The network for 'glucose metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glucose metabolic process

The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.

NameDescriptionProbabilityFunc Analog Organism
Ldhalactate dehydrogenase A0.931
Pkm2pyruvate kinase, muscle0.634
Eno1enolase 1, (alpha)0.482
Tpi1triosephosphate isomerase 10.482
Gpiglucose phosphate isomerase0.453
Aldoaaldolase A, fructose-bisphosphate0.418
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.377
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.268
DbpD site of albumin promoter (albumin D-box) binding protein0.189
Pgam1phosphoglycerate mutase 1 (brain)0.167
Mifmacrophage migration inhibitory factor0.125
Eef2eukaryotic translation elongation factor 20.122
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.122
Ldhdlactate dehydrogenase D0.117
Pgm1phosphoglucomutase 10.111
Pfkmphosphofructokinase, muscle0.099
Pgk1phosphoglycerate kinase 10.089
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.087
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.083
Tkttransketolase0.076
Ly6allymphocyte antigen 6 complex, locus A-like0.076
Nr1d2nuclear receptor subfamily 1, group D, member 20.074
Serinc1serine incorporator 10.061
Pygmphosphorylase, glycogen, muscle0.059
MlxiplMLX interacting protein-like0.059
Hist1h2bahistone cluster 1, H2ba0.058
Ccnd3cyclin D30.058
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.057
Ccl3chemokine (C-C motif) ligand 30.056
Ak1adenylate kinase 10.054
Nfianuclear factor I/A0.051
Nr1h4nuclear receptor subfamily 1, group H, member 40.051
Fitm1fat storage-inducing transmembrane protein 10.049
A1cfAPOBEC1 complementation factor0.048
Metmet proto-oncogene0.048
Acadsacyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain0.048
Acot2acyl-CoA thioesterase 20.048
Impdh2IMP (inosine monophosphate) dehydrogenase 20.047
Irs3insulin receptor substrate 30.047
G6pcglucose-6-phosphatase, catalytic subunit0.047
Ubtfupstream binding transcription factor, RNA polymerase I0.047
Mosc1MOCO sulphurase C-terminal domain containing 10.047
Gse1genetic suppressor element 10.046
Aldobaldolase B, fructose-bisphosphate0.046
Casp2caspase 20.044
Faahfatty acid amide hydrolase0.044
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.043
Il6interleukin 60.043
Rpl3lribosomal protein L3-like0.042
Ss18l1synovial sarcoma translocation gene on chromosome 18-like 10.041
JunJun oncogene0.041
Etfdhelectron-transferring-flavoprotein dehydrogenase0.039
Apoa4apolipoprotein A-IV0.039
Foxo1forkhead box O10.039
Dckdeoxycytidine kinase0.039
Foxa3forkhead box A30.037
Asphaspartate-beta-hydroxylase0.037
Gcgrglucagon receptor0.036
Slc25a42solute carrier family 25, member 420.035
Ptprsprotein tyrosine phosphatase, receptor type, S0.035
Hand2heart and neural crest derivatives expressed 20.035
Espnespin0.035
Smad3SMAD family member 30.035
Obp3alpha-2u globulin PGCL40.035
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.034
Slc37a4solute carrier family 37 (glucose-6-phosphate transporter), member 40.033
Dakdihydroxyacetone kinase 2 homolog (S. cerevisiae)0.032
Ccl20chemokine (C-C motif) ligand 200.032
Hmox1heme oxygenase (decycling) 10.032
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.031
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.031
Aco2aconitase 2, mitochondrial0.031
Cskc-src tyrosine kinase0.031
Lypla1lysophospholipase 10.031
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.030
Macrod1MACRO domain containing 10.030
Nup153nucleoporin 1530.030
Ptpn6protein tyrosine phosphatase, non-receptor type 60.030
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.030
Grinl1aglutamate receptor, ionotropic, N-methyl D-aspartate-like 1A0.029
Ghrgrowth hormone receptor0.029
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.029
Uba3ubiquitin-like modifier activating enzyme 30.029
Btg2BTG family, member 20.029
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.029
Rab1bRAB1B, member RAS oncogene family0.028
Aesamino-terminal enhancer of split0.028
Mylk2myosin light chain kinase 20.027
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.027
Mgat2mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.027
RGD1566085similar to pyridoxal (pyridoxine, vitamin B6) kinase0.027
Syngr2synaptogyrin 20.027
Acot12acyl-CoA thioesterase 120.027
Bmpr1abone morphogenetic protein receptor, type IA0.027
Errfi1ERBB receptor feedback inhibitor 10.027
Tubg1tubulin, gamma 10.027
Stat5bsignal transducer and activator of transcription 5B0.027
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.027
Fut1fucosyltransferase 10.027
Phka1phosphorylase kinase, alpha 10.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PgkPhosphoglycerate kinase0.062
GpdhGlycerol 3 phosphate dehydrogenase0.044
PgmPhosphogluconate mutase0.040
Got2Glutamate oxaloacetate transaminase 20.031
TpiTriose phosphate isomerase0.025
PgiPhosphoglucose isomerase0.019
IdhIsocitrate dehydrogenase0.018
GlyPGlycogen phosphorylase0.017
PyKPyruvate kinase0.017
CG7920CG7920 gene product from transcript CG7920-RA0.016
PgdPhosphogluconate dehydrogenase0.014
ThorCG8846 gene product from transcript CG8846-RA0.013
hephemipterous0.012
CG7998CG7998 gene product from transcript CG7998-RA0.012
MenMalic enzyme0.012
CG5362CG5362 gene product from transcript CG5362-RA0.012
EnoEnolase0.011
InRInsulin-like receptor0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
INSRinsulin receptor0.992
CREBBPCREB binding protein0.958
ESR1estrogen receptor 10.905
IRS1insulin receptor substrate 10.833
ARandrogen receptor0.608
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.559
NCOA1nuclear receptor coactivator 10.480
IRS2insulin receptor substrate 20.420
ENO2enolase 2 (gamma, neuronal)0.410
PGK1phosphoglycerate kinase 10.380
GRB10growth factor receptor-bound protein 100.340
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.321
RXRAretinoid X receptor, alpha0.320
SMAD3SMAD family member 30.305
PTPN1protein tyrosine phosphatase, non-receptor type 10.288
NR0B1nuclear receptor subfamily 0, group B, member 10.286
EGFRepidermal growth factor receptor0.233
C1QAcomplement component 1, q subcomponent, A chain0.221
LIN7Blin-7 homolog B (C. elegans)0.216
KAT2BK(lysine) acetyltransferase 2B0.204
EP300E1A binding protein p3000.203
TADA3transcriptional adaptor 30.188
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.178
PPP4R2protein phosphatase 4, regulatory subunit 20.173
GHRgrowth hormone receptor0.163
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.160
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.157
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.150
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.145
SQSTM1sequestosome 10.133
CREB1cAMP responsive element binding protein 10.133
ACACAacetyl-CoA carboxylase alpha0.128
HNF4Ahepatocyte nuclear factor 4, alpha0.119
MDM2Mdm2 p53 binding protein homolog (mouse)0.118
NOXA1NADPH oxidase activator 10.109
HK1hexokinase 10.108
ISG15ISG15 ubiquitin-like modifier0.107
IFI27interferon, alpha-inducible protein 270.107
DCAF7DDB1 and CUL4 associated factor 70.105
IGF1Rinsulin-like growth factor 1 receptor0.103
NCOA6nuclear receptor coactivator 60.099
PDPK13-phosphoinositide dependent protein kinase-10.093
RARAretinoic acid receptor, alpha0.091
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.084
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.080
NCF1neutrophil cytosolic factor 10.080
SH2B1SH2B adaptor protein 10.079
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.077
FHL2four and a half LIM domains 20.076
GPIglucose-6-phosphate isomerase0.075
GSK3Bglycogen synthase kinase 3 beta0.074
ALDOAaldolase A, fructose-bisphosphate0.074
IFI44Linterferon-induced protein 44-like0.073
TRRAPtransformation/transcription domain-associated protein0.072
SORBS3sorbin and SH3 domain containing 30.071
BADBCL2-associated agonist of cell death0.070
NCOR2nuclear receptor corepressor 20.069
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.069
IFI44interferon-induced protein 440.069
CREBZFCREB/ATF bZIP transcription factor0.067
TTRtransthyretin0.067
IFI6interferon, alpha-inducible protein 60.066
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.066
LCKlymphocyte-specific protein tyrosine kinase0.065
NR0B2nuclear receptor subfamily 0, group B, member 20.064
TRIB3tribbles homolog 3 (Drosophila)0.064
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.059
IFIT3interferon-induced protein with tetratricopeptide repeats 30.059
HIPK2homeodomain interacting protein kinase 20.058
FOXO1forkhead box O10.058
MX2myxovirus (influenza virus) resistance 2 (mouse)0.057
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.057
HSPB1heat shock 27kDa protein 10.056
SEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.056
SIRT1sirtuin 10.053
ZNF746zinc finger protein 7460.049
PINK1PTEN induced putative kinase 10.048
SLC35A3solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A30.047
SORBS1sorbin and SH3 domain containing 10.047
CCDC101coiled-coil domain containing 1010.046
C1QBcomplement component 1, q subcomponent, B chain0.045
TKTtransketolase0.045
C5orf41chromosome 5 open reading frame 410.044
IFIT1interferon-induced protein with tetratricopeptide repeats 10.043
RSAD2radical S-adenosyl methionine domain containing 20.042
TRIM23tripartite motif containing 230.042
PROX1prospero homeobox 10.041
IRF7interferon regulatory factor 70.041
IFIT2interferon-induced protein with tetratricopeptide repeats 20.040
FOXO3forkhead box O30.039
PPARGperoxisome proliferator-activated receptor gamma0.039
USP18ubiquitin specific peptidase 180.039
EPSTI1epithelial stromal interaction 1 (breast)0.038
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.038
ATXN7ataxin 70.038
SYKspleen tyrosine kinase0.037
BST2bone marrow stromal cell antigen 20.037
ATF3activating transcription factor 30.037
DUSP5dual specificity phosphatase 50.037
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.036
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.993
Insrinsulin receptor0.982
Lepleptin0.981
Arntlaryl hydrocarbon receptor nuclear translocator-like0.977
Ppargperoxisome proliferator activated receptor gamma0.970
Clockcircadian locomotor output cycles kaput0.967
Per2period homolog 2 (Drosophila)0.967
Esr1estrogen receptor 1 (alpha)0.959
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.936
Cry2cryptochrome 2 (photolyase-like)0.925
Ins2insulin II0.891
Nos1nitric oxide synthase 1, neuronal0.842
Npy1rneuropeptide Y receptor Y10.818
Igf1rinsulin-like growth factor I receptor0.793
Irs2insulin receptor substrate 20.782
Prlrprolactin receptor0.731
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.701
Onecut1one cut domain, family member 10.694
Ren1renin 1 structural0.682
Atf2activating transcription factor 20.670
JunJun oncogene0.655
Nr3c1nuclear receptor subfamily 3, group C, member 10.624
Ptenphosphatase and tensin homolog0.611
Irs1insulin receptor substrate 10.589
Clk4CDC like kinase 40.584
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.565
Npy2rneuropeptide Y receptor Y20.564
Pdx1pancreatic and duodenal homeobox 10.563
Stat5asignal transducer and activator of transcription 5A0.548
Drd2dopamine receptor D20.540
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.528
Mup5major urinary protein 50.521
Clk1CDC-like kinase 10.512
Mapk14mitogen-activated protein kinase 140.472
Pim1proviral integration site 10.455
Agrpagouti related protein0.443
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.435
Kiss1rKISS1 receptor0.434
Grid2glutamate receptor, ionotropic, delta 20.430
Ldhalactate dehydrogenase A0.420
Klklotho0.411
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.408
Ccnl2cyclin L20.398
Prkceprotein kinase C, epsilon0.392
Pnpla2patatin-like phospholipase domain containing 20.392
Thrbthyroid hormone receptor beta0.387
Per1period homolog 1 (Drosophila)0.376
Igf2insulin-like growth factor 20.375
Atxn1ataxin 10.367
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.361
Cdkn1bcyclin-dependent kinase inhibitor 1B0.361
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.357
Lipelipase, hormone sensitive0.355
Mup10major urinary protein 100.354
LOC100048884novel member of the major urinary protein (Mup) gene family0.354
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.347
Hnf4ahepatic nuclear factor 4, alpha0.346
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.344
Gpi1glucose phosphate isomerase 10.343
Nr1h4nuclear receptor subfamily 1, group H, member 40.332
Trib3tribbles homolog 3 (Drosophila)0.309
Tbrachyury0.287
Hif1ahypoxia inducible factor 1, alpha subunit0.277
Mup4major urinary protein 40.274
Ulk1Unc-51 like kinase 1 (C. elegans)0.268
Crhr1corticotropin releasing hormone receptor 10.262
Ccnt2cyclin T20.255
Fgf5fibroblast growth factor 50.252
FosFBJ osteosarcoma oncogene0.251
Pomcpro-opiomelanocortin-alpha0.251
Grb10growth factor receptor bound protein 100.245
Cry1cryptochrome 1 (photolyase-like)0.242
Cckbrcholecystokinin B receptor0.240
Toxthymocyte selection-associated high mobility group box0.239
Igf1insulin-like growth factor 10.236
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.236
Gckglucokinase0.231
Lmx1bLIM homeobox transcription factor 1 beta0.220
Vegfavascular endothelial growth factor A0.219
F2coagulation factor II0.217
Nfil3nuclear factor, interleukin 3, regulated0.215
Dsg4desmoglein 40.215
Ighimmunoglobulin heavy chain complex0.215
Ep300E1A binding protein p3000.213
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.213
Otporthopedia homolog (Drosophila)0.212
Il9interleukin 90.207
Il7interleukin 70.203
Ambpalpha 1 microglobulin/bikunin0.200
Bcl2B-cell leukemia/lymphoma 20.199
Mup19major urinary protein 190.197
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.192
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.185
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.184
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.183
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.181
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.180
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.179
Socs1suppressor of cytokine signaling 10.177
Lmx1aLIM homeobox transcription factor 1 alpha0.176
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ADH1Adh1p0.964
ENO2Eno2p0.918
FBA1Fba1p0.916
PDC1Pdc1p0.911
FYV10Fyv10p0.889
ENO1Eno1p0.887
CAK1Cak1p0.856
GND1Gnd1p0.856
PGK1Pgk1p0.834
UGP1Ugp1p0.810
TDH2Tdh2p0.801
GID8Gid8p0.778
GND2Gnd2p0.728
ERR3Err3p0.725
WWM1Wwm1p0.655
ALD6Ald6p0.652
MOH1Moh1p0.646
GPM1Gpm1p0.630
TPI1Tpi1p0.569
TDH1Tdh1p0.567
GAL83Gal83p0.565
TDH3Tdh3p0.466
PFK1Pfk1p0.433
GID7Gid7p0.420
CAT8Cat8p0.381
GIP2Gip2p0.355
TAL1Tal1p0.342
HXK2Hxk2p0.334
NDE2Nde2p0.319
HOP1Hop1p0.319
PYC2Pyc2p0.298
PGI1Pgi1p0.277
SDS24Sds24p0.258
RRD1Rrd1p0.251
SIP1Sip1p0.229
RMD5Rmd5p0.215
MLS1Mls1p0.203
ADH3Adh3p0.201
PIG2Pig2p0.198
RDS2Rds2p0.197
ROD1Rod1p0.195
GSY2Gsy2p0.190
PGM2Pgm2p0.188
YAP6Yap6p0.187
VID30Vid30p0.186
PDI1Pdi1p0.185
PCL10Pcl10p0.181
GPH1Gph1p0.175
VID28Vid28p0.173
BBC1Bbc1p0.173
PYC1Pyc1p0.171
MVD1Mvd1p0.171
TMA10Tma10p0.160
CDC19Cdc19p0.158
BDH1Bdh1p0.152
PCH2Pch2p0.151
ZWF1Zwf1p0.150
REG1Reg1p0.141
YLR345Whypothetical protein0.140
PCL9Pcl9p0.138
CMK2Cmk2p0.134
CIT2Cit2p0.134
SWE1Swe1p0.120
SPE3Spe3p0.117
PFK2Pfk2p0.117
MDH2Mdh2p0.116
MBR1Mbr1p0.115
YLR177Whypothetical protein0.113
SSH4Ssh4p0.112
GDB1Gdb1p0.111
GPM2Gpm2p0.110
AZF1Azf1p0.109
ICL1Icl1p0.109
SNF1Snf1p0.108
YEL023Chypothetical protein0.107
TRR1Trr1p0.100
GSY1Gsy1p0.100
SSA4Ssa4p0.097
SPO1Spo1p0.097
NCE103Nce103p0.097
YLR257Whypothetical protein0.095
SOL1Sol1p0.094
RGC1Rgc1p0.093
HUG1Hug1p0.093
RED1Red1p0.092
GAC1Gac1p0.091
PHO81Pho81p0.089
YMR210Whypothetical protein0.088
CLB6Clb6p0.087
ALD4Ald4p0.086
ERT1Ert1p0.086
PSK1Psk1p0.081
YCL042Whypothetical protein0.080
GAL7Gal7p0.079
KIC1Kic1p0.077
RCK1Rck1p0.077
SAP4Sap4p0.076
ALD2Ald2p0.076
PET9Pet9p0.076
THO2Tho2p0.075