The network for 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.

NameDescriptionProbabilityFunc Analog Organism
Ldb3LIM domain binding 30.323
Pygmphosphorylase, glycogen, muscle0.257
Tmod4tropomodulin 40.244
Pgam2phosphoglycerate mutase 2 (muscle)0.217
Ccl4chemokine (C-C motif) ligand 40.171
Myl1myosin, light chain 10.162
Nexnnexilin (F actin binding protein)0.137
Cav3caveolin 30.123
Casq2calsequestrin 2 (cardiac muscle)0.120
Mybpc1myosin binding protein C, slow type0.115
Asb12ankyrin repeat and SOCS box-containing 120.115
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.109
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.100
Map3k8mitogen-activated protein kinase kinase kinase 80.097
Myo9amyosin IXA0.097
Gstm1glutathione S-transferase mu 10.096
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.094
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.093
Unc45bunc-45 homolog B (C. elegans)0.093
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.088
Ckmcreatine kinase, muscle0.079
Phka1phosphorylase kinase, alpha 10.077
Sh3bgrSH3 domain binding glutamic acid-rich protein0.071
Cd4Cd4 molecule0.068
Lrrc39leucine rich repeat containing 390.067
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.064
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.060
Fitm1fat storage-inducing transmembrane protein 10.059
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.057
Rasa2RAS p21 protein activator 20.056
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.055
Tnni3kTNNI3 interacting kinase0.055
Ckmt2creatine kinase, mitochondrial 2, sarcomeric0.053
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.051
Smpxsmall muscle protein, X-linked0.050
Rgs1regulator of G-protein signaling 10.049
CdonCdon homolog (mouse)0.048
Phexphosphate regulating endopeptidase homolog, X-linked0.048
Art1ADP-ribosyltransferase 10.048
RhagRh-associated glycoprotein0.047
Pde3aphosphodiesterase 3A, cGMP inhibited0.045
Trim63tripartite motif-containing 630.045
P2ry1purinergic receptor P2Y, G-protein coupled, 10.044
Rpl3lribosomal protein L3-like0.043
Il1binterleukin 1 beta0.043
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.042
Tnnt3troponin T type 3 (skeletal, fast)0.041
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.040
Hcrtr2hypocretin (orexin) receptor 20.040
Ccr5chemokine (C-C motif) receptor 50.040
Slc26a2solute carrier family 26 (sulfate transporter), member 20.040
Myh4myosin, heavy chain 4, skeletal muscle0.040
Top2atopoisomerase (DNA) II alpha0.039
Inpp4binositol polyphosphate-4-phosphatase, type II0.039
Tnni1troponin I type 1 (skeletal, slow)0.039
Bmp6bone morphogenetic protein 60.039
Capn6calpain 60.038
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.038
Seleselectin E0.038
Lama2laminin, alpha 20.038
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.037
Cacng1calcium channel, voltage-dependent, gamma subunit 10.037
Nrxn1neurexin 10.037
Trim72tripartite motif-containing 720.036
Klra5killer cell lectin-like receptor, subfamily A, member 50.036
Itpr1inositol 1,4,5-triphosphate receptor, type 10.035
Irs1insulin receptor substrate 10.035
Myoz1myozenin 10.034
Neu2sialidase 2 (cytosolic sialidase)0.034
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.034
Myom2myomesin 20.034
LOC681849similar to Protein C6orf142 homolog0.033
Ncr1natural cytotoxicity triggering receptor 10.032
Scn4bsodium channel, voltage-gated, type IV, beta0.032
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.032
Lims1LIM and senescent cell antigen-like domains 10.031
C1qtnf3C1q and tumor necrosis factor related protein 30.031
Akap6A kinase (PRKA) anchor protein 60.030
Selpselectin P0.030
Asb2ankyrin repeat and SOCS box-containing 20.030
Klrk1killer cell lectin-like receptor subfamily K, member 10.029
Nrapnebulin-related anchoring protein0.029
Cntn2contactin 2 (axonal)0.029
Kbtbd10kelch repeat and BTB (POZ) domain containing 100.028
MosMoloney sarcoma oncogene0.028
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.028
Opcmlopioid binding protein/cell adhesion molecule-like0.027
Adrbk2adrenergic, beta, receptor kinase 20.027
Cntn6contactin 60.027
Atp1b4ATPase, (Na+)/K+ transporting, beta 4 polypeptide0.026
Cox8bcytochrome c oxidase, subunit VIIIb0.026
Calcrlcalcitonin receptor-like0.026
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.026
Tnnc2troponin C type 2 (fast)0.025
Cd83CD83 molecule0.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.998
CCR5chemokine (C-C motif) receptor 50.993
GSTM2glutathione S-transferase mu 2 (muscle)0.964
CCL5chemokine (C-C motif) ligand 50.933
CXCL9chemokine (C-X-C motif) ligand 90.483
CCL22chemokine (C-C motif) ligand 220.392
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.382
DTNAdystrobrevin, alpha0.349
CCL2chemokine (C-C motif) ligand 20.317
GSTM4glutathione S-transferase mu 40.285
CCL4chemokine (C-C motif) ligand 40.270
IFNGinterferon, gamma0.209
IL2RBinterleukin 2 receptor, beta0.177
IL8interleukin 80.148
CCL8chemokine (C-C motif) ligand 80.128
CXCR6chemokine (C-X-C motif) receptor 60.119
CCR7chemokine (C-C motif) receptor 70.111
ACVR1Bactivin A receptor, type IB0.102
CCR4chemokine (C-C motif) receptor 40.100
CCR2chemokine (C-C motif) receptor 20.090
IL6interleukin 6 (interferon, beta 2)0.085
IL10interleukin 100.081
CXCL13chemokine (C-X-C motif) ligand 130.074
IL1Binterleukin 1, beta0.057
CCL7chemokine (C-C motif) ligand 70.056
TGFBR1transforming growth factor, beta receptor 10.054
SPTBspectrin, beta, erythrocytic0.049
CCR1chemokine (C-C motif) receptor 10.048
CCL13chemokine (C-C motif) ligand 130.045
CCL19chemokine (C-C motif) ligand 190.040
IRF4interferon regulatory factor 40.037
AKAP6A kinase (PRKA) anchor protein 60.035
CXCR3chemokine (C-X-C motif) receptor 30.033
CD40LGCD40 ligand0.030
LTAlymphotoxin alpha (TNF superfamily, member 1)0.030
IL21Rinterleukin 21 receptor0.029
IDEinsulin-degrading enzyme0.028
CXCL10chemokine (C-X-C motif) ligand 100.028
MYO10myosin X0.028
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.026
DARCDuffy blood group, chemokine receptor0.025
DPP4dipeptidyl-peptidase 40.025
CXCL3chemokine (C-X-C motif) ligand 30.025
KLRD1killer cell lectin-like receptor subfamily D, member 10.025
SLAMF7SLAM family member 70.024
AKT2v-akt murine thymoma viral oncogene homolog 20.023
CCR3chemokine (C-C motif) receptor 30.023
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.023
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.023
EHD1EH-domain containing 10.023
IL1RNinterleukin 1 receptor antagonist0.023
TNFtumor necrosis factor0.022
CXCL11chemokine (C-X-C motif) ligand 110.022
CFL1cofilin 1 (non-muscle)0.022
CXCL2chemokine (C-X-C motif) ligand 20.021
MAPK4mitogen-activated protein kinase 40.020
NR4A3nuclear receptor subfamily 4, group A, member 30.019
DTNBdystrobrevin, beta0.019
GSTM3glutathione S-transferase mu 3 (brain)0.019
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.017
ARRB1arrestin, beta 10.017
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.016
SELEselectin E0.016
IL1F5interleukin 1 family, member 5 (delta)0.016
RGS1regulator of G-protein signaling 10.015
CXCR2chemokine (C-X-C motif) receptor 20.015
CCL11chemokine (C-C motif) ligand 110.015
CCL3chemokine (C-C motif) ligand 30.015
IL1Ainterleukin 1, alpha0.014
TNFRSF9tumor necrosis factor receptor superfamily, member 90.014
CXCL5chemokine (C-X-C motif) ligand 50.013
CD83CD83 molecule0.013
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.013
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.012
IL1R2interleukin 1 receptor, type II0.012
CCL20chemokine (C-C motif) ligand 200.012
CLEC4AC-type lectin domain family 4, member A0.012
IL16interleukin 16 (lymphocyte chemoattractant factor)0.012
CCR6chemokine (C-C motif) receptor 60.012
TRAPPC1trafficking protein particle complex 10.011
ARF3ADP-ribosylation factor 30.011
IL7Rinterleukin 7 receptor0.011
FCER2Fc fragment of IgE, low affinity II, receptor for (CD23)0.011
CD86CD86 molecule0.011
FPR3formyl peptide receptor 30.011
RHAGRh-associated glycoprotein0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ldb3LIM domain binding 30.913
Hrchistidine rich calcium binding protein0.847
Ccr1chemokine (C-C motif) receptor 10.824
Hbb-b1hemoglobin, beta adult major chain0.780
Casq2calsequestrin 20.769
Ryr2ryanodine receptor 2, cardiac0.700
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.614
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.614
Spna1spectrin alpha 10.609
Spnb1spectrin beta 10.587
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.575
Casq1calsequestrin 10.568
Actn2actinin alpha 20.512
Ccl2chemokine (C-C motif) ligand 20.498
Myom2myomesin 20.493
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.469
Srpk3serine/arginine-rich protein specific kinase 30.419
Cav3caveolin 30.387
Myl1myosin, light polypeptide 10.336
Ccr2chemokine (C-C motif) receptor 20.320
Myoz2myozenin 20.221
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.212
Smyd1SET and MYND domain containing 10.208
Yipf7Yip1 domain family, member 70.200
Prkccprotein kinase C, gamma0.169
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.166
Ckmcreatine kinase, muscle0.162
Scn1asodium channel, voltage-gated, type I, alpha0.148
Sh3bgrSH3-binding domain glutamic acid-rich protein0.131
Phkg1phosphorylase kinase gamma 10.130
Klf1Kruppel-like factor 1 (erythroid)0.126
Urosuroporphyrinogen III synthase0.124
Ckmt2creatine kinase, mitochondrial 20.119
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.109
Myom1myomesin 10.106
Dtnadystrobrevin alpha0.099
Gja1gap junction protein, alpha 10.099
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.088
Cep290centrosomal protein 2900.086
Cmya5cardiomyopathy associated 50.084
Alpk3alpha-kinase 30.083
Pygmmuscle glycogen phosphorylase0.082
Actc1actin, alpha, cardiac muscle 10.078
Frmd5FERM domain containing 50.077
Cox8bcytochrome c oxidase, subunit VIIIb0.076
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.076
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.075
Scn1bsodium channel, voltage-gated, type I, beta0.068
Popdc2popeye domain containing 20.068
Snta1syntrophin, acidic 10.063
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.057
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.054
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.054
Add2adducin 2 (beta)0.049
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.049
Gnao1guanine nucleotide binding protein, alpha O0.049
Tnnt2troponin T2, cardiac0.048
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.046
Usp13ubiquitin specific peptidase 13 (isopeptidase T-3)0.046
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.045
Rbm24RNA binding motif protein 240.045
Exoc6exocyst complex component 60.044
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.043
Col19a1collagen, type XIX, alpha 10.041
Hbb-b2hemoglobin, beta adult minor chain0.040
Tnnc2troponin C2, fast0.040
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.038
Tuba8tubulin, alpha 80.037
Pgam2phosphoglycerate mutase 20.034
Txlnbtaxilin beta0.033
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.033
Lmod3leiomodin 3 (fetal)0.032
Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.032
Tnnt3troponin T3, skeletal, fast0.031
Adam23a disintegrin and metallopeptidase domain 230.030
Mpeg1macrophage expressed gene 10.029
Scn5asodium channel, voltage-gated, type V, alpha0.029
Ptproprotein tyrosine phosphatase, receptor type, O0.029
Kcnd2potassium voltage-gated channel, Shal-related family, member 20.027
Myl3myosin, light polypeptide 30.027
Capn3calpain 30.027
Asb12ankyrin repeat and SOCS box-containing 120.026
Smpxsmall muscle protein, X-linked0.026
Cdh13cadherin 130.026
Dag1dystroglycan 10.026
Ryr3ryanodine receptor 30.025
Etl4enhancer trap locus 40.025
Eporerythropoietin receptor0.025
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.024
Hspb3heat shock protein 30.024
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism