The network for 'positive regulation of cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

NameDescriptionProbabilityFunc Analog Organism
Gjb3gap junction protein, beta 30.642
Cgaglycoprotein hormones, alpha polypeptide0.587
Ptpn7protein tyrosine phosphatase, non-receptor type 70.569
Fgfr2fibroblast growth factor receptor 20.567
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.535
Pgcprogastricsin (pepsinogen C)0.520
Cd4Cd4 molecule0.513
Cd40lgCD40 ligand0.500
Ddr1discoidin domain receptor tyrosine kinase 10.500
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.485
Foxd1forkhead box D10.480
Chatcholine acetyltransferase0.460
Fgf7fibroblast growth factor 70.453
Itgamintegrin, alpha M0.452
Ascl1achaete-scute complex homolog 1 (Drosophila)0.426
Sirpasignal-regulatory protein alpha0.410
Prrx1paired related homeobox 10.405
Prl6a1prolactin family 6, subfamily a, member 10.403
Adrb1adrenergic, beta-1-, receptor0.403
Nefmneurofilament, medium polypeptide0.396
Adora2aadenosine A2a receptor0.390
Anxa5annexin A50.388
Cd151CD151 molecule (Raph blood group)0.385
Egr2early growth response 20.384
Gja1gap junction protein, alpha 10.382
Nptxrneuronal pentraxin receptor0.380
Cacng7calcium channel, voltage-dependent, gamma subunit 70.378
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.372
Cdh6cadherin 60.365
Klf6Kruppel-like factor 60.363
Npffr2neuropeptide FF receptor 20.362
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.358
Vom2r27vomeronasal 2 receptor, 270.358
Anxa1annexin A10.358
Il9rinterleukin 9 receptor0.356
Grk1G protein-coupled receptor kinase 10.353
Slco2b1solute carrier organic anion transporter family, member 2b10.351
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.345
Utrnutrophin0.344
Trim66tripartite motif-containing 660.343
Casp2caspase 20.342
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.339
Oprm1opioid receptor, mu 10.332
Bcl2B-cell CLL/lymphoma 20.328
Dchs1dachsous 1 (Drosophila)0.327
Grprgastrin releasing peptide receptor0.324
Mamdc4MAM domain containing 40.323
Gnrhrgonadotropin releasing hormone receptor0.320
Aregamphiregulin0.318
Ptafrplatelet-activating factor receptor0.317
Ccnd1cyclin D10.316
Cd5Cd5 molecule0.314
Olfml2bolfactomedin-like 2B0.314
Hbe2hemoglobin, epsilon 20.313
Sstr5somatostatin receptor 50.312
FosFBJ osteosarcoma oncogene0.309
Fgf16fibroblast growth factor 160.303
S100a10S100 calcium binding protein A100.298
Aqp5aquaporin 50.298
Tas2r107taste receptor, type 2, member 1070.297
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.295
Akr1c18aldo-keto reductase family 1, member C180.294
Col10a1collagen, type X, alpha 10.293
Foxs1forkhead box S10.292
Egr1early growth response 10.292
Shox2short stature homeobox 20.289
Ednraendothelin receptor type A0.289
Gdf10growth differentiation factor 100.287
Dnase1l3deoxyribonuclease 1-like 30.285
Agtr1aangiotensin II receptor, type 1a0.285
Anxa2annexin A20.285
Prss22protease, serine, 220.280
Fosl1fos-like antigen 10.279
Runx1runt-related transcription factor 10.274
Bcanbrevican0.273
Il10rainterleukin 10 receptor, alpha0.271
Gpr20G protein-coupled receptor 200.267
Sfrp4secreted frizzled-related protein 40.265
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.264
Pipprolactin induced protein0.262
Trim47tripartite motif-containing 470.262
Purbpurine rich element binding protein B0.262
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.259
Phox2apaired-like homeobox 2a0.259
Plauplasminogen activator, urokinase0.258
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.258
Ccl4chemokine (C-C motif) ligand 40.256
Pcdhb12protocadherin beta 120.255
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.255
Cx3cr1chemokine (C-X3-C motif) receptor 10.252
Vcanversican0.252
Tbx2T-box 20.250
Twist2twist homolog 2 (Drosophila)0.249
Olr1361olfactory receptor 13610.249
Hcn4hyperpolarization activated cyclic nucleotide-gated potassium channel 40.247
Nos1nitric oxide synthase 1, neuronal0.246
Ptk2bPTK2B protein tyrosine kinase 2 beta0.245
Drd3dopamine receptor D30.241
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.239
Reg3aregenerating islet-derived 3 alpha0.237
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
nhr-67Protein NHR-670.013
egl-18Protein EGL-180.011
unc-73Protein UNC-730.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.983
aldh1a2aldehyde dehydrogenase 1 family, member A20.867
shhasonic hedgehog a0.841
fgf17fibroblast growth factor 170.778
tal1T-cell acute lymphocytic leukemia 10.728
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.662
sulf1sulfatase 10.658
kdrlkinase insert domain receptor like0.616
kitakit receptor a0.601
gli1GLI-Kruppel family member 10.541
ndr2nodal-related 20.522
dlddeltaD0.507
snai1asnail homolog 1a (Drosophila)0.474
mitfamicrophthalmia-associated transcription factor a0.459
tbx2bT-box 2b0.456
mycamyelocytomatosis oncogene a0.412
bocbrother of CDO0.403
eya1eyes absent homolog 10.365
dlx5adistal-less homeobox gene 5a0.357
chdchordin0.344
bmp4bone morphogenetic protein 40.328
jag2jagged 20.309
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.280
her6hairy-related 60.279
fgfr1afibroblast growth factor receptor 1a0.270
hoxd4ahomeo box D4a0.254
hoxb1bhomeo box B1b0.248
wnt5bwingless-type MMTV integration site family, member 5b0.248
tbx16T-box gene 160.229
bmp2bbone morphogenetic protein 2b0.219
dusp6dual specificity phosphatase 60.219
lhx1aLIM homeobox 1a0.206
alcamaactivated leukocyte cell adhesion molecule a0.205
ptch1patched 10.198
mibmind bomb0.190
notch2notch homolog 20.189
neo1neogenin 10.186
itgb1bintegrin, beta 1b0.182
pax6apaired box gene 6a0.177
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.176
nod1nucleotide-binding oligomerization domain containing 10.172
dnmt4DNA (cytosine-5-)-methyltransferase 40.169
gna12guanine nucleotide binding protein (G protein) alpha 120.162
wnt2wingless-type MMTV integration site family member 20.156
etv2ets variant gene 20.149
tshbthyroid stimulating hormone, beta subunit0.148
ascl1aachaete-scute complex-like 1a (Drosophila)0.140
notch3notch homolog 30.136
hoxa2bhomeo box A2b0.136
six1bsine oculis homeobox homolog 1b0.132
otpborthopedia homolog b0.130
tbx1T-box 10.127
gscgoosecoid0.125
tp53tumor protein p530.124
fgf3fibroblast growth factor 30.123
foxi1forkhead box I10.119
flhfloating head0.119
otpaorthopedia homolog a0.118
flt4fms-related tyrosine kinase 40.115
vsx2visual system homeobox 20.113
fgf8afibroblast growth factor 8 a0.113
nkx2.5NK2 transcription factor related 50.108
igf1insulin-like growth factor 10.107
mmp9matrix metalloproteinase 90.106
evx1even-skipped homeobox 10.104
wnt11rwingless-type MMTV integration site family, member 11, related0.101
irx3airoquois homeobox protein 3a0.100
bmp7bbone morphogenetic protein 7b0.099
tie1endothelium-specific receptor tyrosine kinase 10.099
acvr1lactivin A receptor, type I like0.096
eomesaeomesodermin homolog a0.095
fli1afriend leukemia integration 1a0.089
il6stinterleukin 6 signal transducer0.088
wlswntless homolog (Drosophila)0.087
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.086
hoxc8ahomeo box C8a0.085
sox9bSRY-box containing gene 9b0.083
tnfatumor necrosis factor a (TNF superfamily, member 2)0.082
rereaarginine-glutamic acid dipeptide (RE) repeats a0.082
runx2arunt-related transcription factor 2a0.081
smad9MAD homolog 9 (Drosophila)0.080
epha4beph receptor A4b0.080
fras1Fraser syndrome 10.079
nrg1neuregulin 10.078
her7hairy and enhancer of split related-70.076
dzip1DAZ interacting protein 10.075
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.074
dlbdeltaB0.073
loxl3blysyl oxidase-like 3b0.073
gdnfglial cell derived neurotrophic factor0.072
barx1BarH-like homeobox 10.071
mab21l2mab-21-like 20.070
axin2axin 2 (conductin, axil)0.070
jag1bjagged 1b0.070
si:dkey-8l13.4si:dkey-8l13.40.069
msxcmuscle segment homeobox C0.069
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.068
igf1rbinsulin-like growth factor 1b receptor0.067
dkk1bdickkopf 1b0.066
irx4airoquois homeobox protein 4a0.066
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.992
brmbrahma0.928
E(spl)Enhancer of split0.885
nejnejire0.874
stcksteamer duck0.743
NNotch0.721
Akt1CG4006 gene product from transcript CG4006-RA0.712
shnschnurri0.711
MadMothers against dpp0.708
armarmadillo0.684
grogroucho0.668
sosine oculis0.652
stgstring0.561
mnbminibrain0.559
dacdachshund0.517
dshdishevelled0.487
dmdiminutive0.486
InRInsulin-like receptor0.486
Rac2CG8556 gene product from transcript CG8556-RA0.486
DadDaughters against dpp0.478
S6kRPS6-p70-protein kinase0.477
Rac1CG2248 gene product from transcript CG2248-RA0.426
bab2CG9102 gene product from transcript CG9102-RA0.396
Pi3K92ECG4141 gene product from transcript CG4141-RB0.392
stumpsCG31317 gene product from transcript CG31317-RC0.390
drkdownstream of receptor kinase0.389
spispitz0.387
slp1sloppy paired 10.385
HLHmdeltaE(spl) region transcript mdelta0.379
nkdnaked cuticle0.371
rlrolled0.345
norpAno receptor potential A0.340
Ras85DRas oncogene at 85D0.337
AtpalphaNa pump alpha subunit0.334
elavembryonic lethal abnormal vision0.325
shishibire0.324
par-1CG8201 gene product from transcript CG8201-RA0.320
aopanterior open0.317
Snr1Snf5-related 10.316
ushu-shaped0.314
Pk61CProtein kinase 61C0.308
fzfrizzled0.307
domedomeless0.299
eveeven skipped0.296
babobaboon0.292
hhhedgehog0.276
fngfringe0.265
wgwingless0.251
SoxNSoxNeuro0.244
Rab5Rab-protein 50.238
htlheartless0.236
dppdecapentaplegic0.234
tintinman0.221
eyeyeless0.217
HLHmgammaE(spl) region transcript mgamma0.214
EgfrEpidermal growth factor receptor0.206
crbcrumbs0.204
MoeMoesin0.203
Fmr1CG6203 gene product from transcript CG6203-RC0.201
enengrailed0.201
putpunt0.195
exbaextra bases0.193
kniknirps0.191
jubAjuba LIM protein0.187
osoutstretched0.185
sevsevenless0.184
dpndeadpan0.181
IswiImitation SWI0.177
agoarchipelago0.175
ttktramtrack0.174
UbxUltrabithorax0.173
brkbrinker0.166
NetBNetrin-B0.165
dapdacapo0.161
dadaughterless0.159
kibrakibra ortholog0.157
CycBCyclin B0.150
pntpointed0.149
RbfRetinoblastoma-family protein0.147
beta-Specbeta Spectrin0.146
picpiccolo0.144
alaristaless0.141
HLHm5E(spl) region transcript m50.137
Spn27ASerpin 27A0.137
JraJun-related antigen0.137
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.136
hipkhomeodomain interacting protein kinase0.134
MhcMyosin heavy chain0.133
discodisconnected0.133
HLHm7E(spl) region transcript m70.131
cswcorkscrew0.131
grngrain0.130
belbelle0.130
NrtNeurotactin0.128
Su(H)Suppressor of Hairless0.127
TomTwin of m40.126
poloCG12306 gene product from transcript CG12306-RA0.124
thsthisbe0.123
kaykayak0.122
myoglianinCG1838 gene product from transcript CG1838-RD0.122
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1.000
ESR1estrogen receptor 11.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
PTPN1protein tyrosine phosphatase, non-receptor type 10.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
SHC1SHC (Src homology 2 domain containing) transforming protein 10.999
CDK2cyclin-dependent kinase 20.999
SYKspleen tyrosine kinase0.999
RB1retinoblastoma 10.998
TP53tumor protein p530.998
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.995
GRB2growth factor receptor-bound protein 20.995
CAV1caveolin 1, caveolae protein, 22kDa0.993
MDM2Mdm2 p53 binding protein homolog (mouse)0.992
HDAC1histone deacetylase 10.990
JAG1jagged 10.987
FGFR2fibroblast growth factor receptor 20.986
SMAD2SMAD family member 20.983
NME2non-metastatic cells 2, protein (NM23B) expressed in0.983
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.979
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.978
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.976
CD80CD80 molecule0.976
EP300E1A binding protein p3000.974
E2F1E2F transcription factor 10.971
FN1fibronectin 10.970
BCL2B-cell CLL/lymphoma 20.969
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.968
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.965
NOTCH1notch 10.960
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.960
VIMvimentin0.960
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.956
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.955
ICAM1intercellular adhesion molecule 10.951
PTPN6protein tyrosine phosphatase, non-receptor type 60.948
FBLN1fibulin 10.947
FYNFYN oncogene related to SRC, FGR, YES0.945
RUNX1runt-related transcription factor 10.939
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.927
IL6interleukin 6 (interferon, beta 2)0.926
NOTCH3notch 30.918
SOCS3suppressor of cytokine signaling 30.918
TAL1T-cell acute lymphocytic leukemia 10.914
BRCA1breast cancer 1, early onset0.913
PTENphosphatase and tensin homolog0.913
NR4A3nuclear receptor subfamily 4, group A, member 30.910
HDAC2histone deacetylase 20.907
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.904
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.904
RING1ring finger protein 10.904
IL8interleukin 80.902
FGF1fibroblast growth factor 1 (acidic)0.901
SMAD4SMAD family member 40.900
TFDP1transcription factor Dp-10.900
MMP14matrix metallopeptidase 14 (membrane-inserted)0.897
CCR5chemokine (C-C motif) receptor 50.888
PLAURplasminogen activator, urokinase receptor0.885
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.880
POU3F2POU class 3 homeobox 20.877
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.876
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.874
ENGendoglin0.874
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.873
IGF1Rinsulin-like growth factor 1 receptor0.863
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.853
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.851
CCL5chemokine (C-C motif) ligand 50.848
TNFAIP3tumor necrosis factor, alpha-induced protein 30.847
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.846
METmet proto-oncogene (hepatocyte growth factor receptor)0.845
CALM1calmodulin 1 (phosphorylase kinase, delta)0.841
AXLAXL receptor tyrosine kinase0.835
GRB7growth factor receptor-bound protein 70.833
CCNE1cyclin E10.833
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.831
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.826
ARandrogen receptor0.825
CCL22chemokine (C-C motif) ligand 220.823
IRS1insulin receptor substrate 10.822
NR4A1nuclear receptor subfamily 4, group A, member 10.809
RBBP4retinoblastoma binding protein 40.800
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.800
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.799
NCOA6nuclear receptor coactivator 60.797
PLAUplasminogen activator, urokinase0.793
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.792
MAPTmicrotubule-associated protein tau0.790
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.787
CDK1cyclin-dependent kinase 10.782
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.782
TNFtumor necrosis factor0.776
CXCL9chemokine (C-X-C motif) ligand 90.774
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.764
SKP2S-phase kinase-associated protein 2 (p45)0.757
PLCG1phospholipase C, gamma 10.756
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism