The network for 'negative regulation of ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ossification

Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation.

NameDescriptionProbabilityFunc Analog Organism
Nrg1neuregulin 10.050
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.036
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.030
Id1inhibitor of DNA binding 10.027
RhdRh blood group, D antigen0.024
Ccl4chemokine (C-C motif) ligand 40.021
Jak1Janus kinase 10.021
Uoxurate oxidase0.021
Fosl1fos-like antigen 10.020
Id3inhibitor of DNA binding 30.017
Mcammelanoma cell adhesion molecule0.016
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.016
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.016
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.015
Ier5immediate early response 50.015
Slit3slit homolog 3 (Drosophila)0.014
Gzmkgranzyme K0.012
Clec11aC-type lectin domain family 11, member a0.012
Cxcl2chemokine (C-X-C motif) ligand 20.012
Dock6dedicator of cytokinesis 60.011
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.011
Gpr176G protein-coupled receptor 1760.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.985
CCR5chemokine (C-C motif) receptor 50.974
CCL5chemokine (C-C motif) ligand 50.861
CCL4chemokine (C-C motif) ligand 40.836
TAL1T-cell acute lymphocytic leukemia 10.735
CXCL9chemokine (C-X-C motif) ligand 90.542
NCOR2nuclear receptor corepressor 20.525
SKILSKI-like oncogene0.449
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.359
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.349
CCL22chemokine (C-C motif) ligand 220.343
SMAD3SMAD family member 30.259
MEF2Amyocyte enhancer factor 2A0.243
IFNGinterferon, gamma0.232
HDAC4histone deacetylase 40.230
SQSTM1sequestosome 10.221
INSRinsulin receptor0.202
IL2RBinterleukin 2 receptor, beta0.192
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.177
CCL3chemokine (C-C motif) ligand 30.154
JAG1jagged 10.152
CXCL11chemokine (C-X-C motif) ligand 110.142
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.138
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.134
SMAD4SMAD family member 40.134
CCR1chemokine (C-C motif) receptor 10.117
CCR4chemokine (C-C motif) receptor 40.110
MEF2Cmyocyte enhancer factor 2C0.103
CXCR6chemokine (C-X-C motif) receptor 60.095
SIN3ASIN3 homolog A, transcription regulator (yeast)0.089
NCOR1nuclear receptor corepressor 10.086
NEDD4neural precursor cell expressed, developmentally down-regulated 40.085
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.085
HDAC9histone deacetylase 90.084
CCL2chemokine (C-C motif) ligand 20.082
RUNX1runt-related transcription factor 10.082
KLRD1killer cell lectin-like receptor subfamily D, member 10.081
POU5F1POU class 5 homeobox 10.080
CCR7chemokine (C-C motif) receptor 70.078
BCL6B-cell CLL/lymphoma 60.078
EPAS1endothelial PAS domain protein 10.077
CXCR3chemokine (C-X-C motif) receptor 30.075
ING2inhibitor of growth family, member 20.073
CCR2chemokine (C-C motif) receptor 20.072
SMURF2SMAD specific E3 ubiquitin protein ligase 20.071
CCL13chemokine (C-C motif) ligand 130.070
CXCL13chemokine (C-X-C motif) ligand 130.069
SETD8SET domain containing (lysine methyltransferase) 80.067
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.062
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.062
CCND1cyclin D10.062
MAML1mastermind-like 1 (Drosophila)0.058
CCL8chemokine (C-C motif) ligand 80.056
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.056
DPP4dipeptidyl-peptidase 40.053
IL10interleukin 100.052
KDM2Blysine (K)-specific demethylase 2B0.051
SMOsmoothened homolog (Drosophila)0.050
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.050
PCGF1polycomb group ring finger 10.049
NOTCH1notch 10.049
GATA2GATA binding protein 20.046
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.046
SLAMF7SLAM family member 70.044
CCL7chemokine (C-C motif) ligand 70.044
IL16interleukin 16 (lymphocyte chemoattractant factor)0.044
CCL11chemokine (C-C motif) ligand 110.043
EP300E1A binding protein p3000.042
AKT2v-akt murine thymoma viral oncogene homolog 20.042
LTAlymphotoxin alpha (TNF superfamily, member 1)0.041
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein0.040
SPENspen homolog, transcriptional regulator (Drosophila)0.039
VHLvon Hippel-Lindau tumor suppressor0.039
IRF4interferon regulatory factor 40.038
BMP1bone morphogenetic protein 10.038
HIPK3homeodomain interacting protein kinase 30.038
SELLselectin L0.037
IL8interleukin 80.036
TCF12transcription factor 120.036
IL1Binterleukin 1, beta0.035
MYOD1myogenic differentiation 10.035
ARRDC3arrestin domain containing 30.034
CAPRIN2caprin family member 20.034
NR2E3nuclear receptor subfamily 2, group E, member 30.034
MATKmegakaryocyte-associated tyrosine kinase0.034
PRKD2protein kinase D20.033
KLRB1killer cell lectin-like receptor subfamily B, member 10.032
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.032
EGLN1egl nine homolog 1 (C. elegans)0.031
IL1R2interleukin 1 receptor, type II0.031
CREBBPCREB binding protein0.030
IL2RGinterleukin 2 receptor, gamma0.029
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.029
TGFBR1transforming growth factor, beta receptor 10.029
EGLN3egl nine homolog 3 (C. elegans)0.029
FOXP3forkhead box P30.028
SP1Sp1 transcription factor0.028
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Smad6MAD homolog 6 (Drosophila)0.957
Fgfr2fibroblast growth factor receptor 20.948
Mef2dmyocyte enhancer factor 2D0.915
Ctnnb1catenin (cadherin associated protein), beta 10.908
Notch1Notch gene homolog 1 (Drosophila)0.900
Sfrp2secreted frizzled-related protein 20.870
Axin1axin 10.867
Retret proto-oncogene0.854
Ascl1achaete-scute complex homolog 1 (Drosophila)0.798
Smosmoothened homolog (Drosophila)0.747
Hes1hairy and enhancer of split 1 (Drosophila)0.715
Notch3Notch gene homolog 3 (Drosophila)0.714
Map3k14mitogen-activated protein kinase kinase kinase 140.698
Gata4GATA binding protein 40.692
Smad7MAD homolog 7 (Drosophila)0.692
Ptf1apancreas specific transcription factor, 1a0.681
Ltblymphotoxin B0.679
Isl1ISL1 transcription factor, LIM/homeodomain0.617
Fgfr1fibroblast growth factor receptor 10.612
Bcl2B-cell leukemia/lymphoma 20.600
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.587
Gli2GLI-Kruppel family member GLI20.570
Gdnfglial cell line derived neurotrophic factor0.566
Nos3nitric oxide synthase 3, endothelial cell0.559
Sox4SRY-box containing gene 40.529
Pax6paired box gene 60.520
Tcf3transcription factor 30.513
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.513
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.510
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.464
Nf1neurofibromatosis 10.461
Bmpr1abone morphogenetic protein receptor, type 1A0.452
Smad1MAD homolog 1 (Drosophila)0.419
Ptenphosphatase and tensin homolog0.400
Gas1growth arrest specific 10.391
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.389
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.386
Otx2orthodenticle homolog 2 (Drosophila)0.366
Bmp4bone morphogenetic protein 40.362
Neurog2neurogenin 20.357
Pitx1paired-like homeodomain transcription factor 10.352
Tgfb1i1transforming growth factor beta 1 induced transcript 10.347
Hand1heart and neural crest derivatives expressed transcript 10.347
Itgb1integrin beta 1 (fibronectin receptor beta)0.346
Hoxa1homeobox A10.332
Pax3paired box gene 30.324
Ccnd2cyclin D20.322
Pkd1polycystic kidney disease 1 homolog0.321
Tal1T-cell acute lymphocytic leukemia 10.308
Cyldcylindromatosis (turban tumor syndrome)0.307
Hand2heart and neural crest derivatives expressed transcript 20.303
Phox2bpaired-like homeobox 2b0.293
Igfbp5insulin-like growth factor binding protein 50.293
Pcdh12protocadherin 120.287
Tbx3T-box 30.273
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.267
Tcfap2atranscription factor AP-2, alpha0.267
Rnf111ring finger 1110.260
Vegfavascular endothelial growth factor A0.259
Nhlh1nescient helix loop helix 10.244
Fgf8fibroblast growth factor 80.244
Tgfatransforming growth factor alpha0.238
Smad4MAD homolog 4 (Drosophila)0.237
Gata6GATA binding protein 60.236
Shhsonic hedgehog0.230
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.227
Ikzf1IKAROS family zinc finger 10.223
Grb10growth factor receptor bound protein 100.214
Mmp24matrix metallopeptidase 240.214
Hoxb1homeobox B10.213
MecomMDS1 and EVI1 complex locus0.211
Hoxa2homeobox A20.206
Socs1suppressor of cytokine signaling 10.204
Ltalymphotoxin A0.202
Gpr50G-protein-coupled receptor 500.201
Rhbdf1rhomboid family 1 (Drosophila)0.199
Sox11SRY-box containing gene 110.198
Gpc3glypican 30.197
Arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.197
Fn1fibronectin 10.197
Sox7SRY-box containing gene 70.193
Foxf1aforkhead box F1a0.191
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.190
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.189
Tnftumor necrosis factor0.189
Hhexhematopoietically expressed homeobox0.188
Smad3MAD homolog 3 (Drosophila)0.186
Fzd2frizzled homolog 2 (Drosophila)0.184
Edarectodysplasin-A receptor0.183
Trp53transformation related protein 530.182
Efsembryonal Fyn-associated substrate0.180
Phox2apaired-like homeobox 2a0.177
Ror2receptor tyrosine kinase-like orphan receptor 20.175
Dll1delta-like 1 (Drosophila)0.174
Zfp36l1zinc finger protein 36, C3H type-like 10.174
Lef1lymphoid enhancer binding factor 10.174
Gli3GLI-Kruppel family member GLI30.173
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.171
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.170
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism