The network for 'acetylcholine secretion neurotransmission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

acetylcholine secretion neurotransmission

The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS).

NameDescriptionProbabilityFunc Analog Organism
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.036
Syt7synaptotagmin VII0.034
Hpcal4hippocalcin-like 40.028
Adora1adenosine A1 receptor0.028
Strnstriatin, calmodulin binding protein0.024
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.024
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.022
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.021
Begainbrain-enriched guanylate kinase-associated0.019
Fgfr2fibroblast growth factor receptor 20.018
Itgamintegrin, alpha M0.017
Calcrlcalcitonin receptor-like0.017
Cx3cr1chemokine (C-X3-C motif) receptor 10.016
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.016
Orm1orosomucoid 10.015
Drd2dopamine receptor D20.014
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.014
Tacr1tachykinin receptor 10.014
Hand1heart and neural crest derivatives expressed 10.013
Unc5aunc-5 homolog A (C. elegans)0.013
Ptafrplatelet-activating factor receptor0.013
Tnrtenascin R0.012
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.012
Uhmk1U2AF homology motif (UHM) kinase 10.012
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.012
St8sia1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 10.011
Spink3serine peptidase inhibitor, Kazal type 30.011
Grm6glutamate receptor, metabotropic 60.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F32B5.7Protein F32B5.70.016
itr-1Protein ITR-10.013
gpb-1Protein GPB-10.013
gar-2Protein GAR-20.012
egl-8Protein EGL-80.012
pgal-1Protein PGAL-10.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 41.000
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.996
Drd2dopamine receptor D20.923
Thrbthyroid hormone receptor beta0.893
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.868
Thrathyroid hormone receptor alpha0.785
Chrna9cholinergic receptor, nicotinic, alpha polypeptide 90.669
Ryr1ryanodine receptor 1, skeletal muscle0.500
Tbpl2TATA box binding protein like 20.459
Rapsnreceptor-associated protein of the synapse0.414
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.375
Has1hyaluronan synthase10.372
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.340
Rac1RAS-related C3 botulinum substrate 10.339
Duox2dual oxidase 20.320
Cacng1calcium channel, voltage-dependent, gamma subunit 10.319
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.317
En2engrailed 20.310
Chrna10cholinergic receptor, nicotinic, alpha polypeptide 100.303
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.302
Chrngcholinergic receptor, nicotinic, gamma polypeptide0.271
Mybphmyosin binding protein H0.261
Tshrthyroid stimulating hormone receptor0.253
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.229
Hcn3hyperpolarization-activated, cyclic nucleotide-gated K+ 30.225
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.224
Aff2AF4/FMR2 family, member 20.216
Wdr1WD repeat domain 10.206
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.205
Pax8paired box gene 80.200
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.191
Kcnk4potassium channel, subfamily K, member 40.173
Lpar5lysophosphatidic acid receptor 50.172
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.167
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.167
Smyd1SET and MYND domain containing 10.166
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.163
Gprin1G protein-regulated inducer of neurite outgrowth 10.154
Tpothyroid peroxidase0.152
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.150
Homer1homer homolog 1 (Drosophila)0.144
Myf6myogenic factor 60.143
Neurod1neurogenic differentiation 10.139
Fitm1fat storage-inducing transmembrane protein 10.138
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.136
Cgaglycoprotein hormones, alpha subunit0.136
Dynlt1bdynein light chain Tctex-type 1D0.131
Thbs2thrombospondin 20.126
Mas1MAS1 oncogene0.125
Slc17a8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 80.123
Gzmmgranzyme M (lymphocyte met-ase 1)0.122
Adcy4adenylate cyclase 40.116
Psapl1prosaposin-like 10.114
Muskmuscle, skeletal, receptor tyrosine kinase0.105
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.105
Art5ADP-ribosyltransferase 50.102
Myod1myogenic differentiation 10.102
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.102
CblCasitas B-lineage lymphoma0.101
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.101
Isl2insulin related protein 2 (islet 2)0.101
Grem1gremlin 10.100
Vipvasoactive intestinal polypeptide0.098
Tnnt3troponin T3, skeletal, fast0.093
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.090
Ryr2ryanodine receptor 2, cardiac0.090
Ascl1achaete-scute complex homolog 1 (Drosophila)0.089
Cav1caveolin 1, caveolae protein0.089
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.089
Adarb2adenosine deaminase, RNA-specific, B20.085
Prodh2proline dehydrogenase (oxidase) 20.085
Prph2peripherin 20.084
Gnb3guanine nucleotide binding protein (G protein), beta 30.082
Itpr1inositol 1,4,5-trisphosphate receptor 10.080
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.080
Scn8asodium channel, voltage-gated, type VIII, alpha0.079
Ebf3early B-cell factor 30.079
Dccdeleted in colorectal carcinoma0.078
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.077
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.077
Kif5akinesin family member 5A0.076
Aipl1aryl hydrocarbon receptor-interacting protein-like 10.075
Alox12earachidonate lipoxygenase, epidermal0.075
Nell2NEL-like 2 (chicken)0.075
Neurog2neurogenin 20.074
Pramel7preferentially expressed antigen in melanoma like 70.073
Dnajb5DnaJ (Hsp40) homolog, subfamily B, member 50.072
Lcn8lipocalin 80.071
Cdkn1bcyclin-dependent kinase inhibitor 1B0.070
Clcn1chloride channel 10.069
Pde6cphosphodiesterase 6C, cGMP specific, cone, alpha prime0.069
Sfrp4secreted frizzled-related protein 40.069
Sagretinal S-antigen0.069
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism