Protein PLC-10.263
dpy-22Protein DPY-220.256
sym-4Protein SYM-40.256
egl-8Protein EGL-80.256
par-5Protein PAR-50.249
lmn-1Protein LMN-10.249
cst-1Protein CST-10.243
ina-1Protein INA-10.229
fan-1Protein FAN-10.222
mig-5Protein MIG-50.222
daf-1Protein DAF-10.219
unc-52Protein UNC-520.216
msp-49Protein MSP-490.212
epi-1Protein EPI-10.211
ncr-1Protein NCR-10.209
F53F10.2Protein F53F10.20.208
unc-40Protein UNC-400.207
dlk-1Protein DLK-10.206
CELE_F47G4.4Protein F47G4.40.206
gld-1Protein GLD-10.204
jmjd-1.2Protein JMJD-1.20.202
sur-2Protein SUR-20.194
mes-3Protein MES-30.189
unc-94Protein UNC-940.188
lin-12Protein LIN-120.185
daf-4Protein DAF-40.185
K10D6.4Protein K10D6.40.184
stam-1Protein STAM-10.183
unc-73Protein UNC-730.182
unc-83Protein UNC-830.182
cdc-6Protein CDC-60.181
cam-1Protein CAM-10.181
aap-1Protein AAP-10.180
unc-41Protein UNC-410.180
lin-7Protein LIN-70.179
che-2Protein CHE-20.178
inx-19Protein INX-190.177
uig-1Protein UIG-10.176
ten-1Protein TEN-10.174
atg-2Protein ATG-20.174
msp-59Protein MSP-590.173
fln-2Protein FLN-20.170
alx-1Protein ALX-10.170
pdfr-1Protein PDFR-10.168
nipi-3Protein NIPI-30.168
pkn-1Protein PKN-10.167
apl-1Protein APL-10.166
msp-55Protein MSP-550.165
unc-43Protein UNC-430.159
hsr-9Protein HSR-90.156
R11A8.7Protein R11A8.70.156
R148.5Protein R148.50.156
swsn-4Protein SWSN-40.155
soc-2Protein SOC-20.152
F48A11.4Protein F48A11.40.152
F42H10.3Protein F42H10.30.149
msp-40Protein MSP-400.147
unc-32Protein UNC-320.147
rskn-1Protein RSKN-10.144
pxf-1Protein PXF-10.143
lag-1Protein LAG-10.143
afd-1Protein AFD-10.143
npp-22Protein NPP-220.143
miz-1Protein MIZ-10.142
K07E3.1Protein K07E3.10.142
F21A10.2Protein F21A10.20.141
rab-5Protein RAB-50.140
CELE_Y41D4B.4Protein Y41D4B.40.139
msp-76Protein MSP-760.139
rps-15Protein RPS-150.136
bet-2Protein BET-20.135
msp-78Protein MSP-780.134
pkc-1Protein PKC-10.134
osm-5Protein OSM-50.133
msp-19Protein MSP-190.132
egg-6Protein EGG-60.131
gdi-1Protein GDI-10.130
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
efnb2aephrin B2a0.760
wnt2bbwingless-type MMTV integration site family, member 2Bb0.707
lef1lymphocyte enhancer binding factor 10.691
alcambactivated leukocyte cell adhesion molecule b0.627
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.595
traf4atnf receptor-associated factor 4a0.580
tgfb3transforming growth factor, beta 30.565
rag1recombination activating gene 10.522
dkk1bdickkopf 1b0.520
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.505
cav1caveolin 10.495
mpxmyeloid-specific peroxidase0.444
pax2apaired box gene 2a0.424
socs3asuppressor of cytokine signaling 3a0.380
flt4fms-related tyrosine kinase 40.371
odc1ornithine decarboxylase 10.368
cmybtranscription factor cmyb0.366
igf1rbinsulin-like growth factor 1b receptor0.365
trpm7transient receptor potential cation channel, subfamily M, member 70.362
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.356
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.355
otpaorthopedia homolog a0.355
ncor1nuclear receptor co-repressor 10.350
csnk1dacasein kinase 1, delta a0.347
bdnfbrain-derived neurotrophic factor0.339
robo3roundabout homolog 30.339
epha4aeph receptor A4a0.335
bactin1bactin10.331
tbx1T-box 10.330
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.327
myhz2myosin, heavy polypeptide 2, fast muscle specific0.322
hey1hairy/enhancer-of-split related with YRPW motif 10.322
pitx3paired-like homeodomain transcription factor 30.321
gpr126G protein-coupled receptor 1260.309
junjun proto-oncogene0.303
ptenaphosphatase and tensin homolog A0.288
celf1cugbp, Elav-like family member 10.280
fn1fibronectin 10.276
smc3structural maintenance of chromosomes 30.271
igf1insulin-like growth factor 10.270
evx1even-skipped homeobox 10.269
mitfamicrophthalmia-associated transcription factor a0.265
wnt8bwingless-type MMTV integration site family, member 8b0.264
il6rinterleukin 6 receptor0.257
furinafurin (paired basic amino acid cleaving enzyme) a0.252
tie1endothelium-specific receptor tyrosine kinase 10.251
jag2jagged 20.243
cdc42cell division cycle 420.243
tbx20T-box 200.242
pcnaproliferating cell nuclear antigen0.238
tgif1TGFB-induced factor homeobox 10.238
tagln2transgelin 20.223
bocbrother of CDO0.223
nf1aneurofibromin 1a0.223
esr1estrogen receptor 10.221
vedventrally expressed dharma/bozozok antagonist0.220
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.218
eif3haeukaryotic translation initiation factor 3, subunit H, a0.211
adra2badrenergic, alpha-2B-, receptor0.210
msnamoesin a0.209
fzd7afrizzled homolog 7a0.207
ptk2.1protein tyrosine kinase 2a0.206
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.205
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.196
mmp9matrix metalloproteinase 90.195
socs1suppressor of cytokine signaling 10.194
sox11aSRY-box containing gene 11a0.193
lcp1lymphocyte cytosolic plastin 10.193
sema3aasemaphorin 3aa0.190
egr2bearly growth response 2b0.187
myogmyogenin0.184
her6hairy-related 60.183
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.181
atf3activating transcription factor 30.176
bmp2abone morphogenetic protein 2a0.176
frzbfrizzled-related protein0.175
stk11serine/threonine kinase 110.173
nrarpanotch-regulated ankyrin repeat protein a0.172
lama4laminin, alpha 40.170
spry2sprouty homolog 20.169
shhasonic hedgehog a0.167
ass1argininosuccinate synthetase 10.167
tlr3toll-like receptor 30.165
hmga1ahigh mobility group AT-hook 1a0.162
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.161
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.161
baxabcl2-associated X protein, a0.160
LOC100534970hypothetical protein LOC1005349700.160
twist1atwist1a0.160
tac1tachykinin 10.160
tpm4tropomyosin 40.157
esrrgaestrogen-related receptor gamma a0.156
myo6bmyosin VIb0.155
il6stinterleukin 6 signal transducer0.154
fgf3fibroblast growth factor 30.154
yap1Yes-associated protein 10.153
fgfr1afibroblast growth factor receptor 1a0.153
pkd2polycystic kidney disease 20.153
smad5MAD homolog 5 (Drosophila)0.153
inspreproinsulin0.148
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.999
bskbasket0.997
PtenCG5671 gene product from transcript CG5671-RB0.979
Akt1CG4006 gene product from transcript CG4006-RA0.977
MadMothers against dpp0.969
SmoxSmad on X0.966
putpunt0.955
ykiyorkie0.950
phlpole hole0.941
Ras85DRas oncogene at 85D0.939
Sir2CG5216 gene product from transcript CG5216-RA0.932
TlToll0.921
chicchickadee0.919
stcksteamer duck0.912
Mpk2CG5475 gene product from transcript CG5475-RB0.903
pucpuckered0.898
Lis-1Lissencephaly-10.897
p38bCG7393 gene product from transcript CG7393-RA0.896
Rpd3CG7471 gene product from transcript CG7471-RA0.887
Atg1Autophagy-specific gene 10.886
Rac1CG2248 gene product from transcript CG2248-RA0.868
Tak1TGF-beta activated kinase 10.856
Su(H)Suppressor of Hairless0.850
shgshotgun0.849
CaMKIICalcium/calmodulin-dependent protein kinase II0.849
RhebCG1081 gene product from transcript CG1081-RA0.849
emcextra macrochaetae0.848
dmdiminutive0.848
CG5794CG5794 gene product from transcript CG5794-RB0.835
rutrutabaga0.829
keykenny0.828
S6kIIRPS6-protein kinase-II0.814
wtswarts0.808
Cul-5Cullin-50.803
Pk61CProtein kinase 61C0.800
PvrPDGF- and VEGF-receptor related0.799
Rca1Regulator of cyclin A10.790
jebjelly belly0.790
bazbazooka0.787
aopanterior open0.771
PliPellino0.764
egreiger0.764
domedomeless0.762
p120ctnAdherens junction protein p1200.755
SaraSmad anchor for receptor activation0.755
shishibire0.749
neurneuralized0.749
wgwingless0.741
Taf1TBP-associated factor 10.741
mbcmyoblast city0.741
foxoforkhead box, sub-group O0.734
Ada2bCG9638 gene product from transcript CG9638-RA0.732
kaykayak0.726
CkIIbetaCasein kinase II beta subunit0.719
rapretina aberrant in pattern0.717
flwflapwing0.714
Rho1CG8416 gene product from transcript CG8416-RB0.705
Sin3ACG8815 gene product from transcript CG8815-RC0.698
Dsor1Downstream of raf10.692
Cdc42CG12530 gene product from transcript CG12530-RA0.689
MerMerlin0.689
rhorhomboid0.687
twstwins0.684
exexpanded0.678
Zyx102EFCG32018 gene product from transcript CG32018-RA0.678
Atg18Autophagy-specific gene 180.670
S6kRPS6-p70-protein kinase0.660
eIF-4EEukaryotic initiation factor 4E0.654
Mekk1CG7717 gene product from transcript CG7717-RB0.652
ari-2ariadne 20.649
ctpcut up0.649
NNotch0.643
EgfrEpidermal growth factor receptor0.640
sggshaggy0.627
XNPCG4548 gene product from transcript CG4548-RA0.625
htlheartless0.612
Eps-15Epidermal growth factor receptor pathway substrate clone 150.608
rprreaper0.606
locolocomotion defects0.602
osoutstretched0.599
drkdownstream of receptor kinase0.598
cdc2cCG10498 gene product from transcript CG10498-RC0.593
Sra-1specifically Rac1-associated protein 10.586
agoarchipelago0.584
SdcSyndecan0.581
yrtyurt0.579
tkvthickveins0.575
alphalphabet0.575
Src64BSrc oncogene at 64B0.572
osaCG7467 gene product from transcript CG7467-RD0.570
Ten-mTenascin major0.568
ttvtout-velu0.563
Trx-2thioredoxin-20.560
Myo31DFMyosin 31DF0.554
nejnejire0.551
gbbglass bottom boat0.549
rlrolled0.548
cindrCIN85 and CD2AP orthologue0.547
CakiCalcium/calmodulin-dependent protein kinase0.546
armarmadillo0.545
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SHO1Sho1p0.909
CDC55Cdc55p0.902
STE20Ste20p0.895
HOG1Hog1p0.886
ROM2Rom2p0.871
BCK1Bck1p0.869
SNF1Snf1p0.864
RHO1Rho1p0.836
PBS2Pbs2p0.834
MKS1Mks1p0.772
BOI1Boi1p0.745
GPA2Gpa2p0.740
BCY1Bcy1p0.724
TOR1Tor1p0.713
SSK2Ssk2p0.704
CLA4Cla4p0.694
UBP15Ubp15p0.655
TPK2Tpk2p0.637
KSS1Kss1p0.625
SLT2Slt2p0.611
BMH2Bmh2p0.601
CKA1Cka1p0.590
YAK1Yak1p0.577
PHO85Pho85p0.565
MSH3Msh3p0.557
MKK1Mkk1p0.544
TPK1Tpk1p0.538
FUS3Fus3p0.532
TPS1Tps1p0.525
CDC50Cdc50p0.520
BEM3Bem3p0.519
ERP4Erp4p0.487
PTC1Ptc1p0.458
KOG1Kog1p0.453
FAR1Far1p0.449
SSK1Ssk1p0.441
LSP1Lsp1p0.434
SAP185Sap185p0.421
RAS1Ras1p0.418
CHC1Chc1p0.417
ENA5Ena5p0.390
HSP82Hsp82p0.388
NBP2Nbp2p0.383
MSN4Msn4p0.355
CMP2Cmp2p0.354
SKN7Skn7p0.347
VAC8Vac8p0.341
RIM15Rim15p0.338
STE4Ste4p0.320
MKT1Mkt1p0.315
YEL1Yel1p0.314
PPH3Pph3p0.311
MIG1Mig1p0.307
PTP2Ptp2p0.306
VPS27Vps27p0.299
VPS64Vps64p0.297
TOR2Tor2p0.295
SEC2Sec2p0.290
PLC1Plc1p0.283
BEM4Bem4p0.283
HSP30Hsp30p0.282
VPS15Vps15p0.280
SOK1Sok1p0.275
PST2Pst2p0.269
IRA1Ira1p0.267
SLG1Slg1p0.266
YKR017Chypothetical protein0.266
GYL1Gyl1p0.262
PPZ1Ppz1p0.260
EAF3Eaf3p0.251
SYP1Syp1p0.250
MSG5Msg5p0.245
FAR11Far11p0.245
PIL1Pil1p0.244
PAF1Paf1p0.232
STE7Ste7p0.232
BUD14Bud14p0.230
LCB4Lcb4p0.230
IZH4Izh4p0.216
BCK2Bck2p0.214
TOM1Tom1p0.210
BNI1Bni1p0.198
HST1Hst1p0.198
BET3Bet3p0.196
SLM1Slm1p0.194
GTR1Gtr1p0.191
RLM1Rlm1p0.189
FKS1Fks1p0.186
PDR12Pdr12p0.185
SSK22Ssk22p0.184
TPO2Tpo2p0.184
YPK1Ypk1p0.178
ARF2Arf2p0.178
SAC7Sac7p0.175
CCS1Ccs1p0.174
AFI1Afi1p0.173
SEC3Sec3p0.172
LYS5Lys5p0.168
MIG2Mig2p0.166
PDE2Pde2p0.166